Archives of gerontology and geriatrics最新文献

{"title":"Comparative associations of height- and body mass index-adjusted muscle mass with sarcopenia under the Asian Working Group for Sarcopenia 2025 consensus","authors":"Daijo Shiratsuchi , Hyuma Makizako , Kento Tabira , Yuto Miyake , Takuro Kubozono , Mitsuru Ohishi","doi":"10.1016/j.archger.2026.106153","DOIUrl":"10.1016/j.archger.2026.106153","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106153"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting dementia risk: Discrimination accuracy of the NCGG–FAT","authors":"Osamu Katayama ,&nbsp;Ryo Yamaguchi ,&nbsp;Daiki Yamagiwa ,&nbsp;Shoma Akaida ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2026.106150","DOIUrl":"10.1016/j.archger.2026.106150","url":null,"abstract":"<div><h3>Objective</h3><div>Early detection of mild cognitive impairment (MCI) is essential for dementia prevention. We developed the National Center for Geriatrics and Gerontology–Functional Assessment Tool (NCGG-FAT) using age- and education-adjusted norms with a 1.5 standard deviation (SD) cutoff. This study examined the associations between cognitive domains assessed by the NCGG-FAT and incident dementia using the existing and expanded databases.</div></div><div><h3>Method</h3><div>A 5-year prospective cohort of 2,441 participants without dementia at baseline was analyzed. Hazard ratios (HRs) and 95% confidence intervals (CIs) for individual cognitive tests and cognitive states (normal cognition, MCI, and global cognitive impairment) were estimated using Cox proportional hazards models. Competing risk of death was addressed using Fine–Gray models. Predictive models for dementia were also developed and validated.</div></div><div><h3>Results</h3><div>In the expanded database, declines ≥1.5 SD in word list memory, TMT-B, forward and backward digit span, and SDST were significantly associated with dementia onset (HRs 1.77–3.22). Fine–Gray analyses yielded similar results. For cognitive states, amnestic and non-amnestic MCI, particularly moderate subtypes, and global cognitive impairment showed elevated risks (HRs 1.55–2.92), although some associations lost significance after accounting for competing mortality. The NCGG-FAT composite score demonstrated high discrimination for incident dementia (AUC = 0.96; accuracy = 0.95).</div></div><div><h3>Conclusion</h3><div>The expanded NCGG-FAT database is a useful auxiliary tool for assessing future dementia risk in community-dwelling older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106150"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What matters most to older adults? A systematic review of preferences for socially assistive robots","authors":"Jing Wu,&nbsp;Jixia Cao,&nbsp;Pingshuang Li,&nbsp;Can Yang,&nbsp;Ying He","doi":"10.1016/j.archger.2026.106139","DOIUrl":"10.1016/j.archger.2026.106139","url":null,"abstract":"<div><h3>Background</h3><div>The current level of social acceptance of socially assistive robots (SARs) remains limited. Research on user preferences plays an essential role in improving the acceptance of SARs among older adults. This study aimed to integrate evidence on older adults’ preferences for SARs to provide personalized guidance and establish a foundation for their future use in home care environments.</div></div><div><h3>Methods</h3><div>We searched 7 databases to find any studies designed to focus on the preferences of older adults for SARs. The quality of the included studies was assessed using the Mixed Methods Appraisal Tool (MMAT).</div></div><div><h3>Results</h3><div>A total of 21 studies were included. Although studies on older adults’ preferences for SARs varied considerably in design and scope, several consistent patterns emerged: (1) older adults preferred SARs that assist with household tasks; (2) they favored voice-based interaction; (3) they preferred human-like appearances; (4) their preferences regarding privacy, data storage, control, autonomy, and emotional or social interaction; and (5) most viewed SARs as assistants or companions.</div></div><div><h3>Conclusion</h3><div>This review highlights the diversity of older adults’ preferences for SARs, including service functions, communication, appearance, and ethical considerations. Future research should address these preferences to promote acceptance and support the integration of socially assistive robots into home care settings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106139"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and external validation of a mortality prediction model for community-dwelling adults aged ≥50 years with frailty or pre-frailty","authors":"Kang Fu ,&nbsp;Ruizhe Chen ,&nbsp;Shuwen Li ,&nbsp;Yu Zhang ,&nbsp;Kailu Fang ,&nbsp;Luyan Zheng ,&nbsp;Yushi Lin ,&nbsp;Lanjuan Li ,&nbsp;Jie Wu","doi":"10.1016/j.archger.2026.106143","DOIUrl":"10.1016/j.archger.2026.106143","url":null,"abstract":"<div><h3>Background</h3><div>Frailty and pre-frailty raise mortality risk in older adults, yet clinicians lack tailored prognostic tools. We developed and externally validated a model predicting all-cause mortality in community-dwelling adults aged ≥50 years with frailty or pre-frailty.</div></div><div><h3>Methods</h3><div>Using SHARE 2006–07 data (<em>n</em> = 15,195), we fitted a Cox model with backward selection and multiple imputation. Predictors spanned demographics, lifestyle, ADL/IADL limitations, mobility, pain and key comorbidities. We assessed discrimination by integrated and time-specific AUCs and calibration by comparing predicted versus observed mortality. External validation occurred in ELSA (<em>n</em> = 4464) and HRS (<em>n</em> = 7414).</div></div><div><h3>Results</h3><div>Within the SHARE cohort (61.0% female; median follow-up 3.8 years), 18.5% (<em>n</em> = 2811) of participants died. The final model incorporated age, sex, BMI, smoking status, IADL limitations, mobility impairments, physical activity, pain, and major comorbidities. Internal validation demonstrated robust discrimination (optimism-corrected iAUC 0.81, 95% CI 0.79–0.82), with sustained accuracy at 1-, 5-, and 7-year intervals (AUCs 0.80–0.83). External validation in ELSA (iAUC 0.83) and HRS (iAUC 0.82) confirmed strong generalizability, alongside excellent calibration across all time points.</div></div><div><h3>Conclusions</h3><div>We present a rigorously validated prognostic model for mortality in frail and pre-frail older adults, demonstrating high accuracy and clinical utility. By providing personalized risk estimates, this tool can enhance shared decision-making, optimize care planning, and improve outcomes for a growing at-risk population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106143"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature-based approaches to dementia, cognitive impairment, and caregiver well-being: A scoping review of gardening and therapeutic strategies","authors":"Mary Dioise Ramos,&nbsp;Marcy Purnell,&nbsp;Jolie Harris,&nbsp;Gloria Giarratano","doi":"10.1016/j.archger.2026.106152","DOIUrl":"10.1016/j.archger.2026.106152","url":null,"abstract":"<div><h3>Background</h3><div>Dementia is a growing global health concern, with behavioral and psychological symptoms (BPSD) contributing significantly to diminished quality of life and caregiver burden. Non-pharmacological interventions, such as gardening and nature-based therapies, are increasingly recognized for their therapeutic potential.</div></div><div><h3>Objectives</h3><div>This scoping review aimed to: (1) map existing evidence on gardening and garden-based interventions for individuals with dementia; (2) assess impacts on caregivers; (3) identify mechanisms of benefit; and (4) summarize effective design and implementation strategies.</div></div><div><h3>Methods</h3><div>Following Joanna Briggs Institute methodology and PRISMA-ScR guidelines, a comprehensive search was conducted across five databases. Studies were screened using Covidence. Inclusion criteria encompassed peer-reviewed studies where gardening was the primary intervention for people with dementia or their caregivers. Thirty-two studies were included, spanning qualitative, quantitative, mixed-methods, and review designs.</div></div><div><h3>Results</h3><div>Gardening interventions consistently improved psychosocial well-being, mood, and reduced BPSD. Evidence for cognitive benefits was mixed, with stronger support for preventive effects. Caregivers experienced reduced psychological distress and enhanced social support. Mechanisms of benefit included engagement, purpose, identity reinforcement, and sensory stimulation. Effective interventions emphasized active participation, co-design, and integration into routine care. Barriers included staff risk aversion, limited access, and environmental constraints.</div></div><div><h3>Conclusions</h3><div>Gardening and garden-based interventions offer flexible, person-centered strategies to enhance well-being in dementia care. Their success depends on meaningful engagement, supportive design, and organizational commitment. Future research should standardize outcomes, explore caregiver-focused models, and assess economic impact.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106152"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and cross-country inequalities in the global burden of environmental heat and cold exposure among the elderly population from 1990 to 2021: A population-based study","authors":"Shenghao Xu ,&nbsp;Haoyu Li ,&nbsp;Jianlin Xiao","doi":"10.1016/j.archger.2026.106148","DOIUrl":"10.1016/j.archger.2026.106148","url":null,"abstract":"<div><h3>Background</h3><div>Against the backdrop of rapid climate change, environmental heat and cold exposure (EHCE) represents a leading cause of mortality among older adults globally.</div></div><div><h3>Methods</h3><div>This study, based on data from the Global Burden of Disease Study 2021, analyzed the age-standardized incidence (ASIR), prevalence (ASPR), deaths (ASDR), and disability-adjusted life years (DALYs) rates of EHCE among the elderly population and evaluated the temporal trends of the burden, driving factors, and the effects of age, period, and cohort on the burden. Additionally, the slope index of inequality and concentration index were used to evaluate cross-country disparities.</div></div><div><h3>Results</h3><div>Although the ASIR and ASPR decreased by –1.47 % and –1.33 %, respectively, the total number of cases significantly increased. In 2021, the ASPR was 413.24 (95 % uncertainty interval [UI]: 362.36 to 475.62), with a total of 4,427,518.39 cases (95 % UI: 3,879,450.57 to 5,101,795.26), an increase of 52.48 % compared to 1990. At the regional level, Eastern Europe had the highest ASPR, at 1,233.25 (95 % UI: 1,060.62 to 1,428.94). Age had a significant positive impact on the EHCE burden, with the highest risk among individuals aged 95 and older. Decomposition analysis indicated that population growth was the primary driver of increased burden, while epidemiological changes significantly reduced it. Health inequality analysis revealed that the EHCE burden is concentrated in high SDI countries; although absolute inequality has decreased, relative inequality is still increasing.</div></div><div><h3>Conclusion</h3><div>This study underscores the necessity of developing interventions targeted at the elderly population and strengthening global cooperation to address climate change.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106148"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping assistive technologies along the progression of Alzheimer's disease: A scoping review","authors":"Nadia Mirjan ,&nbsp;Aleksandra Zecevic ,&nbsp;Leena Shoemaker","doi":"10.1016/j.archger.2026.106142","DOIUrl":"10.1016/j.archger.2026.106142","url":null,"abstract":"<div><h3>Background and objectives</h3><div>A growing population of people living with Alzheimer’s Disease requires improved supports for aging in place. Assistive technologies (ATs) can delay institutionalization, reduce care partner strain, and improve quality of life for this population. The abilities and needs of this population change during disease progression, but it remains unclear which ATs are best suited for specific stages. The purpose of this scoping review was to provide a snapshot in time by mapping currently available ATs assessed in peer-reviewed research, across the seven stages of Alzheimer’s Disease progression.</div></div><div><h3>Research design and methods</h3><div>The review followed the Arksey and O’Malley framework to identify and harvest information from Medline, Scopus, CINAHL, and Embase databases. Inclusion criteria were Alzheimer’s Disease, technology interventions of any type and duration, English language, and the period between 2000 and 2023. Data was extracted and analyzed using six predetermined domains of ATs for dementia: safety devices, clinical devices, memory aids, ATs for preventing social isolation, ATs for leisure activities, and ATs for supporting everyday tasks.</div></div><div><h3>Results</h3><div>A total of 87 ATs, reported in 47 articles, were mapped along seven stages of the disease. A variety of ATs are available, with high technology (e.g., tracking devices) targeting initial stages, and low technology (e.g., weighted blanket) targeting later stages. Music therapies were present across all disease stages.</div></div><div><h3>Discussion and implications</h3><div>The map has the potential to inform people with Alzheimer’s Disease, care partners, technology companies, policy makers and service providers on current AT availability and need for further development.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106142"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a 90-day complication prediction model for geriatric orthopedic surgery: A multicenter prospective study","authors":"Doudou Li ,&nbsp;Yanmei Ning ,&nbsp;Ting Zhang ,&nbsp;Xinwen Liu ,&nbsp;Jiawen Yu ,&nbsp;Guanghui Chen ,&nbsp;Ronghui Wang ,&nbsp;Jiana Shi ,&nbsp;Ying Hu","doi":"10.1016/j.archger.2026.106163","DOIUrl":"10.1016/j.archger.2026.106163","url":null,"abstract":"<div><h3>Background</h3><div>With the aging population, the demand for geriatric orthopedic surgery is increasing, and the rate of postoperative complications is escalating. This study aimed to construct a prediction model based on geriatric comprehensive assessment data and potential risk factors for surgery to assess the risk of complications in older patients within three months after various surgical procedures.</div></div><div><h3>Methods</h3><div>Using a prospective cohort design, we split a central dataset (7:3 ratio) into training and internal validation sets. We identified relevant variables using LASSO regression and built predictive models using logistic regression. External validation was performed using data from four other centers. Performance was evaluated by AUC, calibration plots, and DCA, and a Shiny web calculator was subsequently deployed.</div></div><div><h3>Results</h3><div>The study incorporated six variables related to frailty, nutrition, ADL, anesthesia modality, surgery complexity, and operation duration for modeling. To validate the model, we employed data from the training and validation sets independently. The AUC of the nomogram model based on the training set was 0.816 (95% CI: 0.769-0.863), and the AUC based on the internal validation set was 0.791 (95% CI: 0.716-0.866); the AUC for external validation was 0.789 (95% CI: 0.710-0.868). All calibration and DCA curves demonstrated good predictive performance.</div></div><div><h3>Conclusions</h3><div>The predictive model effectively identifies the risk of postoperative complications within three months in older individuals undergoing orthopedic surgery, aiding preoperative risk assessment and patient management to enhance clinical decision-making and improve patient outcomes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106163"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative multicomponent exercise rehabilitation for frail elderly patients undergoing surgical procedures: A systematic review and meta-analysis","authors":"Xiaoqing Xie ,&nbsp;Lanping Lei ,&nbsp;Yuan Zhan ,&nbsp;Caiyun He","doi":"10.1016/j.archger.2025.106127","DOIUrl":"10.1016/j.archger.2025.106127","url":null,"abstract":"<div><h3>Background</h3><div>Frailty among elderly patients undergoing surgical procedures constitutes a notable risk factor for adverse postoperative outcomes. Perioperative multicomponent exercise rehabilitation presents a promising strategy; however, its overall efficacy is still uncertain. This systematic review aimed to assess the effects of these programs on frail elderly patients undergoing surgery.</div></div><div><h3>Methods</h3><div>A search was conducted in MEDLINE, Embase, CINAHL, Cochrane CENTRAL, Web of Science, and SPORTDiscus from inception to August 2025 for RCTs examining perioperative (primarily prehabilitation) multicomponent exercise in adults aged ≥ 65 with frailty. The JBI checklist was utilized to assess the risk of bias, while evidence certainty was evaluated using the GRADE system.</div></div><div><h3>Results</h3><div>Out of 663 identified records, 10 RCTs involving 1146 patients were included. A meta-analysis indicated that exercise significantly decreased postoperative complications (RR 0.72, 95% CI 0.58–0.87; high certainty) and enhanced functional capacity, evidenced by a mean difference of 26.7 meters in the Six-Minute Walk Test (95% CI 16.1–37.3; high certainty). A modest yet noteworthy decrease in length of stay (MD -0.51 days) and an enhancement in handgrip strength (MD 0.35 kg) were observed. The impacts on quality of life, disability, frailty, and readmission risk were determined to be non-significant, corroborated by low-to-moderate certainty evidence.</div></div><div><h3>Conclusion</h3><div>Perioperative multicomponent exercise rehabilitation significantly decreases complications and improves physical function in frail elderly patients undergoing surgery. Nonetheless, its impact on wider geriatric syndromes has yet to be established. Clinicians ought to implement these programs to enhance core recovery outcomes, while future research should focus on optimizing patient-centered benefits.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106127"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in memory organization: How depth of processing and learning intention affect free recall and temporal contiguity","authors":"Mariana Teles","doi":"10.1016/j.archger.2026.106157","DOIUrl":"10.1016/j.archger.2026.106157","url":null,"abstract":"<div><div>This exploratory study examined how depth of processing, intention to learn, and age interact to influence free recall performance and the temporal contiguity effect (TCE). A total of 119 participants, being 67 younger adults (<em>M</em> = 19.2 years) and 52 older adults (<em>M</em> = 73.9 years), completed free recall tasks that varied in levels of processing (no-orienting, shallow, deep) and learning intention (intentional vs. incidental). Given modest cell sizes (<em>n</em> = 10–17 per condition), findings should be considered exploratory and hypothesis-generating. Patterns suggest that deeper processing improves overall recall across age groups, while the organization of recall may differ with age and learning intention, though definitive conclusions about interactions require replication with larger samples. Intentional learning strengthened temporal organization compared with incidental learning, but this pattern diverged by age. In younger adults, deeper processing disrupted the TCE during intentional learning, whereas older adults maintained stable temporal organization across processing levels, a pattern that may reflect strategic compensation, reduced encoding flexibility, or preserved temporal binding mechanisms. These findings contribute to understanding how encoding strategies and learning intention shape memory organization across the adult lifespan and highlight potential pathways for supporting episodic memory in aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106157"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}