Archives of gerontology and geriatrics最新文献

{"title":"FI-lab in the emergency department and adverse outcomes among acutely hospitalized older adults","authors":"Masaaki Nagae ,&nbsp;Hiroyuki Umegaki ,&nbsp;Hirotaka Nakashima ,&nbsp;Tatsuya Nishiuchi","doi":"10.1016/j.archger.2024.105649","DOIUrl":"10.1016/j.archger.2024.105649","url":null,"abstract":"<div><h3>Background</h3><div>The emergency department is treating a growing number of older patients with frailty, which has been linked to poorer outcomes. Urgency is generally emphasized in the emergency department based on indicators such as triage scores and early warning scores for decision-making. However, this approach may not be sufficient for frail older people. The Frailty Index-laboratory (FI-lab) has been used as a simple assessment tool for frailty, but it may also reflect disease severity and predict adverse outcomes in the emergency care setting. Therefore, we aimed to evaluate the association between FI-lab in the emergency room and adverse outcomes during hospitalization through comparison with assessments using triage and early warning scores.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study conducted in a tertiary hospital. The study included patients aged 65 years or older who were admitted to the general internal medicine ward after being initially evaluated in the emergency department. FI-lab was calculated using 24 laboratory parameters from blood tests. The National Early Warning Score (NEWS), the Japan Triage and Acuity Scale (JTAS), and the modified JTAS were also used as prognostic indicators, and their association with adverse outcomes was compared with that of FI-lab.</div></div><div><h3>Results</h3><div>In total, 872 patients (mean age, 80.9 years; male, 52.6 %) were analyzed. Patients who died during hospitalization had a higher FI-lab than those who survived. In multiple regression analysis, FI-lab, NEWS, and the modified JTAS were significantly associated with in-hospital death and prolonged length of hospital stay. In contrast, none of these indices were associated with in-hospital falls. The FI-lab was independently associated with the likelihood of discharge to home.</div></div><div><h3>Conclusions</h3><div>FI-lab evaluated in the emergency department reflected the severity of illness in acutely hospitalized older adults, similarly to NEWS and JTAS, and was a useful indicator for predicting adverse outcomes. These results may indicate the value of FI-lab for older adults in the acute care setting.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105649"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of leisure activity participation and associations with cognitive frailty in older adults: A population-based longitudinal study","authors":"Yanyan Li ,&nbsp;Meijun Liu ,&nbsp;Xiang Li ,&nbsp;Yaru Jin ,&nbsp;Qinqin Liu ,&nbsp;Wendie Zhou ,&nbsp;Jiaqi Yu ,&nbsp;Tao Huang ,&nbsp;Cuili Wang","doi":"10.1016/j.archger.2024.105651","DOIUrl":"10.1016/j.archger.2024.105651","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine changes in leisure activity participation and their associations with cognitive frailty among older adults.</div></div><div><h3>Methods</h3><div>The study utilized data from the Chinese Longitudinal Healthy Longevity Survey covering 2008–2018. Three distinct intervals represented short-term (2008–2011), medium-term (2008–2014) and long-term (2008–2018) changes in leisure activity participation, and the change patterns of levels of leisure activities based on the tertile were described. Restricted cubic splines (RCS) were used to determine the inflection point of the absolute value of leisure activity participation over two time points. Group-based trajectory modeling identified trajectories of leisure activity participation among participants from 2008 to 2018. Logistic regression analysis examined how changes in leisure activity participation impacted cognitive frailty.</div></div><div><h3>Results</h3><div>Five patterns of change in leisure activity participation were identified, including the persistently low group, the declining (medium-low, high-low, high-medium) group, persistently medium, rising (low-medium, low-high, medium-high), and persistently high levels of activity. A lower risk of cognitive frailty was found among three groups of persistently medium, rising, and persistently high levels of activity across three distinct intervals and among the declining group over the short-term and long-term intervals but not in the medium-term interval than among the persistently low group, respectively. RCS analysis showed that the inflection point of the association between absolute changes in leisure activity and cognitive frailty was -2.11 (short-term), -0.9 (medium-term), and -3.94 (long-term). Leisure activity trajectories were categorized into persistently low, persistently moderate, and persistently high groups, and both the persistently moderate and persistently high groups exhibited a lower risk of cognitive frailty compared to the persistently low group.</div></div><div><h3>Conclusion</h3><div>Persistently moderate to high levels and increasing levels of leisure activities can reduce the risk of cognitive frailty in the short, medium, and long term, and even the declining in leisure activity participation less than the threshold could protect against cognitive frailty, particularly in the short and long term.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105651"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual burden of sarcopenia and impaired oral status on activities of daily living, cognition and swallowing outcomes in post-stroke patients","authors":"Yoshihiro Yoshimura ,&nbsp;Hidetaka Wakabayashi ,&nbsp;Fumihiko Nagano ,&nbsp;Ayaka Matsumoto ,&nbsp;Sayuri Shimazu ,&nbsp;Ai Shiraishi ,&nbsp;Yoshifumi Kido ,&nbsp;Takahiro Bise ,&nbsp;Takenori Hamada ,&nbsp;Kouki Yoneda","doi":"10.1016/j.archger.2024.105648","DOIUrl":"10.1016/j.archger.2024.105648","url":null,"abstract":"<div><h3>Background and aims</h3><div>Sarcopenia and poor oral health are common in older patients and are associated with negative outcomes. However, evidence of their combined impact on post-stroke rehabilitation outcomes is limited. This study aimed to investigate the combined impact of sarcopenia and impaired oral health on activities of daily living (ADL), cognition, and swallowing outcomes in post-stroke patients.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using 1,012 post-stroke patients (median age 75.6 years; 54.1 % men). Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. Poor oral health was assessed using the Revised Oral Assessment Guide (ROAG) with a score ≥13 indicating impaired oral status. Functional outcomes were measured using the Functional Independence Measure (FIM) for ADL and cognition, and the Food Intake Level Scale (FILS) for swallowing status.</div></div><div><h3>Results</h3><div>The prevalence of sarcopenia was 45.6 % (492/1,080), impaired oral health was 27.5 % (297/1,080), and the coexistence of both conditions was 12.0 % (130/1,080). The coexistence of sarcopenia and impaired oral health was associated with poorer outcomes compared to either condition alone. After adjusting for confounders, the combination of sarcopenia and impaired oral status showed the strongest negative impact on FIM-motor (<em>B</em>=-8.666, 95 % CI -11.484 to -5.847), FIM-cognition (<em>B</em>=-1.122, 95 % CI -1.987 to -0.256), and FILS (<em>B</em>=-0.785, 95 % CI -1.055 to -0.514) scores at discharge.</div></div><div><h3>Conclusion</h3><div>The dual burden of sarcopenia and impaired oral health significantly impacts functional recovery in post-stroke patients. Comprehensive assessments and interventions targeting both conditions may optimize rehabilitation outcomes in this population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105648"},"PeriodicalIF":3.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the feasibility of anticholinergic burden scales and measures in administrative data: A systematic review","authors":"Valentina M. Srikartika ,&nbsp;Ninh Ha ,&nbsp;David Youens ,&nbsp;Rachael Moorin","doi":"10.1016/j.archger.2024.105646","DOIUrl":"10.1016/j.archger.2024.105646","url":null,"abstract":"<div><h3>Aim</h3><div>This systematic review aimed to identify and evaluate the quality and adaptability of existing anticholinergic burden scales and measures by using administrative dispensing data.</div></div><div><h3>Method</h3><div>A comprehensive literature search was conducted using the Medline, Embase, CINAHL, and Google Scholar databases from 2001 to 2022. Studies that introduced, updated, or modified anticholinergic burden scales and measures were included in this review. Quality assessment considered various aspects, including scoring systems, tool development criteria, and specific requirements tailored for administrative data.</div></div><div><h3>Results</h3><div>Twenty-eight anticholinergic burden scales and measures were identified in 14 countries. The Modified Anticholinergic Risk Scale excelled in the scoring system, while the German Anticholinergic Burden Scale stood out in the scale development process. However, significant variability was observed in methodologies, medication listings, and adaptability to administrative data. Quality assessment considers aspects such as potency, dose, exposure duration, longitudinal measurement, clinical interpretation, and compatibility with administrative data variables. The evaluation also considered tool development criteria including evidence for medication selection, panel expertise, relevance, updating methods, international applicability, validation, and clinical guidance.</div></div><div><h3>Conclusion</h3><div>This review emphasizes the importance of adaptable and robust tools that can work well with administrative data to ensure patient safety and better health outcomes, given the ongoing evolution of anticholinergic medications. The findings of this systematic review provide valuable insights for clinicians and researchers in selecting the most appropriate anticholinergic burden scale or measure according to their specific needs and data sources. This systematic review was registered with PROSPERO (registration ID CRD42023423959).</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105646"},"PeriodicalIF":3.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activation","authors":"Yi Xiao ,&nbsp;Li Zhang ,&nbsp;Hanlin Zhou ,&nbsp;Yingwen Cui ,&nbsp;Keer Chen ,&nbsp;Han Zhang ,&nbsp;Qinyi Wu ,&nbsp;Fang Liu","doi":"10.1016/j.archger.2024.105644","DOIUrl":"10.1016/j.archger.2024.105644","url":null,"abstract":"<div><div>Oxidative stress, or the chronic generation of reactive oxygen species (ROS), is thought to contribute to the progression of aging and aging related diseases. However, low degree of ROS generation has repeatedly been shown to be associated with beneficial outcomes via activation of protective signaling pathways. Berberine, a natural alkaloid isolated from <em>Rhizomacoptidis</em>, has a long history of medicinal use in both Ayurvedic and traditional Chinese medicine, which possesses anti-cancer, anti-inflammatory and anti-neurodegenerative properties. In this study, we utilize <em>Caenorhabditis elegans</em> to examine the mechanisms by which berberine influences healthspan and neurodegenerative diseases. We find that 10 μM berberine significantly extends healthy lifespan in wild type <em>C. elegans</em>. We further show that berberine generates ROS, which is followed by activation of PMK-1/SKN-1 to extend healthspan. Intriguingly, berberine also delays neurodegenerative diseases such as Alzheimer's and polyglutamine diseases in a PMK-1/SKN-1dependent manner. Our work suggests that berberine may be a viable candidate for the prevention and treatment of aging and aging related diseases.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"128 ","pages":"Article 105644"},"PeriodicalIF":3.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision-making under uncertainty in healthy and cognitively impaired aging: A systematic review and meta-analysis","authors":"Ilaria Corbo,&nbsp;Francesca Favieri,&nbsp;Giuseppe Forte,&nbsp;Maria Casagrande","doi":"10.1016/j.archger.2024.105643","DOIUrl":"10.1016/j.archger.2024.105643","url":null,"abstract":"<div><div>Decision-making (DM) is a complex cognitive behavior that involves gathering information and assessing options to identify choices under risky and uncertain conditions. Mild Cognitive Impairment (MCI) is a construct that includes a constellation of symptoms ranging from behavioral to cognitive impairments. This cluster of symptoms is frequently associated with poor decision-making. This study aimed to examine decision-making in pathological aging, specifically MCI. Therefore, we conducted a systematic review and meta-analysis to evaluate these relationships. According to the PRISMA 2020 Statement, nine studies were selected for the systematic review and eight for the meta-analysis. The results highlighted that MCI is associated with impaired decision-making in risky and ambiguous situations.</div><div>The systematic review reported that MCI was associated with impaired decision-making in ambiguous and in risky conditions. In contrast, the meta-analysis showed significant differences in overall decision-making and particularly in ambiguous conditions. This difficulty may be due to different impairments that affect MCI. The difficulty in advantageous decision-making could be due to different brain alterations in MCI, which could lead to problems in tasks requiring feedback-based responses.</div><div>These findings advance our understanding of decision-making in aging and suggest how decision-making alterations in MCI would affect the totality of executive functions and daily activities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105643"},"PeriodicalIF":3.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between anemia, hospitalization, and all-cause mortality in patients with heart failure managed in primary care: An analysis of the Swedish heart failure registry","authors":"Anna Ugarph-Morawski ,&nbsp;Per Wändell ,&nbsp;Lina Benson ,&nbsp;Gianluigi Savarese ,&nbsp;Lars H Lund ,&nbsp;Ulf Dahlström ,&nbsp;Björn Eriksson ,&nbsp;Magnus Edner","doi":"10.1016/j.archger.2024.105645","DOIUrl":"10.1016/j.archger.2024.105645","url":null,"abstract":"<div><h3>Background</h3><div>Many patients with heart failure (HF) are managed in primary care, and comorbidities are common. Anemia is one frequent comorbidity. The aim of this study was to assess the prevalence, comorbidities, and prognosis of HF patients in primary care who have anemia.</div></div><div><h3>Method</h3><div>We linked data on 9300 patients managed in primary care from the nationwide SwedeHF registry with other Swedish national register data. A multivariable logistic regression model with anemia as a dependent variable was performed. Multivariate Cox proportional hazards regression analysis was used to model the time to event.</div></div><div><h3>Results</h3><div>The median age (IQR) was 81 (74–86) years, and 45 % of the patients were female. A total of 2852 (30.7 %) had anemia. Anemia was more common in men, in those ≥75 years, and in those with kidney dysfunction. A total of 695 (10.8 %) of patients without and 520 (18.2 %) with anemia had cancer. Cancer was independently associated with anemia (OR 1.5, 95 % CI 1.3–1.7). Other comorbidities significantly associated with anemia were peripheral artery disease (OR 1.39, 95 % CI 1.18–1.65), diabetes (OR 1.29, 95 % CI 1.16–1.44), and liver disease (OR 1.64, 95 % CI 1.09–2.46). If anemia was present, prognosis was worse. Risk of all-cause hospitalization was higher (adjusted HR 1.3, 95 % CI 1.2–1.4), as was risk of all-cause mortality (adjusted HR 1.4, 95 % CI 1.3–1.5).</div></div><div><h3>Conclusions</h3><div>Anemia is common in primary care patients with HF. It is associated with worse prognosis and comorbidities, most notably cancer.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105645"},"PeriodicalIF":3.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social isolation on change in brain volume in community-dwelling older Japanese people: The NEIGE Study","authors":"Hiroshi Murayama ,&nbsp;Ai Iizuka ,&nbsp;Masaki Machida ,&nbsp;Shiho Amagasa ,&nbsp;Shigeru Inoue ,&nbsp;Takeo Fujiwara ,&nbsp;Yugo Shobugawa","doi":"10.1016/j.archger.2024.105642","DOIUrl":"10.1016/j.archger.2024.105642","url":null,"abstract":"<div><h3>Background</h3><div>Several studies have shown that social isolation is a risk factor for cognitive decline and dementia; however, its neurological mechanisms are not fully understood. Using longitudinal data, this study examined the effects of social isolation on hippocampal and total gray matter volumes in community-dwelling older Japanese individuals.</div></div><div><h3>Methods</h3><div>Data were obtained from the Neuron to Environmental Impact Across Generations (NEIGE) Study conducted in Tokamachi City (Niigata Prefecture, Japan), including 279 community-dwelling persons aged 65–84 years who underwent brain magnetic resonance imaging in 2017 and 2021 (male: 47.6 %; mean age: 73.0 years). We investigated two dimensions of social isolation: poor social networks and solitary living.</div></div><div><h3>Results</h3><div>Multiple regression analysis with inverse probability weighting showed that individuals with a social contact frequency of &lt;1 time/week had a greater decrease in hippocampal volume than those with a contact frequency of more than or equal to 4 times/week, whereas those who lived alone tended to have a smaller decrease in hippocampal volume than those who lived with others. We found no association between the frequency of social contact, living alone, and total gray matter volume. Furthermore, there was no interaction between sex and age for any of the outcomes.</div></div><div><h3>Conclusion</h3><div>Our longitudinal analysis suggested that the relationship between social isolation and dementia onset may be mediated by hippocampal atrophy; however, the direction of the influence depends on the isolation type. These findings are expected to contribute to the elucidation of the social mechanisms underlying dementia onset.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105642"},"PeriodicalIF":3.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of antimuscarinic initiation with cholinesterase inhibitor use in Alzheimer's disease","authors":"Soumya G. Chikermane,&nbsp;Jieni Li,&nbsp;Rajender R. Aparasu","doi":"10.1016/j.archger.2024.105629","DOIUrl":"10.1016/j.archger.2024.105629","url":null,"abstract":"<div><h3>Background</h3><p>The use of cholinesterase inhibitors (CHEIs) is commonly associated with urinary incontinence in patients with Alzheimer's disease (AD). This study evaluated the risk of antimuscarinic initiation drugs with the use of CHEIs in AD patients.</p></div><div><h3>Methods</h3><p>The study used a nested case-control study design involving 2013–2015 Medicare data of AD patients 65 years and older without antimuscarinic use in 2013. Cases were defined as those who initiated antimuscarinic treatment in 2014–2015. Controls with no antimuscarinic use were selected through incidence density sampling and matched to cases on age using a variable-ratio method. The CHEI utilization pattern was classified as current (event-30 days), recent (event-31 to event-90 days), and past (event-91 to event-180 days). Conditional logistic regression was used to assess the association between CHEI use and the risk of antimuscarinic initiation.</p></div><div><h3>Results</h3><p>This study included 1,909 cases and 9,064 controls. The adjusted model found that overall CHEI (Adjusted Odds Ratio [aOR] = 1.90, 95 % Confidence Interval [CI]: 1.58–2.28) and current CHEI use (aOR = 1.62, 95 % CI: 1.18–2.21) were associated with an increase in the risk of antimuscarinic initiation compared to non-CHEI use. In addition, the current use of donepezil and rivastigmine significantly increased the risk of antimuscarinic initiation by 48 % (95 % CI: 1.03–2.12) and 171 % (95 % CI: 1.46–5.03), respectively.</p></div><div><h3>Conclusion</h3><p>The study found an increased risk of antimuscarinic initiation with the current use of CHEIs, particularly with donepezil and rivastigmine. These findings underscore the need for careful medication management to minimize prescribing cascades and associated consequences in AD.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"128 ","pages":"Article 105629"},"PeriodicalIF":3.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0167494324003054/pdfft?md5=a7d0abab7bc1edfd2b42da0d52dc404b&pid=1-s2.0-S0167494324003054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-pharmacological interventions on gut microbiota and intestinal permeability in older adults: A systematic review","authors":"Hazwanie Iliana Hairul Hisham ,&nbsp;Siong Meng Lim ,&nbsp;Chin Fen Neoh ,&nbsp;Abu Bakar Abdul Majeed ,&nbsp;Suzana Shahar ,&nbsp;Kalavathy Ramasamy","doi":"10.1016/j.archger.2024.105640","DOIUrl":"10.1016/j.archger.2024.105640","url":null,"abstract":"<div><p>This systematic review appraised previous findings of non-pharmacological interventions on gut microbiota and/ or intestinal permeability in older adults. A literature search was performed using PubMed, Scopus, ScienceDirect and the Cochrane Library. Relevant studies were shortlisted based on the inclusion and exclusion criteria, and evaluated for risks of bias using the “Cochrane Collaboration's Risk of Bias 2” and the “NIH Quality Assessment Tool for Before-After (Pre-Post) Studies with No Control Group”. The primary outcomes were the effects of non-pharmacological interventions on gut microbiota diversity and composition, and intestinal permeability in older adults. Out of 85,114 studies, 38 were shortlisted. Generally, the non-pharmacological interventions were beneficial against dysbiosis and the leaky gut in older adults. Considering specific interventions with two or more studies that reported consistent outcomes, a pattern was observed amongst the Mediterranean diet (MD), polyphenol-rich (PR) diet and supplements (i.e., probiotics, prebiotics and synbiotics). As for the other interventions, the very few studies that have been conducted did not allow a strong conclusion to be made just yet. The MD (single and multidomain interventions) restored gut microbiota by increasing species richness (alpha diversity) and reduced intestinal permeability (zonulin) and inflammation (CRP). The PR diet only showed slight changes in the gut microbiota but improved the gut barrier by reducing zonulin, CRP and IL-6. Probiotics, prebiotics and synbiotics increased the genus <em>Bifidobacterium</em> spp. which are considered beneficial bacteria. This review has uncovered insights into the relationship between gut microbiota and intestinal epithelial barriers of specific non-pharmacological interventions in older adults.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"128 ","pages":"Article 105640"},"PeriodicalIF":3.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0167494324003169/pdfft?md5=d4181f32067df8c126d9f99fbfff0a7b&pid=1-s2.0-S0167494324003169-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}