Archives of gerontology and geriatrics最新文献

{"title":"Effects of different movement velocities during resistance training on bone mineral density in older adults: A systematic review and meta-analysis","authors":"Riccarda A. Quattlaender ,&nbsp;Paul Rothmore ,&nbsp;Mark R. Hutchinson ,&nbsp;Timothy JH. Lathlean","doi":"10.1016/j.archger.2025.105906","DOIUrl":"10.1016/j.archger.2025.105906","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of different movement velocities during progressive resistance training (PRT) on bone mineral density (BMD) in older adults, with an emphasis on program design and training principles.</div></div><div><h3>Methods</h3><div>Seven databases were comprehensively searched to identify studies investigating the effect of PRT at different movement velocities on BMD. The primary outcome was BMD at fracture-relevant sites measured by dual-energy X-ray absorptiometry (DXA). Meta-analysis of within-group changes was conducted using a random-effects model.</div></div><div><h3>Results</h3><div>Of 1830 screened records, 9 studies met the inclusion criteria. No statistical comparison was possible regarding movement velocity. However, the findings suggest benefits of incorporating high-velocity movements. The analysis revealed that moderate-velocity programs frequently failed to prevent bone loss. In terms of program design, significant benefits of variation in PRT programs were observed. Moreover, the interventions demonstrated substantial interindividual variability in efficacy.</div></div><div><h3>Conclusion</h3><div>High-velocity PRT effectively enhanced BMD when overarching training principles were met. Nevertheless, further research is required to confirm the superior efficacy of high-velocity training. Moreover, individualization is essential since responses to programs vary, prompting questions about underlying differences. Considering that osteoporosis involves defective mechanotransduction, factors beyond established confounders may influence the intervention's efficacy.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105906"},"PeriodicalIF":3.5,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intrinsic capacity with ADL and IADL trajectories: Evidence from a nationwide longitudinal study","authors":"Qin Wang ,&nbsp;Yu-Ting Liang ,&nbsp;Yuan Xu ,&nbsp;Ye-ke He ,&nbsp;Teng-Fei Li ,&nbsp;Qi-Rong Qin ,&nbsp;Jie Li","doi":"10.1016/j.archger.2025.105897","DOIUrl":"10.1016/j.archger.2025.105897","url":null,"abstract":"<div><h3>Background</h3><div>With global aging, functional decline in older adults is a major public health concern. The WHO introduced Intrinsic Capacity (IC) as a key indicator of healthy aging, yet longitudinal evidence on its association with Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) trajectories remains limited.</div></div><div><h3>Methods</h3><div>Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS, 2015–2020), including 4368 participants aged ≥60 years. IC was assessed using quartiles, Latent Profile Analysis (LPA) groups, and five IC domains. Group-Based Trajectory Modeling (GBTM) identified ADL and IADL trajectories, while multivariable logistic regression examined associations between IC and ADL/IADL trajectories. Subgroup and sensitivity analyses ensured robustness.</div></div><div><h3>Results</h3><div>Two trajectory groups were identified for both ADL and IADL: Stable (ADL: 76.5 %, IADL: 76.9 %) and Declining (ADL: 23.5 %, IADL: 23.1 %). LPA revealed three IC profiles: Low Sensory Domain, Low Locomotion and Vitality, and High and Stable IC. Lower IC was significantly associated with higher ADL/IADL decline risk. The Low Locomotion and Vitality Group had increased risk, while the Low Sensory Domain Group showed no significant association. Locomotion, vitality, and psychological function were significantly related to decline, whereas sensory and cognitive domains were not.</div></div><div><h3>Conclusion</h3><div>Lower IC is significantly associated with ADL and IADL decline, with locomotion and vitality as key predictors. Early screening and interventions to maintain IC may delay functional impairment and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105897"},"PeriodicalIF":3.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular regulation during active standing orthostatic stress in older adults living with frailty: a systematic review","authors":"Dihogo Gama de Matos ,&nbsp;Jefferson Lima de Santana ,&nbsp;Felipe J. Aidar ,&nbsp;Stephen M. Cornish ,&nbsp;Gordon G. Giesbrecht ,&nbsp;Asher A. Mendelson ,&nbsp;Todd A. Duhamel ,&nbsp;Rodrigo Villar","doi":"10.1016/j.archger.2025.105894","DOIUrl":"10.1016/j.archger.2025.105894","url":null,"abstract":"<div><h3>Background</h3><div>Orthostatic hypotension (OH) is a relevant cardiovascular disorder associated with frailty and delayed cardiovascular regulatory responses, contributing to cardiovascular dysregulation. This dysregulation affects blood pressure (BP) control, increasing the risk of falls and mortality. This systematic review aimed to determine whether older adults living with frailty have impaired cardiovascular regulatory responses during active standing orthostatic stress.</div></div><div><h3>Methods</h3><div>MEDLINE (from 1946), PUBMED (from 1966), EMBASE (from 1974), CINAHL (from 1963), and SCOPUS (from 2004) were systematically searched for studies on cardiovascular regulation during active standing orthostatic stress in older adults living with frailty. The selection of studies involved the following criteria: ≥ 60 years, OH classification, continuous monitoring of beat-by-beat BP, active standing, and frailty status. The nine-point Newcastle-Ottawa Scale was used to assess the study quality.</div></div><div><h3>Results</h3><div>Of 7441 articles identified, 5 articles were included, but 3 independent data sets were extracted due to two studies reporting the same participants' cohort, resulting in an analysis of 726 participants (79±5 years, 41.7 % males). Frailty was associated with a greater drop in BP (-61 mmHg), blunted HR (Frail: 8 bpm; non-frail: 16 bpm), and longer recovery after active standing, occurring between 30–60 s instead of 0–30 s (healthy systems). OH prevalence ranged from 3 to 98 %, being higher in frail people.</div></div><div><h3>Conclusions</h3><div>Older adults living with frailty experience a greater drop in BP, a blunted HR response, and prolonged recovery time following active-standing orthostatic stress. This cardiovascular dysregulation contributes to the highest prevalence of OH among frail individuals.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105894"},"PeriodicalIF":3.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing vision and well-being: eyewear design opportunities for older adults","authors":"Yu-Hsiu Hung ,&nbsp;Wan Zi Lin ,&nbsp;Chih Ming Chen","doi":"10.1016/j.archger.2025.105895","DOIUrl":"10.1016/j.archger.2025.105895","url":null,"abstract":"<div><div>The contemporary society emphasizes the need to prioritize the well-being and independence of older adults. Vision, which constitutes 70–80 % of human perception and interaction with the external world, is of particular significance. However, age-related vision problems present substantial challenges that impact their quality of life. The study aims to comprehensively understand the visual issues affecting older adults, pinpoint gaps in the current market for eyewear tailored to their needs, and propose opportunities for future eyewear design specifically for this demographic to enhance their daily experiences. The study encompasses an extensive literature review, a Visual Activities Questionnaire (VAQ) survey to evaluate daily vision-related issues, an analysis of existing eyewear products to identify market deficiencies, and in-depth interviews with older adults to gain nuanced insights. The findings offer potential guidance for the development of visual-assistance products for older adults and serve as a valuable resource for related research.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105895"},"PeriodicalIF":3.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between self-neglect and incident cognitive impairment among Chinese older adults and its subgroup differences","authors":"Yaqi Wang ,&nbsp;Bowen Wan ,&nbsp;Xueying Xu ,&nbsp;Qingyun Lv ,&nbsp;Yuan He ,&nbsp;Jingwen Liu ,&nbsp;Hairong Chang ,&nbsp;Yue Zhao ,&nbsp;Li Fu ,&nbsp;Xiaoying Zang ,&nbsp;Xiaonan Zhang","doi":"10.1016/j.archger.2025.105893","DOIUrl":"10.1016/j.archger.2025.105893","url":null,"abstract":"<div><h3>Background</h3><div>Population aging has led to growing concerns regarding self-neglect and cognitive impairment among older adults. However, research on the association between self-neglect and incident cognitive impairment remains limited. We aimed to investigate the association between self-neglect and incident cognitive impairment and variations in gender and age.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted involving 2595 Chinese older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) database. Self-neglect was assessed using 17 items from the CLHLS, and cognitive function was evaluated using the Mini-Mental State Examination. Participants with cognitive impairment at baseline were excluded, and incident cognitive impairment during the follow-up period was documented. Cox proportional hazards models, restrictive cubic spline analysis (RCS), and stratified analyses based on gender and age (with 80 as the threshold) were conducted.</div></div><div><h3>Results</h3><div>The study sample comprised 1249 (48.1 %) men and 1346 (51.9 %) women, with an mean age of 79.7 ± 9.8 years. The risk of cognitive impairment was significantly higher for those in the third (Q3) and fourth (Q4) quartiles of self-neglect scores compared to those in the first quartile (Q1). The RCS analysis indicated a significantly linear relationship. The interaction between gender and self-neglect scores was significantly associated with incident cognitive impairment (<em>P</em> for interaction &lt;0.001), suggesting that men are at a higher risk compared to women.</div></div><div><h3>Conclusion</h3><div>Self-neglect is identified as a significant risk factor for incident cognitive impairment among older adults, with a particular impact on men, highlighting the critical need to address self-neglect to prevent cognitive decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105893"},"PeriodicalIF":3.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional and national burden of knee osteoarthritis 1990–2021: A systematic analysis of the Global Burden of Disease study 2021","authors":"Bin-Fei Zhang,&nbsp;Lin Liu,&nbsp;Shuai-Liang Xu,&nbsp;Zhi Yang","doi":"10.1016/j.archger.2025.105867","DOIUrl":"10.1016/j.archger.2025.105867","url":null,"abstract":"<div><h3>Objective</h3><div>The systematic analysis aimed to assess the levels and trends of knee osteoarthritis (KOA) in 204 countries and territories from 1990 to 2021.</div></div><div><h3>Methods</h3><div>We analyzed the data on the Global Burden of Diseases 2021 and reported the KOA burden and the trends from 1990–2021 by age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR) and age-standardized disability-adjusted life years (DALYs) rate (ASDAR) with 95 % uncertainty intervals (UIs). All estimates were presented as counts and age-standardized rates per 100,000 people, calculating the estimating average annual percent change (EAPCs).</div></div><div><h3>Results</h3><div>From 1990 to 2021, the KOA burden still showed an increasing trend globally, faster in females than males; the 35–39 years population has faster KOA symptoms, and 45–49 years have faster prevalence and DALYs. The high-middle SDI regions are experiencing the fastest increase. East Asia has the fastest growth, and North America has shown a stable trend with no change. The top 9 fastest growing countries and territories were Oman, Equatorial Guinea, Thailand, Saudi Arabia, Sudan, China, Taiwan (Province of China), Maldives, and Pakistan. By 2050 of prediction, there may be an obvious decreasing trend in KOA burden. Frontier analysis indicates the presence of unrealized opportunities to close the KOA burden gap in most countries and territories. Decomposition analyses indicate that population growth accounted for &gt;70 % of the global KOA burden. SDI level was positively associated with KOA burden increasing, and ASIR or HDI was not associated with the burden EAPC.</div></div><div><h3>Conclusion</h3><div>KOA is still a major global health challenge. Although there is variation between countries and regions, most countries' KOA burden is increasing, especially among females and young adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105867"},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and study design of multicomponent exercise intervention for frail older patients with acutely decompensated heart failure: Pilot of the randomized controlled trial J REHAB-HF trial","authors":"Yuji Kono ,&nbsp;Nobuaki Hamazaki ,&nbsp;Satoshi Katano ,&nbsp;Shuhei Yamamoto ,&nbsp;Kodai Ishihara ,&nbsp;Kotaro Iwatsu ,&nbsp;Masatsugu Okamura ,&nbsp;Masato Ogawa ,&nbsp;Ken-ichi Kasai ,&nbsp;Masashi Takeuchi ,&nbsp;Kohei Nozaki ,&nbsp;Masashi Yamashita ,&nbsp;Satoshi Yamamoto ,&nbsp;Shohei Yamamoto ,&nbsp;Kentaro Kamiya ,&nbsp;Tetsuya Takahashi ,&nbsp;Hideo Izawa ,&nbsp;Yohei Otaka","doi":"10.1016/j.archger.2025.105892","DOIUrl":"10.1016/j.archger.2025.105892","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, a growing number of older adults with heart failure (HF) are experiencing physical frailty. Healthcare providers recommend multicomponent exercise program for frail patients; however, their effectiveness in older Japanese adults with HF, who differ physiologically from their Western counterparts, remains unclear. In this study, we will compare the feasibility and efficacy of a multicomponent exercise program with those of conventional exercise therapy as pilot study of the randomized controlled trial, Japanese REHAB-HF (J REHAB-HF) trial.</div></div><div><h3>Methods</h3><div>In this multicenter study, frail older adults hospitalized with worsening HF will be randomly assigned to participate in a program of either multicomponent or conventional exercise therapy. We developed a multicomponent exercise program to target characteristics of physical frailty: poor gait performance, balance ability, muscle strength, and exercise tolerance. The primary outcome is the total score on the Short Physical Performance Battery; additional outcome measures include feasibility and safety of the programs.</div></div><div><h3>Conclusion</h3><div>The pilot study of the J REHAB-HF trial is an evaluation of whether a multicomponent exercise program enhances physical function more effectively than does conventional exercise therapy in frail older adults with HF. The findings will guide the design of the main J REHAB-HF trial and improve care for these individuals.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105892"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and combined effects of depressive symptoms and cardiometabolic risk factors on dementia incidence: a cross-country comparison in England, the United States and China","authors":"Panagiota Kontari ,&nbsp;Chris Fife-Schaw ,&nbsp;Kimberley Smith","doi":"10.1016/j.archger.2025.105889","DOIUrl":"10.1016/j.archger.2025.105889","url":null,"abstract":"<div><h3>Background</h3><div>Depression and cardiometabolic conditions are suggested as modifiable risk factors for dementia, yet their combined impact remains unclear. This study assessed the independent and combined effects of depressive symptoms and cardiometabolic conditions on dementia incidence in England, the US and China.</div></div><div><h3>Methods</h3><div>The sample comprised 4472 participants aged 50 and older from the English Longitudinal Study of Ageing (ELSA), 5021 from Health and Retirement Study (HRS), and 8925 from China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the Center for Epidemiological Studies-Depression scale. Cardiometabolic factors included central obesity, low high‐density-lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure (BP), hyperglycemia, diabetes, and inflammation. Dementia incidence was estimated using confounder-adjusted Cox proportional hazards regressions, and pooled estimates were obtained using random-effects meta-analysis.</div></div><div><h3>Results</h3><div>A total of 1218 individuals developed dementia over a median of 6.8–12.2 years. Depressive symptoms (ELSA: <em>HR =</em> 1.47 [95 % CI = 1.09–2.00]; HRS: <em>HR =</em> 1.68 [95 % CI = 1.33–2.13]; CHARLS: <em>HR =</em> 1.35 [95 % CI = 1.12–1.64]) and elevated systolic BP (ELSA: <em>HR =</em> 1.51 [95 % CI = 1.17–1.95]; HRS: <em>HR =</em> 1.48 [95 % CI = 1.24–1.79]; CHARLS: <em>HR =</em> 1.26 [95 % CI = 1.05–1.52]) were linked to dementia risk in all countries. While cardiometabolic multimorbidity (≥2 conditions) was not associated with dementia risk, those with the highest cardiometabolic index (≥4 conditions) had a greater risk of dementia in all samples (ELSA: <em>HR =</em> 1.82 [95 % CI = 1.01–3.26]; HRS: <em>HR =</em> 1.85 [95 % CI = 1.02–3.35]; CHARLS: <em>HR =</em> 1.65 [95 % CI = 1.18–2.30]).</div></div><div><h3>Conclusion</h3><div>Depressive symptoms are independently linked to dementia risk, while having multiple cardiometabolic conditions further increases this risk, especially when co-occurring with depressive symptoms in both Western and Chinese populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105889"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training vs. moderate-intensity continuous training on arterial stiffness in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Ping Luo ,&nbsp;Mingxuan Huang ,&nbsp;Yufang Ye ,&nbsp;Ruixue Wang ,&nbsp;Weiyi Yan ,&nbsp;Lin Zhu ,&nbsp;Shanqi Liu ,&nbsp;Yao Tang ,&nbsp;Kang Liu ,&nbsp;Weifeng Gao","doi":"10.1016/j.archger.2025.105890","DOIUrl":"10.1016/j.archger.2025.105890","url":null,"abstract":"<div><h3>Objective</h3><div>Arterial stiffness (AS) is regarded as an independent predictor of cardiovascular events and all-cause mortality, and it is significantly associated with global mortality rates. Physical activity (PA) plays a positive role in reducing AS and improving cardiovascular health. The aim of this study is to compare the differences between high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in their effects on reducing AS.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search of the PubMed, Cochrane, Embase, Web of Science, and EBSCO electronic databases, covering the period from their inception to January 10, 2025. We used a fixed-effect model to compare the changes in pulse wave velocity (PWV) before and after intervention between the HIIT group and the MICT group. Data were reported using the weighted mean difference (WMD) and 95 % confidence interval (95 % CI).</div></div><div><h3>Results</h3><div>This study included 619 participants from 22 studies. Compared to MICT, HIIT demonstrated a more significant reduction in PWV (-0.10 m/s [95 % CI:0.16 to -0.03], <em>P</em> = 0.005). Additionally, we found that HIIT was superior in reducing CF-PWV (-0.10 m/s [95 % CI:0.17 to -0.02], <em>P</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>HIIT is more effective than MICT in improving PWV and promoting arterial health in adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105890"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynapenic abdominal obesity and chronic kidney disease: Results from a nationwide prospective cohort study of middle-aged and older adults in China","authors":"Zhipeng Chen,&nbsp;Feng Zhao,&nbsp;Siqi Li","doi":"10.1016/j.archger.2025.105879","DOIUrl":"10.1016/j.archger.2025.105879","url":null,"abstract":"<div><h3>Introduction</h3><div>The relationship between dynapenic abdominal obesity (D/AO) and chronic kidney disease (CKD) remains underexplored, particularly among Chinese middle-aged and older adults. This study aimed to address this gap by examining the association between these conditions in a specific population.</div></div><div><h3>Method</h3><div>We conducted a prospective analysis utilizing two waves (2011 and 2015) of data from 5932 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS). Three logistic regression models with covariate adjustment were employed to examine the longitudinal association between D/AO and CKD progression. To strengthen the validity of our results, rigorous sensitivity analyses and subgroup analyses were systematically conducted to assess the robustness of the observed primary association between D/AO and CKD.</div></div><div><h3>Results</h3><div>After adjusting for all covariates, D/AO was associated with a significantly increased risk of CKD (OR, 1.57; 95 % CI, 1.03–2.35). In the subgroup analyses, middle-aged adults with D/AO exhibited a significantly higher incidence of CKD, while showing no significant difference in older populations. Subgroup analyses revealed middle-aged adults with D/AO was associated with a significantly increased risk of CKD (OR, 2.40; 95 % CI, 1.14–4.59; <em>p</em> = 0.01), whereas older adults showed no statistically significant association (OR, 1.56; 95 % CI, 0.96–2.46; <em>p</em> = 0.06).</div></div><div><h3>Conclusion</h3><div>This prospective cohort study demonstrates that D/AO conferred elevated CKD risk in Chinese middle-aged adults, while showing no significant association in older populations. These findings highlight the need for interventions aimed at improving muscle strength and reducing abdominal adiposity in CKD prevention strategies and public health policies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105879"},"PeriodicalIF":3.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}