Archives of gerontology and geriatrics最新文献

{"title":"The association of DNA methylation-based epigenetic age acceleration with facial expression recognition in older adults","authors":"Da-eun Lee ,&nbsp;Yinan Zheng ,&nbsp;Kyoung-Bok Min ,&nbsp;Brian Joyce ,&nbsp;Jun Wang ,&nbsp;Tao Gao ,&nbsp;Lifang Hou ,&nbsp;Sang-Won Ha ,&nbsp;Da-Eun Jeong ,&nbsp;Min-Ju Kang ,&nbsp;Jin-Young Min ,&nbsp;Kyeezu Kim","doi":"10.1016/j.archger.2025.105808","DOIUrl":"10.1016/j.archger.2025.105808","url":null,"abstract":"<div><h3>Background</h3><div>Facial expression recognition (FER) abilities play a crucial role in fostering beneficial social relationships for healthy aging, however, these abilities tend to decline as people age. We investigated the association between epigenetic age acceleration (EAA) and FER among older individuals.</div></div><div><h3>Methods</h3><div>Accuracy rates and response times for six emotions, anger, disgust, fear, happiness, sadness, and surprise, were assessed in outpatients who visited the Veterans Health Service Medical Center. We calculated six EAA measures (intrinsic EAA, extrinsic EAA, PhenoAge acceleration, GrimaAge2 acceleration, skin and blood Age Acceleration, and Dunedin Pace of Aging Calculated from the Epigenome), based on DNA methylation levels across 935,000 CpGs. We employed multiple linear regression models adjusting for demographic and socioeconomic variables.</div></div><div><h3>Results</h3><div>In men, EAA was associated with a lower accuracy rate for fear (DunedinPACE: β= -7.53, 95 % CI= -12.12, -2.95) and a higher rate for sadness (Grim2AA: β= 5.44, 95 % CI= 0.37, 10.51). In women, EAA was associated with a lower accuracy rate for anger (SBAA: β= -5.06, 95 % CI= -9.43, -0.70) and a higher rate for happiness (EEAA: β= 4.79, 95 % CI= 0.85, 8.73). In men, EAA had an association with a faster response for fear (EEAA: β= -0.24, 95 % CI= -0.44, -0.05) and in women, for all emotions except sadness.</div></div><div><h3>Conclusions</h3><div>Greater EAA was associated with higher accuracy rates in recognizing happiness among women and sadness among men. Our findings suggest that biological aging may enhance recognition of positive emotions and empathy for others' sadness, rather than simply reducing FER abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105808"},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction as a biomarker of frailty: The FRAMITO study protocol","authors":"Edoardo Locatelli ,&nbsp;Barbara Torsello ,&nbsp;Sofia De Marco ,&nbsp;Martina Lombardi ,&nbsp;Francesca Remelli ,&nbsp;Giulia Pampolini ,&nbsp;Elena Ferrighi ,&nbsp;Marialucia Bursi ,&nbsp;Andrea Bellotti ,&nbsp;Valentina Pasquale ,&nbsp;Giacomo Ducci ,&nbsp;Ouldouz Navaei ,&nbsp;Raffaella Candeloro ,&nbsp;Maria Cristina Ferrara ,&nbsp;Wenxiang Guo ,&nbsp;Eleonora Cucini ,&nbsp;Giuseppe Bellelli ,&nbsp;Massimiliano Castellazzi ,&nbsp;Elena Sacco ,&nbsp;Giuseppe Paglia ,&nbsp;Caterina Trevisan","doi":"10.1016/j.archger.2025.105803","DOIUrl":"10.1016/j.archger.2025.105803","url":null,"abstract":"<div><div>Frailty syndrome often coexists with multimorbidity, sharing several risk factors and outcomes. Therefore, considering multimorbidity when exploring frailty biomarkers may deepen our understanding of these conditions’ pathophysiology. In this regard, most studies focused on inflammation, but markers of mitochondrial dysfunction, such as mitochondrial DNA damage, cell respiratory impairment, and oxidative stress, are less explored. The FRAMITO project aims to evaluate mitochondrial dysfunction in frailty, with and without multimorbidity. This cross-sectional study will enroll 75 individuals aged ≥65 years from inpatient and outpatient clinics at the Geriatrics Units of the University Hospital of Ferrara (Ferrara, Italy) and Fondazione IRCCS San Gerardo dei Tintori (Monza, Italy). Participants will be categorized into three groups: 25 without frailty and multimorbidity, 25 with frailty but not multimorbidity, and 25 with frailty and multimorbidity. Blood samples will be collected to isolate Peripheral Blood Mononuclear Cells. Frailty biomarkers will be identified using untargeted metabolomics and functional studies on mitochondrial dysfunctions in PBMCs and their subpopulations, evaluating mitochondrial DNA damage, mitochondrial and glycolytic cellular bioenergetics, and intracellular reactive oxygen species. This project will advance our understanding of mitochondrial dysfunctions in frailty, particularly when combined with multimorbidity, revealing potential synergistic effects.</div></div><div><h3>Clinicaltrial.gov registration number</h3><div>NCT06433427.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105803"},"PeriodicalIF":3.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global challenge of multimorbidity in an aging world","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105804","DOIUrl":"10.1016/j.archger.2025.105804","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105804"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of protein intake with the risk of fractures: A prospective cohort study of UK biobank participants","authors":"Haohan Yang ,&nbsp;Yu Jiang ,&nbsp;Yan Luo ,&nbsp;Kaihua Qin ,&nbsp;Chang Yang ,&nbsp;Dingfa Liang ,&nbsp;Yong Xie ,&nbsp;Xiang Cui ,&nbsp;Wen Ju ,&nbsp;Peifu Tang ,&nbsp;Licheng Zhang ,&nbsp;Houchen Lyu","doi":"10.1016/j.archger.2025.105805","DOIUrl":"10.1016/j.archger.2025.105805","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the associations between protein intake and fractures risk in a large population-based cohort.</div></div><div><h3>Methods</h3><div>We conducted a prospective population-based study of UK Biobank. Participants aged 40–69 who completed the Oxford WebQ dietary questionnaire at least once were included. Exposures were percentage of energy provided by protein and its components (animal and vegetable protein). Participants were categorized into quintiles based on these exposures. The primary outcome was composite fracture, and secondary outcomes included osteoporotic and hip fractures, defined by ICD-10 codes. We used Cox proportional hazard models and restricted cubic splines (RCS) to assess the association between exposure and outcomes, as well as their dose-response relationships.</div></div><div><h3>Results</h3><div>This study included 132,807 participants (mean [SD] age, 56.8 [8.0] years; 68,769 [51.8 %] female). During a median follow-up of 12.4 years, 6,673 composite fractures, 4,496 osteoporotic fractures and 930 hip fractures occurred. Regarding protein intake, compared to the lowest quintile (Q1), individuals in the highest quintile (Q5) had significantly lower risks of composite fracture (HR 0.82, 95 % CI 0.75–0.90), osteoporotic fracture (HR 0.81, 95 % CI 0.72–0.91) and hip fracture (HR 0.63, 95 % CI 0.49–0.82). Similar results were observed for animal and vegetable protein intake. RCS revealed a negative linear dose-response relationship between protein intake and fractures risk.</div></div><div><h3>Conclusion</h3><div>Increased protein intake can significantly reduce the risk of fractures and may serve as an important dietary strategy for promoting bone health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105805"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The connection between 91 inflammatory cytokines and frailty mediated by 1400 metabolites: An exploratory two-step Mendelian randomization analysis","authors":"Bo Wen ,&nbsp;Shizhuang Wei ,&nbsp;Daolai Huang ,&nbsp;Chao Zhang ,&nbsp;Hua Wang ,&nbsp;Sisi Liu ,&nbsp;Xianghua Wu","doi":"10.1016/j.archger.2025.105774","DOIUrl":"10.1016/j.archger.2025.105774","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, a common, multifaceted, and significant geriatric condition, involves crucial roles of inflammation and metabolic factors in its onset and progression. Nevertheless, the ambiguities and complexities in earlier observational studies make current research into their interactions somewhat insufficient. Our goals were to clarify the causal link between inflammatory cytokines and frailty and to explore the potential mediating effect of metabolites using Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Utilizing detailed summary-level data from genome-wide association studies, we conducted two-sample Mendelian randomization analyses to evaluate the potential causal connection between 91 inflammatory cytokines and the frailty index, along with the possible mediating pathways that involve 1400 metabolites. For our main analysis, we applied the inverse variance weighted method. To evaluate the potential mediating pathways of metabolites, a two-step MR analysis was utilized.</div></div><div><h3>Results</h3><div>We identified 8 inflammatory cytokines that were genetically associated with the frailty index, we subsequently identified 2 mediated relationships, with 2 metabolites acting as potential mediators between 2 inflammatory cytokines and frailty index. The 8 inflammatory cytokines were fractalkine (CX3CL1), interleukin-33 (IL-33), leukemia inhibitory factor receptor (LIF-R), monocyte chemoattractant protein-1 (CCL8), C<img>C motif chemokine 4 (CCL4), C-X-C motif chemokine 10 (CXCL10), fibroblast growth factor 5 (FGF-5), and TNF-beta (TNFB) levels.</div></div><div><h3>Conclusions</h3><div>The findings of this study demonstrate a direct connection between inflammatory cytokines and the frailty index, as well as two pathways mediated by metabolites. These biomarkers contribute valuable insights into the foundational mechanisms of frailty, presenting a novel research avenue for upcoming clinical studies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105774"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the HLA-DQB1*02 allele with lower tauopathy in Alzheimer's disease","authors":"Taha I. Huda ,&nbsp;Timothy J. Fawcett ,&nbsp;Anthony J. Green ,&nbsp;George Blanck","doi":"10.1016/j.archger.2025.105802","DOIUrl":"10.1016/j.archger.2025.105802","url":null,"abstract":"<div><div>Although many studies have investigated the influence of HLA on the risk of Alzheimer's Disease (AD), there have been inconsistent results. Part of this problem has been attributed to limitations of a clinical assessment in the absence of histopathological confirmation or other quantitative assessments. This study employed a subset of the AD Sequencing Project, representing 2663 cases with histopathological confirmation of AD and confirmation of 881 cognitively normal cases. Two HLA allelic subtypes, DQB1*02:01 and DQB1*02:02, were associated with lower Braak staging, a measure of tauopathy in the brain. These HLA subtypes were also associated with a later age of onset. There was a lower occurrence of HLA-DQB1*02:01 and HLA-DQB1*02:02 in AD cases compared to cognitively normal cases. For all of the above results, replicative sets were confirmatory. The above results were also maintained for both HLA-DQB1*02:01 and HLA-DQB1*02:02 when removing the effect of APOE4 or APOE2. Interestingly, the HLA-DQB1*02 allele binds tau better than all other HLA-DQB1 alleles tested, per an <em>in silico</em> assessment, raising the question of whether deletion of tau binding, auto-reactive T-cells in the thymus could reduce the likelihood of the onset of AD?</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105802"},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis","authors":"Xiangpeng Meng ,&nbsp;Ze Wang ,&nbsp;Linyu Lyu","doi":"10.1016/j.archger.2025.105787","DOIUrl":"10.1016/j.archger.2025.105787","url":null,"abstract":"<div><h3>Purpose</h3><div>Recent research has reported a potential bidirectional association between sarcopenia and depression, yet systematic evidence supporting this relationship is still lacking. This study evaluated the bidirectional association of sarcopenia with depression to provide reliable evidence for the development of specific prevention and control strategies.</div></div><div><h3>Methods</h3><div>Relevant articles were extracted from PubMed, Embase, Cochrane, and Web of Science from inception to July 4, 2024. Quality was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, and the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional studies. Changes in the association between sarcopenia and depression were compared across different study designs, sources of study subjects, and sarcopenia diagnostic criteria by subgroup analyses. Meta-analysis was conducted using R 4.4.1.</div></div><div><h3>Results</h3><div>Thirty-three original studies involving 119,421 subjects were incorporated into this review. Pooled analysis revealed a significant reciprocal relationship between sarcopenia and depression in community populations. The risk of depression increased when sarcopenia was the exposure factor [OR = 2.40(95 % CI: 1.87, 3.08)]. Conversely, the risk of sarcopenia significantly increased when depression was the exposure factor [OR = 1.90(95 % CI: 1.44, 2.50)]. Additionally, there was a markedly increased risk of sarcopenia when depressive symptoms were the exposure factor [OR = 1.38(95 % CI: 1.25, 1.53)]. Similar conclusions were obtained in patients with other diseases<strong>.</strong></div></div><div><h3>Conclusions</h3><div>The significant bidirectional association between sarcopenia and depression enhances the prevention, screening, diagnosis, and treatment of depression, thereby improving quality of life and outcomes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105787"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Otago Exercise Program and aquatic exercise on fall risk in older adults: A systematic review","authors":"Mingyuan Dong ,&nbsp;Xi Liu ,&nbsp;Yongchul Choi ,&nbsp;Ning Li","doi":"10.1016/j.archger.2025.105799","DOIUrl":"10.1016/j.archger.2025.105799","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this systematic review was to determine the processes and forms of participation in Otago Exercise Program (OEP) and Aquatic exercise(AE) for the prevention of falls in older adults, and to compare the effectiveness of the two exercises as interventions for the prevention of falls in older adults.</div></div><div><h3>Methods</h3><div>Using electronic databases such as PubMed, Web of Science, Embase, Scopus, and Google Scholar, we searched for relevant domestic and foreign papers in the last 15 years, and evaluated the methodology and quality of the report by both AMSTAR 2 and PRISMA scales to evaluate the methodology and reporting quality.</div></div><div><h3>Results</h3><div>A total of 33 papers were included by searching various literatures related to the topic of this study and carefully reviewed by the researcher.</div></div><div><h3>Conclusion</h3><div>This systematic review confirms that OEP and AE effectively prevent falls in older adults by improving cognitive function, lower limb muscle strength, and balance. OEP significantly enhances muscle strength, while AE shows slight superiority in improving balance-related abilities like gait stability. These findings highlight the need for optimized training cycles in OEP and AE to maximize muscle adaptation. Both programs are safe and effective, with potential to reduce falls and enhance physical and cognitive functions. Tailored interventions, aligned with home health care guidelines and specific living environments, can improve quality of life. Future research should explore the optimal exercise modalities and intensities, and conduct longitudinal studies to assess long-term outcomes, particularly for older adults with specific health conditions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105799"},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary indices to measure diet quality in older cancer survivors: A scoping review on tools, their components and association with health outcomes","authors":"Andrea Boehmer ,&nbsp;Christina Syu Hong Thio ,&nbsp;Juliana Christina ,&nbsp;Michelle Miller ,&nbsp;Alex Fauer ,&nbsp;Elsa Dent ,&nbsp;Wendy Wing Tak Lam ,&nbsp;Danielle Wing Lam Ng ,&nbsp;Raymond Javan Chan ,&nbsp;Chad Yixian Han","doi":"10.1016/j.archger.2025.105797","DOIUrl":"10.1016/j.archger.2025.105797","url":null,"abstract":"<div><h3>Background</h3><div>Older cancer survivors live with more comorbidities and have a higher mortality rate compared to the general older population. A high-quality diet that adheres to evidence based dietary recommendations and guidelines may help mitigate these issues. This can be assessed using dietary quality indices (DQIs), which objectively summarize scores for selected dietary components.</div></div><div><h3>Objective</h3><div>Identify the DQIs available in the literature for older cancer survivors, and their associations with health outcomes.</div></div><div><h3>Method</h3><div>Five databases were searched to identify peer-reviewed articles in English, from inception to 12th November 2024. Two researchers independently screened 3,145 studies, extracted and qualitatively assessed data from 28 included reports from 16 studies.</div></div><div><h3>Results</h3><div>12 DQIs and 40 unique components within these indices were identified and summarised narratively. Total vegetables (<em>n</em> = 8), total fruits (<em>n</em> = 8), whole grains (<em>n</em> = 6), saturated fat (<em>n</em> = 8), and salt/sodium (<em>n</em> = 8) were the most frequently incorporated components within a DQI. All DQIs were derived from evidence-based dietary guidelines. Only three DQIs were specifically designed for oncology population. Higher diet quality was associated with higher HR-QoL in breast, prostate, and colorectal cancer survivors in all but one study. The associations between mortality and diet quality were inconsistent, depending on the type of cancer and the mortality type i.e., cancer-specific or other causes.</div></div><div><h3>Conclusions</h3><div>DQIs are associated with important health outcomes. A major knowledge gap exists in DQIs suitable for older cancer survivors. Future research should develop DQIs to better assess how high-quality diets enhance health outcomes in older cancer survivors.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105797"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital reminiscence intervention program using a time-traveling road map for community-dwelling older adults with subjective cognitive decline","authors":"Yeon-Ha Kim ,&nbsp;Chung-Min Cho","doi":"10.1016/j.archger.2025.105789","DOIUrl":"10.1016/j.archger.2025.105789","url":null,"abstract":"<div><h3>Background</h3><div>Subjective cognitive decline (SCD) is a common concern among older adults in the South Korean population. Thus, non-pharmacological interventions are needed to reduce cognition, communication, and mood complaints.</div></div><div><h3>Objective</h3><div>This study evaluated the effects of a Roadmap Time-Traveling Intervention program (RMTI), a digital reminiscence therapy intervention, on cognitive measurements, communication, and mood in older adults with SCD.</div></div><div><h3>Methods</h3><div>Fifty participants were randomly assigned to the experimental or control group. Cognitive function, communication difficulties, quality of life (QoL), depression, and anxiety were assessed at baseline (T0), immediately after the intervention (T1), and four weeks post-intervention (T2). Generalized estimation equations were utilized to analyze the program's effectiveness over time (T0-T1) between groups. A repeated measures ANOVA and the Friedman/Wilcoxon signed-rank tests examined changes across the three time points (T0-T1-T2) within the experimental group. The study followed the Consolidated Standards of Reporting Trials guidelines.</div></div><div><h3>Results</h3><div>The experimental group exhibited significant improvements in the Korean version of the Mini-Mental State Examination (MMSE-K) scores (<em>p</em> &lt; .001) and QoL (<em>p</em> &lt; .001) compared with the control group: MMSE-K scores (Ⲭ² = 9.55, <em>p</em> = .008), communication difficulties (Ⲭ² = 8.57, <em>p</em> = .014), and QoL (Ⲭ² = 3.35, <em>p</em> = .046) improved significantly across the three time points (T0-T1-T2).</div></div><div><h3>Conclusions</h3><div>The RMTI effectively enhanced MMSE-K scores, reduced communication difficulties, and enhanced the QoL in older adults with SCD. This program shows promise for broader implementation in community settings for older adults with SCD.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105789"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}