老年人社会孤立、抑郁和性别差异之间的关系：系统回顾和荟萃分析

IF 3.8 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-05-29 DOI:10.1016/j.archger.2025.105915

Yuyan Liu , Yue Zhou , Dan Sun , Yuhang Wen , Hui Zhao , Yu Long , Qiongge Yu , Qiufeng Jia , Yufeng Yu

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引用次数: 0

摘要

抑郁症是世界范围内最常见的心理健康问题。虽然有一些研究探讨了社会孤立与抑郁之间的关系，但具体的联系和性别差异仍然不一致。目的系统评价老年人社会孤立与抑郁的关系及性别差异。方法检索PubMed、Embase、Web of Science、Cochrane Library、Scopus、PsycINFO等数据库，检索时间为成立至2025年1月21日。两位研究者独立进行文献筛选、数据提取和质量评价。meta分析采用Stata 17.0进行。本荟萃分析共纳入11项研究，涉及来自7个不同国家的103,408名老年人，结果显示，经历社会孤立的老年人患抑郁症的风险显著增加（OR 1.46, 95% CI 1.21-1.77）。性别差异分析显示，女性（OR 1.59, 95% CI 1.08-2.33）患抑郁症的风险高于男性（OR 0.98, 95% CI 0.75-1.27）。亚组分析显示，年龄大、受教育程度低的老年人患抑郁症的风险显著增加，在发达国家和发展中国家，尤其是欧洲和亚洲，这一风险都显著增加。横断面和队列研究也显示了很强的相关性。结论社会隔离显著增加了老年人患抑郁症的风险，这一发现在不同年龄、教育水平、地区和经济发展水平中都是一致的。对性别差异的分析表明，老年妇女尤其受影响。加强对老年人社会孤立状况的识别，对于预防老年人抑郁和促进老年人成功老龄化至关重要。

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Association between social isolation and depression, and sex differences in older adults: A systematic review and meta-analysis

Background

Depression is the most common mental health problems worldwide. Although several studies have explored the relationship between social isolation and depression, the specific association and gender differences are still inconsistent.

Objective

To systematically evaluate the association between social isolation and depression, and sex differences in older adults.

Methods

We searched PubMed, Embase, Web of Science, Cochrane Library, Scopus, and PsycINFO databases from inception to January 21, 2025. Two researchers independently conducted literature screening, data extraction, and quality evaluation. Meta-analysis was performed using Stata 17.0.

Results

This meta-analysis included a total of 11 studies, involving 103,408 older people from 7 different countries, which showed a significantly increased risk of depression in older adults who experienced social isolation (OR 1.46, 95 % CI 1.21–1.77). Sex differences analysis revealed that females (OR 1.59, 95 % CI 1.08–2.33) were at greater risk of depression compared to males (OR 0.98, 95 % CI 0.75–1.27). Subgroup analyses showed that the risk of depression was significantly increased in older people with advanced age and low education levels, and was significantly increased in both developed and developing countries, especially Europe and Asia. Cross-sectional and cohort studies also showed strong associations.

Conclusions

Social isolation significantly increases the risk of depression among older adults, with consistent findings across age, education level, region, and level of economic development. Analysis of gender differences suggests that older women are particularly affected. Strengthening the identification of social isolation in older people is essential to prevent depression in older people and promote successful aging.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.