Archives of gerontology and geriatrics最新文献

{"title":"Ultrasound-derived muscle variables and physical function in older adults: A scoping review","authors":"Jeppe Grabov Phillip ,&nbsp;Kristoffer Kittelmann Brockhattingen ,&nbsp;Tobias Kaarsbo ,&nbsp;Morten Tange Kristensen ,&nbsp;Jesper Ryg ,&nbsp;Charlotte Suetta ,&nbsp;Tahir Masud ,&nbsp;Lisbeth Rosenbek Minet","doi":"10.1016/j.archger.2026.106151","DOIUrl":"10.1016/j.archger.2026.106151","url":null,"abstract":"<div><h3>Background</h3><div>Evidence on use of ultrasound to assess muscles in older adults, and its relation to clinically relevant measures is diverse and inconsistent.</div></div><div><h3>Objective</h3><div>To map and synthesize evidence on use of ultrasound-derived muscle variables and their associations with measures of physical function in older adults.</div></div><div><h3>Methods</h3><div>A scoping review was conducted in accordance with PRISMA-ScR and JBI guidance. MEDLINE, Cochrane, Embase, Scopus, CINAHL, and grey literature was searched. Eligible studies included adults ≥65 years, including frail cohorts, reporting association between ultrasound-derived muscle variables (muscle thickness (MT), cross-sectional area (CSA), echo intensity (EI), pennation angle (PA), fascicle length (FL), or shear-wave elastography (SWE)) and physical function measures (handgrip strength (HGS), sit-to-stand (STS), gait speed (GS), timed up-and-go (TUG), or short physical performance battery (SPPB)).</div></div><div><h3>Results</h3><div>Seventy studies met inclusion criteria. Mapping revealed that rectus femoris MT at mid-thigh was most frequently examined, with considerable protocol variation. Most studies used cross-sectional designs, and frail cohorts were underrepresented. MT and CSA showed weak to moderate associations with muscle strength-related measures (HGS and STS) and generally very weak to weak associations with physical performance-related measures (GS, TUG, SPPB). Evidence for EI, SWE, PA, and FL was limited and inconsistent.</div></div><div><h3>Conclusion</h3><div>Current evidence provides limited support for ultrasound-derived muscle variables as markers of physical function in older adults. Muscle thickness and cross-sectional area capture aspects of muscle strength but insufficiently reflect physical performance. Establishing harmonized protocols and exploring responsiveness in frail populations, in longitudinal studies are critical steps for future research and clinical application.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106151"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Watching sports and subsequent health and well-being in older adults: a longitudinal outcome-wide study","authors":"Taishi Tsuji ,&nbsp;Kenjiro Kawaguchi ,&nbsp;Kazushige Ide ,&nbsp;Atsushi Nakagomi ,&nbsp;Yuya Narita ,&nbsp;Satoru Kanamori ,&nbsp;Katsunori Kondo","doi":"10.1016/j.archger.2025.106120","DOIUrl":"10.1016/j.archger.2025.106120","url":null,"abstract":"<div><h3>Background</h3><div>Although watching sports has increasingly been associated with mental health benefits among older adults, its broader implications, positive and negative, across diverse health and well-being outcomes remain unclear. This longitudinal study examined the associations between sports watching and subsequent health and well-being outcomes among older adults.</div></div><div><h3>Methods</h3><div>We analyzed three-wave data (2016, 2019, and 2022) from the Japan Gerontological Evaluation Study (<em>n</em> = 5226 or 6975, depending on the outcome). The exposure was watching sports on-site and via television/internet in 2019. In 2022, 47 health and well-being outcomes across seven domains were assessed. Analyses adjusted for pre-baseline covariates, including corresponding outcome values from 2016.</div></div><div><h3>Results</h3><div>Among 5226 participants, 1260 (24.1 %) reported watching sports on-site at least once per year, and 4155 (79.5 %) reported watching via television or the internet. On-site watching (a few times per year) and media-based watching (regardless of frequency) were associated with a reduced risk of worsening depressive symptoms. Both forms were positively associated with social well-being indicators, including participation in sports groups and the number of friends seen. No significant associations were observed for health behavior outcomes. However, frequent on-site watching was associated with an increased risk of dementia.</div></div><div><h3>Conclusions</h3><div>Watching sports, on-site or via media, was associated with fewer depressive symptoms and enhanced social well-being in older adults. However, no associations were found with health behaviors, and frequent on-site watching may elevate dementia risk. These findings highlight the need to balance the benefits and risks of sports watching in healthy aging strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106120"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic loneliness and incident chronic lung diseases in two prospective cohorts","authors":"Bo Yan ,&nbsp;Yuechang Li ,&nbsp;Haoyu Wu ,&nbsp;Xiaomin Wang ,&nbsp;Hui Zhu ,&nbsp;Xudong Zhou","doi":"10.1016/j.archger.2025.106112","DOIUrl":"10.1016/j.archger.2025.106112","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness has been recognized as an independent predictor of incident chronic lung diseases. However, previous studies only focused on baseline loneliness status, not taking into consideration the changes in loneliness status during follow-up. This study examined the association of chronic loneliness and incident chronic lung diseases.</div></div><div><h3>Methods</h3><div>This multicohort study used data from the US Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS), consisting of participants aged 45 years or older from China and participants aged 50 years or older from the US. Participants’ self-reported loneliness at baseline was treated as both a continuous variable and a dichotomous variable (low vs. High), and its change patterns were categorised as “stable low”, “low-high”, “high-low”, and “stable high”. Cox proportional hazards regression models were used to estimate the risk of developing chronic lung diseases.</div></div><div><h3>Findings</h3><div>A total of 18,031 (HRS: 8636; CHARLS: 9395) individuals were included for loneliness change analyses. Compared with individuals assigned to “stable low” loneliness change status, significant increased risks of incident chronic lung diseases were observed among those belonging to “low-high”, “high-low” and “stable high” groups in both cohorts ([CHARLS] “low-high”, HR:1.46, 95 % CI:1.24–1.72; “high-low”, HR:1.19, 95 % CI:1.02–1.38; “stable high”, HR:1.60, 95 % CI:1.36–1.89; [HRS] “low-high”, HR:1.39, 95 % CI:1.05–1.84; “high-low”, HR:1.34, 95 % CI:1.03–1.75; “stable high”, HR:1.60, 95 % CI:1.20–2.15).</div></div><div><h3>Conclusions</h3><div>Chronic loneliness was associated with higher risks of incident chronic lung diseases. Recovery or relief from loneliness might play an important role in the prevention of chronic lung diseases.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106112"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality prediction among older people in primary care: a comparison of predictive performance of the frailty index with regression-based and machine learning models","authors":"Collin JC Exmann ,&nbsp;Karlijn J Joling ,&nbsp;Robert Verheij ,&nbsp;Iris van der Heide ,&nbsp;Hein PJ van Hout ,&nbsp;Emiel O Hoogendijk","doi":"10.1016/j.archger.2025.106096","DOIUrl":"10.1016/j.archger.2025.106096","url":null,"abstract":"<div><h3>Introduction</h3><div>The frailty index is widely used to identify vulnerable individuals at risk of adverse outcomes like mortality. However, its predictive performance compared to other mortality prediction models, especially in subpopulations like people with dementia, is not well known. This study aimed to compare frailty index’s performance with regression-based and machine learning models for predicting mortality among community-dwelling older adults, and to test performance in a dementia subgroup.</div></div><div><h3>Methods</h3><div>We selected 355,958 community-dwelling adults aged 60 years and older from primary care with electronic health records (EHR) linked to mortality registrations. We developed one- and five-year mortality prediction models using a 36-item frailty index and compared discrimination and calibration of a regression model including the frailty index with two types of regression models and two types of machine learning models using single health deficits as predictors. Lastly, we evaluated the models’ performance in 6394 persons with dementia.</div></div><div><h3>Results</h3><div>The frailty index model showed moderate performance with an AUC-ROC of 0.793 and 0.804 for one- and five-year mortality. The other models, using the single deficits as predictors, reached higher AUC-ROCs up to 0.828 and 0.824, with good calibration. Overall, the models performed worse in the dementia subgroup, with AUC-ROCs between 0.678 and 0.704.</div></div><div><h3>Discussion</h3><div>Regression-based and machine learning prediction models using single frailty deficits outperform the frailty index in predicting one- and five-year mortality. However, these models can be more complex and less interpretable. We found lower performance for people with dementia, suggesting the models are less applicable in this subpopulation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106096"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between frailty and white matter hyperintensities: A systematic review and meta-analysis","authors":"Xuzi Li,&nbsp;Anling Luo,&nbsp;Yiting Deng,&nbsp;Yujia Yang,&nbsp;Qin Yang,&nbsp;Yujie Chen,&nbsp;Li He,&nbsp;Muke Zhou","doi":"10.1016/j.archger.2025.106089","DOIUrl":"10.1016/j.archger.2025.106089","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, common in aging, contributes to cognitive and motor decline. White matter hyperintensity (WMH), markers of cerebral small vessel disease, show similar effects. Although studies suggest an association between frailty and WMH, the evidence is inconsistent, and their relationship remains uncertain.</div></div><div><h3>Objective</h3><div>This research aimed to examine the relationship between frailty and WMH.</div></div><div><h3>Methods</h3><div>Systematic literature search and meta-analytic methods were employed. Study screening and data extraction were conducted, and quality assessment was performed using the Newcastle-Ottawa Scale and American Agency for Healthcare Research and Quality evaluation tools. StataSE 15.0 software was utilized to carry out statistical analyses.</div></div><div><h3>Results</h3><div>Nine articles, including 10 studies, were included. The meta-analysis results demonstrated a significant positive relationship between WMH and frailty (odds ratio [OR] = 1.38, 95 % confidence interval [CI]: 1.17–1.64, <em>P</em> &lt; 0.001). Subgroup analysis showed a consistent association between WMH and frailty, which was stronger in hospitalized patients, Asian populations, and studies using the Fried or Fazekas criteria. Sensitivity analyses validated the robustness of the results. After adjustment for publication bias via the trim-and-fill method, the association was still significant (OR = 1.25, 95 % CI: 1.05–1.50, <em>P</em> = 0.012), though limitations of this method and other potential biases should be considered.</div></div><div><h3>Conclusions</h3><div>WMH is significantly associated with frailty, offering new insights into its potential role in frailty. This meta-analysis suggests that WMH is worth exploring in future longitudinal studies to understand its relevance to frailty mechanisms.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106089"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between pulmonary function and incident cognitive decline : Results of the SONIC cohort study","authors":"Yuka Tachibana ,&nbsp;Keigo Kobayashi ,&nbsp;Mai Kabayama ,&nbsp;Michiko Kido ,&nbsp;Yuya Akagi ,&nbsp;Hiroshi Akasaka ,&nbsp;Yoshio Iwashima ,&nbsp;Saori Yasumoto ,&nbsp;Yukie Masui ,&nbsp;Kazunori Ikebe ,&nbsp;Takumi Hirata ,&nbsp;Yasumichi Arai ,&nbsp;Yasuyuki Gondo ,&nbsp;Koichi Yamamoto ,&nbsp;Kei Kamide","doi":"10.1016/j.archger.2025.106109","DOIUrl":"10.1016/j.archger.2025.106109","url":null,"abstract":"<div><div>Reduced pulmonary function may contribute to cognitive decline in older adults; however, few longitudinal studies adjust for frailty, lifestyle, and comorbidities. This study examined whether baseline spirometry predicts 3-year cognitive decline in community-dwelling older Japanese adults. Data were derived from the SONIC Study, a longitudinal cohort of older Japanese adults. This 3-year follow-up included community-dwelling adults in their 70 s and 80 s, stratified by age and sex. Baseline and follow-up assessed anthropometry, physical frailty indicators (grip strength and gait speed), cognition (Montreal Cognitive Assessment, Japanese version [MoCA-J]) and pulmonary function (percent vital capacity [%VC], percent forced vital capacity [%FVC], percent forced expiratory volume in one second [%FEV₁], forced expiratory volume in one second / forced vital capacity ratio [FEV₁/FVC], and percent peak expiratory flow [%PEF]). Associations with mild cognitive decline were examined using logistic regression, adjusted for comorbidities, health behaviors, and frailty. Most pulmonary function measures markedly decreased over 3 years, whereas the FEV₁/FVC ratio remained stable. MoCA-J scores markedly declined among adults in their 80 s but remained stable in those in their 70 s. Reduced %PEF was markedly associated with cognitive decline only in participants in their 70 s, in males and females. Additionally, reduced FEV₁/FVC ratio was associated with increased cognitive decline in females in their 70 s. No significant associations were found in participants in their 80 s. In older adults, declines in %PEF and FEV₁/FVC ratio increased cognitive decline in the 70 s age group, with sex differences noted. Simple pulmonary measures may help identify those at risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106109"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of daily physical activity and onset of depressive symptoms: A longitudinal cohort study of community-dwelling older adults","authors":"Masanori Morikawa ,&nbsp;Kenji Harada ,&nbsp;Chiharu Nishijima ,&nbsp;Kazuya Fujii ,&nbsp;Daisuke Kakita ,&nbsp;Takuto Okuya ,&nbsp;Kazuki Soma ,&nbsp;Yukari Yamashiro ,&nbsp;Naoto Takayanagi ,&nbsp;Motoki Sudo ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2025.106095","DOIUrl":"10.1016/j.archger.2025.106095","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression is a major public-health concern. Although physical activity is protective, the longitudinal association of physical-activity timing on depressive-symptom onset in older adults remains unclear. We examined the association of physical activity timing with depressive symptoms in older adults.</div></div><div><h3>Methods</h3><div>This study included 2542 community-dwelling adults aged ≥60 years from the NCGG-SGS cohort who were free of depressive symptoms at baseline. Physical activity was measured using an accelerometer and summarized in three-hour intervals. Functional principal component analysis classified participants into early and late active groups. Depressive symptoms (GDS score ≥5) were assessed after 26.4 months. Risk differences were estimated using inverse probability and overlap weighting, adjusting for demographic, health, and lifestyle factors.</div></div><div><h3>Results</h3><div>Depressive symptoms developed in 14.7% of participants. The late active group (activity peak in the afternoon) had a lower incidence (10.1%) than the early active group (16.1%). After inverse probability weighting, the risk difference was −3.9% (95% CI: −7.0% to −0.8%, <em>P</em>= 0.009). After overlap weighting, the risk difference was −3.5% (95% CI: −6.6% to −0.4%, <em>P</em>= 0.011). Subgroup analyses showed consistent results across age, sex, and activity levels.</div></div><div><h3>Conclusions</h3><div>A late active pattern was associated with a reduced risk of depressive symptoms in older adults. Timing of daily activity should be considered in depression-prevention strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106095"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond access: Digital skills as a new social determinant of health among older adults — evidence from a longitudinal panel study","authors":"Hao Ji ,&nbsp;Weiguang Pan ,&nbsp;Junyi Xin","doi":"10.1016/j.archger.2025.106124","DOIUrl":"10.1016/j.archger.2025.106124","url":null,"abstract":"<div><h3>Background</h3><div>As the digital divide shifts from access to skills, the impact of digital competence on older adults’ well-being remains underexplored. This study investigates the longitudinal relationship between digital skills and the multidimensional health of China’s older population.</div></div><div><h3>Methods</h3><div>Using multi-wave data from the China Longitudinal Aging Social Survey (CLASS), a nationally representative longitudinal panel study, we employed individual fixed-effects models. To mitigate endogeneity, we utilized a Bartik-style instrumental variable (IV-2SLS) strategy. A hybrid analytical approach was adopted to examine transmission mechanisms.</div></div><div><h3>Results</h3><div>Self-rated digital skills significantly predicted better health outcomes, including improved self-rated health (<em>β</em>=0.082, <em>p</em> &lt; 0.001), fewer depressive symptoms (<em>β</em>=−0.307, <em>p</em> &lt; 0.001), and greater social health (<em>β</em>=0.280, <em>p</em> &lt; 0.001). These associations remained robust after correcting for endogeneity. The protective effect operates through a dual trajectory: reinforcing social participation and health behaviors, while enabling meaningful engagement with digital health technologies. Heterogeneity analysis revealed a pattern of “inclusive growth”: health returns were substantial for vulnerable groups (low income/education) and the oldest-old, functioning as a “compensatory resource,” though a “digital blind spot” persisted in peri‑urban areas.</div></div><div><h3>Conclusion</h3><div>Digital skills have emerged as a pivotal social determinant of health in later life. Policies must pivot from infrastructure provision to “precision empowerment,” prioritizing skill-building for disadvantaged older adults to ensure the equitable distribution of digital health benefits.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106124"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise modality and dose on improving executive function in stroke patients: A systematic review and Bayesian network dose-response meta-analysis","authors":"Shaoqi Zheng ,&nbsp;Qiuxue Pan ,&nbsp;Liping Chen","doi":"10.1016/j.archger.2025.106117","DOIUrl":"10.1016/j.archger.2025.106117","url":null,"abstract":"<div><h3>Objective</h3><div>This Bayesian network meta-analysis examined exercise effects on executive function in stroke patients, exploring dose-response relationships and comparing the efficacy of different modalities to identify the optimal rehabilitation protocol.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, Embase, the Cochrane Library, Web of Science, and SPORTDiscus from inception to September 15, 2025. Twenty randomized controlled trials (RCTs) were included. Study quality was assessed using the PEDro scale. A Bayesian random-effects network meta-regression model examined the nonlinear dose–response relationship between exercise dosage (in Metabolic Equivalent of Task-minutes, MET-mins) and executive function, with heterogeneity, publication bias, and model robustness evaluated.</div></div><div><h3>Results</h3><div>The analysis demonstrated a significant inverted U-shaped relationship between weekly exercise dose and improvements in executive function, with the peak effect occurring at approximately 1000 MET-minutes per week (mean effect size = 0.65, 95 % credible interval: 0.34–1.00). Among different exercise modalities, exercise combined with cognitive training showed the most favorable and consistent association across a broad weekly dose range (approximately 170–1000 MET-minutes). Multicomponent exercise exhibited apparent benefits only at higher weekly doses (around 890–1000 MET-minutes), though with greater statistical uncertainty, whereas other modalities did not demonstrate clear or consistent effects.</div></div><div><h3>Conclusion</h3><div>The association between exercise and executive function in stroke patients appears to follow an optimal weekly dose (∼1000 MET-minutes) rather than a maximal one. Exercise combined with cognitive training provides synergistic, stable benefits within this range. These findings offer moderate-quality evidence to guide individualized rehabilitation that optimizes cognitive recovery and improves quality of life after stroke.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106117"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between intrinsic capacity transitions and incident cardiovascular disease among middle-aged and older adults","authors":"Shuanglong Hou ,&nbsp;Yi Pan ,&nbsp;Jing Luo ,&nbsp;Rui Liu ,&nbsp;Xueqiang Wang","doi":"10.1016/j.archger.2025.106111","DOIUrl":"10.1016/j.archger.2025.106111","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence suggests that intrinsic capacity (IC) impairments are potential predictors of cardiovascular disease (CVD), yet the impact of longitudinal IC transitions on CVD risk remain incompletely elucidated. This study investigates associations between short-term IC transitions and subsequent incident CVD to address this gap.</div></div><div><h3>Methods</h3><div>Data were derived from the China Health and Retirement Longitudinal Study (CHARLS). Seven biomarkers encompassing five IC domains were evaluated, and IC was categorized as high, moderate, and low levels based on total domain scores. IC transitions were evaluated using baseline and 2-year follow-up data. CVD was defined as self-reported physician-diagnosed heart disease or stroke. Cox proportional hazards models were employed to estimate the associations between IC transitions and incident CVD.</div></div><div><h3>Results</h3><div>Among 5190 eligible participants, 1072 (20.7 %) developed incident CVD. Compared with stable high IC, participants with high baseline IC who declined to moderate (HR 1.34, 95 % CI 1.05–1.71) or low IC (HR 1.61, 95 % CI 1.16–2.22) exhibited elevated risks of incident CVD. Similarly, increased CVD risks were observed in participants who declined from high to moderate IC compared with those stable moderate IC (HR 1.32, 95 % CI 1.04–1.69). In contrast, participants with low baseline IC who improved to high IC showed decreased risks of incident CVD relative to those with stable low IC (HR 0.55, 95 % CI 0.38–0.76).</div></div><div><h3>Conclusion</h3><div>Dynamic transitions in IC are associated with distinct CVD risks. IC decline is linked to a significantly elevated risk, whereas IC improvement correlates with a reduced risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106111"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}