Archives of gerontology and geriatrics最新文献

{"title":"Harmonizing WHO-ICOPE with muscle health to promote healthy longevity","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105891","DOIUrl":"10.1016/j.archger.2025.105891","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105891"},"PeriodicalIF":3.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study","authors":"Mizhgan Fatima ,&nbsp;Ben Kirk ,&nbsp;Sara Vogrin ,&nbsp;Wei-Ju Lee ,&nbsp;Li-Ning Peng ,&nbsp;Liang-Kung Chen ,&nbsp;Gustavo Duque","doi":"10.1016/j.archger.2025.105888","DOIUrl":"10.1016/j.archger.2025.105888","url":null,"abstract":"<div><h3>Background</h3><div>Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk.</div></div><div><h3>Objectives</h3><div>To investigate if osteosarcopenia is associated with frailty risk in community-dwelling older adults.</div></div><div><h3>Design</h3><div>Retrospective analysis of a prospective cohort study.</div></div><div><h3>Setting</h3><div>I–Lan Longitudinal Aging Study (ILAS).</div></div><div><h3>Participants</h3><div>1779 older adults (≥50 years) at baseline, and 998 participants at follow-up.</div></div><div><h3>Measurements</h3><div>Frailty was defined based on the Fried criteria. Osteosarcopenia was defined by the coexistence of osteopenia or osteoporosis (WHO definition) and sarcopenia (Asian Working Group definition). Multinomial logistic regression models were employed to examine the association of osteosarcopenia (at baseline) with frailty risk (at eight years), adjusted for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Out of 1779 adults (mean age 63.9 ± 9.2 SD, women 53.1 %), 998 (mean age 67.1 ± 7.6 SD, women 52.6 %) completed a follow-up at eight years. At baseline, osteosarcopenia was more prevalent in the frail group (27.5 %) compared to the pre-frail (10.8 %) and non-frail groups (0 %). However, neither osteosarcopenia (Odds Ratio [OR] 2.67, 95 %CI 0.85–8.40, <em>p</em> = 0.094) nor its components (sarcopenia (OR 3.13, 95 %CI 0.64–15.21, <em>p</em> = 0.158); osteopenia (OR 1.33, 95 %CI 0.70–2.53, <em>p</em> = 0.386); osteoporosis (OR 1.71, 95 %CI 0.64–4.59, <em>p</em> = 0.287)) were associated with frailty risk at eight years.</div></div><div><h3>Conclusion</h3><div>Neither osteosarcopenia nor its components were associated with frailty risk. However, a greater number of older adults with osteosarcopenia and extended follow-up are needed to re-evaluate whether osteosarcopenia is associated with frailty risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105888"},"PeriodicalIF":3.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationship between diabetes and frailty in middle-aged and older adults: A systematic review and meta-analysis","authors":"Huaxin Si ,&nbsp;Yiran Zhang ,&nbsp;Peng Zhao ,&nbsp;Na Li ,&nbsp;Wendie Zhou ,&nbsp;Yemin Yuan ,&nbsp;Ping He ,&nbsp;Cuili Wang","doi":"10.1016/j.archger.2025.105880","DOIUrl":"10.1016/j.archger.2025.105880","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes and frailty are prevalent and burdensome in middle-aged and older adults. However, current evidence on their association is inconsistent, and no quantitative meta-analysis exists. We conducted a systematic review and meta-analysis to examine whether diabetes increased the risk of frailty and vice versa.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Web of Science, Embase, and CINAHL databases from inception to 10 April 2025. Random-effects models were used to calculate pooled odds ratio (OR) and 95 % confidence interval (CI) for cross-sectional analysis and pooled relative risk (RR) for longitudinal analysis. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</div></div><div><h3>Results</h3><div>From 8559 non-duplicated records, 31 articles were included. People with diabetes had increased risks of prevalent frailty (OR=2.21, 95 %CI: 1.60–3.06, I²=99.0 %, n = 15; GRADE=Low), prevalent pre-frailty (OR=2.23, 95 %CI: 2.19–2.28, I²=0.0 %, n = 2; GRADE=Very low), and incident frailty (RR=1.50, 95 %CI: 1.36–1.65, I²=0.0 %, n = 7; GRADE=Moderate). Those with pre-frailty (OR=1.95, 95 %CI: 1.61–2.36, I²=0.0 %; GRADE=Very low) but not with frailty (OR=2.28, 95 %CI:0.96–5.46, I²=92.3 %; GRADE=Very low) had increased odds of prevalent diabetes in two studies. In 15 studies, the pooled RRs for incident diabetes were 1.47 (95 %CI: 1.37–1.57, I²=91.0 %; GRADE=Moderate) in pre-frail participants and 1.96 (95 %CI: 1.73–2.23, I²=92.7 %; GRADE=Moderate) in frail participants.</div></div><div><h3>Conclusion</h3><div>Our findings support the bidirectional relationship between diabetes and frailty in middle-aged and older adults, with each condition contributing to the development of the other. This highlights the importance of early detection and integrated management strategies for diabetes and frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105880"},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and intrinsic capacity in older adults: A systematic review","authors":"Weslley Barbosa Sales ,&nbsp;Paulo Vitor de Souza Silva ,&nbsp;Bianca Stephany Barbosa Vital ,&nbsp;Marcyo Câmara","doi":"10.1016/j.archger.2025.105875","DOIUrl":"10.1016/j.archger.2025.105875","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia and intrinsic capacity are closely linked factors that impact the health and functional aging of older adults.</div></div><div><h3>Objective</h3><div>This systematic review aims to investigate the associations between the domains of IC and sarcopenia in older adults.</div></div><div><h3>Material and methods</h3><div>The study follows PRISMA guidelines and is registered on PROSPERO. The review included original studies (cohort, cross-sectional, or randomized controlled trials) with participants aged 60+ diagnosed with sarcopenia (based on EWGSOP or other recognized definitions). Intrinsic capacity (IC) was assessed based on the five domains defined within the IC framework—cognition, locomotion, sensory, psychological, and vitality. The Integrated Care for Older People (ICOPE) approach developed by the World Health Organization supports the optimization of IC and functional ability through person-centred and coordinated care. Exclusion criteria included studies with insufficient data on sarcopenia prevalence and IC scores, as well as reviews or studies unrelated to sarcopenia or IC.</div></div><div><h3>Results</h3><div>A total of 397 articles were identified, with 5 meeting the inclusion criteria. These studies, involving 6651 participants aged 60 to 82 years (54.8 % male, 45.2 % female), examined the association between sarcopenia and intrinsic capacity in older adults, using the diagnostic criteria for sarcopenia proposed by the EWGSOP and assessing IC based on its key components. Despite the limited number of studies, the findings suggest a significant link between declining intrinsic capacity and sarcopenia.</div></div><div><h3>Final considerations</h3><div>These results underscore the importance of a multifactorial approach in assessing and managing sarcopenia, which may improve early detection and support healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105875"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between aging, ferroptosis, and common age-related diseases","authors":"Laleh Mavaddatiyan ,&nbsp;SaghiHakimi Naeini ,&nbsp;Sara Khodabandeh ,&nbsp;Fatemeh Hosseini ,&nbsp;RhysJ.P. Skelton ,&nbsp;Vahid Azizi ,&nbsp;Mahmood Talkhabi","doi":"10.1016/j.archger.2025.105877","DOIUrl":"10.1016/j.archger.2025.105877","url":null,"abstract":"<div><div>Aging is a natural biological process that is characterized by the progressive decline in physiological functions and an increased vulnerability to age-related diseases. The aging process is driven by different cell and molecular mechanisms. It has recently been shown that aging is associated with heightened vulnerability to ferroptosis (an intracellular iron-dependent form of programmed cell death). This susceptibility arises from various factors including oxidative stress, impaired antioxidant defences, and dysregulated iron homeostasis. The progressive decline in cellular antioxidant capacity and the accumulation of damaged components contribute to the increased susceptibility of aging cells to ferroptosis. Dysregulation of key regulators involved in ferroptosis, such as glutathione peroxidase 4 (GPX4), iron regulatory proteins, and lipid metabolism enzymes, further exacerbates this vulnerability. The decline in cellular defence mechanisms against ferroptosis during aging contributes to the accumulation of damaged cells and tissues, ultimately resulting in the manifestation of age-related diseases. Understanding the intricate relevance between aging and ferroptosis holds significant potential for developing strategies to counteract the detrimental effects of aging and age-related diseases. This will subsequently act to mitigate the negative consequences of aging and improving overall health in the elderly population. This review aims to clarify the relationship between aging and ferroptosis, and explores the underlying mechanisms and implications for age-related disorders, including neurodegenerative, cardiovascular, and neoplastic diseases. We also discuss the accumulating evidence suggesting that the imbalance of redox homeostasis and perturbations in iron metabolism contribute to the age-associated vulnerability to ferroptosis.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105877"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physical activity trajectories and cognitive function in women 50 years and older: A nationally representative cohort study from the China Health and Retirement Longitudinal Study","authors":"Dehua Gong,&nbsp;Seung-Soo Baek","doi":"10.1016/j.archger.2025.105876","DOIUrl":"10.1016/j.archger.2025.105876","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the longitudinal association between physical activity trajectory changes and cognitive function in women aged 50 years and older.</div></div><div><h3>Methods</h3><div>Data were obtained from the China Health and Retirement Longitudinal Study, collected between 2011 and 2020, involving 2,760 women aged 50 years and older. Group-based trajectory modeling was used to identify four physical activity trajectory groups: Low-Fluctuation Group, Moderate-Increasing Group, Moderate-Stability Group, and High-Fluctuation Group. Cognitive function was assessed based on episodic memory and mental intactness. Linear mixed-effects models were employed to examine the association between physical activity trajectories and cognitive function, including interaction effects and age-stratified analyses.</div></div><div><h3>Results</h3><div>The Moderate-Increasing group was significantly associated with higher levels of global cognitive function (β = 0.45, 95% CI: 0.05–0.85) and episodic memory (β = 0.21, 95% CI: 0.05–0.37), particularly among women aged 50–59 years. In contrast, High-Fluctuation and Low-Fluctuation groups exhibited declining trends across cognitive outcomes. Age-stratified analysis suggested that the association between Moderate-Increasing group and cognitive function was not significant among women aged 60 years and older.</div></div><div><h3>Conclusion</h3><div>In women aged 50–59 years, the Moderate-Increasing group was significantly associated with better global cognitive function and episodic memory; however, this association was attenuated or not observed in older age groups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105876"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-trajectories of physical activity and health in aging: A 20-year nationwide population-based longitudinal study","authors":"Yen-Yun Yu ,&nbsp;Hsi-Yu Lai ,&nbsp;Ching-Hui Loh ,&nbsp;Liang-Kung Chen ,&nbsp;Fei-Yuan Hsiao","doi":"10.1016/j.archger.2025.105878","DOIUrl":"10.1016/j.archger.2025.105878","url":null,"abstract":"<div><h3>Background</h3><div>Although the beneficial effects of exercise in mitigating adverse health outcomes associated with aging are well-established, the optimal intensity, volume, and frequency of exercise, especially for older adults, remain to be fully elucidated. The aim of this study was to examine the longitudinal association between distinct trajectories of various aspects of physical activity and clinical outcomes (mortality and functional disability (Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) disability) at 4- and 8-year follow-ups among community-dwelling middle-aged and older adults.</div></div><div><h3>Methods</h3><div>In this longitudinal cohort study, we identified 1914 community-dwelling adults from the Taiwan Longitudinal Study on Ageing, TLSA (1996–2015). Using group-based multi-trajectory modeling, we analyzed data from the third (1996) through the sixth (2007) wave of TLSA to identify distinct patterns across four self-reported physical activity aspects (frequency, duration, sweating intensity, and breathlessness intensity) among participants stratified by physical activity documented in the third wave survey (active vs. inactive). Cox proportional hazard models were used to examine the associations between these trajectory patterns and clinical outcomes (mortality, ADL/IADL disability) at 4-year (2011) and 8-year (2015) follow-ups.</div></div><div><h3>Results</h3><div>Among initially active participants, we identified three trajectories: \"Declining Active\" (<em>n</em> = 177), \"Re-Engaged Active\" (<em>n</em> = 200), and \"Maintained Active\" (<em>n</em> = 622). The \"Maintained Active\" group showed lower mortality risk at both 4-year (adjusted HR = 0.64, 95 %CI 0.44–0.93) and 8-year (adjusted HR = 0.65, 95 %CI 0.50–0.86) follow-ups compared to the \"Declining Active\" group. Among initially inactive participants, the \"Emerging Active\" group (<em>n</em> = 637) demonstrated lower mortality risk compared to the \"Chronically Inactive\" group (<em>n</em> = 278) at both time points (4-year: adjusted HR = 0.62, 95 %CI 0.43–0.90; 8-year: adjusted HR = 0.68, 95 %CI 0.52–0.89). The \"Re-Engaged Active\" group showed lower risk of ADL impairment (adjusted HR = 0.44, 95 %CI 0.21–0.87) at 8-year follow-up.</div></div><div><h3>Conclusion</h3><div>Maintaining active physical activity or transitioning from inactive to active status was associated with reduced mortality risk. These findings support promoting regular physical activity among older adults, regardless of baseline activity levels.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105878"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of vertebral fractures due to falls from 1990 to 2021 and predictions for the next 15 years: A systematic analysis of the global burden of disease 2021 study","authors":"Xue Yun ,&nbsp;Lintao Zhang ,&nbsp;Zhaopeng Fan ,&nbsp;Yuxin Fu ,&nbsp;Hua Guo","doi":"10.1016/j.archger.2025.105874","DOIUrl":"10.1016/j.archger.2025.105874","url":null,"abstract":"<div><h3>Objectives</h3><div>This study utilized the latest data from the 2021 Global Burden of Disease Study to analyze the incidence, prevalence, and years lived with disability due to vertebral fractures from 1990 to 2021, providing information for effective management and prevention strategies.</div></div><div><h3>Methods</h3><div>This study describes the trends in incidence, prevalence, and years lived with disability (YLDs) due to vertebral fractures caused by falls. It employs methods such as the Age-Period-Cohort (APC) model, joinpoint regression analysis, and decomposition analysis for further investigation, and calculates the ASIR, ASPR, and ASYR. Finally, it predicts the incidence trend for the next 15 years using the Autoregressive Integrated Moving Average (ARIMA) model.</div></div><div><h3>Results</h3><div>In 2021, the number of new cases of vertebral fractures due to falls globally reached 4.7 million, with a total prevalence of 3.67 million cases, and years lived with disability (YLDs) amounted to 370,000. Compared to 1990, the estimated annual percentage change (EAPC) was -0.37 (-0.41, -0.32), -0.35 (-0.39, -0.31), and -0.37 (-0.41, -0.33) respectively, indicating a declining trend. There are significant differences in the disease burden among different countries and regions. The APC model, Joinpoint model, and ARIMA forecasting model indicate a global declining trend in the disease burden of vertebral fractures.</div></div><div><h3>Conclusions</h3><div>Although the burden of vertebral fractures is on a downward trend, it continues to increase in low and middle SDI regions, as well as among the elderly population. Therefore, targeted preventive measures are still necessary to address the health outcomes related to vertebral fractures.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105874"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond SHAP: Reliable feature selection methods for clinical prediction models","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.archger.2025.105873","DOIUrl":"10.1016/j.archger.2025.105873","url":null,"abstract":"<div><div>This study critically examines the limitations of model-dependent feature importance methods used in clinical prediction modeling, specifically addressing inconsistencies in Xu et al.'s (2025) depression prediction research. We demonstrate how algorithm selection fundamentally alters featured rankings despite similar prediction accuracies, revealing a methodological gap where accuracy validation exists but feature importance validation does not. We propose a comprehensive alternative framework combining statistical and information-theoretic approaches: (1) monotonic relationship detection using Spearman's correlation and Kendall's tau with p-value assessment, and (2) complex interaction analysis using Mutual Information and Effective Transfer Entropy. This dual methodology enables identification of both straightforward variable associations and complex nonlinear dependencies, providing more robust and reliable insights for clinical prediction models.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105873"},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor","authors":"Louis J Koizia ,&nbsp;Vincent E.S Allott ,&nbsp;Michael B. Fertleman ,&nbsp;Benjamin H.L Harris","doi":"10.1016/j.archger.2025.105869","DOIUrl":"10.1016/j.archger.2025.105869","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105869"},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}