Archives of gerontology and geriatrics最新文献

{"title":"Behind closed doors: Homeboundness and psychosocial outcomes. Evidence from a longitudinal study of middle-aged and older adults","authors":"André Hajek ,&nbsp;Pinar Soysal ,&nbsp;Razak M. Gyasi ,&nbsp;Karel Kostev ,&nbsp;Supa Pengpid ,&nbsp;Karl Peltzer ,&nbsp;Hans-Helmut König","doi":"10.1016/j.archger.2025.105767","DOIUrl":"10.1016/j.archger.2025.105767","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine how homeboundness is associated with psychosocial outcomes in terms of life satisfaction, positive affect, negative affect and loneliness among middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Longitudinal data were taken from the nationally representative sample German Ageing Survey (wave 1 to wave 4; <em>n</em> = 18,491 observations). This study included community-dwelling individuals aged 40 years and over in Germany. The mean age in the analytic sample was 62.3 years (SD: 11.8 years). Established tools were used to quantify the psychosocial outcomes. Spending six or more days per week at home was defined as homeboundness. It was adjusted for several time-varying covariates. An asymmetric linear FE regression model with cluster-robust standard errors was applied.</div></div><div><h3>Results</h3><div>There was a robust association between the onset of homeboundness and an increase in loneliness. Among individuals aged 40 to 64 years, the onset of homeboundness was significantly associated with decreases in positive affect, whereas the end of homeboundness was significantly associated with decreases in negative affect. In contrast, changes in homeboundness status were not significantly associated with changes in psychosocial outcomes among individuals aged 65 years and over.</div></div><div><h3>Conclusion</h3><div>The onset of homeboundness in particular can contribute to unfavorable psychosocial outcomes, particularly in terms of increases in loneliness. Efforts to avoid homeboundness may assist in ageing successfully.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105767"},"PeriodicalIF":3.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study","authors":"Guolin Zhang ,&nbsp;Yuqing Lu ,&nbsp;Zhen Wang ,&nbsp;Ruicong Ma ,&nbsp;Hongjin Jin ,&nbsp;Jingsi Zhang ,&nbsp;Fengyi Liu ,&nbsp;Yanchun Ding","doi":"10.1016/j.archger.2025.105765","DOIUrl":"10.1016/j.archger.2025.105765","url":null,"abstract":"<div><h3>Introduction</h3><div>Observational studies and clinical trials have suggested a connection between gut microbiota and aging. However, the causal relationship between them remains undetermined.</div></div><div><h3>Objectives</h3><div>This study aimed to use bidirectional two-sample Mendelian randomization (TSMR) analysis to explore the causal relationship between gut microbiota and aging.</div></div><div><h3>Methods</h3><div>Summary statistics from genome-wide association studies (GWAS) on gut microbiota and seven aging-related phenotypes were employed for TSMR analysis. Reverse Mendelian randomization (MR) analysis was performed to assess the potential for reverse causality. Additionally, the relationship between Akkermansia muciniphila and inflammation-related proteins and metabolites was further investigated. The effects of Akkermansia muciniphila on aging were also examined in Caenorhabditis elegans by measuring both lifespan and healthspan.</div></div><div><h3>Results</h3><div>MR analysis of 207 microbial taxa and seven aging phenotypes revealed 44 causal relationships between the gut microbiota and aging. Akkermansia muciniphila was found to be causally linked to several aging-related traits, including mvAge, appendicular lean mass, and grip strength (<em>P</em> &lt; 0.05). Reverse MR analysis identified 23 causal relationships, but no bidirectional causality was observed. Moreover, Akkermansia muciniphila is causally related to ST1A1, taurine bile acid, and mannose (<em>P</em> &lt; 0.05). In Caenorhabditis elegans, treatment with Akkermansia muciniphila significantly extended lifespan (<em>P</em> &lt; 0.05) and improved mobility in aging nematodes.</div></div><div><h3>Conclusion</h3><div>TSMR analysis uncovers multiple potential causal links between gut microbiota and aging, particularly Akkermansia muciniphila. Experimental results support its role in alleviating aging. This study provides a strong foundation for future research on gut microbiota's role in aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105765"},"PeriodicalIF":3.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming exercise evidence into societal action for healthy longevity","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105768","DOIUrl":"10.1016/j.archger.2025.105768","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105768"},"PeriodicalIF":3.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenoprotein P predicting mortallity in acute ill patients with dyspnea","authors":"V Lindblom ,&nbsp;T Wessman ,&nbsp;P Wändell ,&nbsp;O Melander ,&nbsp;AC Carlsson ,&nbsp;T Ruge","doi":"10.1016/j.archger.2025.105766","DOIUrl":"10.1016/j.archger.2025.105766","url":null,"abstract":"<div><h3>Background and aims</h3><div>Good Selenium (Se) status predicts favorable prognoses for various diseases and a reduced overall mortality.</div><div>The primary objective of the study was to determine whether Selenium status, i.e. Selenoprotein P (SeP) levels, is associated with risk of 90-day mortality in elderly patients with acute dyspnea at the Emergency Department (ED).</div></div><div><h3>Methods and results</h3><div>Patients presenting with dyspnea were enrolled from the ED at the University Hospital in Malmö between 2013 and 2018. Cox regression analyses were conducted to evaluate hazard ratios (HRs) for 90-day mortality. This analysis was performed in two steps. Model A included adjustments for age and sex with 95 % confidence intervals (95 % CI) for individual factors such as SeP levels, the Medical Emergency Triage and Treatment System – Adult (METTS-A), BMI levels, comorbidities, and smoking status. Model B was a multivariate analysis with 99 % confidence intervals (99 % CI), incorporating age, sex, and statistically significant factors from Model A, including SeP levels, BMI, heart failure, anemia, and stroke. A lower concentration of SeP was independently associated with a higher risk of death within 90 days. In the continuous model of SeP, the HR was 0.798 (99 % CI 0.678–0.940). When comparing the lowest quartile to the highest quartile of SeP, the HR was 2.462 (99 % CI 1.240–4.891).</div></div><div><h3>Conclusion</h3><div>Low SeP concentrations were found to predict 90-day mortality in ED patients presenting with dyspnea. The assessment of SeP levels could serve as a valuable tool in the initial evaluation of elderly patients in the ED.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105766"},"PeriodicalIF":3.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of insulin resistance estimated by glucose disposal rate with frailty progression","authors":"Jiayu Sun ,&nbsp;Xiaoming Guo ,&nbsp;Wenxin Guo ,&nbsp;Yanlong Li ,&nbsp;Junzhe Han ,&nbsp;Bin Yang ,&nbsp;Lina Meng ,&nbsp;Yang Liu","doi":"10.1016/j.archger.2025.105764","DOIUrl":"10.1016/j.archger.2025.105764","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the relationship between estimated glucose disposal rates (eGDR) and the progression of frailty, using longitudinal data.</div></div><div><h3>Methods</h3><div>We analyzed four waves of data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, involving 6,778 middle-aged and older adults. eGDR was calculated using a specific formula, categorizing participants into high and low eGDR groups based on the lowest quartile (8.5). Frailty status was assessed using the frailty index (FI). Linear mixed-effects models were employed to analyze the association between eGDR and frailty progression, as well as the impact of transitions in eGDR.</div></div><div><h3>Results</h3><div>We found that the baseline FI was significantly higher in the low eGDR group compared to the high eGDR group. Furthermore, participants in the low eGDR group exhibited a faster progression of frailty, compared to those in the high eGDR group. Among non-frail participants at baseline, the association between low eGDR and accelerated frailty progression was even more pronounced. Further analysis revealed that, compared to participants who maintained a stable high eGDR, those who transitioned from high to low eGDR and those who consistently remained in the low eGDR group both experienced significantly accelerated frailty progression. On the contrary, participants who transitioned from low to high eGDR did not show a significant acceleration in frailty progression compared to those who consistently maintained a high eGDR.</div></div><div><h3>Conclusion</h3><div>Low eGDR is linked to accelerated frailty progression in middle-aged and older Chinese adults. Transitioning from low to high eGDR may mitigate this progression, highlighting the importance of eGDR in frailty management.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105764"},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of loneliness and social isolation with multimorbidity over 14 years in older adults in England: A population-based cohort study","authors":"Hilda Hounkpatin ,&nbsp;Nazrul Islam ,&nbsp;Beth Stuart ,&nbsp;Miriam Santer ,&nbsp;Andrew Farmer ,&nbsp;Hajira Dambha-Miller","doi":"10.1016/j.archger.2025.105763","DOIUrl":"10.1016/j.archger.2025.105763","url":null,"abstract":"<div><h3>Background</h3><div>Previous longitudinal studies have linked multimorbidity to loneliness (feeling alienated) and social isolation (having reduced social contact). However, the nature of these associations over time is unclear.</div></div><div><h3>Objective</h3><div>To examine bidirectional associations of multimorbidity with loneliness and social isolation over a 14-year follow-up in a nationally representative cohort of adults aged ≥ 50 years.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used seven waves of data (collected between 2004/2005 and 2018/2019) from adults in the English Longitudinal Study of Ageing. Multimorbidity was defined as the presence of ≥2 long-term conditions. Loneliness was measured using the 3-item University of California Los Angeles (UCLA) scale. Social isolation was derived based on cohabitation status, frequency of contact with children, relatives, and friends, and social organisation membership. We used Cox proportional hazards models adjusted for social isolation or loneliness, demographic and health behaviour variables.</div></div><div><h3>Results</h3><div>The cohort consisted of 6031 adults with baseline and follow-up data on loneliness, social isolation, multimorbidity, and other covariates. Loneliness was associated with increased risk of incident multimorbidity [aHR (95 % CI): 1.38 (1.15–1.65)], whereas social isolation was not [aHR (95 % CI): 0.97 (0.81–1.16)]. Multimorbidity was associated with increased risk of incident loneliness [aHR (95 % CI): 1.55 (1.30–1.84)], but not significantly associated with subsequent risk of incident social isolation [aHR (95 % CI): 1.09 (0.92–1.28)].</div></div><div><h3>Conclusions</h3><div>An independent bidirectional association exists between loneliness and multimorbidity. Interventions targeting loneliness may prevent or delay multimorbidity and also improve wellbeing for people with multimorbidity.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105763"},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying semaphorin 3C as a biomarker for sarcopenia and coronary artery disease via bioinformatics and machine learning","authors":"Shu Ran ,&nbsp;Zhuoqi Li ,&nbsp;Xitong Lin ,&nbsp;Baolin Liu","doi":"10.1016/j.archger.2025.105762","DOIUrl":"10.1016/j.archger.2025.105762","url":null,"abstract":"<div><h3>Objective</h3><div>Sarcopenia not only affects patients' quality of life but also may exacerbate the pathological processes of coronary artery disease (CAD). This study aimed to identify potential biomarkers to improve the combined diagnosis and treatment of sarcopenia and CAD.</div></div><div><h3>Methods</h3><div>Datasets for sarcopenia and CAD were sourced from the Gene Expression Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) was used to identify key module genes. Functional enrichment analysis was conducted to explore biological significance. Three machine learning algorithms were applied to further determine candidate hub genes, including SVM-RFE, LASSO regression, and random forest (RF). Then, we generated receiver operating characteristic (ROC) curves to evaluate the diagnostic efficacy of the candidate genes. Moreover, mendelian randomization (MR) analysis was conducted based on GWAS summary data, along with sensitivity analysis to explore causal relationships.</div></div><div><h3>Results</h3><div>WGCNA analysis identified 278 genes associated with sarcopenia and CAD. The results of the enrichment analysis indicated a complex interplay between RNA metabolism, signaling pathways, and cellular stress responses. Through machine learning methods and ROC curves, we identified the key gene semaphorin 3C (SEMA3C). MR analysis revealed that higher plasma levels of SEMA3C are associated with an increased risk of CAD (OR = 1.068, 95 % CI 1.012—1.128, <em>P</em> = 0.016) and low hand grip strength (HGS) (OR = 1.059, 95 % CI 1.010—1.110, <em>P</em> = 0.018) .</div></div><div><h3>Conclusion</h3><div>SEMA3C has been identified as a key gene for sarcopenia and CAD. This insight suggests that targeting SEMA3C may offer new therapeutic opportunities in related conditions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105762"},"PeriodicalIF":3.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multimorbidity and the risk of dementia: A systematic review and meta-analysis","authors":"Bo Xin ,&nbsp;Di Zhang ,&nbsp;Hong Fu ,&nbsp;Wenhui Jiang","doi":"10.1016/j.archger.2025.105760","DOIUrl":"10.1016/j.archger.2025.105760","url":null,"abstract":"<div><h3>Background</h3><div>Multimorbidity has become increasingly prevalent and poses challenges in managing cognitive function. This study aimed to (1) systematically review and perform a meta-analysis to understand the relationship between multimorbidity and the risk of dementia and (2) examine the impact of different multimorbidity patterns on this relationship.</div></div><div><h3>Method</h3><div>A systematic review was conducted using PubMed, Embase, PsychINFO, CINAHL, and Cochrane Central to gather studies published up to December 16, 2023. For the meta-analysis, studies with consistent study designs, multimorbidity definitions, and stages of dementia were included. Heterogeneity was assessed using the I² statistic, and Egger's and Begg's tests were used to evaluate publication bias.</div></div><div><h3>Results</h3><div>Of the 12,074 studies identified, 11 were deemed suitable for systematic review, and eight were included in the meta-analysis. Meta-analysis of the longitudinal studies revealed that baseline multimorbidity was significantly associated with an increased risk of dementia compared with individuals without multimorbidity (HR: 1.34, 95 % CI: 1.08–1.68). Meta-analysis of the cross-sectional studies indicated that multimorbidity was significantly associated with a higher risk of being in the prodromal stages of dementia than in individuals without multimorbidity (OR: 1.32, 95 % CI: 1.16–1.51). The risk of dementia varied according to diverse multimorbidity patterns, and the cardiovascular-metabolic condition-related patterns were the most common and associated with high dementia risk.</div></div><div><h3>Conclusions</h3><div>Our findings provide quantitative evidence of a significant association between multimorbidity and the risk of dementia. To develop effective dementia prevention strategies, an in-depth understanding of specific multimorbidity patterns is invaluable for managing cognitive function.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105760"},"PeriodicalIF":3.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global, regional, and national late-life depression burden and trends from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021","authors":"Quan Sun ,&nbsp;Yulong Wei ,&nbsp;Hongting Xie ,&nbsp;Jiaxuan Lyu ,&nbsp;Jingpei Zhou ,&nbsp;Xinyu Li ,&nbsp;Wanqing Peng ,&nbsp;Renhui Zhao ,&nbsp;Ziyuan Li ,&nbsp;Zhenhu Chen ,&nbsp;Jun Lyu ,&nbsp;Nanbu Wang","doi":"10.1016/j.archger.2025.105758","DOIUrl":"10.1016/j.archger.2025.105758","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression (LLD) represents a growing global public health concern. This study aimed to assess the worldwide burden of LLD using comprehensive data.</div></div><div><h3>Methods</h3><div>Leveraging the latest evidence from the Global Burden of Disease Study, we analyzed trends in LLD burden from 1990 to 2021, encompassing incidence, prevalence, and disability-adjusted life years (DALYs). We quantified disparities in LLD burden across socioeconomic, gender, regional, and national dimensions. Decomposition analysis was employed to identify key drivers of LLD burden variation. Frontier analysis illustrated the potential for burden reduction in various countries.</div></div><div><h3>Results</h3><div>Globally, there were 49,137,544 new cases, 46,672,175 prevalent cases, and 7,351,377 DALYs attributed to LLD in 2021. Between 1990 and 2021, the agestandardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), and age-standardised DALYs rate (ASDR) of LLD all rose. In 2021, low SDI regions exhibited the highest all ASRs, while middle SDI regions had the fastest growth rates in these indicators. Regionally, Central and Eastern Sub-Saharan Africa had the highest ASIR, ASPR, and ASDR, respectively. Nationally, Uganda ranked highest in all ASRs in 2021. Women had higher burdens than men. Population growth was a primary driver of DALYs increase in middle SDI regions that had the greatest potential for improvement.</div></div><div><h3>Conclusions</h3><div>The global burden of LLD has risen, with marked inequities across SDI, gender, region, and country. The burden is most pronounced in low and middle SDI regions. These findings offer guidance for developing LLD screening guidelines and enhancing prevention and intervention strategies in relevant countries, particularly Uganda.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105758"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthones explore the mechanism of p53/p21 signaling pathway to prevent cardiac aging and epigenetic regulation of Nrf2 gene","authors":"Yuxin Wei,&nbsp;Yanyan Wang,&nbsp;Xuebing Jiang,&nbsp;Yanping Sun,&nbsp;Meng Wang,&nbsp;Zhenyue Wang,&nbsp;Haixue Kuang,&nbsp;Zhibin Wang","doi":"10.1016/j.archger.2025.105759","DOIUrl":"10.1016/j.archger.2025.105759","url":null,"abstract":"<div><div><em>Gentianella acuta</em> (GA) is a folk medicine used by Ewenki people in Inner Mongolia to treat heart disease. Transcriptional inhibition caused by the increase of DNMT1/3A/3B levels inhibited Nrf2, an anti-aging factor with antioxidant effect in aging myocardia, and the level of Nrf2 decreased with the increase of age. The main chemical component of GA, xanthones, can reverse this inhibition. In this study, D-gal was injected subcutaneously to establish an aging mouse model, and echocardiography was helpful to evaluate myocardial damage. Myocardial histological changes were detected by haematoxylin eosin and Masson's trichrome staining. The activities of catalase (CAT) and total superoxide dismutase (T-SOD) and the content of malondialdehyde (MDA) in serum of mice were detected to investigate the relationship between GA and oxidative stress. The serum levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) were determined to investigate the effects of GA on aging mice. Results showed that Xanthones could alleviate myocardial damage and fibrosis, significantly improve diastolic dysfunction, gradually decrease MDA content, gradually increase T-SOD and CAT activities, and decrease serum TNF-α, IL-6 and IL-1β contents in aging mice. Reduce cardiac structural disorders, reduce inflammatory infiltration. In addition, GA reduces inflammation by promoting Nrf2 expression, inhibiting DNMT1/3A/3B levels, and activating the p53/p21 signaling pathway. This study suggests that GA has a protective effect on D-gal-induced cardiac aging, which may be related to the activation of p53/p21 signaling pathway and epigenetic regulation of Nrf2 level.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105759"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}