Archives of gerontology and geriatrics最新文献

{"title":"Trajectory of depressive symptom before and after incident hearing loss: A 24-year population-based longitudinal cohort study","authors":"Qin Li ,&nbsp;Haohong Lai ,&nbsp;Juntao Wu ,&nbsp;Haidi Yang","doi":"10.1016/j.archger.2025.106090","DOIUrl":"10.1016/j.archger.2025.106090","url":null,"abstract":"<div><h3>Background</h3><div>Although hearing loss (HL) is a known risk factor for depressive symptoms, how depressive symptoms progress after its onset remains insufficiently explored. This study aimed to explore whether incident HL is associated with an acute increase and a sustained progress in depressive symptoms, after accounting for pre-HL depressive trajectories.</div></div><div><h3>Methods</h3><div>Using longitudinal data from the Health and Retirement Study (1998–2022), depressive symptoms were assessed biennially using the 8-item Center for Epidemiologic Studies Depression Scale (CES-D). Linear mixed-effects models were employed to estimate acute changes at the time of HL onset and the annual rate of change in depressive symptoms post-HL, while adjusting for pre-HL trajectories and baseline covariates.</div></div><div><h3>Results</h3><div>Among 11,099 participants (mean age 64.8 years), 3024 developed incident HL over a mean follow-up of 15.7 years. Prior to HL onset, the annual increase in depressive symptoms did not differ significantly between those who developed HL and those who remained free of HL. Following HL onset, a significant acute increase in depressive symptoms was observed (β = 0.234; 95 % CI: 0.184 to 0.283). Additionally, there was a sustained acceleration in the annual rate of increase in depressive symptoms post-HL (β = 0.013/year; 95 % CI: 0.005 to 0.022).</div></div><div><h3>Conclusions</h3><div>Incident HL is associated with an immediate increase and a long-term progress in depressive symptoms, independent of pre-onset trajectories. These findings highlight HL as a preventable risk factor for late-life depressive symptoms and underscore the importance of early detection and intervention for hearing to mitigate depressive symptom risk in aging populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106090"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a modified phenoage for biological aging and chronic diseases in a chinese cohort","authors":"Jialiang Zheng ,&nbsp;Tao Liu ,&nbsp;Yumei Luo,&nbsp;Xing Wei","doi":"10.1016/j.archger.2025.106114","DOIUrl":"10.1016/j.archger.2025.106114","url":null,"abstract":"<div><h3>Objective</h3><div>To address the original PhenoAge’s reliance on C-reactive protein (CRP)—a non-routine clinical biomarker—and enhance practical utility in routine healthcare settings, we developed a modified algorithm (PA-CRP) excluding CRP while retaining its core multi-omics integration framework, and further evaluated its associations with chronic diseases and lifestyle factors in a Chinese cohort.</div></div><div><h3>Methods</h3><div>Both PA-CRP and its derivative PA-CRP_Advance (biological age minus chronological age) were first developed and validated for their validity based on the NHANES dataset. Subsequently, the algorithm was applied to a Chinese university-based cohort (<em>n</em> = 4295), with multivariable logistic and linear regression models (adjusted for key confounders) to assess associations with chronic conditions and lifestyle factors.</div></div><div><h3>Results</h3><div>PA-CRP demonstrated strong validity in reflecting biological aging and predicting mortality. In the Chinese cohort, it was significantly associated with hypertension, hyperlipidemia, hyperglycemia, and cataracts, while PA-CRP_Advance showed targeted links to hyperuricemia and hyperglycemia. Smoking was confirmed as a key driver of accelerated biological aging, and physical activity exhibited a non-linear protective effect; alcohol consumption showed no significant association.</div></div><div><h3>Conclusion</h3><div>PA-CRP is a valid, pragmatic tool for assessing biological aging and chronic disease risk in Chinese adults. Its exclusion of CRP enables broad application in routine clinical and public health contexts where CRP is unavailable, supporting its utility as a cross-population applicable biological aging metric.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106114"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of multidimensional frailty among older adults during 2010–2023: A systematic review and cross-temporal meta-analysis","authors":"Huanle Liu ,&nbsp;Bin Chen ,&nbsp;Xianying Lu ,&nbsp;Shi Chen ,&nbsp;Huan Chen ,&nbsp;Xinyu Chen ,&nbsp;Dingxi Bai ,&nbsp;Xiaohui Dong ,&nbsp;Shirui Tang ,&nbsp;Jingyang Wang ,&nbsp;Chaoming Hou ,&nbsp;Jing Gao","doi":"10.1016/j.archger.2025.106092","DOIUrl":"10.1016/j.archger.2025.106092","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the changing trend of multidimensional frailty among the elderly from 2010 to 2023 and its relationship with social changes.</div></div><div><h3>Study design</h3><div>This is a cross-temporal meta-analysis study.</div></div><div><h3>Methods</h3><div>From the establishment of each database to October 2024, eight databases were systematically searched, including PubMed, Web of Science, Embase, CINAHL, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, and SinoMed Database. Two researchers independently screened the studies and extracted the data. Data analysis was conducted using SPSS version 26.0 through correlation analysis and linear regression.</div></div><div><h3>Results</h3><div>96 studies involving 79,810 individuals were ultimately included. The results showed an increasing trend in multidimensional frailty in older adults over time (<em>β</em>= 0.088 to 0.225, all <em>p</em>-values &lt;0.05), and the effect size <em>d</em> varied between 0.23 and 0.7. The predicted mean TFI total score increased from 5.49 in 2010 to 7.21 in 2023. Subgroup analyses showed a more pronounced increasing trend in the levels of multidimensional frailty in older adults in females (<em>β</em>=0.135), and that levels of multidimensional frailty in older adults in community-based (d = 0.55) and institutionalized settings (<em>d</em>=-0.53) were more strongly affected by the year, whereas hospital-sourced older adults (d = 0.39) were less affected. The level of multidimensional frailty among older adults in Asia has declined (<em>β</em>=-0.015), while Europe showed an upward trend (<em>β</em>=0.077). Meanwhile, lagged analyses showed that the correlations between multidimensional frailty scores and the three types of social indicators (economic status, social support, and health care) were mostly significantly positive.</div></div><div><h3>Conclusions</h3><div>Between 2010 and 2023, multidimensional frailty in the elderly showed an upward trend, as well as economic status, social support, and medical care were associated with the rising level of multidimensional frailty in the elderly. Future research should integrate individual-level health management with macro-level social and economic policies, considering factors such as gender, region, and sample source, to develop personalized intervention programs that effectively enhance the overall health and well-being of older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106092"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying multi-dimensional health clusters associated with high hospitalization burden among middle-aged and older adults in China: A 10-Year cohort study","authors":"Jiaman Liao ,&nbsp;Yaoting Su ,&nbsp;Xueliang Huang ,&nbsp;Yiheng Li ,&nbsp;Hao Huang ,&nbsp;Yiqiang Zhan","doi":"10.1016/j.archger.2025.106110","DOIUrl":"10.1016/j.archger.2025.106110","url":null,"abstract":"<div><h3>Objective</h3><div>To identify and characterize health subtypes among middle-aged and older adults in China, and test if individuals in high-burden subtypes experience greater hospitalization over time.</div></div><div><h3>Methods</h3><div>This cohort study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative survey of adults aged ≥45 years, covering five waves (2011–2020). K-means clustering was applied to seven baseline indicators—functional disability, chronic conditions, neuropsychological vulnerability composite (NVC), unhealthy behaviors, social resources composite (SRC), and prior-year hospitalization—to identify distinct health subtypes. The optimal number of clusters was determined using the elbow method and average silhouette width, and cluster stability was assessed via bootstrap resampling with the adjusted Rand index. Associations between the identified subtypes and subsequent hospitalization burden were examined using generalized estimating equation (GEE) models.</div></div><div><h3>Results</h3><div>The analysis included 16,710 participants (mean age, 59.4 years; 51.2 % female). Two health subtypes were identified: high-burden (27.1 %) and low-burden (72.9 %). The high-burden group showed worse health across all indicators and had significantly higher hospitalization rates. GEE models showed that the low-burden group had fewer hospitalization days (β = –0.34; P &lt; .001) and lower costs (β = –2,336; P &lt; .001). Age and education were significant factors (P &lt; .001).</div></div><div><h3>Conclusions</h3><div>Greater functional disability, more chronic diseases, higher NVC, unhealthy behaviors, and lower SRC were significantly associated with a higher hospitalization burden. These findings underscore the importance of subtype-based stratification for designing targeted interventions in older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106110"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of multiple omics reveals key targets and cellular mechanisms for intervention in sarcopenia","authors":"Zhu Zhu ,&nbsp;Wenji Wang ,&nbsp;Qi Zhang ,&nbsp;Xiao Bi ,&nbsp;Shaojun Ma ,&nbsp;Yue Shen ,&nbsp;Feng Ding","doi":"10.1016/j.archger.2025.106113","DOIUrl":"10.1016/j.archger.2025.106113","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia, an age-related syndrome characterized by progressive loss of muscle mass, strength, and function, presents a significant global health burden with limited therapeutic interventions. This study integrates genomic causality, multi-tissue omics, and cellular mediation analyses to identify and prioritize mechanistically grounded therapeutic targets.</div></div><div><h3>Methods</h3><div>A multi-tiered analytical framework was applied, beginning with two-sample Mendelian randomization (MR) to infer causal relationships between 4907 plasma proteins (cis-pQTLs from 35,559 individuals) and sarcopenia traits in Pan-UK Biobank participants. Bayesian colocalization and transcriptomic validation in human sarcopenia muscle biopsies were employed to prioritize targets. Cellular mediation analysis quantified contributions of immune and stromal cell subtypes to protein-trait pathways using transcriptomic deconvolution.</div></div><div><h3>Results</h3><div>MR identified 1237 plasma proteins causally associated with sarcopenia traits, with six targets (HGFAC, GATM, HMOX2, F2, LMAN2L, HPGDS) validated through colocalization, transcriptomic expression, and sarcopenia-related dysregulation. Cellular mediation revealed immune mechanisms underlying HGFAC’s effects, with CD4+ regulatory T cells mediating 3.49 % of its impact on sarcopenia traits. Prothrombin exhibited muscle-protective effects independent of coagulation.</div></div><div><h3>Conclusion</h3><div>This study establishes a causal map linking plasma proteins to sarcopenia through immune-stromal interactions. The integration of MR, multi-omics validation, and cellular mediation prioritizes six proteins as actionable targets, supporting repurposing of thrombin inhibitors and development of immunometabolic therapies. The framework bridges genomic causality with cellular pathophysiology, advancing precision strategies for age-related muscle decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106113"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitamin D intake alone on elderly body composition: A systematic review and meta-analysis of RCTs","authors":"Tomoyuki Matsuyama,&nbsp;Hiroshi Okada,&nbsp;Yuto Saijo,&nbsp;Yuka Hasegawa,&nbsp;Hanako Nakajima,&nbsp;Takuro Okamura,&nbsp;Rieko Nakatani,&nbsp;Emi Ushigome,&nbsp;Naoko Nakanishi,&nbsp;Masahide Hamaguchi,&nbsp;Michiaki Fukui","doi":"10.1016/j.archger.2025.106093","DOIUrl":"10.1016/j.archger.2025.106093","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the effect of vitamin D on body composition in individuals aged 60 years and older.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Cochrane databases were searched from inception to April 22, 2024, for randomized controlled trials reporting skeletal muscle mass index (SMI), lean mass (LM), handgrip strength, and fat mass (FM) as primary or secondary outcomes in elderly individuals with a mean age of 60 years or older were included. The primary outcome was the change in SMI between vitamin D and control groups; secondary outcomes were changes in LM, FM, and handgrip strength.</div></div><div><h3>Results</h3><div>Seven randomized controlled trials met eligibility criteria. Mean age ranged from 60 to 74 years, participants ranged from 50 to 1094, and study durations ranged from 3 to 36 months. The mean baseline 25(OH)D concentration ranged from 15.1 to 33.0 ng/mL. The vitamin D intake group was not associated with an increase in SMI, LM, or handgrip strength compared to the control group, although a decrease in FM was observed. In the meta-analysis excluding studies that used active vitamin D, the vitamin D intake group was not associated with increases in SMI, LM, or handgrip strength, nor with a decrease in FM compared to the control group.</div></div><div><h3>Conclusion</h3><div>In the present study, vitamin D intake did not increase SMI, LM, or handgrip strength in the elderly individuals, although a possible decrease in FM was observed. Further studies are needed to better elucidate the effects of vitamin D on body composition in the elderly.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106093"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of home-based virtual reality aerobic exercise combined with resistance training for reversing sarcopenia and reducing depression in community-dwelling older adults with sarcopenia: a randomized control trial","authors":"Kornanong Yuenyongchaiwat ,&nbsp;Chanakan Chitjamnogchai ,&nbsp;Natsinee Sermsinsaithong ,&nbsp;Wararat Tavonudomgit ,&nbsp;Lucksanaporn Mahawong ,&nbsp;Sasipa Buranapuntalug ,&nbsp;Preeyaphorn Songsorn ,&nbsp;Chusak Thanawattano","doi":"10.1016/j.archger.2025.106108","DOIUrl":"10.1016/j.archger.2025.106108","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is a growing concern owing to an aging global population. Older people with depression are at risk for sarcopenia and vice versa. Although physical exercise is key in preventing and managing sarcopenia, virtual reality (VR)-based exercises have emerged as an engaging alternative that may also alleviate depressive symptoms and enhance quality of life in older adults. However, the effects of VR exercise on depression in individuals with sarcopenia who are at higher risk of both physical decline and psychological distress remain underexplored.</div></div><div><h3>Objective</h3><div>This study aimed to explore the benefits of home-based VR aerobic exercise combined with resistance training for reversing sarcopenia and depression in community-dwelling older adults with sarcopenia.</div></div><div><h3>Methods</h3><div>This blinded randomized controlled trial enrolled 46 community-dwelling older adults with sarcopenia (37 females and 9 males); they were categorized into the home-based VR (<em>n</em> = 23) group receiving non-immersive VR aerobic exercise combined with a resistance program and the control group (CG) receiving self-care education (CG; <em>n</em> = 23). The VR program combined aerobic and resistance exercises, performed three times weekly for 12 weeks. Sarcopenia risk indicators, including gait speed, handgrip strength, skeletal muscle mass index (SMI), and depression scores, were examined before and after the intervention. A two-way mixed repeated-measures analysis of variance was performed.</div></div><div><h3>Results</h3><div>The VR group showed significant improvements in depressive symptoms (F(1,44)=51.80, <em>p</em>&lt; 0.001), SMI (F(1,44) =28.07, <em>p</em>&lt; 0.001), handgrip strength (F(1,44) = 66.74, <em>p</em>&lt; 0.001, np²=0.599), and gait speed (F(1,44)=0.67, <em>p</em>&lt; 0.001), whereas the CG showed reduced SMI (F(1,44) =7.55, <em>p</em>= 0.009) and handgrip strength F(1,44) =14.99, <em>p</em>&lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Home-based VR aerobic exercise combined with resistance training improves muscle mass, muscle strength, and physical performance and reduces depression in older adults with sarcopenia. Thus, it may be applied to effectively prevent or reverse sarcopenia and decrease depression among older adults.</div></div><div><h3>Trial registration</h3><div>The Thai Clinical Trials Registry is TCTR20231005004.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106108"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From co-design to sustainable practice: Reflections on inclusive physical activity for older adults","authors":"Miglė Kiguolytė ,&nbsp;Benjamin H L Harris ,&nbsp;Louis J Koizia","doi":"10.1016/j.archger.2025.106125","DOIUrl":"10.1016/j.archger.2025.106125","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106125"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of gut microbiota and arginine-agmatine metabolism with postoperative delirium in elderly patients following lower limb fracture surgery: a prospective nested case-control study","authors":"Xinyu Cao,&nbsp;Jing Wang,&nbsp;Yv Zhang,&nbsp;Jing Zhang,&nbsp;Jianli Li","doi":"10.1016/j.archger.2025.106094","DOIUrl":"10.1016/j.archger.2025.106094","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study aimed to investigate the role of gut microbiota and arginine-agmatine metabolic levels in the pathogenesis of postoperative delirium (POD) in elderly patients following lower limb fracture surgery.</div></div><div><h3>Methods</h3><div><strong>:</strong> This prospective nested case-control study enrolled 111 patients aged ≥65 years who were scheduled for elective lower limb orthopedic surgery. POD was assessed twice daily (08:00–10:00 and 18:00–20:00) using the Confusion Assessment Method-Chinese Reversion (CAM-CR). Thirty patients who developed POD were matched to thirty non-POD patients via propensity score matching (PSM). Fecal samples collected one day preoperatively underwent gut microbiota analysis using 16S rRNA gene sequencing, with α-diversity, β-diversity, and linear discriminant analysis effect size (LEfSe) analyses performed. Additionally, fasting venous blood samples collected one day preoperatively were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to quantify plasma levels of arginine, agmatine, putrescine, spermidine, and spermine. Spearman correlation analysis was performed to explore associations between differential bacterial genus abundance, arginine-agmatine metabolite levels, and CAM-CR scores.</div></div><div><h3>Results</h3><div><strong>:</strong> Compared to controls, the POD group showed significantly altered gut microbiota β-diversity (P &lt; 0.001) but no change in α-diversity. At the genus level, LEfSe analysis revealed increased abundance of <em>Megasphaera</em> and <em>Clostridium innocuum group</em>, and decreased abundance of <em>Paraprevotella</em> and <em>Akkermansia</em> in the POD group. Additionally, the POD group exhibited significantly elevated arginine levels (P = 0.044) and reduced agmatine (P = 0.016) and spermine (P = 0.005) levels. Correlation analysis demonstrated that arginine levels were positively correlated with <em>Megasphaera</em> abundance and CAM-CR score, but negatively correlated with <em>Paraprevotella</em> and <em>Akkermansia</em> abundance; agmatine concentrations were positively correlated with <em>Akkermansia</em> abundance but negatively correlated with CAM-CR score; putrescine levels were negatively correlated with <em>Clostridium innocuum group</em> abundance; spermine levels were positively correlated with <em>Paraprevotella</em> abundance but negatively correlated with CAM-CR score. CAM-CR score was negatively associated with <em>Akkermansia</em> abundance and positively associated with <em>Megasphaera</em> abundance (all P &lt; 0.05).</div></div><div><h3>Conclusions</h3><div><strong>:</strong> Gut microbiota and arginine-agmatine metabolism are associated with the pathogenesis of POD in elderly lower limb fracture patients, though their precise mechanistic roles require further investigation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106094"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent transition of social participation and its relationship with frailty among older adults with chronic non-communicable diseases in China: A national longitudinal study","authors":"Zitong Gao ,&nbsp;Haihong Qin ,&nbsp;Tong Yue ,&nbsp;Ye Li ,&nbsp;Miao Huo","doi":"10.1016/j.archger.2025.106091","DOIUrl":"10.1016/j.archger.2025.106091","url":null,"abstract":"<div><h3>Objective</h3><div>Older adults’ social participation is associated with frailty, but the transition patterns and their relationship with frailty remain unclear. This longitudinal study aims to explore the latent classes and transition patterns of social participation in older adults with chronic non-communicable diseases and to assess their relationship with subsequent frailty.</div></div><div><h3>Method</h3><div>The data set from the China Health and Retirement Longitudinal Study (CHARLS) in 2018 (T1) and 2020 (T2) was analyzed, including 4793 older adults. Latent profile analyses (LPA) and latent transition analyses (LTA) were employed to identify latent classes and the transition probabilities of social participation at T1 and T2. The ANCOVA was employed to examine the frailty index at T2 was compared across transition patterns.</div></div><div><h3>Results</h3><div>The LPA results supported a 4-class model labeled as inactive group, voluntary group, social interaction group, and omni-engaged group. The probability of transition from the other groups to the inactive group was significant (33.3 %, 53.8 %, 54.4 %). Age, residence, marital status, and other demographic characteristics can significantly impact transition patterns. However, after controlling for baseline frailty and other covariates, transition patterns were not significantly associated with T2 frailty levels.</div></div><div><h3>Conclusion</h3><div>The short-term (two-year) effect of qualitative shifts in social participation on frailty may be limited when pre-existing health status is accounted for. Future interventions should prioritize sustained engagement and investigate the longer-term effects of both qualitative and quantitative changes in social participation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106091"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}