Archives of gerontology and geriatrics最新文献

{"title":"Protein supplementation alone or combined with exercise for sarcopenia and physical frailty: A systematic review and meta-analysis of randomized controlled trials","authors":"Yoshihiro Yoshimura ,&nbsp;Ayaka Matsumoto ,&nbsp;Tatsuro Inoue ,&nbsp;Masatsugu Okamura ,&nbsp;Masafumi Kuzuya","doi":"10.1016/j.archger.2025.105783","DOIUrl":"10.1016/j.archger.2025.105783","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia and physical frailty are age-related syndromes characterized by progressive loss of muscle mass and function, significantly impacting mortality and quality of life in older adults. This systematic review evaluated the effectiveness of protein supplementation interventions for these conditions.</div></div><div><h3>Methods</h3><div>We systematically searched Medline, CENTRAL, and Ichushi Web from January 2000 to March 2023, with additional manual searching extended to March 2024. Randomized controlled trials investigating protein supplementation, alone or combined with exercise, in adults aged ≥65 years with sarcopenia or physical frailty were included. The primary outcomes were changes in muscle mass, strength, and physical performance.</div></div><div><h3>Results</h3><div>The systematic literature search identified 1,506 records through database searching (Medline: 357, CENTRAL: 275, Ichushi Web: 639) and 235 additional records through hand searching. Finally, 13 randomized controlled trials (n=1,057) met the inclusion criteria. Combined protein and exercise interventions demonstrated significant improvements in skeletal muscle index (MD = 0.89 kg/m², 95 % CI: 0.45 to 1.33) and handgrip strength (MD: +2.64 kg, 95 % CI: +0.75 to +4.53) compared to exercise alone. Protein supplementation alone showed modest benefits in muscle strength but limited effects on physical performance. No serious adverse events were reported.</div></div><div><h3>Conclusions</h3><div>While protein supplementation combined with exercise shows promising effects on muscle mass and strength in older adults with sarcopenia or physical frailty, the evidence quality was consistently rated as very low. Further high-quality trials are needed to establish optimal supplementation strategies.</div></div><div><h3>Registration</h3><div>PROSPERO: CRD42023408529</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105783"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis","authors":"Shenbi Yang ,&nbsp;Hongyan Wang ,&nbsp;Yanmin Tao ,&nbsp;Jing Tian ,&nbsp;Zhifei Wen ,&nbsp;Jun Cao ,&nbsp;Wen Zhang ,&nbsp;Sihan Peng ,&nbsp;Xiangeng Zhang","doi":"10.1016/j.archger.2025.105784","DOIUrl":"10.1016/j.archger.2025.105784","url":null,"abstract":"<div><h3>Purpose</h3><div>Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.</div></div><div><h3>Results</h3><div>A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; <em>I²</em> = 82 %, <em>p</em> &lt; 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; <em>I²</em> = 98 %, <em>p</em> &lt; 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.</div></div><div><h3>Conclusions</h3><div>No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105784"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A structural equation modeling approach to investigating the influence of smart kitchen appliance design features on older adults' technology acceptance","authors":"Yongchuan Li ,&nbsp;Cuiping Jiang ,&nbsp;Salwa Hanim Abdul-Rashid ,&nbsp;Raja Ariffin Raja Ghazilla ,&nbsp;Jing Jin","doi":"10.1016/j.archger.2025.105781","DOIUrl":"10.1016/j.archger.2025.105781","url":null,"abstract":"<div><div>This study investigates the influence of smart kitchen appliance design features on older adults' technology acceptance in China using the Smart Kitchen Appliance–Senior Technology Acceptance Model (SKA–STAM). The SKA–STAM extends the Technology Acceptance Model (TAM) with five key design elements: ergonomics, visuals, functions, interactive interfaces, and brands. A cross-sectional survey using a structured questionnaire was administered to 352 Chinese older adults aged 65–84 in first- and second-tier cities from August to October 2024. Participants were recruited through convenience sampling in residential areas, parks, and fitness spaces in Shanghai and Nanjing, and online random sampling in other cities. Structural equation modeling (SEM) was used to analyze the relationships between design elements, older adults' perceptions, and behavioral intention. The results support the significant role of ergonomics, functions, interactive interfaces, and brands in shaping older users' perceived usefulness, ease of use, and enjoyment. Perceived ease of use emerged as a critical mediator linking design elements to usefulness and enjoyment perceptions. The findings contribute to the theoretical understanding of technology acceptance among older adults and provide practical insights for designing senior-friendly smart kitchen appliances.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105781"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and pre-frailty prevalence in community-dwelling elderly with multimorbidity: A systematic review and meta-analysis","authors":"Shiying Cai ,&nbsp;Jue Li ,&nbsp;Yi Fang ,&nbsp;Zikai Feng ,&nbsp;Huanjiang Liu ,&nbsp;Jiaxin Chen ,&nbsp;Xiali Yang ,&nbsp;Bin Lin ,&nbsp;Zhiyuan Tian","doi":"10.1016/j.archger.2025.105782","DOIUrl":"10.1016/j.archger.2025.105782","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between frailty/pre-frailty, and multimorbidity in the elderly is recognized, but specific prevalence among community-dwelling elderly with multimorbidity is unclear. This study aims to determine these rates, analyze subgroup, and identify sources of heterogeneity to bolster evidence-based interventions and health policies.</div></div><div><h3>Methods</h3><div>We searched nine databases from inception to November 16, 2023, for cross-sectional and cohort studies on community-dwelling elderly with multimorbidity. Data were extracted to calculate the prevalence of frailty and pre-frailty. Study quality was assessed using AHRQ and NOS tools.</div></div><div><h3>Results</h3><div>Fifteen studies encompassing 9,683 participants with multimorbidity were analyzed. The pooled prevalence of frailty and pre-frailty was 18.1 % and 48.9 %, respectively. Age-stratified analyses found 17 % frailty and 58.4 % pre-frailty in the 70–74 age group, and 16.7 % and 54.2 % in those above 75 years. Cross-sectional studies showed 18.8 % frailty and 48.1 % pre-frailty, while cohort studies showed 18.1 % and 50.5 %, respectively. Asia had higher rates (22.7 % frailty, 43.5 % pre-frailty) than the Americas (9.9 % frailty, 56.3 % pre-frailty). By sample size, frailty prevalence was 21.3 % (&lt;500), 9.1 % (500–999), and 17.9 % (≥1000), with pre-frailty at 51.1 %, 45.6 %, and 47.7 %. The FP method yielded higher prevalence estimates (17.7 % frailty, 51.6 % pre-frailty) than the FS method (9.5 % frailty, 39.2 % pre-frailty).</div></div><div><h3>Conclusion</h3><div>This study provides insights into the prevalence of frailty and pre-frailty among community-dwelling elderly with multimorbidity. Variations in prevalence rates may be attributed to differences in sample size and measurement tools, which also contribute to heterogeneity observed across subgroups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105782"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of childhood and adulthood socioeconomic status with frailty index trajectories: Using five-wave panel data from the China Health and Retirement Longitudinal Study (CHARLS)","authors":"Kai Zhang,&nbsp;Lirong Chai,&nbsp;Yi Zhang,&nbsp;Weijing Wang,&nbsp;Xiaolin Hu,&nbsp;Weizheng Kong,&nbsp;Dongfeng Zhang,&nbsp;Junning Fan","doi":"10.1016/j.archger.2025.105780","DOIUrl":"10.1016/j.archger.2025.105780","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between childhood and adulthood socioeconomic status (SES) and long-term frailty trajectories is unclear. We aimed to assess the frailty index (FI) dynamic trajectories and examine the associations between childhood and adulthood SES and frailty trajectories.</div></div><div><h3>Methods</h3><div>We included 7321 participants aged 45 and older from the 2011–2020 China Health and Retirement Longitudinal Study (CHARLS). Six childhood SES factors and four adulthood SES factors were included. Group-based trajectory modelling was used to identify frailty trajectories and multinomial logistic regression was used to assess the association between SES and frailty trajectories.</div></div><div><h3>Results</h3><div>Three frailty trajectory groups were identified: low-increase trajectory (LT, 59.9 %), moderate-increase trajectory (MT, 31.7 %) and high-increase trajectory (HT, 8.4 %). With the LT group as reference, for childhood SES, participants with an illiterate mother (relative-risk radio [RRR]=1.67, 95 % confidence interval [CI]: 1.10–2.52), having not enough food (1.67, 1.34–2.09), with family's financial situation (2.35, 1.61–3.42) and childhood health status (2.72, 2.09–3.53) worse than others had higher odds of being in the HT group. For adulthood SES, rural residence (1.86, 1.50–2.31), with an educational level of less than middle school (2.75, 1.83–4.15), had higher odds of being in the HT group. Similar results were found for people of different ages, genders, and residences.</div></div><div><h3>Conclusions</h3><div>Participants with lower SES, including maternal and self- low education, childhood hunger, worse family financial and childhood health status are more likely to experience a high-increase FI trajectory, i.e. aging faster. Attention should be paid to reduce early-life social inequalities thus to promote later-time healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105780"},"PeriodicalIF":3.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which pathway of the possible sarcopenia algorithm of the AWGS 2019 guideline is the best in Korean community-dwelling older men and women?","authors":"Sohee Kim ,&nbsp;Hyung Eun Shin ,&nbsp;Miji Kim ,&nbsp;Chang Won Won","doi":"10.1016/j.archger.2025.105778","DOIUrl":"10.1016/j.archger.2025.105778","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the diagnostic accuracy of possible sarcopenia identification pathways, as suggested by Asian Working Group for Sarcopenia (AWGS) in 2019, by gender among Korean community-dwelling older adults.</div></div><div><h3>Design</h3><div>Cross-sectional analysis of data from 2,129 community-dwelling adults (70–84 years, 50.4% men) enrolled in Korean Frailty and Aging Cohort Study.</div></div><div><h3>Methods</h3><div>Based on AWGS 2019 guideline, possible sarcopenia was defined by low handgrip strength (HGS) or slow five-times chair stand test (5CST) time, referred to as “assessments.” “Case-findings” (low calf circumference [CC], SARC-F ≥4, or SARC-CalF ≥11) were recommended for screening ‘possible sarcopenia’ before assessment. For the six ‘possible sarcopenia’ pathways (combining three case-finding and two assessment tools), area under the curve (AUC) and F₁ score are compared.</div></div><div><h3>Results</h3><div>For case-finding in men, CC demonstrated the highest AUC (0.657) and F₁ score (0.504) for predicting sarcopenia compared with SARC-F and SARC-CalF (<em>p</em> &lt;0.001, =0.001). Among men with low CC, ΔAUC between HGS and 5CST was not significant as assessment (<em>p</em>=0.079) (AUCs: 0.763 vs. 0.707; F₁ scores: 0.713 vs. 0.650). For case-finding in women, SARC-CalF demonstrated the highest AUC (0.631) and F₁ score (0.389) compared with CC and SARC-F (<em>p</em>=0.012, &lt;0.001). Subsequently, ΔAUC between HGS and 5CST was not significant in women (<em>p</em>=0.069) (AUCs: 0.566 vs. 0.636; F₁ scores: 0.387 vs. 0.514).</div></div><div><h3>Conclusions</h3><div>Based on AWGS 2019 guideline, CC in men and SARC-CalF in women was the best case-finding tool for community-dwelling older adults. After the best case-finding in each gender, two assessment pathways demonstrated insignificant difference in both genders.</div></div><div><h3>Brief summary</h3><div>For case-finding of possible sarcopenia, using calf circumference in older men and using SARC-CalF in older women demonstrated the highest diagnostic accuracy for predicting sarcopenia. After the best case-finding in each gender, two assessment pathways (handgrip strength and five-times chair stand test) of possible sarcopenia demonstrated insignificant difference in both genders.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105778"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dance interventions on cognitive function, balance, mobility, and life quality in older adults: A systematic review and Bayesian network meta-analysis","authors":"Hongli Zhang,&nbsp;Yilun Gao,&nbsp;Yuexin Zhang,&nbsp;Hongtao Ma","doi":"10.1016/j.archger.2025.105775","DOIUrl":"10.1016/j.archger.2025.105775","url":null,"abstract":"<div><h3>Background</h3><div>Physical inactivity in older adults is strongly associated with a variety of health problems that may lead to cognitive decline and impaired physical and mental health. The aim of this study was to investigate the effectiveness of five different dances on cognitive function and quality of life in older adults.</div></div><div><h3>Methods</h3><div>seven databases were systematically searched. Two reviewers independently completed the screening, quality assessment and data extraction of the study. Standardized mean differences (SMDs) were calculated using the Network package in Stata software and network meta-analyses (NMAs) were conducted using Bayesian consistency models using the GeMTC package in R software.</div></div><div><h3>Results</h3><div>The NMA consisted of 28 studies involving 1967 older adults aged 60 years or older, focusing on five different types of dance interventions. The results of the NMA showed that only ballroom dancing significantly improved cognitive function (SMD = 0.89, 95 % confidence interval [CI] (0.07, 1.70)), whereas tango and folk dancing significantly improved balance (SMD = 1. 62, 95 % CI (0.50, 2.76), (SMD = 1.43, 95 % CI (0.15, 2.81)), while tango and self-created dance enhanced mobility (SMD = -1.42, 95 % CI (-2.60, -0.25), (SMD = -1.20, 95 % CI (-2.10, -0.37)). Furthermore, square dancing was the only intervention that significantly improved mental health (SMD = 1.11, 95 % CI (0.03, 2.31)).</div></div><div><h3>Conclusion</h3><div>Ballroom dancing and square dancing appear to be the most effective interventions for improving cognitive ability and mental health, respectively, while tango shows promise as an intervention for improving balance and mobility.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105775"},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differing risk factors for potentially preventable and fall-related injury readmissions of older residents in long-term care facilities after hip fracture","authors":"Seigo Mitsutake ,&nbsp;Reidar P. Lystad ,&nbsp;Tolesa Okuba ,&nbsp;Janet C. Long ,&nbsp;Jeffrey Braithwaite ,&nbsp;Takumi Hirata ,&nbsp;Rebecca Mitchell","doi":"10.1016/j.archger.2025.105779","DOIUrl":"10.1016/j.archger.2025.105779","url":null,"abstract":"<div><h3>Background</h3><div>Although most fall-related injury readmissions are preventable, there may be differences between risk factors for other potentially preventable readmissions (PPR) and fall-related injury readmissions. This study examined the differences between risk factors for 30-day PPR and fall-related injury readmissions among older adults living in residential aged care facilities (RACFs) after a hip fracture.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used linked hospitalization and mortality data in New South Wales, Australia. Residents aged ≥65 years who live in RACFs and were admitted after a hip fracture between 2014 and 2023. Demographic data, the number of Charlson comorbidities, and frailty risk were used. The 30-day PPR was identified using 22 conditions as defined by the Australian government, and three additional conditions (pressure injury, dehydration, sepsis). Multivariable logistic regression examined the predictors for 30-day PPR and fall-related injury readmissions.</div></div><div><h3>Results</h3><div>Among 12,335 residents, there were 266 residents who experienced PPR, and 361 residents who experienced fall-related injury readmissions. Although residents with one (odds ratios: 1.98, 95 % confidence interval: 1.50–2.61) or ≥2 comorbidities (2.38, 1.67–3.37) had a higher risk of 30-day PPR than residents without comorbidities, there was no association of comorbidities with 30-day fall-related injury readmissions. Frailty risk was not associated with 30-day PPR, but residents with high (0.58, 0.37–0.92) and moderate frailty risk (0.63, 0.40–0.99) were less likely to experience fall-related injury readmissions than residents with no frailty risk.</div></div><div><h3>Conclusions</h3><div>Targeted approaches for 30-day PPR and fall-related injury readmissions should be optimized based on their specific predictors for preventing 30-day readmissions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105779"},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ikigai is associated with lower incidence of frailty during a 5-year follow-up in older women: The possible role of interleukin-6","authors":"Bo-Kyung Son ,&nbsp;Michiko Nanao-Hamai ,&nbsp;Yumi Umeda-Kameyama ,&nbsp;Weida Lyu ,&nbsp;Tomoki Tanaka ,&nbsp;Yasuyo Yoshizawa ,&nbsp;Masahiro Akishita ,&nbsp;Katsuya Iijima","doi":"10.1016/j.archger.2025.105776","DOIUrl":"10.1016/j.archger.2025.105776","url":null,"abstract":"<div><h3>Purpose</h3><div><em>Ikigai</em>, a psychological concept in Japanese culture representing a life worth living, contributes to health outcomes. This study examined the association between <em>Ikigai</em> and the incidence of frailty and sought to investigate the underlying biological mechanism by exploring inflammatory cytokines.</div></div><div><h3>Materials and methods</h3><div>In the 2016 Kashiwa Cohort Study, 832 community-dwelling older adults without frailty were enrolled. Participants reported their <em>Ikigai</em> status at baseline. Frailty was defined as meeting three of Fried's five phenotypic criteria. Plasma concentrations of inflammatory cytokines, including interleukins (ILs) and tumor necrosis factor α, were measured at baseline using immunoassays. Cox regression was used to analyze the association between <em>Ikigai</em> and new-onset frailty stratified by sex after adjusting for relevant confounders.</div></div><div><h3>Results</h3><div>Overall, 7.1 % of 832 participants (75.8 ± 4.7 years, women 47.0 %) developed new-onset frailty during the 5-year follow-up. Older adults with <em>Ikigai</em> (<em>n</em> = 749) had better vitality and mental health and fewer depressive symptoms than those without <em>Ikigai</em>. In women, <em>Ikigai</em> was associated with a lower risk of developing frailty (a fully-adjusted hazard ratio=0.24, 95 % confidence interval: 0.08–0.73, <em>P</em> = 0.012). Notably, a significantly lower prevalence of exhaustion was observed in women with <em>Ikigai</em> (<em>P</em> &lt; 0.001). A higher concentration of IL-6 was observed in women with <em>Ikigai</em> at baseline than in those without <em>Ikigai</em> who developed frailty (<em>P</em> = 0.036).</div></div><div><h3>Conclusions</h3><div>This study demonstrated that <em>Ikigai</em> could prevent frailty in women, which might be attributed to mitigate exhaustion. Furthermore, the biological actions of <em>Ikigai</em> are associated with high IL-6 levels. Our findings suggest that sex-specific frailty prevention should be considered with <em>Ikigai</em>.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105776"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143355441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear ageing gero-marker dynamics of transcriptomic profile during calcific aortic valve mouse modeling","authors":"Hongzheng Li ,&nbsp;Xiaoshan Cui ,&nbsp;Zucheng Shang ,&nbsp;Wenwen Yang ,&nbsp;Aimei Lu ,&nbsp;Hao Guo ,&nbsp;Zhi'ang Cheng ,&nbsp;Jiayan Zhou ,&nbsp;Yue Wei ,&nbsp;Mengfan Li ,&nbsp;Guang Chen ,&nbsp;Zikai Yu","doi":"10.1016/j.archger.2025.105777","DOIUrl":"10.1016/j.archger.2025.105777","url":null,"abstract":"<div><div>The prevention and management of degenerative heart disease remain challenging and could potentially be significantly improved by understanding of ageing biomarker dynamics. In this study, we constructed the calcific aortic valve mouse model at different age points, measured valve function degeneration along with valve calcification, and investigated the nonlinear dynamics using sequencing data and deep learning models. In C57BL/6 N mouse model, the older mice had higher levels of peak transvalvular jet velocity in terms of valve function. Regarding valve calcification, collagen and elastic fiber calcification in the middle layer increased significantly at 48-week-old (<em>p</em> &lt; 0.001), and the calcification spread to the inner endothelial cells at 72-week-old (<em>p</em> &lt; 0.0001). RNA sequencing illustrated that 30 genes, including <em>Acadsb, L2hgdh</em>, and <em>Cpped1</em>, showed increased expression with age. Among them, four genes, namely <em>Hipk2, 9430069I07Rik, Peli3</em>, and <em>Slc22a12</em>, increased more than threefold in aortic tissues in 72-week-old mice compared to 6-week-old mice. Moreover, a large proportion of genes changed in a nonlinear pattern (6,325 out of 12,160, 52%). In conclusion, both linear and nonlinear gero-markers were found in the calcific aortic valve mouse modeling, which highlighted specific periods of significant wave with accelerated ageing (48-week-old in mice).</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105777"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}