Archives of gerontology and geriatrics最新文献

{"title":"Independent and combined effects of depressive symptoms and cardiometabolic risk factors on dementia incidence: a cross-country comparison in England, the United States and China","authors":"Panagiota Kontari ,&nbsp;Chris Fife-Schaw ,&nbsp;Kimberley Smith","doi":"10.1016/j.archger.2025.105889","DOIUrl":"10.1016/j.archger.2025.105889","url":null,"abstract":"<div><h3>Background</h3><div>Depression and cardiometabolic conditions are suggested as modifiable risk factors for dementia, yet their combined impact remains unclear. This study assessed the independent and combined effects of depressive symptoms and cardiometabolic conditions on dementia incidence in England, the US and China.</div></div><div><h3>Methods</h3><div>The sample comprised 4472 participants aged 50 and older from the English Longitudinal Study of Ageing (ELSA), 5021 from Health and Retirement Study (HRS), and 8925 from China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the Center for Epidemiological Studies-Depression scale. Cardiometabolic factors included central obesity, low high‐density-lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure (BP), hyperglycemia, diabetes, and inflammation. Dementia incidence was estimated using confounder-adjusted Cox proportional hazards regressions, and pooled estimates were obtained using random-effects meta-analysis.</div></div><div><h3>Results</h3><div>A total of 1218 individuals developed dementia over a median of 6.8–12.2 years. Depressive symptoms (ELSA: <em>HR =</em> 1.47 [95 % CI = 1.09–2.00]; HRS: <em>HR =</em> 1.68 [95 % CI = 1.33–2.13]; CHARLS: <em>HR =</em> 1.35 [95 % CI = 1.12–1.64]) and elevated systolic BP (ELSA: <em>HR =</em> 1.51 [95 % CI = 1.17–1.95]; HRS: <em>HR =</em> 1.48 [95 % CI = 1.24–1.79]; CHARLS: <em>HR =</em> 1.26 [95 % CI = 1.05–1.52]) were linked to dementia risk in all countries. While cardiometabolic multimorbidity (≥2 conditions) was not associated with dementia risk, those with the highest cardiometabolic index (≥4 conditions) had a greater risk of dementia in all samples (ELSA: <em>HR =</em> 1.82 [95 % CI = 1.01–3.26]; HRS: <em>HR =</em> 1.85 [95 % CI = 1.02–3.35]; CHARLS: <em>HR =</em> 1.65 [95 % CI = 1.18–2.30]).</div></div><div><h3>Conclusion</h3><div>Depressive symptoms are independently linked to dementia risk, while having multiple cardiometabolic conditions further increases this risk, especially when co-occurring with depressive symptoms in both Western and Chinese populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105889"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training vs. moderate-intensity continuous training on arterial stiffness in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Ping Luo ,&nbsp;Mingxuan Huang ,&nbsp;Yufang Ye ,&nbsp;Ruixue Wang ,&nbsp;Weiyi Yan ,&nbsp;Lin Zhu ,&nbsp;Shanqi Liu ,&nbsp;Yao Tang ,&nbsp;Kang Liu ,&nbsp;Weifeng Gao","doi":"10.1016/j.archger.2025.105890","DOIUrl":"10.1016/j.archger.2025.105890","url":null,"abstract":"<div><h3>Objective</h3><div>Arterial stiffness (AS) is regarded as an independent predictor of cardiovascular events and all-cause mortality, and it is significantly associated with global mortality rates. Physical activity (PA) plays a positive role in reducing AS and improving cardiovascular health. The aim of this study is to compare the differences between high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in their effects on reducing AS.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search of the PubMed, Cochrane, Embase, Web of Science, and EBSCO electronic databases, covering the period from their inception to January 10, 2025. We used a fixed-effect model to compare the changes in pulse wave velocity (PWV) before and after intervention between the HIIT group and the MICT group. Data were reported using the weighted mean difference (WMD) and 95 % confidence interval (95 % CI).</div></div><div><h3>Results</h3><div>This study included 619 participants from 22 studies. Compared to MICT, HIIT demonstrated a more significant reduction in PWV (-0.10 m/s [95 % CI:0.16 to -0.03], <em>P</em> = 0.005). Additionally, we found that HIIT was superior in reducing CF-PWV (-0.10 m/s [95 % CI:0.17 to -0.02], <em>P</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>HIIT is more effective than MICT in improving PWV and promoting arterial health in adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105890"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynapenic abdominal obesity and chronic kidney disease: Results from a nationwide prospective cohort study of middle-aged and older adults in China","authors":"Zhipeng Chen,&nbsp;Feng Zhao,&nbsp;Siqi Li","doi":"10.1016/j.archger.2025.105879","DOIUrl":"10.1016/j.archger.2025.105879","url":null,"abstract":"<div><h3>Introduction</h3><div>The relationship between dynapenic abdominal obesity (D/AO) and chronic kidney disease (CKD) remains underexplored, particularly among Chinese middle-aged and older adults. This study aimed to address this gap by examining the association between these conditions in a specific population.</div></div><div><h3>Method</h3><div>We conducted a prospective analysis utilizing two waves (2011 and 2015) of data from 5932 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS). Three logistic regression models with covariate adjustment were employed to examine the longitudinal association between D/AO and CKD progression. To strengthen the validity of our results, rigorous sensitivity analyses and subgroup analyses were systematically conducted to assess the robustness of the observed primary association between D/AO and CKD.</div></div><div><h3>Results</h3><div>After adjusting for all covariates, D/AO was associated with a significantly increased risk of CKD (OR, 1.57; 95 % CI, 1.03–2.35). In the subgroup analyses, middle-aged adults with D/AO exhibited a significantly higher incidence of CKD, while showing no significant difference in older populations. Subgroup analyses revealed middle-aged adults with D/AO was associated with a significantly increased risk of CKD (OR, 2.40; 95 % CI, 1.14–4.59; <em>p</em> = 0.01), whereas older adults showed no statistically significant association (OR, 1.56; 95 % CI, 0.96–2.46; <em>p</em> = 0.06).</div></div><div><h3>Conclusion</h3><div>This prospective cohort study demonstrates that D/AO conferred elevated CKD risk in Chinese middle-aged adults, while showing no significant association in older populations. These findings highlight the need for interventions aimed at improving muscle strength and reducing abdominal adiposity in CKD prevention strategies and public health policies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105879"},"PeriodicalIF":3.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonizing WHO-ICOPE with muscle health to promote healthy longevity","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105891","DOIUrl":"10.1016/j.archger.2025.105891","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105891"},"PeriodicalIF":3.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study","authors":"Mizhgan Fatima ,&nbsp;Ben Kirk ,&nbsp;Sara Vogrin ,&nbsp;Wei-Ju Lee ,&nbsp;Li-Ning Peng ,&nbsp;Liang-Kung Chen ,&nbsp;Gustavo Duque","doi":"10.1016/j.archger.2025.105888","DOIUrl":"10.1016/j.archger.2025.105888","url":null,"abstract":"<div><h3>Background</h3><div>Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk.</div></div><div><h3>Objectives</h3><div>To investigate if osteosarcopenia is associated with frailty risk in community-dwelling older adults.</div></div><div><h3>Design</h3><div>Retrospective analysis of a prospective cohort study.</div></div><div><h3>Setting</h3><div>I–Lan Longitudinal Aging Study (ILAS).</div></div><div><h3>Participants</h3><div>1779 older adults (≥50 years) at baseline, and 998 participants at follow-up.</div></div><div><h3>Measurements</h3><div>Frailty was defined based on the Fried criteria. Osteosarcopenia was defined by the coexistence of osteopenia or osteoporosis (WHO definition) and sarcopenia (Asian Working Group definition). Multinomial logistic regression models were employed to examine the association of osteosarcopenia (at baseline) with frailty risk (at eight years), adjusted for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Out of 1779 adults (mean age 63.9 ± 9.2 SD, women 53.1 %), 998 (mean age 67.1 ± 7.6 SD, women 52.6 %) completed a follow-up at eight years. At baseline, osteosarcopenia was more prevalent in the frail group (27.5 %) compared to the pre-frail (10.8 %) and non-frail groups (0 %). However, neither osteosarcopenia (Odds Ratio [OR] 2.67, 95 %CI 0.85–8.40, <em>p</em> = 0.094) nor its components (sarcopenia (OR 3.13, 95 %CI 0.64–15.21, <em>p</em> = 0.158); osteopenia (OR 1.33, 95 %CI 0.70–2.53, <em>p</em> = 0.386); osteoporosis (OR 1.71, 95 %CI 0.64–4.59, <em>p</em> = 0.287)) were associated with frailty risk at eight years.</div></div><div><h3>Conclusion</h3><div>Neither osteosarcopenia nor its components were associated with frailty risk. However, a greater number of older adults with osteosarcopenia and extended follow-up are needed to re-evaluate whether osteosarcopenia is associated with frailty risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105888"},"PeriodicalIF":3.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationship between diabetes and frailty in middle-aged and older adults: A systematic review and meta-analysis","authors":"Huaxin Si ,&nbsp;Yiran Zhang ,&nbsp;Peng Zhao ,&nbsp;Na Li ,&nbsp;Wendie Zhou ,&nbsp;Yemin Yuan ,&nbsp;Ping He ,&nbsp;Cuili Wang","doi":"10.1016/j.archger.2025.105880","DOIUrl":"10.1016/j.archger.2025.105880","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes and frailty are prevalent and burdensome in middle-aged and older adults. However, current evidence on their association is inconsistent, and no quantitative meta-analysis exists. We conducted a systematic review and meta-analysis to examine whether diabetes increased the risk of frailty and vice versa.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Web of Science, Embase, and CINAHL databases from inception to 10 April 2025. Random-effects models were used to calculate pooled odds ratio (OR) and 95 % confidence interval (CI) for cross-sectional analysis and pooled relative risk (RR) for longitudinal analysis. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</div></div><div><h3>Results</h3><div>From 8559 non-duplicated records, 31 articles were included. People with diabetes had increased risks of prevalent frailty (OR=2.21, 95 %CI: 1.60–3.06, I²=99.0 %, n = 15; GRADE=Low), prevalent pre-frailty (OR=2.23, 95 %CI: 2.19–2.28, I²=0.0 %, n = 2; GRADE=Very low), and incident frailty (RR=1.50, 95 %CI: 1.36–1.65, I²=0.0 %, n = 7; GRADE=Moderate). Those with pre-frailty (OR=1.95, 95 %CI: 1.61–2.36, I²=0.0 %; GRADE=Very low) but not with frailty (OR=2.28, 95 %CI:0.96–5.46, I²=92.3 %; GRADE=Very low) had increased odds of prevalent diabetes in two studies. In 15 studies, the pooled RRs for incident diabetes were 1.47 (95 %CI: 1.37–1.57, I²=91.0 %; GRADE=Moderate) in pre-frail participants and 1.96 (95 %CI: 1.73–2.23, I²=92.7 %; GRADE=Moderate) in frail participants.</div></div><div><h3>Conclusion</h3><div>Our findings support the bidirectional relationship between diabetes and frailty in middle-aged and older adults, with each condition contributing to the development of the other. This highlights the importance of early detection and integrated management strategies for diabetes and frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105880"},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and intrinsic capacity in older adults: A systematic review","authors":"Weslley Barbosa Sales ,&nbsp;Paulo Vitor de Souza Silva ,&nbsp;Bianca Stephany Barbosa Vital ,&nbsp;Marcyo Câmara","doi":"10.1016/j.archger.2025.105875","DOIUrl":"10.1016/j.archger.2025.105875","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia and intrinsic capacity are closely linked factors that impact the health and functional aging of older adults.</div></div><div><h3>Objective</h3><div>This systematic review aims to investigate the associations between the domains of IC and sarcopenia in older adults.</div></div><div><h3>Material and methods</h3><div>The study follows PRISMA guidelines and is registered on PROSPERO. The review included original studies (cohort, cross-sectional, or randomized controlled trials) with participants aged 60+ diagnosed with sarcopenia (based on EWGSOP or other recognized definitions). Intrinsic capacity (IC) was assessed based on the five domains defined within the IC framework—cognition, locomotion, sensory, psychological, and vitality. The Integrated Care for Older People (ICOPE) approach developed by the World Health Organization supports the optimization of IC and functional ability through person-centred and coordinated care. Exclusion criteria included studies with insufficient data on sarcopenia prevalence and IC scores, as well as reviews or studies unrelated to sarcopenia or IC.</div></div><div><h3>Results</h3><div>A total of 397 articles were identified, with 5 meeting the inclusion criteria. These studies, involving 6651 participants aged 60 to 82 years (54.8 % male, 45.2 % female), examined the association between sarcopenia and intrinsic capacity in older adults, using the diagnostic criteria for sarcopenia proposed by the EWGSOP and assessing IC based on its key components. Despite the limited number of studies, the findings suggest a significant link between declining intrinsic capacity and sarcopenia.</div></div><div><h3>Final considerations</h3><div>These results underscore the importance of a multifactorial approach in assessing and managing sarcopenia, which may improve early detection and support healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105875"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between aging, ferroptosis, and common age-related diseases","authors":"Laleh Mavaddatiyan ,&nbsp;SaghiHakimi Naeini ,&nbsp;Sara Khodabandeh ,&nbsp;Fatemeh Hosseini ,&nbsp;RhysJ.P. Skelton ,&nbsp;Vahid Azizi ,&nbsp;Mahmood Talkhabi","doi":"10.1016/j.archger.2025.105877","DOIUrl":"10.1016/j.archger.2025.105877","url":null,"abstract":"<div><div>Aging is a natural biological process that is characterized by the progressive decline in physiological functions and an increased vulnerability to age-related diseases. The aging process is driven by different cell and molecular mechanisms. It has recently been shown that aging is associated with heightened vulnerability to ferroptosis (an intracellular iron-dependent form of programmed cell death). This susceptibility arises from various factors including oxidative stress, impaired antioxidant defences, and dysregulated iron homeostasis. The progressive decline in cellular antioxidant capacity and the accumulation of damaged components contribute to the increased susceptibility of aging cells to ferroptosis. Dysregulation of key regulators involved in ferroptosis, such as glutathione peroxidase 4 (GPX4), iron regulatory proteins, and lipid metabolism enzymes, further exacerbates this vulnerability. The decline in cellular defence mechanisms against ferroptosis during aging contributes to the accumulation of damaged cells and tissues, ultimately resulting in the manifestation of age-related diseases. Understanding the intricate relevance between aging and ferroptosis holds significant potential for developing strategies to counteract the detrimental effects of aging and age-related diseases. This will subsequently act to mitigate the negative consequences of aging and improving overall health in the elderly population. This review aims to clarify the relationship between aging and ferroptosis, and explores the underlying mechanisms and implications for age-related disorders, including neurodegenerative, cardiovascular, and neoplastic diseases. We also discuss the accumulating evidence suggesting that the imbalance of redox homeostasis and perturbations in iron metabolism contribute to the age-associated vulnerability to ferroptosis.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105877"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physical activity trajectories and cognitive function in women 50 years and older: A nationally representative cohort study from the China Health and Retirement Longitudinal Study","authors":"Dehua Gong,&nbsp;Seung-Soo Baek","doi":"10.1016/j.archger.2025.105876","DOIUrl":"10.1016/j.archger.2025.105876","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the longitudinal association between physical activity trajectory changes and cognitive function in women aged 50 years and older.</div></div><div><h3>Methods</h3><div>Data were obtained from the China Health and Retirement Longitudinal Study, collected between 2011 and 2020, involving 2,760 women aged 50 years and older. Group-based trajectory modeling was used to identify four physical activity trajectory groups: Low-Fluctuation Group, Moderate-Increasing Group, Moderate-Stability Group, and High-Fluctuation Group. Cognitive function was assessed based on episodic memory and mental intactness. Linear mixed-effects models were employed to examine the association between physical activity trajectories and cognitive function, including interaction effects and age-stratified analyses.</div></div><div><h3>Results</h3><div>The Moderate-Increasing group was significantly associated with higher levels of global cognitive function (β = 0.45, 95% CI: 0.05–0.85) and episodic memory (β = 0.21, 95% CI: 0.05–0.37), particularly among women aged 50–59 years. In contrast, High-Fluctuation and Low-Fluctuation groups exhibited declining trends across cognitive outcomes. Age-stratified analysis suggested that the association between Moderate-Increasing group and cognitive function was not significant among women aged 60 years and older.</div></div><div><h3>Conclusion</h3><div>In women aged 50–59 years, the Moderate-Increasing group was significantly associated with better global cognitive function and episodic memory; however, this association was attenuated or not observed in older age groups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105876"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-trajectories of physical activity and health in aging: A 20-year nationwide population-based longitudinal study","authors":"Yen-Yun Yu ,&nbsp;Hsi-Yu Lai ,&nbsp;Ching-Hui Loh ,&nbsp;Liang-Kung Chen ,&nbsp;Fei-Yuan Hsiao","doi":"10.1016/j.archger.2025.105878","DOIUrl":"10.1016/j.archger.2025.105878","url":null,"abstract":"<div><h3>Background</h3><div>Although the beneficial effects of exercise in mitigating adverse health outcomes associated with aging are well-established, the optimal intensity, volume, and frequency of exercise, especially for older adults, remain to be fully elucidated. The aim of this study was to examine the longitudinal association between distinct trajectories of various aspects of physical activity and clinical outcomes (mortality and functional disability (Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) disability) at 4- and 8-year follow-ups among community-dwelling middle-aged and older adults.</div></div><div><h3>Methods</h3><div>In this longitudinal cohort study, we identified 1914 community-dwelling adults from the Taiwan Longitudinal Study on Ageing, TLSA (1996–2015). Using group-based multi-trajectory modeling, we analyzed data from the third (1996) through the sixth (2007) wave of TLSA to identify distinct patterns across four self-reported physical activity aspects (frequency, duration, sweating intensity, and breathlessness intensity) among participants stratified by physical activity documented in the third wave survey (active vs. inactive). Cox proportional hazard models were used to examine the associations between these trajectory patterns and clinical outcomes (mortality, ADL/IADL disability) at 4-year (2011) and 8-year (2015) follow-ups.</div></div><div><h3>Results</h3><div>Among initially active participants, we identified three trajectories: \"Declining Active\" (<em>n</em> = 177), \"Re-Engaged Active\" (<em>n</em> = 200), and \"Maintained Active\" (<em>n</em> = 622). The \"Maintained Active\" group showed lower mortality risk at both 4-year (adjusted HR = 0.64, 95 %CI 0.44–0.93) and 8-year (adjusted HR = 0.65, 95 %CI 0.50–0.86) follow-ups compared to the \"Declining Active\" group. Among initially inactive participants, the \"Emerging Active\" group (<em>n</em> = 637) demonstrated lower mortality risk compared to the \"Chronically Inactive\" group (<em>n</em> = 278) at both time points (4-year: adjusted HR = 0.62, 95 %CI 0.43–0.90; 8-year: adjusted HR = 0.68, 95 %CI 0.52–0.89). The \"Re-Engaged Active\" group showed lower risk of ADL impairment (adjusted HR = 0.44, 95 %CI 0.21–0.87) at 8-year follow-up.</div></div><div><h3>Conclusion</h3><div>Maintaining active physical activity or transitioning from inactive to active status was associated with reduced mortality risk. These findings support promoting regular physical activity among older adults, regardless of baseline activity levels.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105878"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}