Feedback mechanisms between physical frailty and cognitive declines in older community-dwelling adults: The Rancho Bernardo Study

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Kai Zhang
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Abstract

This study investigates bidirectional feedback mechanisms between physical frailty and cognitive decline in older adults using 12-year longitudinal data from the Rancho Bernardo Study. Frailty phenotypes were assessed through measures of body composition (appendicular lean mass, adjusted by BMI and height squared), weakness (handgrip strength), and physical functioning (Timed Up-and-Go test and 5-times chair stand test). Cognitive function was evaluated using the Mini-Mental State Examination (global cognitive function), Trail Making Test (executive function), Category Fluency Test (semantic memory), and Buschke–Fuld Selective Reminding Test (verbal episodic memory). We propose a mediation-based approach to model the temporal sequences within the complex system of frailty, and found significant reciprocal associations between physical and cognitive decline. For example, muscle strength fully mediated the association between prior body composition and subsequent cognitive functions, and vice versa. These findings advance the understanding of frailty as a dynamic, multifaceted syndrome by elucidating the direct and indirect pathways across its functional domains, highlighting muscle strength as a pivotal target for screening and interventions to mitigate frailty progression.
社区老年人身体虚弱和认知能力下降之间的反馈机制:Rancho Bernardo研究
本研究利用Rancho Bernardo研究的12年纵向数据,调查老年人身体虚弱和认知能力下降之间的双向反馈机制。虚弱表型通过测量身体组成(经BMI和身高平方调整的阑尾瘦质量)、虚弱(握力)和身体功能(定时起身测试和5次椅子站立测试)来评估。认知功能评估采用迷你精神状态检查(整体认知功能)、轨迹测试(执行功能)、类别流畅性测试(语义记忆)和Buschke-Fuld选择性提醒测试(言语情景记忆)。我们提出了一种基于中介的方法来模拟脆弱复杂系统中的时间序列,并发现身体和认知衰退之间存在显著的相互关联。例如,肌肉力量完全介导了先前的身体组成和随后的认知功能之间的关联,反之亦然。这些发现通过阐明其功能域的直接和间接途径,促进了对虚弱作为一种动态的、多方面的综合征的理解,强调肌肉力量是筛查和干预以减轻虚弱进展的关键目标。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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