{"title":"Feedback mechanisms between physical frailty and cognitive declines in older community-dwelling adults: The Rancho Bernardo Study","authors":"Kai Zhang","doi":"10.1016/j.archger.2025.105870","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates bidirectional feedback mechanisms between physical frailty and cognitive decline in older adults using 12-year longitudinal data from the Rancho Bernardo Study. Frailty phenotypes were assessed through measures of body composition (appendicular lean mass, adjusted by BMI and height squared), weakness (handgrip strength), and physical functioning (Timed Up-and-Go test and 5-times chair stand test). Cognitive function was evaluated using the Mini-Mental State Examination (global cognitive function), Trail Making Test (executive function), Category Fluency Test (semantic memory), and Buschke–Fuld Selective Reminding Test (verbal episodic memory). We propose a mediation-based approach to model the temporal sequences within the complex system of frailty, and found significant reciprocal associations between physical and cognitive decline. For example, muscle strength fully mediated the association between prior body composition and subsequent cognitive functions, and vice versa. These findings advance the understanding of frailty as a dynamic, multifaceted syndrome by elucidating the direct and indirect pathways across its functional domains, highlighting muscle strength as a pivotal target for screening and interventions to mitigate frailty progression.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105870"},"PeriodicalIF":3.5000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of gerontology and geriatrics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016749432500127X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates bidirectional feedback mechanisms between physical frailty and cognitive decline in older adults using 12-year longitudinal data from the Rancho Bernardo Study. Frailty phenotypes were assessed through measures of body composition (appendicular lean mass, adjusted by BMI and height squared), weakness (handgrip strength), and physical functioning (Timed Up-and-Go test and 5-times chair stand test). Cognitive function was evaluated using the Mini-Mental State Examination (global cognitive function), Trail Making Test (executive function), Category Fluency Test (semantic memory), and Buschke–Fuld Selective Reminding Test (verbal episodic memory). We propose a mediation-based approach to model the temporal sequences within the complex system of frailty, and found significant reciprocal associations between physical and cognitive decline. For example, muscle strength fully mediated the association between prior body composition and subsequent cognitive functions, and vice versa. These findings advance the understanding of frailty as a dynamic, multifaceted syndrome by elucidating the direct and indirect pathways across its functional domains, highlighting muscle strength as a pivotal target for screening and interventions to mitigate frailty progression.
期刊介绍:
Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published.
Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.