探索双重感觉障碍和神经精神疾病之间的联系：来自英国生物银行前瞻性队列研究的见解

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-04-18 DOI:10.1016/j.archger.2025.105865

Hai-Hua Guo , Wei Zhang , Shuang-Ling Han , Ya-Nan Ou , Yan Fu , Pei-Yang Gao , Qiong-Yao Li , Hao-Chen Chi , Wei Xu , Lan Tan , Hui-Fu Wang

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引用次数: 0

摘要

背景：在神经精神疾病中，以听觉障碍（HI）和视觉障碍（VI）合并症为特征的双重感觉障碍（DSI）的证据有限。此外，潜在的机制仍然难以捉摸。方法使用来自英国生物银行169,165名参与者的数据，我们比较了无感觉障碍、HI、VI和DSI组的认知和心理健康状况，并在纵向COX分析中调查了感觉障碍数量与神经精神疾病之间的关系。我们还分析了感觉功能及其与脑结构、功能连通性、炎症标志物和代谢物的相互作用的关联，并探讨了它们的介导作用。结果与单纯HI/VI患者相比，dsi患者表现出较差的认知和心理健康状况，并且有较高的神经精神疾病风险。HI和VI均与海马、丘脑、楔前叶、顶叶皮层、颞中回等的萎缩性改变以及白质完整性降低有关。与HI和VI相关的大脑区域与其他皮层的功能连通性下降。听觉和视觉表现在认知功能、心理健康和代谢物方面表现出显著的相互作用。与HI和VI显著相关的脑结构、炎症和代谢生物标志物介导了感觉障碍与认知/心理健康之间的关系。结论：与单独的HI/VI相比，DSI与较差的认知功能、心理健康和较高的神经精神疾病风险相关，这可能是HI和VI之间相互作用的结果。此外，HI和VI与脑萎缩、白质完整性降低和功能连接改变有关。此外，大脑结构、炎症和代谢生物标志物介导了感觉障碍与认知/心理健康之间的关系。

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Exploring associations between dual sensory impairment and neuropsychiatric disorders: Insights from a prospective cohort study in the UK Biobank

Background

Evidence of dual sensory impairment (DSI) characterized by comorbid hearing impairment (HI) and visual impairment (VI) is limited in neuropsychiatric disorders. Moreover, the underlying mechanisms remain elusive.

Methods

Using data from 169,165 UK Biobank participants, we compared cognition and mental health across the no sensory impairment, HI, VI, and DSI groups and investigated the association between the number of sensory impairments and neuropsychiatric disorders in longitudinal COX analyses. We also analyzed the associations of sensory function and its interaction with brain structure, functional connectivity, inflammatory markers, and metabolites and explored their mediating roles.

Results

DSI participants exhibited poor cognition and mental health, and had a higher risk of neuropsychiatric disorders compared to those with HI/VI alone. Both HI and VI were linked to atrophic changes in the hippocampus, thalamus, precuneus, parietal cortex, middle temporal gyrus, etc., and reduced white matter integrity. Brain regions associated with HI and VI exhibited decreased functional connectivity with other cortexes. Hearing and visual performance exhibit a significant interaction in relation to cognitive function, mental health, and metabolites. Brain structures, inflammation, and metabolic biomarkers significantly associated with HI and VI mediated the relationship between sensory impairments and cognition/mental health.

Conclusion

Compared to HI/VI alone, DSI is associated with poorer cognitive function, mental health, and a higher risk of neuropsychiatric disorders, potentially driven by the interaction between HI and VI. Additionally, HI and VI are linked to brain atrophy, reduced white matter integrity, and altered functional connectivity. Furthermore, brain structure, inflammation, and metabolic biomarkers mediate the relationship between sensory impairments and cognition/mental health.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.