Archives of oral biology最新文献

{"title":"Characterization of craniofacial tissue aging in genetically diverse HET3 male mice with longevity treatment of 17-alpha estradiol","authors":"Rami Alsabbagh ,&nbsp;Leah LaVerde ,&nbsp;Emma Chufar ,&nbsp;Jake W. Willows ,&nbsp;Kristy L. Townsend ,&nbsp;Sarah B. Peters","doi":"10.1016/j.archoralbio.2024.106170","DOIUrl":"10.1016/j.archoralbio.2024.106170","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of our study was to 1) characterize craniofacial tissue aging in the new, genetically diverse HET3 mouse model; and 2) ascertain whether increased longevity with 17-alpha estradiol (17αE2) treatment in male mice also improved the health of these tissues. The HET3 mice are a four-strain cross preferred and recommended by the National Institute of Aging to identify longevity treatments and test their ability to reduce age-related pathologies. Previous reports demonstrated increased longevity in male, but not female, HET3 mice with 17αE2 administration.</div></div><div><h3>Design</h3><div>Male mice were raised to approximately 8 months (young), 16 months (middle-aged), and 25 months (old). Middle-aged and old mice were administered a diet supplemented with 17αE2 for 19 weeks. We quantified craniofacial tissue volume and density changes with micro-computed tomography followed by histology.</div></div><div><h3>Results</h3><div>Micro-CT showed that the alveolar bone volume and density did not change with age or treatment. Enamel volume and density changed with age but not treatment. Histology revealed region-specific degeneration of periodontal ligaments (PDLs) with age. Cellular cementum demonstrated age-related density decreases but no change in volume. However, cementum volume and density increased with 17αE2 treatment. Dentin volume increased with age whereas density decreased with age, which were attenuated by 17αE2 treatment.</div></div><div><h3>Conclusions</h3><div>The HET3 mice present an excellent model with which to study the heterogeneous nature of tooth aging and the effects of longevity interventions. We provide novel data on how 17αE2 improves healthspan by modifying age-related changes in the molar dentin and cementum of male mice.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106170"},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the influence of sports-induced trauma on temporomandibular disorders: A systematic review and meta-analysis","authors":"Ravinder S. Saini ,&nbsp;Abdulmajeed Okshah ,&nbsp;Mohammed Haneef ,&nbsp;Syed Altafuddin Quadri ,&nbsp;Mudita Chaturvedi ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.archoralbio.2024.106168","DOIUrl":"10.1016/j.archoralbio.2024.106168","url":null,"abstract":"<div><h3>Objective</h3><div>The main aim of this study was to identify the existing literature on the association between sporting activities and temporomandibular disorders and to critically appraise evidence of this association through a systematic review and meta-analysis.</div></div><div><h3>Design</h3><div>A comprehensive search was conducted using PubMed, ScienceDirect, Dimensions, Google Scholar, Cochrane Library, and the Education Resources Information Centre (ERIC). Articles were selected using pre-specified eligibility criteria. In addition, the quality of eligible studies was assessed using the National Institutes of Health (NIH) for observational cohort and cross-sectional studies. Data were systematically extracted and analyzed.</div></div><div><h3>Results</h3><div>Temporomandibular disorder symptoms, such as myofascial pain, clicking sounds, and musculoskeletal symptoms, were comparably prevalent among athletes and non-athletes, with some studies reporting contrasting results. However, meta-analyses of the comparisons demonstrated statistically insignificant differences between athletes and non-athletes. Additionally, there was a significant reduction in temporomandibular disorder symptoms when mouthguards were used.</div></div><div><h3>Conclusions</h3><div>This comprehensive analysis of existing evidence highlights the various symptoms and clinical manifestations of TMD among athletes, including myofascial pain, clicking sounds, and musculoskeletal symptoms. This study established different prevalence rates in different sports.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"172 ","pages":"Article 106168"},"PeriodicalIF":2.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral microbiome dysbiosis and Sjogren Syndrome. A systematic review of clinical studies","authors":"Ravleen Nagi ,&nbsp;Sanjana Santhosh Kumar ,&nbsp;Megha Sheth ,&nbsp;Ashwini Deshpande ,&nbsp;Junad Khan","doi":"10.1016/j.archoralbio.2024.106167","DOIUrl":"10.1016/j.archoralbio.2024.106167","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review investigates the association of oral microbiome dysbiosis with Sjogren Syndrome (SS).</div></div><div><h3>Materials and methods</h3><div>Indexed databases (PubMed/Medline, EMBASE, OVID, Web of Science, and Scopus) were independently searched for relevant manuscripts published until August 2024. Clinical studies on oral microbial flora count and diversity in SS patients were included. Risk of bias across individual studies was performed using the Risk of Bias in Nonrandomized Studies of Interventions tool.</div></div><div><h3>Results</h3><div>Out of the initial 295 studies, 15 clinical studies met the selection criteria. The protocols were similar across the studies but varied in diagnostic criteria for SS, salivary flow estimation methods, dental and periodontal status findings, and the type of oral microbes observed. Out of 15 studies, 14 showed an alteration in the oral microbiome and differences in microbial diversity in SS patients. Higher oral microbial counts of Prevotella, Viellonella, and Firmicutes in SS were reported, whereas a higher prevalence of caries-associated bacteria Streptococcus, Lactobacillus, and Viellonella was found in SS patients. Overall, the studies had a low risk of bias.</div></div><div><h3>Conclusions</h3><div>The findings of the present review have shown the existence of significant oral microbial dysbiosis and differences in microbial diversity in SS patients compared to healthy subjects. Future well-designed longitudinal studies are needed to validate the results.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"172 ","pages":"Article 106167"},"PeriodicalIF":2.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of bidirectional causal association between temporomandibular disorders and five mental disorders","authors":"Yifan Wu ,&nbsp;Zhenguo Shen ,&nbsp;Bohan Chen ,&nbsp;Shuyan Sheng ,&nbsp;Zhenghan Zhang ,&nbsp;Wei Shao ,&nbsp;Tian Xing","doi":"10.1016/j.archoralbio.2024.106169","DOIUrl":"10.1016/j.archoralbio.2024.106169","url":null,"abstract":"<div><h3>Objective</h3><div>This study utilized two-sample Mendelian randomization (TSMR) to investigate the bidirectional causal associations between temporomandibular disorders (TMD) and five mental disorders.</div></div><div><h3>Methods</h3><div>Single-nucleotide polymorphisms (SNPs) linked to TMD were extracted from the Genome-Wide Association Studies (GWAS) database. The SNPs selected as instrumental variables (IVs) were required to have strong associations with the exposure phenotype and to meet the assumptions of Mendelian randomization (MR) analysis. The primary method employed for TSMR analysis was the Inverse Variance-Weighted (IVW) method. Additionally, the Weighted Median, Weighted Mode, and MR Egger methods were used as secondary approaches to ensure the reliability and credibility of the results. Furthermore, heterogeneity, pleiotropy, and sensitivity tests were conducted to ensure the accuracy and robustness of the findings. After MR analysis, we performed reverse analysis to explore the bidirectional association between TMD and five mental disorders.</div></div><div><h3>Results</h3><div>Our study provided evidence of a positive correlation between TMD and both anxiety (P = 5.94 × 10⁻¹⁵, OR = 1.5253, 95 % CI = 1.3719–1.6959) and depression (P = 3.79 × 10⁻¹², OR = 1.4243, 95 % CI = 1.2890–1.5738). In the reverse TSMR analysis, a positive association was found between anxiety and TMD (P = 0.0126, OR = 1.0664, 95 % CI = 1.0139–1.1217). However, no causal relationship was found between TMD and depression, insomnia, bipolar disorder, or schizophrenia (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>These evidences indicated a bidirectional relationship between TMD and anxiety, and TMD may also contribute to the development of depression.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106169"},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological comparison and cytokeratin-10 expression between Lichen planus and oral lichenoid lesions","authors":"Milena Duarte Moreira,&nbsp;Luanna Canal Pereira,&nbsp;Tahyna Duda Deps,&nbsp;Tânia Regina Grão Velloso,&nbsp;Letícia Nogueira da Gama-de-Souza,&nbsp;Liliana Aparecida Pimenta-Barros,&nbsp;Danielle Resende Camisasca","doi":"10.1016/j.archoralbio.2024.106166","DOIUrl":"10.1016/j.archoralbio.2024.106166","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to compare clinicopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesions.</div></div><div><h3>Design</h3><div>This was a retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service that analyzed sociodemographic and clinicopathological data and CK10 expression. Chi-square tests, Fisher's exact tests and Mann-Whitney tests or Student's t tests were used when appropriate, and p values &lt; 0.05 were considered significant.</div></div><div><h3>Results</h3><div>A total of 23 lichen planus and 23 lichenoid lesions were included. There was an association between oral lichen planus and symptomatology (p = 0.031). The buccal mucosa was the most affected site in both groups: 20 patients (87.0 %) showed oral lichen planus, and 16 patients (69.6 %) oral lichenoid lesions. Bilateral (p &lt; 0.001) striae (p = 0.004) are more characteristic of oral lichen planus. Oral lichen planus was associated with degeneration of the basal layer (p = 0.049) and with mild epithelial dysplasia (p &lt; 0.001). Cytokeratin-10 immunostaining was similar between the groups.</div></div><div><h3>Conclusions</h3><div>A continuous follow-up is necessary to identify different patterns of malignant transformation between groups of lesions, as well as for comparisons with lesions with a higher malignant transformation rate.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106166"},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative proteomics in rat saliva stimulated with pilocarpine and isoprenaline","authors":"Marcin Pasternak ,&nbsp;Weronika Pogoda ,&nbsp;Piotr Ceranowicz ,&nbsp;Jakub Cieszkowski ,&nbsp;Józef Madej ,&nbsp;Rafał Olszanecki ,&nbsp;Maciej Suski","doi":"10.1016/j.archoralbio.2024.106165","DOIUrl":"10.1016/j.archoralbio.2024.106165","url":null,"abstract":"<div><h3>Objective</h3><div>Saliva is increasingly being recognized as a convenient and informative reservoir of proteins that could serve as indicators of various diseases. As the literature remains taciturn with regard to saliva collection methods in rodents, our objective was to provide the protocol for a comprehensive quantitative proteomic assessment of stimulated rat saliva.</div></div><div><h3>Design</h3><div>We applied the next-generation proteomic methodology (directDIA) to compare qualitatively and quantitatively stimulated rat saliva specimens obtained from pilocarpine alone and pilocarpine in combination with isoprenaline.</div></div><div><h3>Results</h3><div>Collectively, we identified 581 protein groups with high confidence across all samples included in the analysis, with the dynamic range of the identifications estimated to cover 5 orders of magnitude difference between the most abundant and least abundant salivary proteins. Our data evidenced that pilocarpine-stimulated saliva collection showed a trend towards more protein groups identified; however, quantitative reproducibility was preferable after dual stimulation.</div></div><div><h3>Conclusions</h3><div>The main advantage of the double stimulation strategy is the quantitative stability of the salivary proteome, crucial for quantitative salivaomic experiments. We postulate that the latter in combination with the depth of proteome analysis provided by the directDIA technique constitutes a novel analytical tool in research studies designed to unravel the saliva protein composition and its changes in vivo.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106165"},"PeriodicalIF":2.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The periodicity of enamel laminations in human deciduous molars","authors":"Petrina Barnard ,&nbsp;Gina McFarlane ,&nbsp;Chris Deter ,&nbsp;Carolina Loch ,&nbsp;Patrick Mahoney","doi":"10.1016/j.archoralbio.2024.106164","DOIUrl":"10.1016/j.archoralbio.2024.106164","url":null,"abstract":"<div><h3>Objective</h3><div>Enamel laminations are closely spaced incremental lines that run parallel to Retzius lines or the developing enamel surface. Here, the timing of enamel laminations is calculated for naturally exfoliated deciduous molars (n = 111) from three modern-day populations (Aotearoa New Zealand, Britain and Canada).</div></div><div><h3>Design</h3><div>Teeth were sectioned using standard histological methods and examined using a high-powered microscope. Mean daily secretion rates (DSR) were calculated for the outer enamel of each molar in cuspal, lateral and cervical enamel regions. These DSRs were used to determine the periodicity of enamel growth across laminations in each region. Lamination periodicity was compared between populations and sexes, and within molars to assess the relationship between lamination periodicity and the angle between laminations and the outer surface.</div></div><div><h3>Results</h3><div>Laminations were present in 57 % of all molars (<em>n</em> = 63 out of <em>n</em> = 111). Their presence did not vary between populations or by sex. A mean two-day periodicity was observed in cuspal and lateral outer enamel sampling regions. A mean one-day periodicity was observed in the cervical outer enamel. The angle of laminations relative to the outermost surface of the enamel was significantly related to the presence of laminations.</div></div><div><h3>Conclusions</h3><div>A two-day periodicity for laminations indicates that this incremental marking is not a reliable proxy for a circadian 24-hour rhythm in human deciduous molars. The orientation of laminations was similar to Retzius lines but differed to the orientation of cross-striations.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106164"},"PeriodicalIF":2.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regulatory role of BMP9 on lipopolysaccharide-induced matrix metalloproteinases in human stem cells from the apical papilla","authors":"Gang Wang ,&nbsp;Qin Yi ,&nbsp;Butu Hu ,&nbsp;Mengtian Peng ,&nbsp;Tiwei Fu ,&nbsp;Enyi Huang","doi":"10.1016/j.archoralbio.2024.106154","DOIUrl":"10.1016/j.archoralbio.2024.106154","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate changes in the expression of members of the matrix metalloproteinases (MMPs) family in response to lipopolysaccharide (LPS) stimulation and to investigate the regulatory effects of BMP9 on MMPs.</div></div><div><h3>Design</h3><div>The extracted human stem cells from the apical papilla (hSCAPs) were identified by flow cytometry, Alizarin Red staining, Oil Red O staining, and alkaline phosphatase staining. The appropriate LPS concentration for inducing inflammation in hSCAPs was determined using real-time quantitative PCR (RT-qPCR) and Cell Counting Kit-8 (CCK-8) assays. MMP expression in LPS-stimulated hSCAPs was evaluated by RT-qPCR. BMP9 was overexpressed in hSCAPs via recombinant adenovirus, and its effects on MMP regulation were assessed using RT-qPCR, Western blotting, and ELISA. All experiments were conducted in vitro. Data were analyzed by one-way ANOVA followed by Tukey’s post-hoc comparison, with p &lt; 0.05 considered significant.</div></div><div><h3>Results</h3><div>The results showed that on the 3rd and 5th day after LPS stimulation, the expression of MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-12, and MMP-13 in hSCAPs was significantly upregulated. On the 7th day after LPS induction, the expression of MMP-3, MMP-8, MMP-9 and MMP-13 in hSCAPs was significantly increased. When BMP9 was overexpressed in hSCAPs, the elevated MMPs were inhibited to varying degrees.</div></div><div><h3>Conclusions</h3><div>In the LPS-induced inflammatory environment, certain MMPs are elevated in hSCAP, with MMP-13 being the most significant. Overexpression of BMP9 can significantly inhibit elevated MMPs, suggesting that BMP9 may provide new insights and targets for the treatment of periapical periodontitis.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106154"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between occlusal contacts and masticatory muscle activity: A comparative study of cotton and wax normalization methods showing improved repeatability and comfort","authors":"Claudia Adriana Abrão Biasuz,&nbsp;Rafael Reimann Baptista","doi":"10.1016/j.archoralbio.2024.106163","DOIUrl":"10.1016/j.archoralbio.2024.106163","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to correlate occlusal marks on posterior teeth and cusp tips, recorded using an analog qualitative method, with digital evaluations of masseter and temporal muscle activity through electromyography indexes, comparing two normalization techniques (cotton and wax) using the standardized Percentage Overlap Coefficient of the Anterior Temporal muscle and Percentage Overlap Coefficient of the Masseter muscle indexes.</div></div><div><h3>Design</h3><div>This is a comparative cross-sectional observational study. Occlusal contact and electromyography records of the anterior temporal and masseter muscles were detected in 30 individuals with an average age of 34.9 years. During the electromyography examination, two repetitions of normalization were performed, each with maximum voluntary clenches of 5 seconds on cotton and on wax. The average electromyography amplitude was calculated from three repetitions for each material. According to the average obtained for each pair of muscles, the muscle activity index was calculated and correlated to the number of contacts, which were converted into percentages.</div></div><div><h3>Results</h3><div>Normalization with cotton showed a positive correlation between occlusal contacts and muscle activity (rs = 0.465, p = 0.010). The mean muscle activity index for cotton was 79.4 ± 13.9 for the masseter and 83.3 ± 9.2 for the temporal muscle, with no significant difference between the two muscles (p = 0.195). Normalization with wax showed better intra-subject repeatability with less than 5 % variation (masseter: 4.9 %, temporal: 4.2 %). There was no significant difference in muscle contraction between the different normalization materials (p = 0.902).</div></div><div><h3>Conclusion</h3><div>Both normalization methods demonstrated a variation of less than 10 %, with wax being considered more comfortable by the participants, indicating occlusal and muscular adaptation to the different methods. The results showed a positive correlation between posterior occlusal contacts and masticatory muscle activity, especially with cotton normalization, suggesting that occlusal contacts significantly influence muscle activity, potentially leading to muscle fatigue or hyperactivity.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106163"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between miRNA expression and glucose metabolism in oral squamous cell carcinoma","authors":"Talita de Carvalho Kimura ,&nbsp;João Figueira Scarini ,&nbsp;Moisés Willian Aparecido Gonçalves ,&nbsp;Iara Vieira Ferreira ,&nbsp;Erika Said Abu Egal ,&nbsp;Albina Altemani ,&nbsp;Fernanda Viviane Mariano","doi":"10.1016/j.archoralbio.2024.106162","DOIUrl":"10.1016/j.archoralbio.2024.106162","url":null,"abstract":"<div><h3>Objective</h3><div>Given the urgent need for improved diagnostic and therapeutic strategies in oral squamous cell carcinoma (OSCC), this review aims to explore the intricate interplay between OSCC and alterations in glucose metabolism, with a particular focus on the pivotal role of microRNAs (miRNAs) in this context.</div></div><div><h3>Material and methods</h3><div>Data were extracted from a vast literature survey by using PubMed, Embase, and Web of Science search engines with relevant keywords.</div></div><div><h3>Results</h3><div>In OSCC, miRNAs exert regulatory control over the expression of genes involved in glucose metabolism pathways. Dysregulation of specific miRNAs has been implicated in the modulation of key glycolytic enzymes and glucose transporters, intracellular signaling cascades, and interaction with transcription factors, all of which collectively affect glucose uptake and glycolysis, contributing significantly to the observed metabolic alterations in OSCC cells.</div></div><div><h3>Conclusion</h3><div>A comprehensive understanding of these intricate molecular interactions holds significant promise for the development of targeted therapeutic interventions and refined diagnostic approaches to treat OSCC patients.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"171 ","pages":"Article 106162"},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}