Archives of oral biology最新文献

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Corrigendum to “m6A-related genes ALKBH5 and RBMX as prognostic and progression biomarkers in Chinese oral squamous cell carcinoma patients” [Archives of Oral Biology 170 (2024) 106149] “m6a相关基因ALKBH5和RBMX作为中国口腔鳞状细胞癌患者预后和进展的生物标志物”的勘误表[口腔生物学档案170 (2024)106149]
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-05-01 DOI: 10.1016/j.archoralbio.2025.106230
Yong Liu , Jiaying Nie , Ying Huang , Yunyan Yang , Wenen Su , Yumei Zhang , Zhuoqiao Gao , Shaohui Deng , Meilin Li , Shaoyan Lian , Jieying Li , Chaoqun Liu
{"title":"Corrigendum to “m6A-related genes ALKBH5 and RBMX as prognostic and progression biomarkers in Chinese oral squamous cell carcinoma patients” [Archives of Oral Biology 170 (2024) 106149]","authors":"Yong Liu , Jiaying Nie , Ying Huang , Yunyan Yang , Wenen Su , Yumei Zhang , Zhuoqiao Gao , Shaohui Deng , Meilin Li , Shaoyan Lian , Jieying Li , Chaoqun Liu","doi":"10.1016/j.archoralbio.2025.106230","DOIUrl":"10.1016/j.archoralbio.2025.106230","url":null,"abstract":"","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106230"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-205-3p inhibits porphyromonas gingivalis lipopolysaccharide-induced human umbilical vein endothelial cells inflammation and apoptosis by targeting PRMT5 miR-205-3p通过靶向PRMT5抑制牙龈卟啉单胞菌脂多糖诱导的人脐静脉内皮细胞炎症和凋亡
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-29 DOI: 10.1016/j.archoralbio.2025.106276
Jinsheng Wu , Weiyi Li , Ying Tang , Chang Wu , Weishan Li
{"title":"miR-205-3p inhibits porphyromonas gingivalis lipopolysaccharide-induced human umbilical vein endothelial cells inflammation and apoptosis by targeting PRMT5","authors":"Jinsheng Wu ,&nbsp;Weiyi Li ,&nbsp;Ying Tang ,&nbsp;Chang Wu ,&nbsp;Weishan Li","doi":"10.1016/j.archoralbio.2025.106276","DOIUrl":"10.1016/j.archoralbio.2025.106276","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the regulatory mechanism of miR-205–3p in <em>Porphyromonas gingivalis</em> lipopolysaccharide (P.g-LPS)-induced atherosclerosis.</div></div><div><h3>Design</h3><div>In an in vitro setting, human umbilical vein endothelial cells (HUVECs) were exposed to P.g-LPS to simulate the vascular endothelial damage induced by periodontitis. Subsequently, ELISA and flow cytometry were employed to assess the inflammatory response and apoptotic status of these cells.To quantify the expression levels of protein arginine methyltransferase 5 (PRMT5), BCL2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), P65 and miR-205–3p within the HUVECs, Western Blot and qPCR were respectively utilized. Moreover, small interfering RNA (siRNA) targeting PRMT5 and miR-205–3p were applied to monitor the changes in PRMT5 expression. Bioinformatics analysis was carried out to predict the potential binding sites between miR-205–3p and PRMT5. Finally, the interaction between miR-205–3p and PRMT5 was validated through the dual-luciferase reporter assay.</div></div><div><h3>Results</h3><div>The results indicate that P.g-LPS intervention exacerbates damage to HUVECs and increases the expression of PRMT5. Silencing PRMT5 reduces cell inflammation and apoptosis. After stimulation with P.g-LPS, the level of miR-205–3p decreases, and its overexpression alleviates inflammation and apoptosis in the cells. Bioinformatics analysis and dual luciferase reporter assays confirm that PRMT5 is a target of miR-205–3p, and the overexpression of PRMT5 can reverse the protective effects of miR-205–3p.</div></div><div><h3>Conclusion</h3><div>miR-205–3p can mitigate vascular endothelial injury by decreasing PRMT5 expression, providing new insights for potential treatments.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106276"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between pica practice, oral health, and cariogenic microorganisms of US pregnant women: A cross-sectional study 美国孕妇异食癖、口腔健康和致龋齿微生物之间的关系:一项横断面研究
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-29 DOI: 10.1016/j.archoralbio.2025.106277
Yan Wu , Jin Xiao , Noha Rashwan , Abigail Morrissey , Dina Yousif , Nisreen Al Jallad , Kevin Fiscella , TongTong Wu , Brenda A.Z. Abu
{"title":"Association between pica practice, oral health, and cariogenic microorganisms of US pregnant women: A cross-sectional study","authors":"Yan Wu ,&nbsp;Jin Xiao ,&nbsp;Noha Rashwan ,&nbsp;Abigail Morrissey ,&nbsp;Dina Yousif ,&nbsp;Nisreen Al Jallad ,&nbsp;Kevin Fiscella ,&nbsp;TongTong Wu ,&nbsp;Brenda A.Z. Abu","doi":"10.1016/j.archoralbio.2025.106277","DOIUrl":"10.1016/j.archoralbio.2025.106277","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of pica practices during pregnancy on oral health risks and outcomes.</div></div><div><h3>Design</h3><div>A cross-sectional study was conducted among pregnant women in New York. Demographic, medical history and oral hygiene practice data were collected using validated questionnaires. Comprehensive oral examinations included caries and periodontal status (plaque index and bleeding on probing). Clinical samples (saliva, plaque, and pica substances obtained from participants) were processed to assess the carriage of cariogenic microorganisms (<em>Streptococcus mutans</em> and <em>Candida</em> species) using culturing-dependent and -independent methods. We statistically compared oral clinical and microbial outcomes of pica and non-pica participants.</div></div><div><h3>Results</h3><div>Among 20 women enrolled (8 (40 %) with pica and 12 (60 %) without pica), the mean gestational age was 25.55 ± 8.82 weeks. <em>Candida</em> species were detected in 25 % of pica samples (n = 2), predominantly from ice samples. The pica group exhibited poorer oral health conditions, showing more decayed-missing-filled teeth and surfaces than the non-pica counterparts (<em>p</em> = 0.016). Although not statistically significant, salivary carriage of <em>C. albicans</em> was 2.8 times higher in women with pica compared to those without (3.3 ± 5.7 × 10<sup>3</sup> CFU/ml versus 1.2 ± 3.8 × 10<sup>3</sup> CFU/ml in non-pica, <em>p</em> = 0.093). Women with pica reported markedly higher prevalence of anemia (50 %) compared to non-pica participants (8.3 %) (<em>p</em> = 0.035).</div></div><div><h3>Conclusions</h3><div>Pica practices were associated with maternal oral health risks, imploring that clinicians manage pica behaviors to mitigate oral diseases during pregnancy.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106277"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palatal morphology: A systematic review of the association of palatal shape with genetic ancestry, sex and age 腭形态:腭形状与遗传祖先,性别和年龄的关联的系统综述
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-26 DOI: 10.1016/j.archoralbio.2025.106275
Thao Liang Chiam , Harry Perkins , Toby Hughes , Lyle Palmer , Denice Higgins
{"title":"Palatal morphology: A systematic review of the association of palatal shape with genetic ancestry, sex and age","authors":"Thao Liang Chiam ,&nbsp;Harry Perkins ,&nbsp;Toby Hughes ,&nbsp;Lyle Palmer ,&nbsp;Denice Higgins","doi":"10.1016/j.archoralbio.2025.106275","DOIUrl":"10.1016/j.archoralbio.2025.106275","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to review the literature regarding palatal shape variation, and its influence on estimating genetic ancestry, sex, and age.</div></div><div><h3>Design</h3><div>A literature search was performed using PubMed, Scopus and Embase databases, from inception up to January 2025. Original research articles in English examining variation in shape of human hard palate were included, irrespective of study type or publication year. Articles regarding craniofacial anomalies, pathologies and orthodontic treatment were excluded. The risk of bias was assessed independently by two reviewers using the Joanna Briggs Institute critical appraisal tool.</div></div><div><h3>Results</h3><div>Twenty-two studies fulfilled the selection criteria. Dental casts (<em>n</em> = 13) and crania (<em>n</em> = 8) were predominantly utilised in the studies. Geometric morphometrics emerged as the predominant method for palatal shape analysis, followed by fourth-order polynomial curve fitting, visual assessments and ratios. Five studies examined ancestral variation in palatal shape, with four reporting differences between population groups. These studies, however, utilised fixed landmarks only, offering limited insight. Sexual dimorphism of palatal shape was extensively investigated (<em>n</em> = 12), with large numbers of semi-landmarks employed in two studies, but association was reported in four studies only. Palatal shape was reported to change from birth to adulthood but remained unchanged after adulthood.</div></div><div><h3>Conclusion</h3><div>This review highlights that palatal shape may aid ancestry classification but remains inconsistent to classify sex. Palatal shape changes during growth are allometric and hence need to be considered in forensic investigations. More standardised and robust methods may better evaluate the effects of ancestry, sex and age on 3D palatal variation.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106275"},"PeriodicalIF":2.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential expression reveals inflammatory response and oxidative stress genes in dentin caries 牙本质龋的差异表达揭示了炎症反应和氧化应激基因
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-23 DOI: 10.1016/j.archoralbio.2025.106274
Simone G. Oliveira , Rodrigo Jardim , Nelson Kotowski , Alberto M.R. Dávila , Hélio R. Sampaio-Filho , Karina G.S. Ruiz , Flávio H.B. Aguiar
{"title":"Differential expression reveals inflammatory response and oxidative stress genes in dentin caries","authors":"Simone G. Oliveira ,&nbsp;Rodrigo Jardim ,&nbsp;Nelson Kotowski ,&nbsp;Alberto M.R. Dávila ,&nbsp;Hélio R. Sampaio-Filho ,&nbsp;Karina G.S. Ruiz ,&nbsp;Flávio H.B. Aguiar","doi":"10.1016/j.archoralbio.2025.106274","DOIUrl":"10.1016/j.archoralbio.2025.106274","url":null,"abstract":"<div><h3>Objective</h3><div>This study employs RNA-Seq to investigate differentially expressed genes involved in extracellular matrix (ECM) degradation, focusing on collagenases (MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2).</div></div><div><h3>Design</h3><div>Total RNA from caries and caries-free teeth was extracted from pulp, predentin, and dentin. Samples were sequenced using Illumina® technology. Quality validation was done with FASTQC, and low-quality bases were removed using TRIMMOMATIC. Reads were aligned using SALMON against the human transcriptome (CHR38), followed by quantification using Transcripts Per Million. Differential gene expression analysis was conducted using DESeq2 (FDR &lt; 0.05, |log2FC| ≥ 1). Functional enrichment analyses employed Gene Ontology and KEGG databases.</div></div><div><h3>Results</h3><div>Sequencing produced 16–37 million reads per sample, with an average alignment rate of 88.08 %. A total of 334 differentially expressed genes (DEGs) were identified: 195 upregulated and 139 downregulated. Upregulated genes included SAA1 (log2FC = 2.3, p-adj = 0.001) and ORM1 (log2FC = 2.0, p-adj = 0.002), associated with inflammation. MMP-9 was significantly downregulated (log2FC = −1.8, p-adj = 0.003), while MMP-2 showed higher expression in decayed tissues. TIMP-1 expression increased in decayed dentin; TIMP-2 was upregulated in both decayed and caries-free dentin. Protein interaction analysis identified EGFR and metallothioneins as key acute-phase proteins.</div></div><div><h3>Conclusions</h3><div>This study reveals the role of inflammatory and oxidative stress-related genes in dentin caries and shows disruption in the ECM degradation-repair balance. Increased MMP-2 and TIMP-1 expression suggests a compensatory response. MMP activity may serve as a therapeutic target to enhance tissue resilience and slow caries progression.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106274"},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of recombinant human sclerostin on proliferation and migration in human cementoblast lineage cells 重组人硬化蛋白对人成水泥细胞系细胞增殖和迁移的影响
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-19 DOI: 10.1016/j.archoralbio.2025.106273
Naonobu Okimura , Ryo Kunimatsu , Isamu Kado , Ayaka Nakatani , Shuzo Sakata , Kazutaka Ikeda , Shota Ito , Tomohiro Ogasawara , Shintaro Ogashira , Mutsumi Miyauchi , Takashi Takata , Kotaro Tanimoto
{"title":"Effects of recombinant human sclerostin on proliferation and migration in human cementoblast lineage cells","authors":"Naonobu Okimura ,&nbsp;Ryo Kunimatsu ,&nbsp;Isamu Kado ,&nbsp;Ayaka Nakatani ,&nbsp;Shuzo Sakata ,&nbsp;Kazutaka Ikeda ,&nbsp;Shota Ito ,&nbsp;Tomohiro Ogasawara ,&nbsp;Shintaro Ogashira ,&nbsp;Mutsumi Miyauchi ,&nbsp;Takashi Takata ,&nbsp;Kotaro Tanimoto","doi":"10.1016/j.archoralbio.2025.106273","DOIUrl":"10.1016/j.archoralbio.2025.106273","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of sclerostin on the proliferation and migration of human cementoblasts and periodontal ligament cells.</div></div><div><h3>Design</h3><div>Sclerostin expression in human cementoblasts and periodontal ligament cells was assessed using immunochemical staining. Human cementoblasts and periodontal ligament cells were cultured and treated with 100 ng/mL of recombinant human sclerostin. Cell proliferation was evaluated using a 5-bromo-2-deoxyuridine enzyme-linked immunosorbent assay and quantified with a live-cell imaging and analysis platform (IncuCyte® S3 system). Furthermore, sclerostin’s impact on apoptosis in human cementoblasts and periodontal ligament cells was evaluated using IncuCyte® Caspase-3/7 green dye. Additionally, cell migration was analyzed through quantitative wound healing assessment using the IncuCyte® S3 system. Polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blotting were then performed to confirm the effect of sclerostin on CEMP-1. The data obtained were statistically analyzed using the Mann–Whitney U test.</div></div><div><h3>Results</h3><div>Intracellular sclerostin localization in human cementoblasts and periodontal ligament cells were confirmed form the immunochemical staining. The sclerostin-treated group showed suppressed proliferation and migration of human cementoblasts and periodontal ligament cells compared with the non-treated group. Furthermore, the sclerostin-treated group showed significantly elevated caspase-3/7 activity compared with the non-treated group. However, the addition of sclerostin did not result in any significant changes in CEMP-1.</div></div><div><h3>Conclusion</h3><div>Sclerostin is crucial in regulating the proliferation and migration of cementoblasts and periodontal ligament cells. This highlights its importance in regenerating the cementum and periodontal ligament.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106273"},"PeriodicalIF":2.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential impact of micro-196a2 and Toll-like receptor 2 gene polymorphisms on oral cancer prognosis and susceptibility 微-196a2和toll样受体2基因多态性对口腔癌预后和易感性的潜在影响
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-14 DOI: 10.1016/j.archoralbio.2025.106271
Marko Simonovic , Debora Misic , Ruzica Kozomara , Aleksandra Petkovic Curcin , Sasa Jovic , Marko Brkic , Dragan Pandzic , Srboljub Stosic , Gordana Supic
{"title":"Potential impact of micro-196a2 and Toll-like receptor 2 gene polymorphisms on oral cancer prognosis and susceptibility","authors":"Marko Simonovic ,&nbsp;Debora Misic ,&nbsp;Ruzica Kozomara ,&nbsp;Aleksandra Petkovic Curcin ,&nbsp;Sasa Jovic ,&nbsp;Marko Brkic ,&nbsp;Dragan Pandzic ,&nbsp;Srboljub Stosic ,&nbsp;Gordana Supic","doi":"10.1016/j.archoralbio.2025.106271","DOIUrl":"10.1016/j.archoralbio.2025.106271","url":null,"abstract":"<div><h3>Objective</h3><div>Despite advances in diagnosis and treatment in recent years, oral squamous cell carcinoma (OSCC) is still associated with a high recurrence rate and poor survival. MiR-196a2 and TLR2 have been implicated in cancer progression and prognosis, but the significance of their genetic variants in OSCC remains unelucidated.</div></div><div><h3>Design</h3><div>This study investigated the <em>miR-196a2</em> rs11614913 and <em>TLR2</em> rs5743708 genetic variants in Caucasian HPV-negative OSCC patients (n = 95) and age- and sex-matched healthy controls (n = 108) using real-time PCR. An assessment was conducted on their association with clinicopathological features, overall survival (OS), recurrence-free survival (RFS) and OSCC risk.</div></div><div><h3>Results</h3><div>OSCC patients carrying the <em>miR-196a2</em> rs11614913 TT genotype had a higher risk of tumor recurrence (P = 0.045) and shorter RFS (P = 0.041). The proportional hazards assumption was violated for tumor stage. Stage-stratified Kaplan-Meier analysis showed that <em>miR-196a2</em> rs11614913 genotypes and combined CC+CT vs. TT variants significantly affected RFS in stage I/II OSCC patients (<em>P</em> = 0.012 and <em>P</em> = 0.003, respectively), but not in advanced stage III/IV patients (<em>P</em> = 0.545 and <em>P</em> = 0.287, respectively). Cox regression confirmed <em>miR-196a2</em> rs11614913 as an independent predictor of RFS in early stage (HR=3.407, <em>P</em> = 0.015), but not in advance stage patients (HR=1.090, <em>P</em> = 0.711). No significant associations with OS were found. Additionally, the <em>TLR2</em> rs5743708 variant allele A was significantly associated with a lower risk of OSCC (Adjusted OR=0.406, P = 0.013).</div></div><div><h3>Conclusions</h3><div>These findings suggest that <em>miR-196a2</em> rs11614913 could play a stage-dependent role in RFS, influencing early-stage OSCC but losing prognostic significance in advanced disease. Additionally, <em>TLR2</em> rs5743708 may contribute to the decreased OSCC risk.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106271"},"PeriodicalIF":2.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and phenotypic heterogeneity of tooth agenesis: An update including candidate genes 牙齿发育的遗传和表型异质性:包括候选基因的更新
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-11 DOI: 10.1016/j.archoralbio.2025.106270
Wantao Li , Wenjing Xu
{"title":"Genetic and phenotypic heterogeneity of tooth agenesis: An update including candidate genes","authors":"Wantao Li ,&nbsp;Wenjing Xu","doi":"10.1016/j.archoralbio.2025.106270","DOIUrl":"10.1016/j.archoralbio.2025.106270","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to further investigate the genetic etiology as well as the corresponding characteristics of tooth agenesis (TA). It focuses on expanding the gene spectrum and exploring genotype-phenotype correlations and potential candidate genes for TA.</div></div><div><h3>Design</h3><div>The narrative review approach was conducted, providing a comprehensive perspective of tooth agenesis-related literature.</div></div><div><h3>Results</h3><div>We describe the (candidate) causal genes of syndromic TA and nonsyndromic TA respectively. There is overlap between the gene spectrum of the two forms. Tooth phenotypes (either the number of missing teeth or the malformations) of syndromic form are more severe than that of nonsyndromic form. The phenomenon even exists among family members carried the same variant, highlighting the disorder’s complexity and the causal genes’ expression variability. Besides, the candidate genes, corresponding functional and case evidence are updated, which contributes to improve the diagnosis of TA.</div></div><div><h3>Conclusions</h3><div>TA is a group of complex disorder regulated by multiple genetic signaling pathways. We review the previously known and novel found genes/candidate genes related to TA, emphasizing the genetic and phenotypic heterogeneity. The enlarged spectrum is useful for further promoting the understanding of TA and early diagnosis. It is suggested that molecular diagnosis is particularly vital for early management and genetic counseling.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106270"},"PeriodicalIF":2.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of azurocidin and its implications in periodontal and peri-implant disease: A systematic review 吡唑啉在牙周和种植周疾病中的作用及其意义:一项系统综述
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-07 DOI: 10.1016/j.archoralbio.2025.106256
Mario Alberto Alarcón-Sánchez , Sarah Monserrat Lomelí-Martínez , Ruth Rodríguez-Montaño , Julieta Sarai Becerra-Ruiz , Cristina Hermila Martínez-Bugarin , Seyed Ali Mosaddad , Artak Heboyan
{"title":"The role of azurocidin and its implications in periodontal and peri-implant disease: A systematic review","authors":"Mario Alberto Alarcón-Sánchez ,&nbsp;Sarah Monserrat Lomelí-Martínez ,&nbsp;Ruth Rodríguez-Montaño ,&nbsp;Julieta Sarai Becerra-Ruiz ,&nbsp;Cristina Hermila Martínez-Bugarin ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.archoralbio.2025.106256","DOIUrl":"10.1016/j.archoralbio.2025.106256","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aimed to explore the role of Azurocidin (Azu) in the pathogenesis of periodontal and peri-implant disease and its potential use as an inflammatory biomarker.</div></div><div><h3>Materials and methods</h3><div>Four electronic databases were used for study identification: PubMed, Google Scholar, ScienceDirect, and Scopus from Oct 10, 1991 to Jul 15, 2024. Study selection and data extraction were performed in a blinded and independent manner. The Joanna Briggs Institute (JBI) tool was used to assess the quality of cross-sectional articles, and the Newcastle-Ottawa scale was used to assess cohort studies<em>.</em></div></div><div><h3>Results</h3><div>Out of 222 identified articles, nine studies met the inclusion criteria. These studies included 462 participants: 156 with healthy teeth and implants and 306 with periodontal conditions such as gingivitis, periodontitis, apical periodontitis, peri-implant mucositis, and peri-implantitis. A total of 1313 samples were analyzed (163 saliva, 118 PICF, 1003 GCF, 11 gingival tissue, and 18 infected root canals). ELISA was the most common method for azurocidin analysis (66.6 %), followed by LC-MS/MS (33.3 %), nLC-MS/MS (11.1 %), and Western Blot (11.1 %). Azu levels were consistently elevated in individuals with periodontitis compared to periodontally healthy subjects.</div></div><div><h3>Conclusions</h3><div>Azu may contribute to the inflammatory processes in periodontal and peri-implant diseases. Although elevated levels are observed in periodontitis, its diagnostic value remains unclear due to limited and heterogeneous data.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106256"},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogen peroxide-induced oxidative stress alters protein expression in two rat salivary acinar cell lines 过氧化氢诱导的氧化应激改变了两种大鼠唾液腺泡细胞系的蛋白表达
IF 2.2 4区 医学
Archives of oral biology Pub Date : 2025-04-07 DOI: 10.1016/j.archoralbio.2025.106254
Golnaz Golnarnik , Bernd Thiede , Tine M. Søland , Hilde K. Galtung , Trude M. Haug
{"title":"Hydrogen peroxide-induced oxidative stress alters protein expression in two rat salivary acinar cell lines","authors":"Golnaz Golnarnik ,&nbsp;Bernd Thiede ,&nbsp;Tine M. Søland ,&nbsp;Hilde K. Galtung ,&nbsp;Trude M. Haug","doi":"10.1016/j.archoralbio.2025.106254","DOIUrl":"10.1016/j.archoralbio.2025.106254","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the impact of hydrogen peroxide-induced oxidative stress on the protein expression profiles of submandibular and parotid acinar cells using a proteomic approach. We sought to evaluate how oxidative stress might contribute to salivary gland dysfunction and whether the two glands respond differently.</div></div><div><h3>Design</h3><div>Immortalized rat parotid gland (PG) and submandibular gland (SMG) acinar epithelial cell lines were exposed to 50 µM and 150 µM hydrogen peroxide for 24 hr, followed by protein identification and quantification via liquid chromatography-mass spectrometry. Immunofluorescence microscopy and western blot analysis validated selected protein expressions, and cell viability was assessed using trypan blue exclusion assays.</div></div><div><h3>Results</h3><div>Compared to controls, histone H4 expression increased in both cell types after hydrogen peroxide exposure, whereas voltage-dependent anion-selective channel 1, keratin 7, and keratin 8 increased only in parotid gland cells. Conversely, mitochondrial aldehyde dehydrogenase and kidney isoform glutaminase were downregulated in parotid gland cells. Basal expression of mitochondrial aldehyde dehydrogenase and catalase was higher in submandibular gland cells. At higher hydrogen peroxide concentrations, antioxidant proteins expression and cell viability were greater in submandibular gland cells compared to parotid gland cells.</div></div><div><h3>Conclusions</h3><div>Our results suggest that submandibular gland acinar cells exhibit greater resistance to oxidative stress compared to parotid gland cells, potentially due to distinct antioxidant and metabolic coping strategies. Understanding these gland-specific responses may contribute to future approaches to protect salivary glands from oxidative damage under pathological conditions.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"175 ","pages":"Article 106254"},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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