口腔鳞状细胞癌中miRNA表达与糖代谢的相互作用。

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2024-12-11 DOI:10.1016/j.archoralbio.2024.106162

Talita de Carvalho Kimura , João Figueira Scarini , Moisés Willian Aparecido Gonçalves , Iara Vieira Ferreira , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano

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引用次数: 0

摘要

目的：鉴于改善口腔鳞状细胞癌（OSCC）诊断和治疗策略的迫切需要，本综述旨在探讨OSCC与葡萄糖代谢改变之间错综复杂的相互作用，尤其关注微RNA（miRNA）在其中的关键作用：通过使用PubMed、Embase和Web of Science搜索引擎和相关关键词，从大量文献调查中提取数据：结果：在 OSCC 中，miRNAs 对参与葡萄糖代谢通路的基因表达进行调控。特定 miRNAs 的失调与关键糖酵解酶和葡萄糖转运体的调节、细胞内信号级联以及与转录因子的相互作用有关，所有这些因素共同影响着葡萄糖摄取和糖酵解，在很大程度上导致了 OSCC 细胞中观察到的代谢改变：全面了解这些错综复杂的分子相互作用，对于开发治疗 OSCC 患者的靶向治疗干预措施和精细诊断方法大有希望。

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Interplay between miRNA expression and glucose metabolism in oral squamous cell carcinoma

Objective

Given the urgent need for improved diagnostic and therapeutic strategies in oral squamous cell carcinoma (OSCC), this review aims to explore the intricate interplay between OSCC and alterations in glucose metabolism, with a particular focus on the pivotal role of microRNAs (miRNAs) in this context.

Material and methods

Data were extracted from a vast literature survey by using PubMed, Embase, and Web of Science search engines with relevant keywords.

Results

In OSCC, miRNAs exert regulatory control over the expression of genes involved in glucose metabolism pathways. Dysregulation of specific miRNAs has been implicated in the modulation of key glycolytic enzymes and glucose transporters, intracellular signaling cascades, and interaction with transcription factors, all of which collectively affect glucose uptake and glycolysis, contributing significantly to the observed metabolic alterations in OSCC cells.

Conclusion

A comprehensive understanding of these intricate molecular interactions holds significant promise for the development of targeted therapeutic interventions and refined diagnostic approaches to treat OSCC patients.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry