Lena E. Dressler, Karl-Heinz Frommolt, Mirjam Knörnschild, Martina Nagy
{"title":"Cryptic Vocal Communication in the Proboscis Bat (Rhynchonycteris naso)","authors":"Lena E. Dressler, Karl-Heinz Frommolt, Mirjam Knörnschild, Martina Nagy","doi":"10.1111/nyas.70345","DOIUrl":"10.1111/nyas.70345","url":null,"abstract":"<p>Cryptic-living animals face the trade-off between communicating effectively while avoiding detection. To examine how this trade-off shapes vocal behavior, we studied the vocal repertoire of the cryptic-living, neotropical proboscis bat (<i>Rhynchonycteris naso</i>; Emballonuridae). <i>R. naso</i> produces 22 syllable types and 17 vocalization types, including song. One common social vocalization type resembles modified echolocation calls and may also provide sensory information. Vocalizations shaped by natural selection appeared adapted to minimize predation risk: they are short, span broad frequency ranges, have limited detection ranges, and are mostly emitted during rocking, a behavior that maintains crypsis. In contrast, sexually selected vocalizations such as song are more conspicuous, highlighting a tension between effective signaling and remaining undetected. A phylogenetic analysis across 38 emballonurid bat species revealed that <i>R. naso</i> emits exceptionally high-frequency echolocation calls, beyond expectation from body size alone, and beyond the hearing range of most predators and prey, probably reflecting acoustic crypsis. The high-frequency echolocation calls of <i>R. naso</i> reduce detection distances for hearing moths and likely increase capture success. Overall, our study shows that <i>R. naso</i> employs diverse acoustic adaptations to communicate effectively while minimizing detection risk, offering rare insight into the evolution of vocal behaviors in cryptic species.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148522277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TMEM87a Maintains Cardiomyocyte Integrity by Limiting Ferroptosis in Dilated Cardiomyopathy","authors":"Keke Wang, Qian Chen, Jingchao Lu, Chengjian Guan, Yangxuan Peng, Yuhan Yao, Zhaoxu Qiu, Jie Zhang, Lu Geng, Bing Xiao, Sheng Jin, Yuming Wu","doi":"10.1111/nyas.70339","DOIUrl":"10.1111/nyas.70339","url":null,"abstract":"<div>\u0000 \u0000 <p>Dilated cardiomyopathy (DCM) is a major cause of heart failure, but the organelle-level mechanisms linking cardiomyocyte stress to maladaptive remodeling remain incompletely defined. Transmembrane protein 87a (TMEM87a) is a Golgi-associated transmembrane protein implicated in organelle homeostasis and ion conductance. Here, we investigated whether TMEM87a regulates cardiomyocyte integrity and DCM pathogenesis. In a doxorubicin-induced mouse model of DCM, cardiac TMEM87a expression was increased, suggesting engagement of this pathway during myocardial stress. Cardiomyocyte-specific <i>Tmem87a</i> knockout mice developed spontaneous DCM-like disease, including impaired systolic function, ventricular dilation, elevated plasma brain natriuretic peptide, myocardial fibrosis, and cardiomyocyte hypertrophy. Quantitative proteomics of knockout hearts identified ferroptosis as the most significantly enriched pathway. Consistent with disrupted iron and redox homeostasis, <i>Tmem87a</i>-null hearts showed increased iron-handling proteins, myocardial iron deposition, elevated hydrogen peroxide and malondialdehyde levels, reduced GPX4, and increased PTGS2. Pharmacological inhibition of ferroptosis with ferrostatin-1 improved cardiac function and attenuated pathological remodeling in <i>Tmem87a</i> knockout mice. These findings identify TMEM87a as a previously unrecognized regulator of cardiomyocyte homeostasis and implicate ferroptosis as an important downstream effector of cardiac injury caused by <i>Tmem87a</i> knockout.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148522276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuerui Wu, Dana T. Hartman, Miranda Kramer, Claire Mitchell, Kara Long, Nathalie Moriarty, Jinghuan Xiong, Gail S. Goodman
{"title":"Interpersonal Familiarity Affects Children's Reports of Alleged Transgressions: Children's Eyewitness Memory","authors":"Yuerui Wu, Dana T. Hartman, Miranda Kramer, Claire Mitchell, Kara Long, Nathalie Moriarty, Jinghuan Xiong, Gail S. Goodman","doi":"10.1111/nyas.70341","DOIUrl":"10.1111/nyas.70341","url":null,"abstract":"<div>\u0000 \u0000 <p>Although extensive research has examined children's eyewitness memory, relatively little attention has been paid to how children's interpersonal familiarity (contact) with an adult—such as a parent versus a stranger—can affect their memory reports, especially about transgressions. To shed light on this issue, we conducted an experiment in which children were randomly assigned to interact with their own father or with a stranger (e.g., a male confederate). Fathers were then divided as to whether, among all caregivers, they spent the most or equal time in a caregiving role with their child (i.e., majority-contact father vs. nonmajority-contact father). Children's executive function and their memory were then measured. Children who interacted with a majority-contact father, compared to those who interacted with a stranger, were more accurate about the adult's alleged transgressions (falsely suggested during the memory interview). Children's executive function significantly predicted suggestibility. Implications of the findings in relation to the United States’ legal system are discussed.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148522275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mattia Bozzetti, Alessio Lo Cascio, Daniele Napolitano
{"title":"Fear of Missing Out in Academic Workers: A Theoretical Framework","authors":"Mattia Bozzetti, Alessio Lo Cascio, Daniele Napolitano","doi":"10.1111/nyas.70338","DOIUrl":"10.1111/nyas.70338","url":null,"abstract":"<p>This paper proposes the middle-range theory “academic fear of missing out” (academic FoMO) as a situational and dynamic phenomenon emerging within competitive academic environments. Drawing on self-determination theory, the model defines academic FoMO as a response to visibility pressure, motivational frustration, and perceived professional exclusion. Key constructs include overengagement, digital hypervigilance, and performance-driven relational anxiety. The theory outlines antecedents, attributes, and psychological and behavioral consequences, particularly among early-career and structurally vulnerable researchers. This framework aims to support empirical investigation and guide interventions to promote healthier academic cultures in the nursing and health professions.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela Gutchess, Yong Sheng Tan, James Qian, Joshua Oon Soo Goh
{"title":"The Importance of Studying the Cognitive Neuroscience of Aging Across Cultures","authors":"Angela Gutchess, Yong Sheng Tan, James Qian, Joshua Oon Soo Goh","doi":"10.1111/nyas.70336","DOIUrl":"10.1111/nyas.70336","url":null,"abstract":"<p>It is now widely appreciated that culture can shape cognition and neural engagement. However, research investigating the effects of culture across the adult lifespan, with a focus on cognitive aging, is lacking. In this article, we consider why this integration of topics is useful and discuss the ways in which culture has been proposed to affect cognition and the cognitive neuroscience of aging. The literature thus far is reviewed from the perspectives of long-term memory and decision-making, which broadly encompass information processing in the brain and reflect a person's worldview and resulting actions. We argue for the importance of integrating aging into the study of cultural neuroscience, making the case from two different perspectives: the importance of studying cultural influences over the trajectory of the adult lifespan and the importance of understanding the cognitive neuroscience of aging across cultural groups. We discuss challenges and opportunities for future research, concluding that studying the cognitive neuroscience of aging across cultures has the potential to broaden understanding of the factors that contribute to successful cognitive aging as well as age-related decline and pathology.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arianna Felisatti, Matteo Macchinizzi, Lucia Ronconi, Rosa Rugani
{"title":"Numbers Driving Space: Experience With Numerical Sequences Modulates Spatial Behavior in Newborn Chicks (Gallus gallus)","authors":"Arianna Felisatti, Matteo Macchinizzi, Lucia Ronconi, Rosa Rugani","doi":"10.1111/nyas.70325","DOIUrl":"10.1111/nyas.70325","url":null,"abstract":"<p>The preferential engagement of the right hemisphere in vertebrates biases visuospatial attention to the left. This attentional bias has been proposed as the basis for the organization of numbers along a left-to-right mental number line, with small numbers associated with the left and large ones with the right. In humans, this predisposition is modulated by culture, education, and even short exposure to spatial positions of numbers; yet data on animals are lacking. Here, in day-old chicks, we explore whether experience with increasing and decreasing numerical sequences influences the left-to-right visual exploration of numerosities. We conducted two experiments with day-old chicks (<i>n</i> = 70), training them to circumnavigate a sagittal sequence of three number sequences. In Experiment 1, chicks saw stimuli with either 2-5-8 (increasing-group) or 8-5-2 (decreasing-group) elements and then evaluated for searching behavior from left to right; in Experiment 2, we used larger numerosities, 8-20-32 or 32-20-8, and controlled for non-numerical cues. At test, chicks faced the stimuli arranged horizontally. We found that the increasing-group consistently approached the number stimuli from the left, regardless of the number arrangement. In contrast, the decreasing-group showed no directional preference. These results demonstrate that early exposure to numerical sequences can modulate the spontaneous left-to-right bias in newborn chicks, shedding light on the flexibility of cognitive biases in visuospatial and numerical cognition early in life.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Singing Enhances Poetry Learning and Memorization in Preschool Children","authors":"Weijin Hu, Baishen Liang, Yi Du","doi":"10.1111/nyas.70335","DOIUrl":"10.1111/nyas.70335","url":null,"abstract":"<p>Preschool years are a critical period for developing advanced sociolinguistic skills, and poetry education provides unique cognitive and cultural benefits. Singing, as an alternative to rote recitation, may enhance this learning, yet empirical evidence remains limited. Across two experiments, we investigated the effects of singing versus recitation on memorizing classical Chinese poems in 118 Mandarin-speaking preschool children. In Experiment 1a, children aged 4–5 years who learned poetry through singing recalled the material more rapidly and fluently than those who learned through rote recitation. Experiment 1b showed that these advantages persisted over a 6-month interval. Experiment 2 demonstrated that singing continued to improve memorization speed, accuracy, and fluency even with increased semantic complexity in children aged 5–6 years. Together, these findings provide strong evidence for a “singing superiority effect,” whereby singing enhances both immediate and long-term poem memorization in preschoolers. We discuss potential sensorimotor and motivational mechanisms by which melodic structure supports language memory and propose singing as a practical, developmentally appropriate strategy for early language acquisition.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Escape From X-Chromosome Inactivation Enables Survival in a Male With an Unbalanced X;19 Translocation","authors":"Onur Emre Onat, Tayfun Ozcelik","doi":"10.1111/nyas.70340","DOIUrl":"10.1111/nyas.70340","url":null,"abstract":"<p>X;autosome translocations allow us to study how X-chromosome inactivation (XCI) spreads into autosomal DNA in vivo. We re-evaluated a male patient with an inherited unbalanced X;19 translocation to assess XCI-associated silencing of the translocated chromosome 19 segment. High-resolution SNP array analysis refined the rearrangement to a terminal 19p13.3 deletion of <0.21 Mb and a ∼95.4 Mb duplication spanning Xq11.1-Xqter. XCI testing showed opposite patterns in mother and son: the balanced carrier mother preferentially inactivated the normal X chromosome, whereas the proband preferentially inactivated der(19), which carries the duplicated Xq containing the X-inactivation center. To determine whether autosomal genes on der(19) were silenced, we performed allele-specific expression assays across chromosome 19 loci. Several informative loci showed biallelic expression in the proband, suggesting incomplete silencing of the translocated autosomal segment. Informative and less clearly interpretable loci were interspersed without an obvious positional gradient, favoring gene-specific variation in silencing susceptibility over a simple distance-dependent model. These findings are consistent with incomplete and heterogeneous silencing across the autosomal segment and provide a plausible molecular explanation for survival with this otherwise severe unbalanced rearrangement.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro T. Palhares, Sasha D'Ambrosio, Óscar F. Gonçalves
{"title":"TMS–EEG Reveals Causal Dynamics of the Premotor Cortex during Musical Improvisation","authors":"Pedro T. Palhares, Sasha D'Ambrosio, Óscar F. Gonçalves","doi":"10.1111/nyas.70351","DOIUrl":"10.1111/nyas.70351","url":null,"abstract":"<div>\u0000 \u0000 <p>Musical improvisation illustrates the brain's capacity for flexible, creative motor control, yet the causal mechanisms underlying this complex behavior remain poorly understood. We employed transcranial magnetic stimulation combined with electroencephalography (TMS–EEG) to probe state-dependent cortical dynamics in the left dorsal premotor cortex (PMd) of professional jazz pianists (<i>n</i> = 3) during improvisation, sight-reading, and rest. This proof-of-concept study demonstrates the feasibility of combining perturbational neuroscience with ecologically valid musical performance. Multiple convergent analyses revealed distinct cortical signatures during improvisation: reduced local mean field power, decreased phase-locking of evoked responses, and preserved but gain-modulated early components as revealed by correlated components analysis. These findings suggest that improvisation is characterized by attenuated PMd excitability and more variable response timings, while preserving the fundamental architecture of cortical responses. This perturbational signature supports a neural efficiency model of expertise whereby expert musicians achieve creative flexibility through training-induced streamlined, optimized cortical processing. Our results establish TMS–EEG as a powerful approach for investigating the causal dynamics of creative cognition and demonstrate how the brain reconfigures its response properties to support internally driven motor performance.</p>\u0000 </div>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chanyuan Zhang, Siyao Chen, He Zhao, Yan Wang, Lingyan Zhou, Haixia Fan, Yan Sun
{"title":"Phase Separation Drives Pathological Aggregation in Neurodegenerative Diseases: A 15-Year Bibliometric Landscape (2009–2024)","authors":"Chanyuan Zhang, Siyao Chen, He Zhao, Yan Wang, Lingyan Zhou, Haixia Fan, Yan Sun","doi":"10.1111/nyas.70311","DOIUrl":"10.1111/nyas.70311","url":null,"abstract":"<p>Liquid–liquid phase separation (LLPS), a biophysical driver of membraneless organelle assembly, is central to pathological aggregation in neurodegenerative diseases. Initially linked to amyotrophic lateral sclerosis (ALS), LLPS dysregulation has now been implicated in Alzheimer's, Parkinson's, and frontotemporal dementia, where aberrant transitions convert dynamic condensates into insoluble fibrils. To systematically map this landscape, we employed CiteSpace-based bibliometrics to analyze 784 Web of Science articles from 2009 to 2024. Our analyses reveal dominant contributions from the United States, China, and Germany, with collaborative networks focusing on protein dynamics. Key hotspots include LLPS-driven aggregation of TARDBP (TDP-43), FUS, and α-synuclein, alongside stress granule dysfunction and nucleocytoplasmic transport defects. Emerging frontiers highlight therapeutic strategies targeting pathological condensates utilizing small-molecule chaperones and posttranslational modification modulators to restore cellular homeostasis. Our findings underscore LLPS as a critical axis bridging molecular pathology and translational innovation. The field is rapidly shifting from mechanistic exploration to therapeutic applications, emphasizing interventions to halt or reverse aggregation. By delineating global trends and changing priorities, our study highlights the transformative potential of phase-targeted interventions and provides a roadmap of groundbreaking interdisciplinary research into neurodegenerative disorders.</p>","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1561 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.70311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148408138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}