Annals of the New York Academy of Sciences最新文献_第8页

Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential kisspeptin与骨骼之间的相互作用：细胞机制、临床证据和未来潜力

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-13 DOI: 10.1111/nyas.15213

Edouard G. Mills, Ali Abbara, Waljit S. Dhillo, Alexander N. Comninos

{"title":"Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential","authors":"Edouard G. Mills, Ali Abbara, Waljit S. Dhillo, Alexander N. Comninos","doi":"10.1111/nyas.15213","DOIUrl":"10.1111/nyas.15213","url":null,"abstract":"The neuropeptide kisspeptin and its cognate receptor have been extensively studied in reproductive physiology, with diverse and well-established functions, including as an upstream regulator of pubertal onset, reproductive hormone secretion, and sexual behavior. Besides classical reproduction, both kisspeptin and its receptor are extensively expressed in bone-resorbing osteoclasts and bone-forming osteoblasts, which putatively permits direct bone effects. Accordingly, this sets the scene for recent compelling findings derived from in vitro experiments through to in vivo and clinical studies revealing prominent regulatory interactions for kisspeptin signaling in bone metabolism, as well as certain oncological aspects of bone metabolism. Herein, we comprehensively examine the experimental evidence obtained to date supporting the interaction between kisspeptin and bone. A comprehensive understanding of this emerging facet of kisspeptin biology is fundamental to exploiting the future therapeutic potential of kisspeptin-based medicines as a novel strategy for treating bone-related disorders.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"47-60"},"PeriodicalIF":4.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bouillon fortification as a strategy to address inequities in micronutrient adequacy of diets in Nigeria 将肉汤强化作为解决尼日利亚膳食中微量营养素不平等问题的一项战略

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-10 DOI: 10.1111/nyas.15207

Katherine P. Adams, Stephen A. Vosti, Emily Becher, Faith Ishaya, Reina Engle-Stone

{"title":"Bouillon fortification as a strategy to address inequities in micronutrient adequacy of diets in Nigeria","authors":"Katherine P. Adams, Stephen A. Vosti, Emily Becher, Faith Ishaya, Reina Engle-Stone","doi":"10.1111/nyas.15207","DOIUrl":"10.1111/nyas.15207","url":null,"abstract":"Bouillon is a widely consumed condiment in many West African countries, including Nigeria. Although Nigeria has mandatory fortification standards for multiple food vehicles, bouillon fortification could help address remaining gaps in micronutrient intake. Using household food consumption data, we used the nutrient density method to model the additional contribution of bouillon fortified with vitamin A (40–250 µg/g bouillon), folic acid (20–120 µg/g), vitamin B12 (0.2–2 µg/g), iron (0.6–5 mg/g), and zinc (0.6–5 mg/g) for meeting micronutrient requirements of women of reproductive age (WRA) and children aged 6–59 months. Accounting for existing fortification programs, our results showed that, except for iron, the prevalence of inadequacy was substantially higher among WRA and children living in poorer and rural households. Given the ubiquity of bouillon consumption, bouillon fortification has the potential to virtually eliminate vitamin A, folate, and vitamin B12 inadequacy, reduce the prevalence of zinc inadequacy by over 20 percentage points, and improve equity in the micronutrient adequacy of diets across socioeconomic strata and urban and rural residence. Our results also suggested that designing a bouillon fortification program would require careful planning to balance reductions in inadequacy with the risk of high intakes. This evidence provides important input into decisions around bouillon fortification in Nigeria.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"235-250"},"PeriodicalIF":4.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142161090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of World Health Organization international reference standards in the product life cycle of biosimilars 世界卫生组织国际参考标准在生物仿制药产品生命周期中的重要性

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-10 DOI: 10.1111/nyas.15217

Hye-Na Kang, Meenu Wadhwa, Ivana Knezevic, Chris Burns, Elwyn Griffiths

引用次数: 0

Cardiovascular disease and testosterone therapy in male hypogonadism 男性性腺功能减退症患者的心血管疾病和睾酮治疗。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-07 DOI: 10.1111/nyas.15211

Nipun Lakshitha de Silva, Bonnie Grant, Suks Minhas, Channa N. Jayasena

{"title":"Cardiovascular disease and testosterone therapy in male hypogonadism","authors":"Nipun Lakshitha de Silva, Bonnie Grant, Suks Minhas, Channa N. Jayasena","doi":"10.1111/nyas.15211","DOIUrl":"10.1111/nyas.15211","url":null,"abstract":"This review assesses the evidence of the physiological effects of testosterone on cardiovascular health, the association between male hypogonadism and cardiovascular health, and the effects of testosterone therapy on cardiovascular health in male hypogonadism. Preclinical studies suggest complex effects of testosterone on cardiovascular risk by acting on skeletal muscle, cardiomyocytes, vasculature, adipocytes, insulin action, and erythropoiesis. Furthermore, low testosterone has a bi-directional association with cardiometabolic risk. Observational studies have reported worse metabolic profiles in men with organic hypogonadism. However, a consistent association between major cardiovascular events and male hypogonadism has not been established. Hematocrit increases with testosterone therapy; however, most studies do not report an increase in venous thromboembolism risk. Although some observational studies and a small randomized controlled study reported an increased risk of cardiovascular disease, recent data confirm the medium-term cardiovascular safety of testosterone therapy in middle-aged and older men with low testosterone.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"121-132"},"PeriodicalIF":4.1,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Process evaluation of the initial implementation of the Moments that Matter parenting program in Kenya 对肯尼亚初步实施 "重要时刻 "为人父母计划的过程进行评估

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-09-01 DOI: 10.1111/nyas.15212

Joshua Jeong, Juliet K. McCann, Alina Bhojani, Yuri Kim, Malia Uyehara, Zane Maguet, Wilson Ochuka, Michael Ochieng

{"title":"Process evaluation of the initial implementation of the Moments that Matter parenting program in Kenya","authors":"Joshua Jeong, Juliet K. McCann, Alina Bhojani, Yuri Kim, Malia Uyehara, Zane Maguet, Wilson Ochuka, Michael Ochieng","doi":"10.1111/nyas.15212","DOIUrl":"10.1111/nyas.15212","url":null,"abstract":"The Moments that Matter® parenting program aims to promote nurturing care and healthy early childhood development (ECD) through monthly home visits and monthly community group meetings that are delivered by ECD promoters and coordinated with faith leaders in rural Western Kenya. We designed a process evaluation in August 2023 during the first quarter of program implementation. We conducted in-depth interviews and focus group discussions with caregivers, ECD promoters, faith leaders, and program staff to capture their program experiences, assess program quality, and explore the implementation barriers and facilitators during this early stage of program roll-out. Although ECD promoters delivered the program with fidelity, the roles and responsibilities of faith leaders were relatively weaker and inconsistent. Key facilitators of quality implementation included visual aids of key messages and supportive supervision. Barriers included a lack of clarity about faith leaders’ roles and relatively long group session duration. We highlight several key recommendations for improving fidelity, quality, and eventual program effects with respect to enhancing nurturing care and early child development. Overall, our study showcases how a process evaluation conducted during the early phase of program implementation can reveal practical insights that can be used to inform program adaptations and quality improvement.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"279-290"},"PeriodicalIF":4.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142101267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current landscape of fertility induction in males with congenital hypogonadotropic hypogonadism 先天性性腺功能减退症男性生育诱导的现状。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-08-27 DOI: 10.1111/nyas.15214

Andrew A. Dwyer, Isabella R. McDonald, Richard Quinton

{"title":"Current landscape of fertility induction in males with congenital hypogonadotropic hypogonadism","authors":"Andrew A. Dwyer, Isabella R. McDonald, Richard Quinton","doi":"10.1111/nyas.15214","DOIUrl":"10.1111/nyas.15214","url":null,"abstract":"Congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder caused by deficient secretion or action of gonadotropin-releasing hormone (GnRH) and is a hormonally treatable form of male infertility. Both pulsatile GnRH treatment and combined gonadotropin therapy effectively induce spermatogenesis in 75%–80% of males with CHH, albeit the ejaculate does not usually approach normal semen parameters by WHO criteria. This is in some contrast to the cumulative fertility outcomes in females with CHH on gonadotropin treatment that are indistinguishable from those of reproductively normal females. Emerging data provide insights into early life determinants of male fertility (i.e., minipuberty), and research has identified key predictors of outcomes for fertility-inducing treatment in men with CHH. Such developments provide mounting evidence for tailoring approaches to maximize fertility potential in CHH, although there is no clear consensus to date on the optimal approach to fertility-inducing treatment. This review provides an up-to-date review on the current evidence underpinning therapeutic approaches for inducing spermatogenesis in males with CHH. In the absence of evidence-based clinical guidelines, this synthesis of current evidence provides guidance for clinicians working with males with CHH seeking fertility.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"133-146"},"PeriodicalIF":4.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical compensation of retinal nerve fiber layer improves the detection of glaucoma between ethnicities 视网膜神经纤维层的解剖补偿改善了不同种族间青光眼的检测。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-08-23 DOI: 10.1111/nyas.15208

Jacqueline Chua, Chi Li, Damon W. K. Wong, Rachel S. Chong, Rahat Husain, Tina T. Wong, Clemens Vass, Ching-Yu Cheng, Tin Aung, Leopold Schmetterer

{"title":"Anatomical compensation of retinal nerve fiber layer improves the detection of glaucoma between ethnicities","authors":"Jacqueline Chua, Chi Li, Damon W. K. Wong, Rachel S. Chong, Rahat Husain, Tina T. Wong, Clemens Vass, Ching-Yu Cheng, Tin Aung, Leopold Schmetterer","doi":"10.1111/nyas.15208","DOIUrl":"10.1111/nyas.15208","url":null,"abstract":"The study aimed to evaluate the impact of compensating retinal nerve fiber layer (RNFL) thickness for demographic and anatomical factors on glaucoma detection in Chinese and Indian adults. A population-based study included 1995 healthy participants (1076 Chinese and 919 Indians) to construct a multivariable linear regression compensation model. This model was applied to 357 Chinese glaucoma patients, 357 healthy Chinese, and 357 healthy Indians using Cirrus spectral-domain optical coherence tomography (OCT). The compensated RNFL thickness considered age, refractive error, optic disc parameters, and retinal vessel density. Results showed that although the average RNFL thickness was significantly higher in Chinese participants compared to Indians, the compensation model reduced this difference to nonsignificance. Moreover, the compensation model significantly improved the area under the receiver operating characteristic curve (0.90 vs. 0.78; p<0.001), sensitivity (75% vs. 51%), and specificity (67% vs. 32%) in distinguishing Chinese glaucoma patients from healthy Indian individuals. The compensation model significantly enhanced the diagnostic accuracy of RNFL thickness in distinguishing glaucoma in the Chinese ethnic group compared to the OCT instrument's default values. These results suggest that modifying RNFL measurements based on individual characteristics can yield substantial benefits for glaucoma detection across ethnicities.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"338-349"},"PeriodicalIF":4.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert Consensus on an Open-Access UNIMMAP MMS Product Specification: 2024 revision 关于开放存取的 UNIMMAP 彩信产品规格的专家共识：2024 年修订版。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-08-21 DOI: 10.1111/nyas.15204

Clayton A. Ajello, John Atwater, Jarno de Lange

{"title":"Expert Consensus on an Open-Access UNIMMAP MMS Product Specification: 2024 revision","authors":"Clayton A. Ajello, John Atwater, Jarno de Lange","doi":"10.1111/nyas.15204","DOIUrl":"10.1111/nyas.15204","url":null,"abstract":"The United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) of a multiple micronutrient supplement (MMS) for pregnant women is a proven evidence-based nutrition intervention and is listed on the World Health Organization (WHO) Model List of Essential Medicines. The 2024 revision of the Expert Consensus on an Open-Access UNIMMAP MMS Product Specification provides both purchasers and manufacturers with unified guidance on the production of UNIMMAP MMS. More specifically, it outlines the minimum requirements for the manufacture of UNIMMAP MMS and provides guidance on quality and regulatory standards based on whether the product is manufactured as a medicinal product or a dietary supplement. The product specification includes ingredients, excipients/food additives, and processing aids used in manufacturing UNIMMAP MMS; stability testing for different climatic zones; packaging and labeling considerations; pharmacopeial standards, manufacturing practices, certificates of analysis, change control, and quality agreement; finished product test specifications, including tablet characterization and purity/strength assay; analytical test methods; and storage and transportation requirements.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1540 1","pages":"166-177"},"PeriodicalIF":4.1,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NPCC4: Advancing climate justice in climate adaptation strategies for New York City NPCC4：在纽约市气候适应战略中推进气候正义。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-08-19 DOI: 10.1111/nyas.15148

Sheila R. Foster, Ana Baptista, Khai Hoan Nguyen, Jack Tchen, Marco Tedesco, Robin Leichenko

{"title":"NPCC4: Advancing climate justice in climate adaptation strategies for New York City","authors":"Sheila R. Foster, Ana Baptista, Khai Hoan Nguyen, Jack Tchen, Marco Tedesco, Robin Leichenko","doi":"10.1111/nyas.15148","DOIUrl":"10.1111/nyas.15148","url":null,"abstract":"The Advancing Climate Justice in Climate Adaptation Strategies for New York City (Equity) chapter of NPCC4 builds on the findings and recommendations from NPCC3 to identify additional metrics and adaptation efforts that can advance climate justice. First, the chapter assesses the efforts of the City to incorporate equity into climate adaptation efforts since NPCC3 and describes how the communities profiled in NPCC3 have implemented and evolved their approaches to addressing the intersecting climate, environmental, and social stressors that they continue to face. Second, it adds to the historical context of climate inequity by linking the bioregion's history of colonization, land dispossession, and slavery building on emerging evidence demonstrating how historical and contemporary land use patterns and decisions shape present and future climate risks and social vulnerability, including climate displacement. Third, it recommends a NYC-focused metric to identify areas of the city that are most vulnerable to the intersection of climate hazards, social vulnerability, and displacement. Finally, it highlights approaches to more equitable and just climate adaptation drawn from local, national, and international examples. As such, the chapter offers best practices that prioritize community-driven climate resilience approaches that are integrated, more equitable, and racially just.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1539 1","pages":"77-126"},"PeriodicalIF":4.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.15148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NPCC4: Tail risk, climate drivers of extreme heat, and new methods for extreme event projections NPCC4：尾部风险、极端高温的气候驱动因素以及极端事件预测的新方法。

IF 4.1 3区综合性期刊

Annals of the New York Academy of Sciences Pub Date : 2024-08-19 DOI: 10.1111/nyas.15180

Luis Ortiz, Christian Braneon, Radley Horton, Daniel Bader, Philip Orton, Vivien Gornitz, Bernice Rosenzweig, Timon McPhearson, Lauren Smalls-Mantey, Hadia Sheerazi, Franco A. Montalto, Mobin Rahimi Golkhandan, Colin Evans, Arthur DeGaetano, Evan Mallen, Latonya Carter, Kathryn McConnell, Talea Mayo, Maya Buchanan

{"title":"NPCC4: Tail risk, climate drivers of extreme heat, and new methods for extreme event projections","authors":"Luis Ortiz, Christian Braneon, Radley Horton, Daniel Bader, Philip Orton, Vivien Gornitz, Bernice Rosenzweig, Timon McPhearson, Lauren Smalls-Mantey, Hadia Sheerazi, Franco A. Montalto, Mobin Rahimi Golkhandan, Colin Evans, Arthur DeGaetano, Evan Mallen, Latonya Carter, Kathryn McConnell, Talea Mayo, Maya Buchanan","doi":"10.1111/nyas.15180","DOIUrl":"10.1111/nyas.15180","url":null,"abstract":"We summarize historic New York City (NYC) climate change trends and provide the latest scientific analyses on projected future changes based on a range of global greenhouse gas emissions scenarios. Building on previous NPCC assessment reports, we describe new methods used to develop the projections of record for sea level rise, temperature, and precipitation for NYC, across multiple emissions pathways and analyze the issue of the “hot models” associated with the 6th phase of the Coupled Model Intercomparison Project (CMIP6) and their potential impact on NYC's climate projections. We describe the state of the science on temperature variability within NYC and explain both the large-scale and regional dynamics that lead to extreme heat events, as well as the local physical drivers that lead to inequitable distributions of exposure to extreme heat. We identify three areas of tail risk and potential for its mischaracterization, including the physical processes of extreme events and the effects of a changing climate. Finally, we review opportunities for future research, with a focus on the hot model problem and the intersection of spatial resolution of projections with gaps in knowledge in the impacts of the climate signal on intraurban heat and heat exposure.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"1539 1","pages":"49-76"},"PeriodicalIF":4.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0