Dace Gao, Tom P A van der Pol, Chiara Musumeci, Deyu Tu, Simone Fabiano
{"title":"Organic Mixed Conductors for Neural Biomimicry and Biointerfacing.","authors":"Dace Gao, Tom P A van der Pol, Chiara Musumeci, Deyu Tu, Simone Fabiano","doi":"10.1146/annurev-chembioeng-082323-114810","DOIUrl":"10.1146/annurev-chembioeng-082323-114810","url":null,"abstract":"<p><p>Organic mixed ionic-electronic conductors (OMIECs) could revolutionize bioelectronics by enabling seamless integration with biological systems. This review explores their role in neural biomimicry and biointerfacing, with a focus on how backbone design, sidechain optimization, and antiambipolarity impact performance. Recent advances highlight OMIECs' biocompatibility and mechanical compliance, making them ideal for bioelectronic applications. However, challenges such as mechanical mismatch and electrical impedance remain. We discuss innovative solutions to these issues to enhance OMIEC functionality. In neuromorphic bioelectronics, OMIECs show promise for bridging artificial and biological neural systems, though further improvements in conductivity and resolution are needed. Continued innovation in materials and design is crucial to unlocking their full potential, driving advancements in both technology and medicine.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"293-320"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacklyn N Hall, Jacob H Miller, Rajeev S Assary, Frederick G Baddour, Robert Dagle, Vanessa Dagle, Michael B Griffin, Susan E Habas, Kristiina Iisa, Theodore R Krause, Adarsh Kumar, Jeffrey G Linger, Ashutosh Mittal, Calvin Mukarakate, James E Parks, Daniel A Ruddy, Andrew Schmidt, Andrew D Sutton, Michael R Thorson, Kinga A Unocic, Huamin Wang, Austin Winkelman, Xiaokun Yang, Joshua A Schaidle
{"title":"State of the Art in Thermal Catalytic Upgrading of Biomass and Biomass-Derived Intermediates.","authors":"Jacklyn N Hall, Jacob H Miller, Rajeev S Assary, Frederick G Baddour, Robert Dagle, Vanessa Dagle, Michael B Griffin, Susan E Habas, Kristiina Iisa, Theodore R Krause, Adarsh Kumar, Jeffrey G Linger, Ashutosh Mittal, Calvin Mukarakate, James E Parks, Daniel A Ruddy, Andrew Schmidt, Andrew D Sutton, Michael R Thorson, Kinga A Unocic, Huamin Wang, Austin Winkelman, Xiaokun Yang, Joshua A Schaidle","doi":"10.1146/annurev-chembioeng-082323-122317","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082323-122317","url":null,"abstract":"<p><p>Biomass-derived energy sources represent a promising domestic route for fuel and chemical production, taking advantage of largely underutilized biological and waste resources. Heterogeneous catalysis plays a key role in these biomass conversion processes, as reflected by all American Society for Testing and Materials-approved pathways for producing sustainable aviation fuel proceeding through a catalytic step. This concise review seeks to establish the state of the art in thermal catalytic process development for various biomass-derived feedstocks and the current enabling capabilities that aid this development. Research needs are identified and described throughout the article, as further advancements in heterogeneous catalysis are required to improve the affordability and realize the full potential of biomass-derived products.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"16 1","pages":"371-408"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On-Demand Polymer Materials for Sustainability and Space.","authors":"Micah S Ziegler, Blair Brettmann","doi":"10.1146/annurev-chembioeng-082223-101241","DOIUrl":"10.1146/annurev-chembioeng-082223-101241","url":null,"abstract":"<p><p>Production of polymer material goods on-demand is a recurring science fiction element, but advances in chemistry and engineering have pushed it closer to reality. Experienced at a hobby scale by 3D printing enthusiasts and at an industrial level through rapid prototyping and modular manufacturing, the approach is on its way to further flexibility and high-performance material production. We review the advances in on-demand materials design as well as manufacturing, using examples in space exploration and sustainability, because these are cases where the value proposition for rapid changes in materials is strong. Despite the promising technological base for on-demand production, challenges still exist for commercial viability. We thus also review business strategy and private and public policy considerations for transitioning polymer materials markets to on-demand production. Combined analysis of the chemistry, manufacturing, and business/policy advances provides a more comprehensive picture of the status and remaining challenges.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"271-292"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Entropic Bonding-Not Quite So Simple Behaviors from Simple Hard Particles.","authors":"Thi Vo","doi":"10.1146/annurev-chembioeng-082323-092941","DOIUrl":"10.1146/annurev-chembioeng-082323-092941","url":null,"abstract":"<p><p>Advances in experimental synthesis and computer simulations have led to the proliferation of anisotropy and particle geometry as popular handles for directed self-assembly. This paradigm employs entropy to direct building block organization into desired spatial and orientational orderings. Yet, how does a metric associated primarily with disorder give rise to ordered assemblies? We first explain the governing principles behind entropic crystallization and entropy maximization processes. We then show how entropic forces can produce emergent, attractive, and bond-like interactions between otherwise sterically repulsive particles. Building on these ideas, we establish entropy as a mediator of interparticle attraction in hard particle systems that relies on extrinsic, systems-level behaviors as opposed to intrinsic, particle-level properties. Finally, we present a theory of entropic bonding that formalizes the phenomena discussed into a rigorous mathematical framework and discuss relevant next steps for its development and applications of entropic crystallization in materials design.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"147-168"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"My Struggles and Dreams as a Chemical Engineer.","authors":"Robert Langer","doi":"10.1146/annurev-chembioeng-082223-110952","DOIUrl":"10.1146/annurev-chembioeng-082223-110952","url":null,"abstract":"<p><p>My career has not been straightforward. Although I am a chemical engineer, and I'm proud of that, I took a path from chemistry and engineering to one that also involved experimental biology and medicine. This was very unusual many decades ago. In so doing, I met with rejection and ridicule early in my career. However, by going down that path, I was able to make discoveries and inventions that I hope have saved and improved lives, and I've been able to train a great number of people who are going down the road I began traveling over many years ago.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"1-22"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kin Gomez, Victoria R Yarmey, Hrishikesh Mane, Adriana San-Miguel
{"title":"Microfluidic and Computational Tools for Neurodegeneration Studies.","authors":"Kin Gomez, Victoria R Yarmey, Hrishikesh Mane, Adriana San-Miguel","doi":"10.1146/annurev-chembioeng-082223-054547","DOIUrl":"10.1146/annurev-chembioeng-082223-054547","url":null,"abstract":"<p><p>Understanding the molecular, cellular, and physiological components of neurodegenerative diseases (NDs) is paramount for developing accurate diagnostics and efficacious therapies. However, the complexity of ND pathology and the limitations associated with conventional analytical methods undermine research. Fortunately, microfluidic technology can facilitate discoveries through improved biomarker quantification, brain organoid culture, and small animal model manipulation. Because this technology can increase experimental throughput and the number of metrics that can be studied in concert, it demands more sophisticated computational tools to process and analyze results. Advanced analytical algorithms and machine learning platforms can address this challenge in data generated from microfluidic systems, but they can also be used outside of devices to discern patterns in genomic, proteomic, anatomical, and cognitive data sets. We discuss these approaches and their potential to expedite research discoveries and improve clinical outcomes through ND characterization, diagnosis, and treatment platforms.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"195-216"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pravini S Fernando, Yen-Chi Chen, Janice M Baek, Ying Diao
{"title":"Chiral Assemblies of π-Conjugated Molecules: Fundamentals, Processing Strategies, and Applications in (Opto)Electronics.","authors":"Pravini S Fernando, Yen-Chi Chen, Janice M Baek, Ying Diao","doi":"10.1146/annurev-chembioeng-100722-104224","DOIUrl":"10.1146/annurev-chembioeng-100722-104224","url":null,"abstract":"<p><p>Chirality, a fundamental attribute of asymmetry, pervades in both nature and functional soft materials. In chiral material systems design, achieving global symmetry breaking of building blocks during assembly, with or without the aid of additives, has emerged as a promising strategy across domains including chiral sensing, electronics, photonics, spintronics, and biomimetics. We first introduce the fundamental aspects of chirality, including its structural basis and symmetry-breaking mechanisms considering free energy minimization. We particularly emphasize supramolecular assembly, such as through the formation of chiral liquid crystal phases. Next, we summarize processing strategies to control chiral symmetry breaking, exploiting external fields such as flow, magnetic fields, and templates. The final section discusses interactions between chiral molecular assemblies with circularly polarized (CP) light and electronic spin and their applications in CP light detectors, CP-spin-organic light-emitting diodes, CP displays, and spintronic devices based on the chirality-induced spin selectivity effect.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"59-91"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modeling the Growth of Bulk, Single Crystals: Seeing What Is Hidden.","authors":"Jeffrey J Derby","doi":"10.1146/annurev-chembioeng-082223-110559","DOIUrl":"10.1146/annurev-chembioeng-082223-110559","url":null,"abstract":"<p><p>Modeling is an indispensable tool for understanding and improving the growth of bulk, single crystals. Such crystals are required for the fabrication of the electronic and photonic devices that enable information technology, communications, sensing, solid-state lighting, solar energy production, and many other applications. These materials are much more than simply very pure, specialty chemicals. They must meet strict requirements for solid-state structural perfection and must be produced with high yields and low costs. Successful manufacturing techniques have been developed that utilize thermodynamic phase change to solidify a high-temperature melt into a crystal of high quality. However, harsh conditions and batch operation limit both diagnostic measurements and data available to connect growth conditions to outcomes, making modeling even more important for process improvement. Challenges and opportunities are discussed for melt crystal growth processes, with research examples that demonstrate how modeling has provided important insight into crystal-melt interface shape, dopant segregation, morphological instability, and defect formation.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"217-248"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Yao, Kai Lan, Thomas E Graedel, Narasimha D Rao
{"title":"Models for Decarbonization in the Chemical Industry.","authors":"Yuan Yao, Kai Lan, Thomas E Graedel, Narasimha D Rao","doi":"10.1146/annurev-chembioeng-100522-114115","DOIUrl":"10.1146/annurev-chembioeng-100522-114115","url":null,"abstract":"<p><p>Various technologies and strategies have been proposed to decarbonize the chemical industry. Assessing the decarbonization, environmental, and economic implications of these technologies and strategies is critical to identifying pathways to a more sustainable industrial future. This study reviews recent advancements and integration of systems analysis models, including process analysis, material flow analysis, life cycle assessment, techno-economic analysis, and machine learning. These models are categorized based on analytical methods and application scales (i.e., micro-, meso-, and macroscale) for promising decarbonization technologies (e.g., carbon capture, storage, and utilization, biomass feedstock, and electrification) and circular economy strategies. Incorporating forward-looking, data-driven approaches into existing models allows for optimizing complex industrial systems and assessing future impacts. Although advances in industrial ecology-, economic-, and planetary boundary-based modeling support a more holistic systems-level assessment, more efforts are needed to consider impacts on ecosystems. Effective applications of these advanced, integrated models require cross-disciplinary collaborations across chemical engineering, industrial ecology, and economics.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"139-161"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction.","authors":"Michael F Doherty, Rachel A Segalman, Ravi S Kane","doi":"10.1146/annurev-ch-15-040824-100001","DOIUrl":"https://doi.org/10.1146/annurev-ch-15-040824-100001","url":null,"abstract":"","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"15 1","pages":"i"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}