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Annual review of chemical and biomolecular engineering最新文献

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Beyond Clean: Unraveling Phase Behavior and Rheology of Soaps. 超越清洁：肥皂的相行为和流变性。
IF 13.1 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-04-08 DOI: 10.1146/annurev-chembioeng-082223-055237
Yogesh M Joshi, Teanoosh Moaddel, Janhavi S Raut
{"title":"Beyond Clean: Unraveling Phase Behavior and Rheology of Soaps.","authors":"Yogesh M Joshi, Teanoosh Moaddel, Janhavi S Raut","doi":"10.1146/annurev-chembioeng-082223-055237","DOIUrl":"10.1146/annurev-chembioeng-082223-055237","url":null,"abstract":"<p><p>Soaps are some of the oldest surfactants known to humans and remain indispensable in modern health, personal care, and sustainability agendas. Still, the simple chemistry of salts of fatty acids reveals a rich, multiscale landscape of self-assembly and flow behavior that controls soap processing and sensorial attributes. This review integrates phase behavior with rheological analysis to demonstrate how distinct microstructures, ranging from micellar to liquid-crystalline phases, possess unique rheological signatures. We further demonstrate how the coexistence and combination of these phases in a product such as a soap bar introduce additional levels of structural and rheological complexity. In addition, we highlight how linear viscoelastic analysis resolves relaxation hierarchies and how yield stress and thixotropic responses are inherent to the multiphase brick-and-mortar microstructures in products such as soap bars. The complex rheology of soap bars necessitates constitutive models that incorporate elasticity, plasticity, and time-dependent structure to predict extrusion or stamping performance. We also explore how the microstructure relates to cleaning efficacy, foam richness, lather dynamics, and rinse feel by coupling rheology measures with in-use dilution behavior. Finally, we discuss open questions, challenges, and future directions for developing more sustainable products.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"91-115"},"PeriodicalIF":13.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are We Chasing After Windmills? Barriers to Carbon Dioxide Utilization. 我们是在追逐风车吗？二氧化碳利用的障碍。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1146/annurev-chembioeng-100724-080823
Daniel A Hickman
{"title":"Are We Chasing After Windmills? Barriers to Carbon Dioxide Utilization.","authors":"Daniel A Hickman","doi":"10.1146/annurev-chembioeng-100724-080823","DOIUrl":"10.1146/annurev-chembioeng-100724-080823","url":null,"abstract":"<p><p>The conversion of CO<sub>2</sub> into fuels and chemicals requires significant energy input to break C-O bonds and create C-C and C-H bonds. This review explores the energy and capital barriers to CO<sub>2</sub> utilization, using ethylene production as a case study by comparing CO<sub>2</sub> electroreduction with other carbon mitigation options, including carbon capture and sequestration. The world's energy and capital resources are limited-scarce, in the parlance of economics-and choosing to use them to implement one path to decarbonization displaces other options for decarbonization or other priorities. These opportunity costs are significant and should not be ignored. Instead of breaking the C-O bonds in CO<sub>2</sub> to produce chemicals and fuels, society should prioritize the higher CO<sub>2</sub> mitigation efficiencies of alternative approaches, such as carbon capture and sequestration, new process and catalyst technologies for key molecules, and capital-efficient hydrogen production.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"71-90"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to Improve the Stability and Translation of Therapeutic mRNAs. 提高治疗性mrna稳定性和翻译的策略。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-03-06 DOI: 10.1146/annurev-chembioeng-100724-084241
Baizhen Gao, Shujun He, Qing Sun
{"title":"Strategies to Improve the Stability and Translation of Therapeutic mRNAs.","authors":"Baizhen Gao, Shujun He, Qing Sun","doi":"10.1146/annurev-chembioeng-100724-084241","DOIUrl":"10.1146/annurev-chembioeng-100724-084241","url":null,"abstract":"<p><p>Therapeutic messenger RNAs (mRNAs) offer a versatile platform for treating a wide range of diseases, but their clinical efficacy hinges on optimizing both stability and translational efficiency. This review summarizes recent advances in strategies to enhance mRNA performance, with a focus on human therapeutics. We discuss secondary structure optimization, including artificial intelligence-guided design tools like RNAdegformer and LinearDesign, which balance structural stability and translational output. The roles of 5' and 3' untranslated regions in ribosome recruitment and mRNA decay are examined, highlighting sequence motifs and empirical design strategies that facilitate these processes. Chemical modifications, such as pseudouridine substitution, are shown to improve stability and reduce immunogenicity. Emerging approaches using circular RNA further extend transcript longevity. Finally, we review delivery technologies, including lipid nanoparticles, polymers, and extracellular vesicles, that protect mRNA and enable targeted cellular uptake. Together, these advances provide a road map for developing stable, efficient, and clinically viable mRNA-based therapeutics.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"309-324"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances and Sustainable Implementation of Nanomaterials in Water Remediation: A Comprehensive Review. 纳米材料在水修复中的进展与可持续应用综述
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-02-24 DOI: 10.1146/annurev-chembioeng-100724-073202
Yunjia Ling, Cui Zhang, Lingjie Zhang, Feifei Jia, Deshou Wang, Yang Bao, Shaoxian Song, Jun Chen, Yali Cheng, Mildred Quintana
{"title":"Advances and Sustainable Implementation of Nanomaterials in Water Remediation: A Comprehensive Review.","authors":"Yunjia Ling, Cui Zhang, Lingjie Zhang, Feifei Jia, Deshou Wang, Yang Bao, Shaoxian Song, Jun Chen, Yali Cheng, Mildred Quintana","doi":"10.1146/annurev-chembioeng-100724-073202","DOIUrl":"10.1146/annurev-chembioeng-100724-073202","url":null,"abstract":"<p><p>To overcome global water scarcity and pollution, nanomaterials have emerged as revolutionary tools for water remediation owing to their unique physicochemical properties, in particular, their ultrahigh specific surface area and programmable interface for molecular recognition. This review integrates multifaceted perspectives on contaminant treatment and compares the relative performance strength of nanomaterials for diverse contaminants, surpassing fragmented assessments focused on single contaminants. We taxonomize nanomaterial classes and highlight their recent advances across four domains: heavy metals removal, critical metals recovery, microbial contamination control, and emerging organic contaminants degradation. For each domain, we dissect scalability bottlenecks and define future research priorities, including database integration, graph neural networks, machine learning, and artificial intelligence. We provide design principles for high-performance water remediation by synthesizing cutting-edge materials using cross-disciplinary strategies. We describe eco-safe nanomaterials that guide industrial water management toward sustainable transformation, propelling global water remediation toward green, intelligent, and resource-recycling models.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"19-44"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Chemical Engineers in the Pharmaceutical Industry. 化学工程师在制药工业中的作用。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-01-21 DOI: 10.1146/annurev-chembioeng-100724-081046
Paul C Collins, Jean W Tom
{"title":"The Role of Chemical Engineers in the Pharmaceutical Industry.","authors":"Paul C Collins, Jean W Tom","doi":"10.1146/annurev-chembioeng-100724-081046","DOIUrl":"10.1146/annurev-chembioeng-100724-081046","url":null,"abstract":"<p><p>Chemical engineers have played a vital role in the pharmaceutical industry for more than a century, bridging the gap between scientific discovery and large-scale drug manufacturing. This review examines the evolution in the role of chemical engineers and their impact on the development of small molecules, biologics, and emerging modalities such as oligonucleotides and gene therapies. We provide historical context, from early breakthroughs in insulin and penicillin production to the integration of continuous processing and advanced modeling. Key areas of focus include reaction engineering, separations, crystallization, fluid dynamics, process control, and continuous manufacturing. Looking ahead, chemical engineers will be central to addressing challenges in sustainability, advanced delivery systems, and the application of artificial intelligence and data-driven technologies. As therapeutic complexity grows, the application of engineering fundamentals, integrated with life and natural sciences, remains essential for ensuring safe, efficient, and scalable manufacturing of medicines that advance global health.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"375-396"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable Refrigerants, Policy Drivers, and Emerging Technologies. 可持续制冷剂、政策驱动因素和新兴技术。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 DOI: 10.1146/annurev-chembioeng-100724-073851
Emmanuel Ababio, David R Corbin, Mark B Shiflett
{"title":"Sustainable Refrigerants, Policy Drivers, and Emerging Technologies.","authors":"Emmanuel Ababio, David R Corbin, Mark B Shiflett","doi":"10.1146/annurev-chembioeng-100724-073851","DOIUrl":"10.1146/annurev-chembioeng-100724-073851","url":null,"abstract":"<p><p>Heating, ventilation, air conditioning, and refrigeration (HVACR) systems are essential across residential, commercial, and industrial sectors but are critical energy consumers, and their refrigerant emissions and energy use present a major challenge to global sustainability goals. This state-of-the-art review moves beyond tracing the evolution of refrigerants to evaluate key international agreements, including the Kigali Amendment, and national regulations as primary drivers of the transition to sustainable refrigerants. It critically assesses current sustainable alternatives, including natural refrigerants and low-global warming potential synthetic options, such as hydrofluoroolefins, highlighting the trade-offs in their technical application, economic viability, safety, and infrastructure implications. Emerging solutions, including not-in-kind cooling technologies, innovative thermodynamic cycles, advanced materials, artificial intelligence, digitalization, and refrigerant lifecycle management, are examined to provide critical perspectives and guide future research, development, and deployment. By integrating regulatory, market, and technological insights, this review offers a comprehensive road map toward a sustainable, low-emission, and energy-efficient HVACR sector.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"17 1","pages":"325-349"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Genetic Code Expansion in Live Cells Through Metabolic Engineering. 通过代谢工程推进活细胞遗传密码扩展。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-03-02 DOI: 10.1146/annurev-chembioeng-100724-081506
D'Jana R Wyllis, Saloni P Gupta, Shelby R Anderson, Aditya M Kunjapur
{"title":"Advancing Genetic Code Expansion in Live Cells Through Metabolic Engineering.","authors":"D'Jana R Wyllis, Saloni P Gupta, Shelby R Anderson, Aditya M Kunjapur","doi":"10.1146/annurev-chembioeng-100724-081506","DOIUrl":"10.1146/annurev-chembioeng-100724-081506","url":null,"abstract":"<p><p>Genetic code expansion (GCE) is the ability to encode polypeptide building blocks beyond the standard 20 the ribosome uses for protein translation, known as nonstandard amino acids (nsAAs). The broadening of chemical functionalities in proteins produced by live cells has generated substantial value across fundamental and applied research settings. However, a common limitation of GCE approaches is their reliance on the supplementation of chemically synthesized nsAAs to cell culture media. To overcome this limitation of nsAA sourcing, efforts have engineered systems for nsAA biosynthesis, often in the same host that performs GCE. In recent years, these works have reported new chemical targets obtained through biosynthesis, as well as additional rationale for combining metabolic engineering and GCE, particularly for synthetic biology applications. Here, we review this rapidly advancing field and provide our perspectives on technical and conceptual innovations.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"45-69"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Understanding of Free-Energy Landscapes. 自由能景观的分子理解。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-03-25 DOI: 10.1146/annurev-chembioeng-100724-082451
Marcello Sega, Matteo Salvalaglio
{"title":"Molecular Understanding of Free-Energy Landscapes.","authors":"Marcello Sega, Matteo Salvalaglio","doi":"10.1146/annurev-chembioeng-100724-082451","DOIUrl":"10.1146/annurev-chembioeng-100724-082451","url":null,"abstract":"<p><p>Free-energy surfaces (FESs) offer a unifying framework for understanding molecular-level structures, transformations, and thermodynamic stability. They distill the complexity of atomistic simulations into interpretable landscapes of metastable states, bridging molecular-level detail with macroscopic observables. This review provides researchers in molecular simulations, computational physical chemistry, and chemical engineering with a conceptual and practical guide to computing and interpreting FESs, from their statistical-mechanical foundations to modern machine learning approaches that are transforming the sampling, representation, and analysis of molecular systems.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"213-243"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Polymer Engineering in Achieving Desirable Properties for Tissue Engineering Applications: Bulk Modification and Bioconjugation of Aliphatic Polyesters. 聚合物工程在组织工程应用中实现理想性能的作用：脂肪族聚酯的体修饰和生物偶联。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-01-16 DOI: 10.1146/annurev-chembioeng-100724-081005
Heloísa Bremm Madalosso, Camila Guindani, Pedro Henrique Hermes de Araújo, Claudia Sayer
{"title":"The Role of Polymer Engineering in Achieving Desirable Properties for Tissue Engineering Applications: Bulk Modification and Bioconjugation of Aliphatic Polyesters.","authors":"Heloísa Bremm Madalosso, Camila Guindani, Pedro Henrique Hermes de Araújo, Claudia Sayer","doi":"10.1146/annurev-chembioeng-100724-081005","DOIUrl":"10.1146/annurev-chembioeng-100724-081005","url":null,"abstract":"<p><p>Tissue engineering aims to restore, maintain, or improve damaged tissues through the use of polymer scaffolds that support cellular growth and regeneration. Copolymerization enables the fine-tuning of thermal, structural, and mechanical polymer properties, facilitating scaffold fabrication via techniques like electrospinning and 3D printing. Functionalization and bioconjugation approaches, including thiol-ene click chemistry, allow for targeted surface modification without altering bulk properties, improving interaction with biological environments and enhancing the specificity and functionality of polyester-based scaffolds. This review highlights the central role of polymer reaction engineering in advancing aliphatic polyesters for tissue engineering, focusing on recent innovations in synthetic strategies and functionalization techniques that expand their applicability in regenerative medicine.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"397-415"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nonequilibrium Self-Consistent Generalized Langevin Equation Theory of Glasses and Gels. 玻璃和凝胶的非平衡自洽广义朗之万方程理论。
IF 12.8 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2026-06-01 Epub Date: 2026-03-30 DOI: 10.1146/annurev-chembioeng-100724-073012
R Peredo-Ortiz, E Lázaro-Lázaro, O Joaquín-Jaime, M Medina-Noyola, L F Elizondo-Aguilera
{"title":"The Nonequilibrium Self-Consistent Generalized Langevin Equation Theory of Glasses and Gels.","authors":"R Peredo-Ortiz, E Lázaro-Lázaro, O Joaquín-Jaime, M Medina-Noyola, L F Elizondo-Aguilera","doi":"10.1146/annurev-chembioeng-100724-073012","DOIUrl":"10.1146/annurev-chembioeng-100724-073012","url":null,"abstract":"<p><p>The nonequilibrium self-consistent generalized Langevin equation theory of irreversible processes in liquids is a first-principles approach that allows for the derivation of general equations that describe the out-of-equilibrium and nonstationary relaxation of a liquid after a sudden quench or compression into an amorphous state. Proposed in 2010, the theory has since been systematically applied to describe a wide variety of model systems, with predictions rigorously and successfully validated against both experimental and simulated results. In this work, we briefly review the progress of this theoretical framework over the past 15 years, focusing on its applications to the description of the structural, dynamical, and rheological behavior of model glass- and gel-forming systems.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"351-373"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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