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Annual review of chemical and biomolecular engineering最新文献

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RNAs as Sensors of Oxidative Stress in Bacteria. 作为细菌氧化应激传感器的 RNA。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-chembioeng-101121-070250
Ryan Buchser, Phillip Sweet, Aparna Anantharaman, Lydia Contreras
{"title":"RNAs as Sensors of Oxidative Stress in Bacteria.","authors":"Ryan Buchser, Phillip Sweet, Aparna Anantharaman, Lydia Contreras","doi":"10.1146/annurev-chembioeng-101121-070250","DOIUrl":"10.1146/annurev-chembioeng-101121-070250","url":null,"abstract":"<p><p>Oxidative stress is an important and pervasive physical stress encountered by all kingdoms of life, including bacteria. In this review, we briefly describe the nature of oxidative stress, highlight well-characterized protein-based sensors (transcription factors) of reactive oxygen species that serve as standards for molecular sensors in oxidative stress, and describe molecular studies that have explored the potential of direct RNA sensitivity to oxidative stress. Finally, we describe the gaps in knowledge of RNA sensors-particularly regarding the chemical modification of RNA nucleobases. RNA sensors are poised to emerge as an essential layer of understanding and regulating dynamic biological pathways in oxidative stress responses in bacteria and, thus, also represent an important frontier of synthetic biology.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery. 基于肽的载体：基因传递的生物分子工程策略。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-chembioeng-101121-070232
Sandeep Urandur, Millicent O Sullivan
{"title":"Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery.","authors":"Sandeep Urandur, Millicent O Sullivan","doi":"10.1146/annurev-chembioeng-101121-070232","DOIUrl":"10.1146/annurev-chembioeng-101121-070232","url":null,"abstract":"<p><p>From the first clinical trial by Dr. W.F. Anderson to the most recent US Food and Drug Administration-approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis, 2019), gene therapy has revamped thinking and practice around cancer treatment and improved survival rates for adult and pediatric patients with genetic diseases. A major challenge to advancing gene therapies for a broader array of applications lies in safely delivering nucleic acids to their intended sites of action. Peptides offer unique potential to improve nucleic acid delivery based on their versatile and tunable interactions with biomolecules and cells. Cell-penetrating peptides and intracellular targeting peptides have received particular focus due to their promise for improving the delivery of gene therapies into cells. We highlight key examples of peptide-assisted, targeted gene delivery to cancer-specific signatures involved in tumor growth and subcellular organelle-targeting peptides, as well as emerging strategies to enhance peptide stability and bioavailability that will support long-term implementation.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical Manufacturing Routes for Organic Chemical Commodities. 有机化学产品的电化学制造路线。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-17 DOI: 10.1146/annurev-chembioeng-101121-090840
Ricardo Mathison, Alexandra L Ramos Figueroa, Casey Bloomquist, Miguel A Modestino
{"title":"Electrochemical Manufacturing Routes for Organic Chemical Commodities.","authors":"Ricardo Mathison, Alexandra L Ramos Figueroa, Casey Bloomquist, Miguel A Modestino","doi":"10.1146/annurev-chembioeng-101121-090840","DOIUrl":"10.1146/annurev-chembioeng-101121-090840","url":null,"abstract":"<p><p>Electrochemical synthesis of organic chemical commodities provides an alternative to conventional thermochemical manufacturing and enables the direct use of renewable electricity to reduce greenhouse gas emissions from the chemical industry. We discuss electrochemical synthesis approaches that use abundant carbon feedstocks for the production of the largest petrochemical precursors and basic organic chemical products: light olefins, olefin oxidation derivatives, aromatics, and methanol. First, we identify feasible routes for the electrochemical production of each commodity while considering the reaction thermodynamics, available feedstocks, and competing thermochemical processes. Next, we summarize successful catalysis and reaction engineering approaches to overcome technological challenges that prevent electrochemical routes from operating at high production rates, selectivity, stability, and energy conversion efficiency. Finally, we provide an outlook on the strategies that must be implemented to achieve large-scale electrochemical manufacturing of major organic chemical commodities.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drying Drops of Colloidal Dispersions. 胶体分散体的干燥滴剂。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-chembioeng-101121-085056
Sumesh P Thampi, Madivala G Basavaraj
{"title":"Drying Drops of Colloidal Dispersions.","authors":"Sumesh P Thampi,&nbsp;Madivala G Basavaraj","doi":"10.1146/annurev-chembioeng-101121-085056","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-101121-085056","url":null,"abstract":"<p><p>Drying drops of colloidal dispersions have attracted attention from researchers since the nineteenth century. The multiscale nature of the problem involving physics at different scales, namely colloidal and interfacial phenomena as well as heat, mass, and momentum transport processes, combined with the seemingly simple yet nontrivial shape of the drops makes drying drop problems rich and interesting. The scope of such studies widens as the physical and chemical nature of dispersed entities in the drop vary and as evaporation occurs in more complex configurations. This review summarizes past and contemporary developments in the field, emphasizing the physicochemical and hydrodynamical principles that govern the processes occurring within a drying drop and the resulting variety of patterns generated on the substrate.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9602537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production. 扩大光化学反应的规模：从实验室规模过渡到工业生产。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-13 DOI: 10.1146/annurev-chembioeng-101121-074313
Stefan D A Zondag, Daniele Mazzarella, Timothy Noël
{"title":"Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production.","authors":"Stefan D A Zondag, Daniele Mazzarella, Timothy Noël","doi":"10.1146/annurev-chembioeng-101121-074313","DOIUrl":"10.1146/annurev-chembioeng-101121-074313","url":null,"abstract":"<p><p>In the past two decades, we have witnessed a rapid emergence of new and powerful photochemical and photocatalytic synthetic methods. Although these methods have been used mostly on a small scale, there is a growing need for efficient scale-up of photochemistry in the chemical industry. This review summarizes and contextualizes the advancements made in the past decade regarding the scale-up of photo-mediated synthetic transformations. Simple scale-up concepts and important fundamental photochemical laws have been provided along with a discussion concerning suitable reactor designs that should facilitate scale-up of this challenging class of organic reactions.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active Colloids as Models, Materials, and Machines. 作为模型、材料和机器的活性胶体。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-17 DOI: 10.1146/annurev-chembioeng-101121-084939
Kyle J M Bishop, Sibani Lisa Biswal, Bhuvnesh Bharti
{"title":"Active Colloids as Models, Materials, and Machines.","authors":"Kyle J M Bishop, Sibani Lisa Biswal, Bhuvnesh Bharti","doi":"10.1146/annurev-chembioeng-101121-084939","DOIUrl":"10.1146/annurev-chembioeng-101121-084939","url":null,"abstract":"<p><p>Active colloids use energy input at the particle level to propel persistent motion and direct dynamic assemblies. We consider three types of colloids animated by chemical reactions, time-varying magnetic fields, and electric currents. For each type, we review the basic propulsion mechanisms at the particle level and discuss their consequences for collective behaviors in particle ensembles. These microscopic systems provide useful experimental models of nonequilibrium many-body physics in which dissipative currents break time-reversal symmetry. Freed from the constraints of thermodynamic equilibrium, active colloids assemble to form materials that move, reconfigure, heal, and adapt. Colloidal machines based on engineered particles and their assemblies provide a basis for mobile robots with increasing levels of autonomy. This review provides a conceptual framework for understanding and applying active colloids to create material systems that mimic the functions of living matter. We highlight opportunities for chemical engineers to contribute to this growing field.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9658546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction. 介绍。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-ch-14-040723-100001
Michael F Doherty, Rachel A Segalman, Ravi S Kane
{"title":"Introduction.","authors":"Michael F Doherty,&nbsp;Rachel A Segalman,&nbsp;Ravi S Kane","doi":"10.1146/annurev-ch-14-040723-100001","DOIUrl":"https://doi.org/10.1146/annurev-ch-14-040723-100001","url":null,"abstract":"","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ/Operando Characterization Techniques of Electrochemical CO2 Reduction. 电化学二氧化碳还原的现场/操作表征技术。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-chembioeng-101121-071735
Bjorn Hasa, Yaran Zhao, Feng Jiao
{"title":"In Situ/Operando Characterization Techniques of Electrochemical CO<sub>2</sub> Reduction.","authors":"Bjorn Hasa, Yaran Zhao, Feng Jiao","doi":"10.1146/annurev-chembioeng-101121-071735","DOIUrl":"10.1146/annurev-chembioeng-101121-071735","url":null,"abstract":"<p><p>Electrocatalytic conversion of carbon dioxide to valuable chemicals and fuels driven by renewable energy plays a crucial role in achieving net-zero carbon emissions. Understanding the structure-activity relationship and the reaction mechanism is significant for tuning electrocatalyst selectivity. Therefore, characterizing catalyst dynamic evolution and reaction intermediates under reaction conditions is necessary but still challenging. We first summarize the most recent progress in mechanistic understanding of heterogeneous CO<sub>2</sub>/CO reduction using in situ/operando techniques, including surface-enhanced vibrational spectroscopies, X-ray- and electron-based techniques, and mass spectroscopy, along with discussing remaining limitations. We then offer insights and perspectives to accelerate the future development of in situ/operando techniques.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining Machine Learning with Physical Knowledge in Thermodynamic Modeling of Fluid Mixtures. 在流体混合物热力学建模中结合机器学习与物理知识。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-21 DOI: 10.1146/annurev-chembioeng-092220-025342
Fabian Jirasek, Hans Hasse
{"title":"Combining Machine Learning with Physical Knowledge in Thermodynamic Modeling of Fluid Mixtures.","authors":"Fabian Jirasek, Hans Hasse","doi":"10.1146/annurev-chembioeng-092220-025342","DOIUrl":"10.1146/annurev-chembioeng-092220-025342","url":null,"abstract":"<p><p>Thermophysical properties of fluid mixtures are important in many fields of science and engineering. However, experimental data are scarce in this field, so prediction methods are vital. Different types of physical prediction methods are available, ranging from molecular models over equations of state to models of excess properties. These well-established methods are currently being complemented by new methods from the field of machine learning (ML). This review focuses on the rapidly developing interface between these two approaches and gives a structured overview of how physical modeling and ML can be combined to yield hybrid models. We illustrate the different options with examples from recent research and give an outlook on future developments.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9604031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outsmarting Pathogens with Antibody Engineering. 用抗体工程战胜病原体。
IF 8.4 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-14 DOI: 10.1146/annurev-chembioeng-101121-084508
Ahlam N Qerqez, Rui P Silva, Jennifer A Maynard
{"title":"Outsmarting Pathogens with Antibody Engineering.","authors":"Ahlam N Qerqez, Rui P Silva, Jennifer A Maynard","doi":"10.1146/annurev-chembioeng-101121-084508","DOIUrl":"10.1146/annurev-chembioeng-101121-084508","url":null,"abstract":"<p><p>There is growing interest in identifying antibodies that protect against infectious diseases, especially for high-risk individuals and pathogens for which no vaccine is yet available. However, pathogens that manifest as opportunistic or latent infections express complex arrays of virulence-associated proteins and are adept at avoiding immune responses. Some pathogens have developed strategies to selectively destroy antibodies, whereas others create decoy epitopes that trick the host immune system into generating antibodies that are at best nonprotective and at worst enhance pathogenesis. Antibody engineering strategies can thwart these efforts by accessing conserved neutralizing epitopes, generating Fc domains that resist capture or degradation and even accessing pathogens hidden inside cells. Design of pathogen-resistant antibodies can enhance protection and guide development of vaccine immunogens against these complex pathogens. Here, we discuss general strategies for design of antibodies resistant to specific pathogen defense mechanisms.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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