Annual review of chemical and biomolecular engineering最新文献_第4页

Three-Dimensional Morphology of Polymeric Membranes from Electron Tomography. 从电子断层扫描看聚合物膜的三维形态。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2024-02-29 DOI: 10.1146/annurev-chembioeng-100722-104623

Masoud Ghasemi, Michael Geitner, Agatha O'Connell, Enrique D Gomez

{"title":"Three-Dimensional Morphology of Polymeric Membranes from Electron Tomography.","authors":"Masoud Ghasemi, Michael Geitner, Agatha O'Connell, Enrique D Gomez","doi":"10.1146/annurev-chembioeng-100722-104623","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100722-104623","url":null,"abstract":"Recent advances in the water-energy landscape hinge upon our improved understanding of the complex morphology of materials involved in water treatment and energy production. Due to their versatility and tunability for applications ranging from drug delivery to fuel cells, polymeric systems will play a crucial role in shaping the future of water-energy nexus applications. Electron tomography (ET) stands as a transformative approach for elucidating the intricate structures inherent to polymers, offering unparalleled insights into their nanoscale architectures and functional properties in three dimensions. In particular, the various morphological and chemical characteristics of polymer membranes provide opportunities for perturbations to standard ET for the study of these systems. We discuss the applications of transmission electron microscopy in establishing structure-function relationships in polymeric membranes with an emphasis on traditional ET and cryogenic ET (cryo-ET). The synergy between ET and cryo-ET to unravel structural complexities and dynamic behaviors of polymer membranes holds immense potential in driving progress and innovation across frontiers related to water-energy nexus applications. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering , Volume 15 is June 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilms for Production of Chemicals and Energy 用于生产化学品和能源的生物膜

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2024-02-21 DOI: 10.1146/annurev-chembioeng-100522-110939

Janek Weiler, Miriam Edel, Johannes Gescher

引用次数: 0

Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment. 针对疾病靶向治疗的多特异性抗体的机制驱动设计。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2024-01-26 DOI: 10.1146/annurev-chembioeng-100522-102155

Justyn Fine, Bunyarit Meksiriporn, Jiacheng Tan, Jamie B Spangler

{"title":"Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment.","authors":"Justyn Fine, Bunyarit Meksiriporn, Jiacheng Tan, Jamie B Spangler","doi":"10.1146/annurev-chembioeng-100522-102155","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100522-102155","url":null,"abstract":"Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat complex diseases. To expand the utility of antibody therapies, significant efforts have been invested in designing multispecific antibodies, which engage multiple targets using a single molecule. These efforts have culminated in remarkable translational progress, including nine US Food and Drug Administration-approved multispecific antibodies, with countless others in various stages of preclinical or clinical development. In this review, we discuss several categories of multispecific antibodies that have achieved clinical approval or shown promise in earlier stages of development. We focus on the molecular mechanisms used by multispecific antibodies and how these mechanisms inform their customized design and formulation. In particular, we discuss multispecific antibodies that target multiple disease markers, multiparatopic antibodies, and immune-interfacing antibodies. Overall, these innovative multispecific antibody designs are fueling exciting advances across the immunotherapeutic landscape. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering , Volume 15 is June 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing Multivalent and Multispecific Biologics 设计多价和多特异性生物制剂

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-12-08 DOI: 10.1146/annurev-chembioeng-100722-112440

Jennifer J. Kang, Ayako Ohoka, Casim A. Sarkar

{"title":"Designing Multivalent and Multispecific Biologics","authors":"Jennifer J. Kang, Ayako Ohoka, Casim A. Sarkar","doi":"10.1146/annurev-chembioeng-100722-112440","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100722-112440","url":null,"abstract":"In the era of precision medicine, multivalent and multispecific therapeutics present a promising approach for targeted disease intervention. These therapeutics are designed to interact with multiple targets simultaneously, promising enhanced efficacy, reduced side effects, and resilience against drug resistance. We dissect the principles guiding the design of multivalent biologics, highlighting challenges and strategies that must be considered to maximize therapeutic effect. Engineerable elements in multivalent and multispecific biologic design—domain affinities, valency, and spatial presentation—must be considered in the context of the molecular targets as well as the balance of important properties such as target avidity and specificity. We illuminate recent applications of these principles in designing protein and cell therapies and identify exciting future directions in this field, underscored by advances in biomolecular and cellular engineering and computational approaches.Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering , Volume 15 is June 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"60 3 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138563717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production. 木质纤维素生物炼油厂的工程创新、挑战和机遇：利用生物基聚合物生产。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-04-11 DOI: 10.1146/annurev-chembioeng-101121-084152

Alison J Shapiro, Robert M O'Dea, Sonia C Li, Jamael C Ajah, Garrett F Bass, Thomas H Epps

{"title":"Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production.","authors":"Alison J Shapiro, Robert M O'Dea, Sonia C Li, Jamael C Ajah, Garrett F Bass, Thomas H Epps","doi":"10.1146/annurev-chembioeng-101121-084152","DOIUrl":"10.1146/annurev-chembioeng-101121-084152","url":null,"abstract":"Alternative polymer feedstocks are highly desirable to address environmental, social, and security concerns associated with petrochemical-based materials. Lignocellulosic biomass (LCB) has emerged as one critical feedstock in this regard because it is an abundant and ubiquitous renewable resource. LCB can be deconstructed to generate valuable fuels, chemicals, and small molecules/oligomers that are amenable to modification and polymerization. However, the diversity of LCB complicates the evaluation of biorefinery concepts in areas including process scale-up, production outputs, plant economics, and life-cycle management. We discuss aspects of current LCB biorefinery research with a focus on the major process stages, including feedstock selection, fractionation/deconstruction, and characterization, along with product purification, functionalization, and polymerization to manufacture valuable macromolecular materials. We highlight opportunities to valorize underutilized and complex feedstocks, leverage advanced characterization techniques to predict and manage biorefinery outputs, and increase the fraction of biomass converted into valuable products.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"14 ","pages":"109-140"},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Everything You Wanted to Know about Deep Eutectic Solvents but Were Afraid to Be Told. 关于深共晶溶剂，你想知道却又害怕被告知的一切。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-chembioeng-101121-085323

Dinis O Abranches, João A P Coutinho

引用次数: 0

RNAs as Sensors of Oxidative Stress in Bacteria. 作为细菌氧化应激传感器的 RNA。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-chembioeng-101121-070250

Ryan Buchser, Phillip Sweet, Aparna Anantharaman, Lydia Contreras

引用次数: 0

Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery. 基于肽的载体：基因传递的生物分子工程策略。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-chembioeng-101121-070232

Sandeep Urandur, Millicent O Sullivan

{"title":"Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery.","authors":"Sandeep Urandur, Millicent O Sullivan","doi":"10.1146/annurev-chembioeng-101121-070232","DOIUrl":"10.1146/annurev-chembioeng-101121-070232","url":null,"abstract":"From the first clinical trial by Dr. W.F. Anderson to the most recent US Food and Drug Administration-approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis, 2019), gene therapy has revamped thinking and practice around cancer treatment and improved survival rates for adult and pediatric patients with genetic diseases. A major challenge to advancing gene therapies for a broader array of applications lies in safely delivering nucleic acids to their intended sites of action. Peptides offer unique potential to improve nucleic acid delivery based on their versatile and tunable interactions with biomolecules and cells. Cell-penetrating peptides and intracellular targeting peptides have received particular focus due to their promise for improving the delivery of gene therapies into cells. We highlight key examples of peptide-assisted, targeted gene delivery to cancer-specific signatures involved in tumor growth and subcellular organelle-targeting peptides, as well as emerging strategies to enhance peptide stability and bioavailability that will support long-term implementation.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"14 ","pages":"243-264"},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Manufacturing Routes for Organic Chemical Commodities. 有机化学产品的电化学制造路线。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 Epub Date: 2023-03-17 DOI: 10.1146/annurev-chembioeng-101121-090840

Ricardo Mathison, Alexandra L Ramos Figueroa, Casey Bloomquist, Miguel A Modestino

{"title":"Electrochemical Manufacturing Routes for Organic Chemical Commodities.","authors":"Ricardo Mathison, Alexandra L Ramos Figueroa, Casey Bloomquist, Miguel A Modestino","doi":"10.1146/annurev-chembioeng-101121-090840","DOIUrl":"10.1146/annurev-chembioeng-101121-090840","url":null,"abstract":"Electrochemical synthesis of organic chemical commodities provides an alternative to conventional thermochemical manufacturing and enables the direct use of renewable electricity to reduce greenhouse gas emissions from the chemical industry. We discuss electrochemical synthesis approaches that use abundant carbon feedstocks for the production of the largest petrochemical precursors and basic organic chemical products: light olefins, olefin oxidation derivatives, aromatics, and methanol. First, we identify feasible routes for the electrochemical production of each commodity while considering the reaction thermodynamics, available feedstocks, and competing thermochemical processes. Next, we summarize successful catalysis and reaction engineering approaches to overcome technological challenges that prevent electrochemical routes from operating at high production rates, selectivity, stability, and energy conversion efficiency. Finally, we provide an outlook on the strategies that must be implemented to achieve large-scale electrochemical manufacturing of major organic chemical commodities.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"14 ","pages":"85-108"},"PeriodicalIF":8.4,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drying Drops of Colloidal Dispersions. 胶体分散体的干燥滴剂。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-chembioeng-101121-085056

Sumesh P Thampi, Madivala G Basavaraj

引用次数: 4