Annual review of chemical and biomolecular engineering最新文献_第10页

Isolation and Characterization Photo Degradation Impurities of Drug Product Olopatadine Hydrochloride by Spectral Techniques 药品盐酸奥洛他定光降解杂质的光谱分离与表征

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-17 DOI: 10.11648/J.CBE.20190402.11

Shivaji Jadhav, A. Gosar, A. Jadkar, R. Ankam, C. Dhatrak

{"title":"Isolation and Characterization Photo Degradation Impurities of Drug Product Olopatadine Hydrochloride by Spectral Techniques","authors":"Shivaji Jadhav, A. Gosar, A. Jadkar, R. Ankam, C. Dhatrak","doi":"10.11648/J.CBE.20190402.11","DOIUrl":"https://doi.org/10.11648/J.CBE.20190402.11","url":null,"abstract":"Unknown impurities were detected during Photo degradation of Olopatadine Hydrochloride ophthalmic solution 0.5% (w/v) when analyzed using the High performance liquid chromatographic technique with Photo Diode Array Detection. For further investigation was carried out by isolating these impurities from impurity rich sample of Olopatadine Hydrochloride ophthalmic solution 0.5% (w/v) using preparative isolation technique. The Olopatadine Hydrochloride ophthalmic solution 0.5% (w/v) was subjected to photolytic forced degradation in the presence of Benzalkonium chloride and other excipients like Hypromellose, Mannitol, Hydroxypropyl, Boric acid, Kollidon 30 LP and mixture of solvents (Acetonitrile: Methanol; 1: 1 (v/v) under Ultra violet visible light. This led to the formation of the said impurities in higher concentration. This sample was then subjected to preparative HPLC for isolation of these unknown impurities. The structure of these unknown impurities was further elucidated using a different technique like Infra Ray Spectroscopy, Direct infusion (DI) Mass Spectroscopy, Ultra violet-Visible Spectroscopy, Proton Nuclear Magnetic Resonance Spectroscopy, carbon Nuclear Magnetic Resonance and Distortionless Enhancement by Polarization Transfer (DEPT) Spectroscopy which helped to confirm the structure of the impurities. Structure elucidation of the two impurities revealed that these are E and Z isomers of the Olopatadine hydrochloride Carbaldehyde. Olopatadine Z- isomer is used in the formulation of the Olopatadine Hydrochloride Ophthalmic Solution 0.5% (w/v). The minor amount of E- isomer also remains present in this solution as a potential impurity. However, the amount of E-isomer may increase in the solution form due to racemization. Hence, the respective Carbaldehyde impurities (both E and Z isomers) are forming during Photolytic degradation. This formation is happening through photolytic Norrish type-1 reaction which is elaborated in the paper.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"80 3 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2019-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83868269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deinking of Black Toner Ink from Laser Printed Paper by Using Anionic Surfactant 阴离子表面活性剂对激光打印纸黑色墨粉油墨的脱墨研究

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-13 DOI: 10.11648/J.CBE.20190401.15

M. Abraha, Zebene Kifle

{"title":"Deinking of Black Toner Ink from Laser Printed Paper by Using Anionic Surfactant","authors":"M. Abraha, Zebene Kifle","doi":"10.11648/J.CBE.20190401.15","DOIUrl":"https://doi.org/10.11648/J.CBE.20190401.15","url":null,"abstract":"The objective of this research was to synthesize natural anionic surfactant from renewable material and use of this surfactant for ink removal from printed paper via flotation deinking in paper recycling process. The work included the preparation of the castor seed raw material, extraction of castor oil, preparation of anionic surfactant and deinking flotation of waste printed paper. Foamability and foam stability, critical micelle concentration and hydrophilic lipophilic balance of the surfactant was characterized and used to evaluate its fundamental deinking ability properties for the purpose of deinking flotation. The hydrophilic-lipophilic balance (HLB) of the fatty acid soap of 19.48, average Foamability height of 49cm and critical micelle concentration (CMC) of 0.0065M was obtained. Lab scale flotation deinking process was done and the basic flotation parameters like flotation time, fatty acid soap dosage and pH were optimized for evaluating deinking efficiency. The flotation deinking efficiency was probed by measuring the residual ink concentration of the hand sheet via Perkin Elmer spectroscopy before and after deinking flotation. The individual and interaction effects between the basic parameters were studied by using design Expert Software 6.0.8. For the deinking flotation, the maximum ink removal efficiency was determined to be 78.02% at the flotation time of 90min, fatty acid soap dosage of 1.5% and pH of 9. Increasing flotation time from 30min up to 90 min and decreasing fatty acid dosage from 3% to 1.5% and increasing of pH from 3 up to 9 were found to have increased the ink removal efficiency.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"99 10 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87717318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glückliche Reise. 祝旅途平安.

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 DOI: 10.1146/annurev-chembioeng-060718-030112

John M Prausnitz

{"title":"Glückliche Reise.","authors":"John M Prausnitz","doi":"10.1146/annurev-chembioeng-060718-030112","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030112","url":null,"abstract":"Following Forest Hills High School in New York City, I attended Cornell University for a five-year program leading to a Bachelor of Chemical Engineering degree. After spending one year at the University of Rochester to obtain a Master of Science in Chemical Engineering, I came to Princeton University in 1951. Four years later, with a fresh PhD, I joined the faculty at the University of California, Berkeley, where I remained, interrupted only by sabbatical leaves in Switzerland, Germany, England, New Zealand, and Australia. Most of my professional work has been in applied chemical thermodynamics for process design, in particular, development of molecular-thermodynamic models for calculating phase equilibria for large-scale separation operations. I have also worked on the properties of electrolytes and hydrates, critical phenomena in fluid mixtures, properties of polymers and gels, adsorption of fluid mixtures, and separation of biomolecules. For many years I was a consultant for Air Projects and Chemicals and for the Fluor Corporation. Throughout my long teaching career, I have stressed the importance of context and of integrating science and engineering with humanities and with the needs of society. Such integration makes better engineers and contributes to personal happiness.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"1-15"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37307648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications. 用于工程亚单位疫苗和免疫治疗的蛋白质和肽生物材料。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 DOI: 10.1146/annurev-chembioeng-060718-030347

Alexandra N Tsoras, Julie A Champion

{"title":"Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications.","authors":"Alexandra N Tsoras, Julie A Champion","doi":"10.1146/annurev-chembioeng-060718-030347","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030347","url":null,"abstract":"Although vaccines have been the primary defense against widespread infectious disease for decades, there is a critical need for improvement to combat complex and variable diseases. More control and specificity over the immune response can be achieved by using only subunit components in vaccines. However, these often lack sufficient immunogenicity to fully protect, and conjugation or carrier materials are required. A variety of protein and peptide biomaterials have improved effectiveness and delivery of subunit vaccines for infectious, cancer, and autoimmune diseases. They are biodegradable and have control over both material structure and immune function. Many of these materials are built from naturally occurring self-assembling proteins, which have been engineered for incorporation of vaccine components. In contrast, others are de novo designs of structures with immune function. In this review, protein biomaterial design, engineering, and immune functionality as vaccines or immunotherapies are discussed.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"337-359"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37307646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Perspectives on Low-Temperature Electrolysis and Potential for Renewable Hydrogen at Scale. 低温电解和大规模可再生氢的潜力展望。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 DOI: 10.1146/annurev-chembioeng-060718-030241

Katherine Ayers, Nemanja Danilovic, Ryan Ouimet, Marcelo Carmo, Bryan Pivovar, Marius Bornstein

{"title":"Perspectives on Low-Temperature Electrolysis and Potential for Renewable Hydrogen at Scale.","authors":"Katherine Ayers, Nemanja Danilovic, Ryan Ouimet, Marcelo Carmo, Bryan Pivovar, Marius Bornstein","doi":"10.1146/annurev-chembioeng-060718-030241","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030241","url":null,"abstract":"Hydrogen is an important part of any discussion on sustainability and reduction in emissions across major energy sectors. In addition to being a feedstock and process gas for many industrial processes, hydrogen is emerging as a fuel alternative for transportation applications. Renewable sources of hydrogen are therefore required to increase in capacity. Low-temperature electrolysis of water is currently the most mature method for carbon-free hydrogen generation and is reaching relevant scales to impact the energy landscape. However, costs still need to be reduced to be economical with traditional hydrogen sources. Operating cost reductions are enabled by the recent availability of low-cost sources of renewable energy, and the potential exists for a large reduction in capital cost withmaterial and manufacturing optimization. This article focuses on the current status and development needs by component for the low-temperature electrolysis options.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"219-239"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37308585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 166

Thermodynamic Principles for the Design of Polymers for Drug Formulations. 设计用于药物配方的聚合物的热力学原理。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 Epub Date: 2019-03-22 DOI: 10.1146/annurev-chembioeng-060718-030304

Michael Fischlschweiger, Sabine Enders

{"title":"Thermodynamic Principles for the Design of Polymers for Drug Formulations.","authors":"Michael Fischlschweiger, Sabine Enders","doi":"10.1146/annurev-chembioeng-060718-030304","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030304","url":null,"abstract":"Polymers play an essential role in drug formulation and production of medical devices, implants, and diagnostics. Following drug discovery, an appropriate formulation is selected to enable drug delivery. This task can be exceedingly challenging owing to the large number of potential delivery methods and formulation and process variables that can interact in complex ways. This evolving solubility challenge has inspired an increasing emphasis on the developability of drug candidates in early discovery as well as various advanced drug solubilization strategies. Among the latter, formulation approaches that lead to prolonged drug supersaturation to maximize the driving force for sustained intestinal absorption of an oral product, or to allow sufficient time for injection after reconstitution of a parenteral lyophile formulation, have attracted increasing interest. Although several kinetic and thermodynamic components are involved in stabilizing amorphous dispersions, it is generally assumed that maximum physical stability, defined in terms of inhibition of drug crystallization, requires that the drug and excipient remain intimately mixed. Phase separation of the drug from its excipient may be the first step that ultimately leads to crystallization. We discuss the role of advanced thermodynamics using two examples: ASD and vitamin E-stabilized ultrahigh-molecular weight polyethylene implants.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"311-335"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37081581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Advances in the Use of Microfluidics to Study Crystallization Fundamentals. 微流体学研究结晶原理的进展。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 Epub Date: 2019-04-24 DOI: 10.1146/annurev-chembioeng-060718-030312

Nadine Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

引用次数: 12

Polymer-Based Marine Antifouling and Fouling Release Surfaces: Strategies for Synthesis and Modification. 聚合物基海洋防污和污垢释放表面:合成和改性策略。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 DOI: 10.1146/annurev-chembioeng-060718-030401

Amanda K Leonardi, Christopher K Ober

引用次数: 98

Toward Sustainable Chemical Engineering: The Role of Process Systems Engineering. 走向可持续化学工程:过程系统工程的作用。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 Epub Date: 2019-03-27 DOI: 10.1146/annurev-chembioeng-060718-030332

Bhavik R Bakshi

{"title":"Toward Sustainable Chemical Engineering: The Role of Process Systems Engineering.","authors":"Bhavik R Bakshi","doi":"10.1146/annurev-chembioeng-060718-030332","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030332","url":null,"abstract":"Products from chemical engineering are essential for human well-being, but they also contribute to the degradation of ecosystem goods and services that are essential for sustaining all human activities. To contribute to sustainability, chemical engineering needs to address this paradox by developing chemical products and processes that meet the needs of present and future generations. Unintended harm of chemical engineering has usually appeared outside the discipline's traditional system boundary due to shifting of impacts across space, time, flows, or disciplines, and exceeding nature's capacity to supply goods and services. Being a subdiscipline of chemical engineering, process systems engineering (PSE) is best suited for ensuring that chemical engineering makes net positive contributions to sustainable development. This article reviews the role of PSE in the quest toward a sustainable chemical engineering. It focuses on advances in metrics, process design, product design, and process dynamics and control toward sustainability. Efforts toward contributing to this quest have already expanded the boundary of PSE to consider economic, environmental, and societal aspects of processes, products, and their life cycles. Future efforts need to account for the role of ecosystems in supporting industrial activities, and the effects of human behavior and markets on the environmental impacts of chemical products. Close interaction is needed between the reductionism of chemical engineering science and the holism of process systems engineering, along with a shift in the engineering paradigm from wanting to dominate nature to learning from it and respecting its limits.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"265-288"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37096060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Colloidal Materials for 3D Printing. 胶体材料用于3D打印。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 Epub Date: 2019-04-05 DOI: 10.1146/annurev-chembioeng-060718-030133

Cheng Zhu, Andrew J Pascall, Nikola Dudukovic, Marcus A Worsley, Joshua D Kuntz, Eric B Duoss, Christopher M Spadaccini

{"title":"Colloidal Materials for 3D Printing.","authors":"Cheng Zhu, Andrew J Pascall, Nikola Dudukovic, Marcus A Worsley, Joshua D Kuntz, Eric B Duoss, Christopher M Spadaccini","doi":"10.1146/annurev-chembioeng-060718-030133","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030133","url":null,"abstract":"In recent years, 3D printing has led to a disruptive manufacturing revolution that allows complex architected materials and structures to be created by directly joining sequential layers into designed 3D components. However, customized feedstocks for specific 3D printing techniques and applications are limited or nonexistent, which greatly impedes the production of desired structural or functional materials. Colloids, with their stable biphasic nature, have tremendous potential to satisfy the requirements of various 3D printing methods owing to their tunable electrical, optical, mechanical, and rheological properties. This enables materials delivery and assembly across the multiple length scales required for multifunctionality. Here, a state-of-the-art review on advanced colloidal processing strategies for 3D printing of organic, ceramic, metallic, and carbonaceous materials is provided. It is believed that the concomitant innovations in colloid design and 3D printing will provide numerous possibilities for the fabrication of new constructs unobtainable using traditional methods, which will significantly broaden their applications.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"10 ","pages":"17-42"},"PeriodicalIF":8.4,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-chembioeng-060718-030133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37124129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40