代谢的动态控制。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Cynthia Ni, Christina V Dinh, Kristala L J Prather
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引用次数: 21

摘要

代谢工程重新编程细胞以合成增值产品。这样做,内源基因被改变,外源基因可以被引入来实现必要的酶促反应。代谢通量的动态调节是一种强有力的控制方案,可以缓解和克服由引入这些生产途径引起的竞争性细胞目标。这篇综述探讨了动态调节策略,这些策略通过针对特定挑战的代谢节点显示出显著的生产效益。我们总结了在这些策略中使用的刺激-反应控制电路,这些策略确定了驱动动态响应的标准,然后检查了将刺激-反应电路与代谢通量转移相结合的控制点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic Control of Metabolism.

Metabolic engineering reprograms cells to synthesize value-added products. In doing so, endogenous genes are altered and heterologous genes can be introduced to achieve the necessary enzymatic reactions. Dynamic regulation of metabolic flux is a powerful control scheme to alleviate and overcome the competing cellular objectives that arise from the introduction of these production pathways. This review explores dynamic regulation strategies that have demonstrated significant production benefits by targeting the metabolic node corresponding to a specific challenge. We summarize the stimulus-responsive control circuits employed in these strategies that determine the criterion for actuating a dynamic response and then examine the points of control that couple the stimulus-responsive circuit to a shift in metabolic flux.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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