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Annual review of chemical and biomolecular engineering最新文献

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Modeling the Growth of Bulk, Single Crystals: Seeing What Is Hidden.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-24 DOI: 10.1146/annurev-chembioeng-082223-110559
Jeffrey J Derby
{"title":"Modeling the Growth of Bulk, Single Crystals: Seeing What Is Hidden.","authors":"Jeffrey J Derby","doi":"10.1146/annurev-chembioeng-082223-110559","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-110559","url":null,"abstract":"<p><p>Modeling is an indispensable tool for understanding and improving the growth of bulk, single crystals. Such crystals are required for the fabrication of the electronic and photonic devices that enable information technology, communications, sensing, solid-state lighting, solar energy production, and many other applications. These materials are much more than simply very pure, specialty chemicals. They must meet strict requirements for solid-state structural perfection and must be produced with high yields and low costs. Successful manufacturing techniques have been developed that utilize thermodynamic phase change to solidify a high-temperature melt into a crystal of high quality. However, harsh conditions and batch operation limit both diagnostic measurements and data available to connect growth conditions to outcomes, making modeling even more important for process improvement. Challenges and opportunities are discussed for melt crystal growth processes, with research examples that demonstrate how modeling has provided important insight into crystal-melt interface shape, dopant segregation, morphological instability, and defect formation.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Protein-Polyelectrolyte Interactions for Cellular Applications.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-13 DOI: 10.1146/annurev-chembioeng-100722-105929
Rachel S Fisher, Jane Liao, So Yeon Ahn, Nisha Modi, Aaron K Kidane, Allie C Obermeyer
{"title":"Engineering Protein-Polyelectrolyte Interactions for Cellular Applications.","authors":"Rachel S Fisher, Jane Liao, So Yeon Ahn, Nisha Modi, Aaron K Kidane, Allie C Obermeyer","doi":"10.1146/annurev-chembioeng-100722-105929","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100722-105929","url":null,"abstract":"<p><p>Protein-polyelectrolyte interactions are fundamental interactions in biology that occur at every length scale, from protein-DNA complexes to phase-separated organelles. They drive processes ranging from gene transcription and DNA synthesis to viral assembly. Protein engineering is a powerful way to modulate these interactions, both to probe endogenous function and to engineer novel interactions between species. In this review, we consider the various noncovalent interactions that govern the formation and behavior of these complexes, and we discuss how protein modifications such as changes to structure, charge, and charge patterning affect them. We highlight recent examples where engineering changes to protein-polyelectrolyte interactions have helped elucidate biological function, and we then focus on recent efforts toward de novo material design of synthetic biomolecular condensates and functional nanoassemblies.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle-Based Pulmonary Immune Engineering.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-12 DOI: 10.1146/annurev-chembioeng-082223-105117
Michael Trautmann-Rodriguez, Catherine A Fromen
{"title":"Nanoparticle-Based Pulmonary Immune Engineering.","authors":"Michael Trautmann-Rodriguez, Catherine A Fromen","doi":"10.1146/annurev-chembioeng-082223-105117","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-105117","url":null,"abstract":"<p><p>Respiratory conditions represent a significant global healthcare burden impacting hundreds of millions worldwide and necessitating new treatment paradigms. Pulmonary immune engineering using synthetic nanoparticle (NP) platforms can reprogram immune responses for therapeutically beneficial or protective responses directly within the lung tissue. However, effectively localizing these game-changing approaches to the lung remains a significant challenge due to the lung's natural defense. We highlight the target pulmonary immune cells and address advances to localize NPs to the lung via both aerosol and vascular delivery. For each administration route, we discuss physiochemical design rules and recent immune-modulatory successes of synthetic, extracellular vesicle, and cell-mediated NP delivery. We aim to provide readers with an updated summary of this emerging field and offer a roadmap for future research aimed at enhancing the efficacy of pulmonary immunotherapies.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic Covalent Hydrogels for Wound Healing.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-11 DOI: 10.1146/annurev-chembioeng-082323-093537
Joey Hui Min Wong, Jun Jie Chang, Cally Owh, Yee Lin Tan, Qianyu Lin, Valerie Ow, Belynn Sim, Yihao Leow, Rubayn Goh, Xian Jun Loh
{"title":"Dynamic Covalent Hydrogels for Wound Healing.","authors":"Joey Hui Min Wong, Jun Jie Chang, Cally Owh, Yee Lin Tan, Qianyu Lin, Valerie Ow, Belynn Sim, Yihao Leow, Rubayn Goh, Xian Jun Loh","doi":"10.1146/annurev-chembioeng-082323-093537","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082323-093537","url":null,"abstract":"<p><p>Given their hydrophilic nature, hydrogels have shown great potential as wound dressing materials. However, traditional hydrogel dressing materials are static and do not adapt to dynamic wound environments, which in turn limits their wound healing efficacy. Introducing dynamic covalent chemistries can be an effective strategy to improve hydrogel properties for effective wound healing, such as shape adaptability, stimuli responsiveness, self-healing capability, and antibacterial properties. We discuss the properties and chemistries of dynamic covalent bonds for wound healing. We critically analyze the advances of dynamic covalent hydrogels for wound healing and further propose new dynamic covalent chemistries for wound healing.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral Assemblies of π-Conjugated Molecules: Fundamentals, Processing Strategies, and Applications in (Opto)Electronics.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-07 DOI: 10.1146/annurev-chembioeng-100722-104224
Pravini S Fernando, Yen-Chi Chen, Janice M Baek, Ying Diao
{"title":"Chiral Assemblies of π-Conjugated Molecules: Fundamentals, Processing Strategies, and Applications in (Opto)Electronics.","authors":"Pravini S Fernando, Yen-Chi Chen, Janice M Baek, Ying Diao","doi":"10.1146/annurev-chembioeng-100722-104224","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100722-104224","url":null,"abstract":"<p><p>Chirality, a fundamental attribute of asymmetry, pervades in both nature and functional soft materials. In chiral material systems design, achieving global symmetry breaking of building blocks during assembly, with or without the aid of additives, has emerged as a promising strategy across domains including chiral sensing, electronics, photonics, spintronics, and biomimetics. We first introduce the fundamental aspects of chirality, including its structural basis and symmetry-breaking mechanisms considering free energy minimization. We particularly emphasize supramolecular assembly, such as through the formation of chiral liquid crystal phases. Next, we summarize processing strategies to control chiral symmetry breaking, exploiting external fields such as flow, magnetic fields, and templates. The final section discusses interactions between chiral molecular assemblies with circularly polarized (CP) light and electronic spin and their applications in CP light detectors, CP-spin-organic light-emitting diodes, CP displays, and spintronic devices based on the chirality-induced spin selectivity effect.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Mechanochemistry: A Chemical Tool to Bridge Polymer Physics and Mechanics of Soft Polymer Networks.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-04 DOI: 10.1146/annurev-chembioeng-092220-113154
Gabriel E Sanoja, Costantino Creton
{"title":"Quantitative Mechanochemistry: A Chemical Tool to Bridge Polymer Physics and Mechanics of Soft Polymer Networks.","authors":"Gabriel E Sanoja, Costantino Creton","doi":"10.1146/annurev-chembioeng-092220-113154","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-092220-113154","url":null,"abstract":"<p><p>In recent years, mechanochemistry has imposed itself as a novel promising chemical tool to bridge the gap between polymer physics and continuum mechanics in soft materials. The suitable incorporation of force-sensitive molecules (mechanophores) in load-bearing positions in soft (entropic) polymer networks and in linear chains has provided a tool to detect stresses and bond scission in 2D and 3D through the intensity of an optical signal. We review recent results linking the optical signal detected upon mechanophore activation with the applied mechanical load. Recent investigations have addressed critical questions, such as detecting and quantifying stress fields and measuring quantitative damage by bond scission in diverse cases, including failure in uniaxial tension, crack propagation in continuous loading, cyclic fatigue, or crack initiation in uniaxial and triaxial tension. We also discuss the requirements to go from simple imaging to quantitative detection, enabling comparisons between different materials and the calibration of continuum mechanics models. In ideal cases, the optical signal provides highly sensitive information on the size and intensity of damage zones in front of cracks-regions that would otherwise be undetectable.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
My Struggles and Dreams as a Chemical Engineer.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-03-03 DOI: 10.1146/annurev-chembioeng-082223-110952
Robert Langer
{"title":"My Struggles and Dreams as a Chemical Engineer.","authors":"Robert Langer","doi":"10.1146/annurev-chembioeng-082223-110952","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-110952","url":null,"abstract":"<p><p>My career has not been straightforward. Although I am a chemical engineer, and I'm proud of that, I took a path from chemistry and engineering to one that also involved experimental biology and medicine. This was very unusual many decades ago. In so doing, I met with rejection and ridicule early in my career. However, by going down that path, I was able to make discoveries and inventions that I hope have saved and improved lives, and I've been able to train a great number of people who are going down the road I began traveling over many years ago.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selected Chemical Engineering Applications in Nuclear-Waste Processing at the Savannah River Site.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-02-27 DOI: 10.1146/annurev-chembioeng-082223-053509
Steven H Crouse, Rupanjali Prasad, Nischal Maharjan, Viviana Cardenas Ocampo, Wesley H Woodham, Dan P Lambert, Ronald W Rousseau, Martha A Grover
{"title":"Selected Chemical Engineering Applications in Nuclear-Waste Processing at the Savannah River Site.","authors":"Steven H Crouse, Rupanjali Prasad, Nischal Maharjan, Viviana Cardenas Ocampo, Wesley H Woodham, Dan P Lambert, Ronald W Rousseau, Martha A Grover","doi":"10.1146/annurev-chembioeng-082223-053509","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-053509","url":null,"abstract":"<p><p>The Savannah River Site has been successfully processing and immobilizing nuclear waste since 1996. However, recent developments in both the scientific understanding of chemical principles and the engineering of immobilizing nuclear-waste systems demand a review of the state of the art. These recent advances have significance to other locations that immobilize nuclear waste. The subject matter of this review may find special applicability to chemical engineers interested in hazardous chemical processes (such as processing toxic and radioactive nuclear waste) and to those in the nuclear industry curious about current research in nuclear-waste processing at a site that has eclipsed the quarter-century mark of large-scale (136 million L total) nuclear-waste processing.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Entropic Bonding-Not Quite So Simple Behaviors from Simple Hard Particles.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-02-27 DOI: 10.1146/annurev-chembioeng-082323-092941
Thi Vo
{"title":"Entropic Bonding-Not Quite So Simple Behaviors from Simple Hard Particles.","authors":"Thi Vo","doi":"10.1146/annurev-chembioeng-082323-092941","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082323-092941","url":null,"abstract":"<p><p>Advances in experimental synthesis and computer simulations have led to the proliferation of anisotropy and particle geometry as popular handles for directed self-assembly. This paradigm employs entropy to direct building block organization into desired spatial and orientational orderings. Yet, how does a metric associated primarily with disorder give rise to ordered assemblies? We first explain the governing principles behind entropic crystallization and entropy maximization processes. We then show how entropic forces can produce emergent, attractive, and bond-like interactions between otherwise sterically repulsive particles. Building on these ideas, we establish entropy as a mediator of interparticle attraction in hard particle systems that relies on extrinsic, systems-level behaviors as opposed to intrinsic, particle-level properties. Finally, we present a theory of entropic bonding that formalizes the phenomena discussed into a rigorous mathematical framework and discuss relevant next steps for its development and applications of entropic crystallization in materials design.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging the Immunological Impacts of Irreversible Electroporation as a New Frontier for Cancer Therapy.
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-02-04 DOI: 10.1146/annurev-chembioeng-082223-054259
Joseph R Vallin, Samira M Azarin
{"title":"Leveraging the Immunological Impacts of Irreversible Electroporation as a New Frontier for Cancer Therapy.","authors":"Joseph R Vallin, Samira M Azarin","doi":"10.1146/annurev-chembioeng-082223-054259","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-054259","url":null,"abstract":"<p><p>Irreversible electroporation (IRE) is a nonthermally mediated tissue ablation modality that makes use of short pulsed electric fields to destroy cancerous lesions in situ. In the past two decades, IRE has established itself not only as an effective means to ablate small, unresectable tumor masses but also as a tool particularly qualified to modulate the tumor microenvironment in a way that dismantles pathways of cancer immunosuppression and permits the development of a systemic antitumor immune response. However, despite its immune-stimulating tendencies, for most cancers conventional IRE alone is insufficient to establish an immune response robust enough to fully eliminate disseminated disease and prevent recurrence. Here, we describe the current understanding of the histological and immunological effects of IRE, as well as recent efforts to optimize IRE parameters and develop rational combination therapies to increase the efficacy of the resulting immune response.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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