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Leveraging the Immunological Impacts of Irreversible Electroporation as a New Frontier for Cancer Therapy. 利用不可逆电穿孔的免疫学影响作为癌症治疗的新前沿。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-02-04 DOI: 10.1146/annurev-chembioeng-082223-054259
Joseph R Vallin, Samira M Azarin
{"title":"Leveraging the Immunological Impacts of Irreversible Electroporation as a New Frontier for Cancer Therapy.","authors":"Joseph R Vallin, Samira M Azarin","doi":"10.1146/annurev-chembioeng-082223-054259","DOIUrl":"10.1146/annurev-chembioeng-082223-054259","url":null,"abstract":"<p><p>Irreversible electroporation (IRE) is a nonthermally mediated tissue ablation modality that makes use of short pulsed electric fields to destroy cancerous lesions in situ. In the past two decades, IRE has established itself not only as an effective means to ablate small, unresectable tumor masses but also as a tool particularly qualified to modulate the tumor microenvironment in a way that dismantles pathways of cancer immunosuppression and permits the development of a systemic antitumor immune response. However, despite its immune-stimulating tendencies, for most cancers conventional IRE alone is insufficient to establish an immune response robust enough to fully eliminate disseminated disease and prevent recurrence. Here, we describe the current understanding of the histological and immunological effects of IRE, as well as recent efforts to optimize IRE parameters and develop rational combination therapies to increase the efficacy of the resulting immune response.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"169-193"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selected Chemical Engineering Applications in Nuclear-Waste Processing at the Savannah River Site. 选择化学工程在萨凡纳河核废物处理中的应用。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-02-27 DOI: 10.1146/annurev-chembioeng-082223-053509
Steven H Crouse, Rupanjali Prasad, Nischal Maharjan, Viviana Cardenas Ocampo, Wesley H Woodham, Dan P Lambert, Ronald W Rousseau, Martha A Grover
{"title":"Selected Chemical Engineering Applications in Nuclear-Waste Processing at the Savannah River Site.","authors":"Steven H Crouse, Rupanjali Prasad, Nischal Maharjan, Viviana Cardenas Ocampo, Wesley H Woodham, Dan P Lambert, Ronald W Rousseau, Martha A Grover","doi":"10.1146/annurev-chembioeng-082223-053509","DOIUrl":"10.1146/annurev-chembioeng-082223-053509","url":null,"abstract":"<p><p>The Savannah River Site has been successfully processing and immobilizing nuclear waste since 1996. However, recent developments in both the scientific understanding of chemical principles and the engineering of immobilizing nuclear-waste systems demand a review of the state of the art. These recent advances have significance to other locations that immobilize nuclear waste. The subject matter of this review may find special applicability to chemical engineers interested in hazardous chemical processes (such as processing toxic and radioactive nuclear waste) and to those in the nuclear industry curious about current research in nuclear-waste processing at a site that has eclipsed the quarter-century mark of large-scale (136 million L total) nuclear-waste processing.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"349-370"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction. 介绍。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 DOI: 10.1146/annurev-chembioeng-043025-010930
{"title":"Introduction.","authors":"","doi":"10.1146/annurev-chembioeng-043025-010930","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-043025-010930","url":null,"abstract":"","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"16 1","pages":"i-ii"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Phase Equilibria: Selecting Suitable Solvent Systems for Reactive Extraction of Carboxylic Acids. 超越相平衡：选择合适的溶剂体系反应萃取羧酸。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 DOI: 10.1146/annurev-chembioeng-082323-120010
Katharina Maria Saur, Nina A Fridley, Marcel Gausmann, Andreas Jupke
{"title":"Beyond Phase Equilibria: Selecting Suitable Solvent Systems for Reactive Extraction of Carboxylic Acids.","authors":"Katharina Maria Saur, Nina A Fridley, Marcel Gausmann, Andreas Jupke","doi":"10.1146/annurev-chembioeng-082323-120010","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082323-120010","url":null,"abstract":"<p><p>Reactive extraction is an attractive separation technology that can replace energy-intensive water evaporation steps in the industrial production of carboxylic acids. We systematically review the current literature on the extraction of low-value bioproducts and thereby identify the reduced availability of predictive models, limited selectivity, and challenging phase separation as possible bottlenecks in the industrial implementation of reactive extraction. Furthermore, we discuss requirements and strategies for closing the material cycles for batch and continuous processes. With these challenges in mind, we analyze the most widely used extractants (trioctylamine, trioctylphosphine oxide, and tributyl phosphate) in combination with common diluents (e.g., long-chain alcohols and alkanes) in terms of their ability to meet process needs. We illustrate the subordinate role of equilibrium constants in overall process design while emphasizing the potential for flexible reactive extraction systems tailored to process requirements.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"16 1","pages":"23-58"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Chemical Engineers Can Learn from Shrimp. 化学工程师能从虾身上学到什么？
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 DOI: 10.1146/annurev-chembioeng-082223-102200
Aniruddha B Pandit, Manisha V Bagal, Parag R Gogate
{"title":"What Chemical Engineers Can Learn from Shrimp.","authors":"Aniruddha B Pandit, Manisha V Bagal, Parag R Gogate","doi":"10.1146/annurev-chembioeng-082223-102200","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-082223-102200","url":null,"abstract":"<p><p>This review focuses on how the cavitation mechanism in the snapping shrimp can be explored to intensify various chemical engineering applications. Effective bubble collapse can lead to hot spot formation, increased transport coefficients (momentum, heat, and mass), and enhanced interfacial area and also results in the formation of highly reactive radicals. Cavitation's ability to induce rapid micromixing, enhance mass transfer, and facilitate nucleophilic chemical reactions can find applications in various industries. An overview of cavitation applications, reactors used for cavitation, effects of operating parameters, and conclusions drawn from the studies so far is presented. Cavitation provides significant benefits for applications in synthesis reactions, wastewater treatment, food processing, emulsification, extraction, and crystallization. Learnings from snapping shrimp can be translated into process intensification of physicochemical and biological transformations in chemical engineering by harnessing these cavitational effects.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"16 1","pages":"433-453"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Mechanochemistry: A Chemical Tool to Bridge Polymer Physics and Mechanics of Soft Polymer Networks. 定量力学化学：连接聚合物物理和软聚合物网络力学的化学工具。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-03-04 DOI: 10.1146/annurev-chembioeng-092220-113154
Gabriel E Sanoja, Costantino Creton
{"title":"Quantitative Mechanochemistry: A Chemical Tool to Bridge Polymer Physics and Mechanics of Soft Polymer Networks.","authors":"Gabriel E Sanoja, Costantino Creton","doi":"10.1146/annurev-chembioeng-092220-113154","DOIUrl":"10.1146/annurev-chembioeng-092220-113154","url":null,"abstract":"<p><p>In recent years, mechanochemistry has imposed itself as a novel promising chemical tool to bridge the gap between polymer physics and continuum mechanics in soft materials. The suitable incorporation of force-sensitive molecules (mechanophores) in load-bearing positions in soft (entropic) polymer networks and in linear chains has provided a tool to detect stresses and bond scission in 2D and 3D through the intensity of an optical signal. We review recent results linking the optical signal detected upon mechanophore activation with the applied mechanical load. Recent investigations have addressed critical questions, such as detecting and quantifying stress fields and measuring quantitative damage by bond scission in diverse cases, including failure in uniaxial tension, crack propagation in continuous loading, cyclic fatigue, or crack initiation in uniaxial and triaxial tension. We also discuss the requirements to go from simple imaging to quantitative detection, enabling comparisons between different materials and the calibration of continuum mechanics models. In ideal cases, the optical signal provides highly sensitive information on the size and intensity of damage zones in front of cracks-regions that would otherwise be undetectable.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"321-347"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle-Based Pulmonary Immune Engineering. 基于纳米颗粒的肺免疫工程。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1146/annurev-chembioeng-082223-105117
Michael Trautmann-Rodriguez, Catherine A Fromen
{"title":"Nanoparticle-Based Pulmonary Immune Engineering.","authors":"Michael Trautmann-Rodriguez, Catherine A Fromen","doi":"10.1146/annurev-chembioeng-082223-105117","DOIUrl":"10.1146/annurev-chembioeng-082223-105117","url":null,"abstract":"<p><p>Respiratory conditions represent a significant global healthcare burden impacting hundreds of millions worldwide and necessitating new treatment paradigms. Pulmonary immune engineering using synthetic nanoparticle (NP) platforms can reprogram immune responses for therapeutically beneficial or protective responses directly within the lung tissue. However, effectively localizing these game-changing approaches to the lung remains a significant challenge due to the lung's natural defense. We highlight the target pulmonary immune cells and address advances to localize NPs to the lung via both aerosol and vascular delivery. For each administration route, we discuss physiochemical design rules and recent immune-modulatory successes of synthetic, extracellular vesicle, and cell-mediated NP delivery. We aim to provide readers with an updated summary of this emerging field and offer a roadmap for future research aimed at enhancing the efficacy of pulmonary immunotherapies.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"249-270"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic Covalent Hydrogels for Wound Healing. 动态共价水凝胶用于伤口愈合。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1146/annurev-chembioeng-082323-093537
Joey Hui Min Wong, Jun Jie Chang, Cally Owh, Yee Lin Tan, Qianyu Lin, Valerie Ow, Belynn Sim, Yihao Leow, Rubayn Goh, Xian Jun Loh
{"title":"Dynamic Covalent Hydrogels for Wound Healing.","authors":"Joey Hui Min Wong, Jun Jie Chang, Cally Owh, Yee Lin Tan, Qianyu Lin, Valerie Ow, Belynn Sim, Yihao Leow, Rubayn Goh, Xian Jun Loh","doi":"10.1146/annurev-chembioeng-082323-093537","DOIUrl":"10.1146/annurev-chembioeng-082323-093537","url":null,"abstract":"<p><p>Given their hydrophilic nature, hydrogels have shown great potential as wound dressing materials. However, traditional hydrogel dressing materials are static and do not adapt to dynamic wound environments, which in turn limits their wound healing efficacy. Introducing dynamic covalent chemistries can be an effective strategy to improve hydrogel properties for effective wound healing, such as shape adaptability, stimuli responsiveness, self-healing capability, and antibacterial properties. We discuss the properties and chemistries of dynamic covalent bonds for wound healing. We critically analyze the advances of dynamic covalent hydrogels for wound healing and further propose new dynamic covalent chemistries for wound healing.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"93-117"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Matter/Life Nexus in Biological Cells. 生物细胞中的物质/生命关系。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 DOI: 10.1146/annurev-chembioeng-100722-104442
Vishal S Sivasankar, Roseanna N Zia
{"title":"The Matter/Life Nexus in Biological Cells.","authors":"Vishal S Sivasankar, Roseanna N Zia","doi":"10.1146/annurev-chembioeng-100722-104442","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-100722-104442","url":null,"abstract":"<p><p>The search for what differentiates inanimate matter from living things began in antiquity as a search for a fundamental life force embedded deep within living things-a special material unit owned only by life-later transforming to a more circumspect search for unique gains in function that transform nonliving matter to that which can reproduce, adapt, and survive. Aristotelian thinking about the matter/life distinction and Vitalistic philosophy's vital force persisted well into the Scientific Revolution, only to be debunked by Pasteur and Brown in the nineteenth century. Acceptance of the atomic reality and understanding of the uniqueness of life's heredity, evolution, and reproduction led to formation of the Central Dogma. With startling speed, technological development then gave rise to structural biology, systems biology, and synthetic biology-and a search to replicate and synthesize that gain in function that transforms matter to life. Yet one still cannot build a living cell de novo from its atomic and molecular constituents, and \"what I cannot create, I do not understand,\" in the words of Richard Feynman. In the last two decades, new recognition of old ideas-spatial organization and compartmentalization-has renewed focus on Brownian and flow physics. In this article, we explore how experimental and computational advances in the last decade have embraced the deep coupling between physics and cellular biochemistry to shed light on the matter/life nexus. Whole-cell modeling and synthesis are offering promising new insights that may shed light on this nexus in the cell's watery, crowded milieu.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"16 1","pages":"409-432"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Protein-Polyelectrolyte Interactions for Cellular Applications. 工程蛋白-聚电解质相互作用在细胞中的应用。
IF 7.6 2区 工程技术
Annual review of chemical and biomolecular engineering Pub Date : 2025-06-01 Epub Date: 2025-03-13 DOI: 10.1146/annurev-chembioeng-100722-105929
Rachel S Fisher, Jane Liao, So Yeon Ahn, Nisha Modi, Aaron K Kidane, Allie C Obermeyer
{"title":"Engineering Protein-Polyelectrolyte Interactions for Cellular Applications.","authors":"Rachel S Fisher, Jane Liao, So Yeon Ahn, Nisha Modi, Aaron K Kidane, Allie C Obermeyer","doi":"10.1146/annurev-chembioeng-100722-105929","DOIUrl":"10.1146/annurev-chembioeng-100722-105929","url":null,"abstract":"<p><p>Protein-polyelectrolyte interactions are fundamental interactions in biology that occur at every length scale, from protein-DNA complexes to phase-separated organelles. They drive processes ranging from gene transcription and DNA synthesis to viral assembly. Protein engineering is a powerful way to modulate these interactions, both to probe endogenous function and to engineer novel interactions between species. In this review, we consider the various noncovalent interactions that govern the formation and behavior of these complexes, and we discuss how protein modifications such as changes to structure, charge, and charge patterning affect them. We highlight recent examples where engineering changes to protein-polyelectrolyte interactions have helped elucidate biological function, and we then focus on recent efforts toward de novo material design of synthetic biomolecular condensates and functional nanoassemblies.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"119-145"},"PeriodicalIF":7.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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