{"title":"Does Food Engineering Still Need High Pressure?","authors":"Robert Sevenich, Julia Matysek, Cornelia Rauh","doi":"10.1146/annurev-chembioeng-082323-120912","DOIUrl":"10.1146/annurev-chembioeng-082323-120912","url":null,"abstract":"<p><p>High-pressure processing (HPP), also known as high hydrostatic pressure (HHP), is essential in contemporary food engineering. This review evaluates its significance through aspects like microbial safety, nutritional and sensory quality, sustainability, market acceptance, economic viability, and technological versatility. By critically examining the current state and potential of HPP, this article highlights that, despite emerging alternatives, food engineering remains strongly reliant on high pressure as an irreplaceable technology due to its unique benefits in ensuring sustainable, high-quality, and safe food products.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"117-132"},"PeriodicalIF":13.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Machine Learning and Large Language Models in Chemical Information Extraction.","authors":"Yufan Chen, Yuxuan Zhang, Haifan Zhou, Ching Ting Leung, Hanyu Gao","doi":"10.1146/annurev-chembioeng-100724-080433","DOIUrl":"10.1146/annurev-chembioeng-100724-080433","url":null,"abstract":"<p><p>Rich information in the chemical literature presents unprecedented opportunities for accelerating discovery and optimization in chemistry through data-driven approaches. Nevertheless, converting raw information in the literature into structured databases relies primarily on manual curation, which is time-consuming and costly. In this review, we comprehensively examine recent advances in automatic chemical information extraction from the literature, focusing on image and text modalities. We trace the evolution from early rule-based and machine learning approaches to state-of-the-art methods leveraging large language models (LLMs) and vision language models. We discuss core tasks such as optical chemical structure recognition, reaction diagram parsing, named entity recognition, and experimental procedure extraction, highlighting representative methods, benchmark data sets, and practical challenges such as multimodal integration and data annotation. By systematically comparing these approaches, we identify key trends and persistent limitations and outline promising future directions toward robust, scalable, and automated chemical information extraction frameworks. This review aims to provide a practical guide for researchers seeking to harness machine learning and LLM technologies to accelerate the digital transformation of chemical science.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"417-441"},"PeriodicalIF":13.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Amorim, Patrice Crosby, Jennifer Tran, Wren Kitchings, Rong Yang, Eleftheria Roumeli
{"title":"Microbial Polymers and Living Interfaces: Interplay Between Matter and Microbes.","authors":"Julia Amorim, Patrice Crosby, Jennifer Tran, Wren Kitchings, Rong Yang, Eleftheria Roumeli","doi":"10.1146/annurev-chembioeng-100724-081311","DOIUrl":"10.1146/annurev-chembioeng-100724-081311","url":null,"abstract":"<p><p>Polymer design is being reshaped by demands for low-carbon fabrication and bioactive/living function. We trace the bidirectional interface between microbes and polymers. First, we analyze how microbes synthesize polymers like polysaccharides, polyesters, and proteins and how post-synthesis processing (via mechanical and/or chemical treatments) reshapes molecular architecture and mechanical and thermal properties. We compare reported properties, highlight missing metrics, and evaluate sustainability levers including solvent recovery, cradle-to-gate impacts, and biodegradation/biocontainment constraints. Second, we examine how polymers shape the behavior of living organisms in the context of engineered living materials. Design is organized around four axes-regulating adhesion and detachment, sustaining or directing growth for regeneration, imposing spatial organization on consortia, and tuning phenotype-with implementations in drug delivery, carbon capture, antimicrobial screening, and structural composites. Finally, we outline how automation, artificial intelligence-guided experimentation, and robust sustainability metrics can couple performance with responsible deployment.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"179-212"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fati Lukeman, Piyush Deshpande, Jennifer L Schaefer
{"title":"Polymer Electrolytes for Rechargeable Sodium Batteries: Review of Characterization of Bulk and Interfacial Properties.","authors":"Fati Lukeman, Piyush Deshpande, Jennifer L Schaefer","doi":"10.1146/annurev-chembioeng-100724-083133","DOIUrl":"10.1146/annurev-chembioeng-100724-083133","url":null,"abstract":"<p><p>Sodium-based batteries are gaining momentum as a cost-effective, sustainable alternative to lithium-based batteries, driven by the global demand for scalable energy storage. At the same time, polymer electrolytes are being widely pursued as safer, more electrochemically stable alternatives to liquid electrolytes. Sodium polymer electrolytes require advancement in various aspects, such as ion transport and electrode compatibility, before application in rechargeable sodium-ion or sodium metal batteries. This review examines the progress in characterization of the bulk properties of sodium polymer electrolytes, molecular interactions in the bulk, and their interfaces/interphases with electrodes, with attention paid to differences between characterization methodology and select properties of sodium versus lithium analogs. Highlighted topics include ionic conductivity, sodium transference, ion speciation, electrochemical stability, safety, and electrochemical and chemical characterization of interfaces, interphases, and with sodium sulfur cathodes.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"267-290"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhinendra Singh, Hojin Kim, Jeffrey F Morris, Heinrich M Jaeger
{"title":"Jamming and Yielding in Dense Suspensions.","authors":"Abhinendra Singh, Hojin Kim, Jeffrey F Morris, Heinrich M Jaeger","doi":"10.1146/annurev-chembioeng-100724-075250","DOIUrl":"10.1146/annurev-chembioeng-100724-075250","url":null,"abstract":"<p><p>Suspensions of particles dispersed in liquids are ubiquitous materials in industry and geophysics; relevant examples include cement and mud. At high particle concentration, in what is called a dense suspension, crowding induces multiscale interactions ranging from local, particle-level contact forces to macroscopic, system-spanning contact networks that dynamically evolve under applied shear. As the number of constraints on relative particle movement increases, the suspension viscosity rises, and eventually the material reaches a jammed state. In this review, we discuss frameworks developed to predict the rheological behavior of dense suspensions in the vicinity of jamming and describe the resulting flow-state diagram. Going beyond mean-field models, we discuss recent advances in understanding the contact network of spatially correlated particles. We also review recent developments for tailoring flow constraints at the particle level, both by particle geometry and by interactions induced by chemical bonds, which can be used to engineer the location and extent of different regimes in the flow-state diagram. We end with a set of issues and perspectives for future research, including possible ways to extend the current theoretical framework, apply simulations to suspensions comprising particles with more complex nonspherical or highly anisotropic shapes, and develop approaches to predict how molecular-scale details influence macroscopic flows.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"157-178"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Resonant Life.","authors":"Jeffrey A Reimer","doi":"10.1146/annurev-chembioeng-110824-075256","DOIUrl":"10.1146/annurev-chembioeng-110824-075256","url":null,"abstract":"<p><p>I embody the quintessential Californian spirit: Raised in Los Angeles, I spent weekends either at the beach or skiing at Big Bear, rode motorcycles, hiked the Sierras, and cherished the sounds of the Beach Boys and Creedence Clearwater Revival. Restless, undisciplined, and irreverent, I applied to only one college-UC Santa Barbara-mainly because that is where my high school friends were going. Although we like to think our intellect transcends culture, my childhood and teenage years were shaped by the rhythms of the 1960s: space flight, NASA, and virtually every episode of <i>Star Trek</i> (often watched multiple times). Unmoored, I entered college intending to major in biochemistry but drifted into chemistry while also immersing myself in the physics curriculum. I earned a PhD in chemical physics at Caltech, yet chose to work with a chemical engineer. When my thesis advisor was suddenly killed, I completed my dissertation at Xerox Palo Alto Research Center, working on solar cell materials alongside Cambridge-educated physicists. While my chemistry peers pursued academic postdocs, I went instead to IBM Yorktown Heights, dividing my time between silane reactor engineering and amorphous semiconductor physics. Would I ever become anchored? Here is the rest of the story that led to 43 years on the Berkeley faculty. Including motorcycles.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"17 1","pages":"1-17"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Néstor E Valadez-Pérez, Florian Platten, Alejandro Gil-Villegas, Ramón Castañeda-Priego
{"title":"Extended Law of Corresponding States: Origins, Challenges, and Applications to Protein Solutions.","authors":"Néstor E Valadez-Pérez, Florian Platten, Alejandro Gil-Villegas, Ramón Castañeda-Priego","doi":"10.1146/annurev-chembioeng-100724-073401","DOIUrl":"10.1146/annurev-chembioeng-100724-073401","url":null,"abstract":"<p><p>The phase diagram of colloidal systems strongly depends on the nature of interparticle interactions, which reflect the physical mechanisms that stabilize the particles in the medium. In systems with dominant short-range attractions, where interactions act over distances much shorter than the particle diameter, the extended law of corresponding states asserts that an interaction potential can be described by three key parameters: effective diameter, interaction strength, and second virial coefficient. If these parameters are the same, then different systems exhibit identical phase behavior, structure, and dynamics. In this review, we outline the origin and formulation of this law and the evidence that supports it. We further examine its applicability to protein solutions near liquid-liquid phase separation and to colloidal systems with short-range attraction and long-range repulsion, exploring the possibility of a universal phase diagram and extending its relevance for understanding the nature of these complex fluids.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"133-155"},"PeriodicalIF":13.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction.","authors":"Michael F Doherty, Rachel A Segalman, Ravi S Kane","doi":"10.1146/annurev-chembioeng-040826-103908","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-040826-103908","url":null,"abstract":"","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":"17 1","pages":"i"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protein Vesicles as Emerging Platforms for Drug Delivery, Vaccines, and Immunotherapy.","authors":"Nishat Tasnim, Yeongseon Jang","doi":"10.1146/annurev-chembioeng-100724-084456","DOIUrl":"10.1146/annurev-chembioeng-100724-084456","url":null,"abstract":"<p><p>Protein vesicles are spherical, hollow structures made entirely of folded proteins, fusion proteins, or polypeptides. Their intrinsic biocompatibility, nontoxicity, structural tunability, and cargo-loading capacity make them promising candidates for diverse biomedical applications. Although diverse forms of protein-based carriers have long been employed in drug, gene, and vaccine delivery, as well as in artificial antigen-presenting cells, vesicle architectures provide distinct advantages over free proteins, including enhanced stability, targeted delivery, and controlled release. We summarize recent advances in engineering protein vesicles and assess their current status within the broader landscape of synthetic vesicles in biomedicine. By comparing protein vesicles with liposomes, polymersomes, and virus-like particles, we highlight the limitations of conventional systems and underscore the unique benefits of protein-based assemblies. We further examine the emerging applications of protein vesicles in therapeutic delivery, diagnostics, and immunotherapy and discuss future directions needed to advance protein vesicle technologies toward clinical translation.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"291-308"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David T Allen, Qining Chen, Arvind P Ravikumar, Erin E Tullos
{"title":"Multiscale Measurement and Modeling of Methane Emissions in US Oil and Gas Production Regions.","authors":"David T Allen, Qining Chen, Arvind P Ravikumar, Erin E Tullos","doi":"10.1146/annurev-chembioeng-100724-074807","DOIUrl":"10.1146/annurev-chembioeng-100724-074807","url":null,"abstract":"<p><p>The emergence of the United States as the leading global producer of oil and gas has driven increased interest in the greenhouse gas emissions from US energy supply chains. Methane emissions are a major portion of these greenhouse gas emissions, and the spatial and temporal patterns of methane emissions from oil and gas sources are complex. A wide variety of measurement and modeling approaches for estimating methane emissions from US oil and gas supply chains have emerged over the last decade, and this review summarizes their current status and prospects for improvement. Although no single measurement method or modeling approach will be successful in accurately characterizing all emissions, the integration of multi-scale measurement and modeling approaches can provide accurate and comprehensive estimates of emissions.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":" ","pages":"245-265"},"PeriodicalIF":12.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}