设计多价和多特异性生物制剂

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Jennifer J. Kang, Ayako Ohoka, Casim A. Sarkar
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引用次数: 0

摘要

在精准医疗时代,多价和多特异性疗法为靶向疾病干预提供了一种前景广阔的方法。这些疗法旨在同时与多个靶点相互作用,有望提高疗效、减少副作用并抵御耐药性。我们剖析了指导多价生物制剂设计的原则,强调了为实现最大疗效而必须考虑的挑战和策略。多价和多特异性生物制剂设计中的可设计元素--域亲和性、效价和空间展示--必须结合分子靶点以及靶点热敏性和特异性等重要特性的平衡来考虑。我们阐明了这些原则在设计蛋白质和细胞疗法中的最新应用,并指出了这一领域令人兴奋的未来发展方向,生物分子和细胞工程以及计算方法的进步对此尤为突出。《化学与生物分子工程年度综述》第 15 卷的最终在线出版日期预计为 2024 年 6 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Designing Multivalent and Multispecific Biologics
In the era of precision medicine, multivalent and multispecific therapeutics present a promising approach for targeted disease intervention. These therapeutics are designed to interact with multiple targets simultaneously, promising enhanced efficacy, reduced side effects, and resilience against drug resistance. We dissect the principles guiding the design of multivalent biologics, highlighting challenges and strategies that must be considered to maximize therapeutic effect. Engineerable elements in multivalent and multispecific biologic design—domain affinities, valency, and spatial presentation—must be considered in the context of the molecular targets as well as the balance of important properties such as target avidity and specificity. We illuminate recent applications of these principles in designing protein and cell therapies and identify exciting future directions in this field, underscored by advances in biomolecular and cellular engineering and computational approaches.Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering , Volume 15 is June 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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