重新评估理解幽门螺杆菌偏性迁移的标准趋化性框架。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Jyot D Antani, Aakansha Shaji, Rachit Gupta, Pushkar P Lele
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引用次数: 0

摘要

幽门螺杆菌感染是消化性溃疡和胃癌的主要原因。这些鞭毛细菌引起的强烈炎症反应与预后不良有关。趋化性在幽门螺杆菌定植中起着至关重要的作用,使细菌能够向有利的化学环境游泳。与细菌趋化性的模式种大肠杆菌不同,幽门螺杆菌细胞具有极性鞭毛。它们通过逆时针旋转鞭毛向前跑,而通过顺时针旋转鞭毛向后跑。我们深入研究了趋化性规范模型的某些特征对我们对极性鞭毛细菌(如幽门螺杆菌)偏向迁移的理解的影响。特别是,我们预测在向后运行过程中,幽门螺杆菌细胞的平移位移如何在规范框架内引起趋化性错误。此外,幽门螺杆菌缺乏大肠杆菌中发现的关键趋化酶,没有这种酶,对大动态范围配体的敏感检测似乎是不可能的。尽管存在这些问题,幽门螺杆菌仍表现出向富含尿素的来源迁移的强大能力。我们强调了幽门螺杆菌趋化性的生物物理机制中各种尚未解决的问题,为未来的研究指明了方向。了解幽门螺杆菌偏向性迁移的复杂性可以为了解病原体如何破坏人类宿主的各种保护屏障提供有价值的见解。预计《化学与生物分子工程年度评论》第15卷的最终在线出版日期为2024年6月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in Helicobacter pylori.

Helicobacter pylori infections are a major cause of peptic ulcers and gastric cancers. The development of robust inflammation in response to these flagellated, motile bacteria is correlated with poor prognosis. Chemotaxis plays a crucial role in H. pylori colonization, enabling the bacteria to swim toward favorable chemical environments. Unlike the model species of bacterial chemotaxis, Escherichia coli, H. pylori cells possess polar flagella. They run forward by rotating their flagella counterclockwise, whereas backward runs are achieved by rotating their flagella clockwise. We delve into the implications of certain features of the canonical model of chemotaxis on our understanding of biased migration in polarly flagellated bacteria such as H. pylori. In particular, we predict how the translational displacement of H. pylori cells during a backward run could give rise to chemotaxis errors within the canonical framework. Also, H. pylori lack key chemotaxis enzymes found in E. coli, without which sensitive detection of ligands with a wide dynamic range seems unlikely. Despite these problems, H. pylori exhibit robust ability to migrate toward urea-rich sources. We emphasize various unresolved questions regarding the biophysical mechanisms of chemotaxis in H. pylori, shedding light on potential directions for future research. Understanding the intricacies of biased migration in H. pylori could offer valuable insights into how pathogens breach various protective barriers in the human host.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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