Jyot D Antani, Aakansha Shaji, Rachit Gupta, Pushkar P Lele
{"title":"重新评估理解幽门螺杆菌偏性迁移的标准趋化性框架。","authors":"Jyot D Antani, Aakansha Shaji, Rachit Gupta, Pushkar P Lele","doi":"10.1146/annurev-chembioeng-100722-114625","DOIUrl":null,"url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infections are a major cause of peptic ulcers and gastric cancers. The development of robust inflammation in response to these flagellated, motile bacteria is correlated with poor prognosis. Chemotaxis plays a crucial role in <i>H. pylori</i> colonization, enabling the bacteria to swim toward favorable chemical environments. Unlike the model species of bacterial chemotaxis, <i>Escherichia coli</i>, <i>H. pylori</i> cells possess polar flagella. They run forward by rotating their flagella counterclockwise, whereas backward runs are achieved by rotating their flagella clockwise. We delve into the implications of certain features of the canonical model of chemotaxis on our understanding of biased migration in polarly flagellated bacteria such as <i>H. pylori</i>. In particular, we predict how the translational displacement of <i>H. pylori</i> cells during a backward run could give rise to chemotaxis errors within the canonical framework. Also, <i>H. pylori</i> lack key chemotaxis enzymes found in <i>E. coli</i>, without which sensitive detection of ligands with a wide dynamic range seems unlikely. Despite these problems, <i>H. pylori</i> exhibit robust ability to migrate toward urea-rich sources. We emphasize various unresolved questions regarding the biophysical mechanisms of chemotaxis in <i>H. pylori</i>, shedding light on potential directions for future research. Understanding the intricacies of biased migration in <i>H. pylori</i> could offer valuable insights into how pathogens breach various protective barriers in the human host.</p>","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":7.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in <i>Helicobacter pylori</i>.\",\"authors\":\"Jyot D Antani, Aakansha Shaji, Rachit Gupta, Pushkar P Lele\",\"doi\":\"10.1146/annurev-chembioeng-100722-114625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Helicobacter pylori</i> infections are a major cause of peptic ulcers and gastric cancers. The development of robust inflammation in response to these flagellated, motile bacteria is correlated with poor prognosis. Chemotaxis plays a crucial role in <i>H. pylori</i> colonization, enabling the bacteria to swim toward favorable chemical environments. Unlike the model species of bacterial chemotaxis, <i>Escherichia coli</i>, <i>H. pylori</i> cells possess polar flagella. They run forward by rotating their flagella counterclockwise, whereas backward runs are achieved by rotating their flagella clockwise. We delve into the implications of certain features of the canonical model of chemotaxis on our understanding of biased migration in polarly flagellated bacteria such as <i>H. pylori</i>. In particular, we predict how the translational displacement of <i>H. pylori</i> cells during a backward run could give rise to chemotaxis errors within the canonical framework. Also, <i>H. pylori</i> lack key chemotaxis enzymes found in <i>E. coli</i>, without which sensitive detection of ligands with a wide dynamic range seems unlikely. Despite these problems, <i>H. pylori</i> exhibit robust ability to migrate toward urea-rich sources. We emphasize various unresolved questions regarding the biophysical mechanisms of chemotaxis in <i>H. pylori</i>, shedding light on potential directions for future research. Understanding the intricacies of biased migration in <i>H. pylori</i> could offer valuable insights into how pathogens breach various protective barriers in the human host.</p>\",\"PeriodicalId\":8234,\"journal\":{\"name\":\"Annual review of chemical and biomolecular engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of chemical and biomolecular engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-chembioeng-100722-114625\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of chemical and biomolecular engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1146/annurev-chembioeng-100722-114625","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in Helicobacter pylori.
Helicobacter pylori infections are a major cause of peptic ulcers and gastric cancers. The development of robust inflammation in response to these flagellated, motile bacteria is correlated with poor prognosis. Chemotaxis plays a crucial role in H. pylori colonization, enabling the bacteria to swim toward favorable chemical environments. Unlike the model species of bacterial chemotaxis, Escherichia coli, H. pylori cells possess polar flagella. They run forward by rotating their flagella counterclockwise, whereas backward runs are achieved by rotating their flagella clockwise. We delve into the implications of certain features of the canonical model of chemotaxis on our understanding of biased migration in polarly flagellated bacteria such as H. pylori. In particular, we predict how the translational displacement of H. pylori cells during a backward run could give rise to chemotaxis errors within the canonical framework. Also, H. pylori lack key chemotaxis enzymes found in E. coli, without which sensitive detection of ligands with a wide dynamic range seems unlikely. Despite these problems, H. pylori exhibit robust ability to migrate toward urea-rich sources. We emphasize various unresolved questions regarding the biophysical mechanisms of chemotaxis in H. pylori, shedding light on potential directions for future research. Understanding the intricacies of biased migration in H. pylori could offer valuable insights into how pathogens breach various protective barriers in the human host.
期刊介绍:
The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.