Annals of translational medicine最新文献

{"title":"Erratum to butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis.","authors":"","doi":"10.21037/atm-2024-14","DOIUrl":"10.21037/atm-2024-14","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-2158.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to Transthyretin-induced increase in circ_0007411 represses neovascularization of human retinal microvascular endothelial cells in hyperglycemia via the miR-548m/PTPN12/SKP1/EGFR pathway.","authors":"","doi":"10.21037/atm-2024-13","DOIUrl":"10.21037/atm-2024-13","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-1276.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography retinal imaging: narrative review of technological advancements and clinical applications.","authors":"Christopher S Langlo, Aana Amin, Susanna S Park","doi":"10.21037/atm-24-211","DOIUrl":"10.21037/atm-24-211","url":null,"abstract":"<p><strong>Background and objective: </strong>Optical coherence tomography (OCT) is a non-invasive imaging tool that can provide rapid cross-sectional images of the retina, cornea, and optic nerve head in live patients. The objective of this review is to provide an overview of the technical advancements and current clinical applications of OCT for managing patients with retinal disorders.</p><p><strong>Methods: </strong>Narrative overview synthesizing the findings of literature retrieved from searches of computerized database, authoritative texts and authors' clinical experience and expertise.</p><p><strong>Key content and findings: </strong>Unlike the first-generation time-domain OCT (TD-OCT) instruments, the newer spectral-domain OCT (SD-OCT) instruments use a broadband light source to increase axial image resolution. In addition, the decreased image acquisition time also increases the transverse image resolution, reduces motion artifacts, and allows serial cross-sectional images of the retina to be obtained rapidly. A three-dimensional (3D) image of the retina, reconstructed using serial two-dimensional (2D) OCT images, can be used to quantitate retinal thickness and volume and perform analysis of retinal topography. Currently, commercial SD-OCT instruments are used routinely in clinical practice to obtain morphologic information used to diagnose and manage patients with various retinal disorders including macular degeneration and diabetic retinopathy. Newer swept-source OCT technology with faster image acquisition, provides wider field imaging of the peripheral retina. SD-OCT instruments can be incorporated into surgical microscopes to allow imaging of the retina during retinal surgery so that morphologic changes in the retina from surgical maneuvers can be observed in real time. More recently, OCT angiography (OCTA) has been developed which allows rapid, non-invasive 3D imaging of retinal and choroidal vascular flow. This is achieved by processing rapid serial SD-OCT images to detect movement of blood cells within vessels. Research has been done to further improve image resolution of SD-OCT to a cellular level by adding adaptive optics (AO) technology. The latest in SD-OCT technology is optoretinography (ORG), a technique to derive functional information from OCT images of the retina.</p><p><strong>Conclusions: </strong>Advancement in OCT technology has made it possible to obtain high resolution retinal images that can provide anatomic, physiologic and functional information of the retina in live patients.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.","authors":"Ho Geol Woo, Ju-Young Park, Moo-Seok Park, Tae-Jin Song","doi":"10.21037/atm-24-218","DOIUrl":"10.21037/atm-24-218","url":null,"abstract":"<p><strong>Background: </strong>Studies evaluating the association between hemorrhoids and heart failure (HF) have been limited. We aimed to evaluate the association between increased incidence of HF and the presence of hemorrhoids using a population-based longitudinal cohort.</p><p><strong>Methods: </strong>We included 356,033 participants in this study, derived from health screening data collected between 2003 and 2007 from the South Korean health screening cohort database. Hemorrhoid presence was identified as having a minimum of two claims based on the International Classification of Diseases, Tenth Revision (ICD-10) code I84. Propensity score matching (PSM) was used to assign participants to two groups according to the presence and treatment of hemorrhoids. The primary outcome was the incidence of HF, defined as having two or more claims based on the ICD-10 code I50.</p><p><strong>Results: </strong>Among the participants, the presence of hemorrhoids was observed in 24,363 (6.8%) individuals. Over a median follow-up period of 13.33 years (interquartile range, 10.4-16.26), 55,167 cumulative cases of HF (15.5%) occurred. In multivariate analysis, the group with hemorrhoids consistently showed a higher incidence of HF compared to those without hemorrhoids, both before [hazard ratio (HR): 1.073; 95% confidence interval (CI): 1.028-1.121] and after PSM (HR: 1.073; 95% CI: 1.018-1.131). Regarding surgical procedures/treatments for hemorrhoids, participants who underwent surgical procedures or treatment for hemorrhoids showed a lower incidence of HF before PSM (HR, 0.919; 95% CI: 0.845-1.001) and after PSM (HR, 0.941; 95% CI: 0.880-1.001).</p><p><strong>Conclusions: </strong>Our study revealed a significantly increased incidence of HF among participants with hemorrhoids. Therefore, it should be noted that when hemorrhoids are present, the risk of developing HF in the future may be increased.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to aloe-emodin inhibits the proliferation, migration, and invasion of melanoma cells via inactivation of the Wnt/beta-catenin signaling pathway.","authors":"","doi":"10.21037/atm-2024-5","DOIUrl":"10.21037/atm-2024-5","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-5437.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma.","authors":"Yang Gao, Chengtao Liu, Xiaoling Zhao, Chaojun Liu, Wenzhi Bi, Jinpeng Jia","doi":"10.21037/atm-2024-7","DOIUrl":"10.21037/atm-2024-7","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/atm-21-3076.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of isometric resistance exercise on blood pressure in normotensive adults: a systematic review of randomized clinical trials.","authors":"Ramon Martins Barbosa, Alan Carlos Nery Dos Santos, Marvyn de Santana do Sacramento, Clarcson Plácido Conceição Dos Santos, Pedro Elias Santos Souza, Uilma Sacramento Santana, Jefferson Petto","doi":"10.21037/atm-24-124","DOIUrl":"10.21037/atm-24-124","url":null,"abstract":"<p><strong>Background: </strong>Isometric resistance exercise (IRE), characterized by static muscle contractions, has demonstrated potential in reducing blood pressure (BP). A meta-analysis revealed significant reductions in systolic (SBP) (6 mmHg), diastolic (DBP) (3 mmHg) and mean (3 mmHg) blood pressure. Although the effects of IRE in hypertensive individuals are known, its impact in normotensive adults is still poorly studied. This study evaluates IRE as a preventive strategy for hypertension. The objective of this study is to describe the effect of IRE on BP in normotensive adults.</p><p><strong>Methods: </strong>A systematic review registered with PROSPERO (CRD42024496749) was carried out using the PubMed, Virtual Health Library (VHL), Web of Science, Scopus, and Physiotherapy Evidence Database (PEDro). The descriptors \"Resistance Training\", \"Isometric Exercise\" and \"Blood Pressure\" were used. Randomized clinical trials investigating IRE in normotensive adult individuals were included, assessing the outcomes of SBP, DBP and/or mean arterial pressure (MAP). There were no restrictions on the period of publication. The risk of bias was assessed using the PEDro scale.</p><p><strong>Results: </strong>A total of 3,195 articles were identified, but only 5 were included in the review. The included studies, published between 2000 and 2022, had a parallel design and involved 142 normotensive, sedentary or regularly active volunteers aged between 19 and 34 years old. The exercise protocols for the experimental group consisted of IRE at an intensity of 20% to 34% of maximum voluntary contraction, 4 sets of 2 to 3 minutes each, with rest intervals of 2 to 3 minutes, performed 2 to 5 times a week for 3 to 8 weeks. IRE led to a significant reduction in SBP, DBP and MAP. The main mechanisms associated with this reduction were the release of vasodilator substances, a reduction in oxidative stress and an improvement in autonomic balance. All the studies included had moderate to high methodological quality.</p><p><strong>Conclusions: </strong>IRE reduces systolic, diastolic and MAP in normotensive individuals.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in personalized medicine: translating genomic insights into targeted therapies for cancer treatment.","authors":"Mohamad Jamalinia, Ralf Weiskirchen","doi":"10.21037/atm-25-34","DOIUrl":"10.21037/atm-25-34","url":null,"abstract":"<p><strong>Background: </strong>Personalized medicine has revolutionized cancer treatment by utilizing genomic insights to tailor therapies based on individual molecular profiles. This approach enhances therapeutic efficacy, minimizes adverse effects, and addresses tumor heterogeneity through precision-targeted interventions.</p><p><strong>Methods: </strong>A scoping review was conducted through a comprehensive literature search in PubMed, using MeSH terms and keywords related to genomic profiling and targeted cancer therapies. Eligible studies included original research involving cancer patients who underwent genomic profiling and targeted therapies from January 1, 1950, to February 9, 2025.</p><p><strong>Results: </strong>Advances in next-generation sequencing (NGS) and bioinformatics have accelerated the identification of clinically relevant mutations-such as epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) and BRAF V600E in melanoma-enabling the development of effective targeted therapies. Emerging technologies like clustered regularly interspaced short palindromic repeats (CRISPR) gene editing and artificial intelligence (AI) are further refining treatment selection by enabling more precise and adaptive therapeutic strategies. Despite these innovations, challenges persist regarding data interpretation, equitable access, costs, regulatory frameworks, and integration into routine clinical workflows.</p><p><strong>Conclusions: </strong>Genomic profiling is central to the advancement of precision oncology. The convergence of genomics, gene editing, and AI is paving the way toward more personalized, efficient, and inclusive cancer care. Realizing the full potential of personalized medicine will require interdisciplinary collaboration, investment in infrastructure, and ethical oversight to ensure broad, equitable, and responsible implementation in clinical practice.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All that glitters ain't gold.","authors":"Alessandro Pruna, Yuki Kotani, Laura Pasin, Giovanni Landoni","doi":"10.21037/atm-25-35","DOIUrl":"10.21037/atm-25-35","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using half-hitch knots to uncouple surgical knot security and loop tautness.","authors":"Thomas J O'Keefe, Louis A Perkins, Isabella Guajardo, Laura M Adams, Bard C Cosman, William D Ardill, Bruce M Potenza","doi":"10.21037/atm-25-2","DOIUrl":"10.21037/atm-25-2","url":null,"abstract":"<p><strong>Background: </strong>Most surgeons tie half-hitch knots, but many are unfamiliar with the principles underlying their security leading to insecure knots. When presented with evidence regarding tying technique and knot security, we note a proclivity among surgeons towards resistance to change with rationalizations such as concerns regarding tissue strangulation with increasing knot security. We hypothesize that this concern is unfounded. The aim of this study was to identify whether the impact of loop tautness on knot security is mediated through the configuration of the knot.</p><p><strong>Methods: </strong>Six-throw knots were tied with 0 silk. The loop of the knot encompassed two brass rings and a piece of latex hose. Four knot types were tied and tested: non-taut and taut single post knots (SxSxSxSxSxS in Dinsmore notation), and non-taut and taut alternating post knots (SxSxS#S#S#S in Dinsmore notation). The latex hose was then removed from the loop and the brass rings were distracted on a tensiometer to assess knot security. The main outcome for the study was knot security, including maximum force resisted by each knot type to 1 and 2 mm slippage and ultimate failure defined by slippage to unraveling or breakage of the suture. Differences of means were tested with 2-sided <i>t</i>-test.</p><p><strong>Results: </strong>By 1 mm slippage, the tautly tied alternating post knots were more secure than the single post knots, and the non-taut single post knots were less secure than all other configurations. By 2 mm slippage, the tautly tied alternating post knots were more secure than all other configurations and the non-taut alternating post knots were more secure than the tautly tied and non-taut single post knots. By ultimate failure, the tautly tied and non-taut alternating post knots were comparable and both more secure than both single post knots.</p><p><strong>Conclusions: </strong>Surgeons can utilize single and alternating post throws to independently confer knot security and loop tautness and thereby tie the knot needed under a given set of circumstances.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 2","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}