Annals of translational medicine最新文献

{"title":"C9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia.","authors":"Maria Elena Cicardi, Davide Trotti","doi":"10.21037/atm-24-86","DOIUrl":"https://doi.org/10.21037/atm-24-86","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"120"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide trends and outcomes of percutaneous coronary intervention for stable ischemic heart disease in end-stage kidney disease: a longitudinal study.","authors":"Rhythm Vasudeva, Harsh Mehta, Wan-Chi Chan, Sania Jiwani, Sri G Yarlagadda, Prakash Acharya, Prasad Gunasekaran, Georges Hajj, Mark Wiley, Eric Hockstad, Peter Tadros, Kamal Gupta","doi":"10.21037/atm-24-85","DOIUrl":"10.21037/atm-24-85","url":null,"abstract":"<p><strong>Background: </strong>Patients with end-stage kidney disease (ESKD) are at high risk for coronary artery disease. We investigate the trends and outcomes of percutaneous coronary intervention (PCI) for stable ischemic heart disease (SIHD) in patients with ESKD.</p><p><strong>Methods: </strong>We utilized the United States Renal Data System [2010-2018] to include adult patients with ESKD on dialysis for at least 3 months who underwent PCI for SIHD. Patients with myocardial infarction during index hospitalization, history of coronary artery bypass graft or renal transplantation and without Medicare AB coverage were excluded. Trends and related outcomes, including mortality and revascularization rate, were studied.</p><p><strong>Results: </strong>The mean age was 65.1 years with 57.5% male and a majority White (64.5%). The dialysis duration was ≤5 years in 83.3% patients. Hypertension (97.6%) and diabetes mellitus (76.8%) were the most common comorbidities. PCI procedures per 1,000 ESKD patients dropped from 6.2 in 2010 to 2.6 in 2018 (P<0.001) while the index hospitalization mortality increased from 0.9% to 3.0% (P<0.001). The 30-day and 1-year mortality also significantly increased from 3.2% to 6.1% and 26.5% to 31.9%, respectively. However, 1-year repeat revascularization rates dropped from 19.8% to 17.0% between 2010-2018 (P<0.001). A significant increase in comorbidity burden was also noted.</p><p><strong>Conclusions: </strong>We demonstrate a consistent decrease in PCI rates for SIHD in ESKD patients. However, the in-hospital mortality has increased significantly, in part, due to an increasing high-risk profile of these patients. Our results call for individualized clinical decision-making when exploring revascularization options in ESRD patients with SIHD.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin-producing cells derived from expandable stem cell-derived endoderm are effective for the treatment of type 2 diabetes.","authors":"Eiji Yoshihara","doi":"10.21037/atm-24-129","DOIUrl":"https://doi.org/10.21037/atm-24-129","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"121"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining tomorrow: the evolution of plastic and reconstructive surgery.","authors":"Johnny Ionut Efanov, Omar Elsewify","doi":"10.21037/atm-24-75","DOIUrl":"10.21037/atm-24-75","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"108"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.","authors":"Xue-Qin Tang, Ruo-Yi Liao, Li-Jun Zheng, Ling-Ling Yang, Zhi-Lin Ma, Chan Yi, Jin Liu, Jin-Can Liu, Yi-Jin Kuang, Hua-An Cai, Liang Huang","doi":"10.21037/atm-2024-29","DOIUrl":"https://doi.org/10.21037/atm-2024-29","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/atm-22-5443.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"128"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis.","authors":"Long Zhao, Tao Chen, Xiaoping Tang, Shun Li, Ruofei Liang, Yuanchuan Wang","doi":"10.21037/atm-2024-8","DOIUrl":"https://doi.org/10.21037/atm-2024-8","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/atm-20-5006.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"129"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: SIRT3-mediated mitochondrial autophagy in refeeding syndrome-related myocardial injury in sepsis rats.","authors":"","doi":"10.21037/atm-2024-53","DOIUrl":"https://doi.org/10.21037/atm-2024-53","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-222.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"124"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) in locally advanced and borderline resectable pancreatic cancer.","authors":"Zhu Chuen Oong, Ganesh Radhakrishna","doi":"10.21037/atm-24-170","DOIUrl":"https://doi.org/10.21037/atm-24-170","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"122"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expedited infection control and wound healing by combining Matriderm^®, a dermal matrix, and Stimulan^® absorbable antibiotic beads: a case report.","authors":"Benjamin Min Hao Chew, Hargaven Singh Gill, Priya Tiwari, O-Wern Low, Jing Tzer Lee, Jane Lim, Thiam Chye Lim, Yan Lin Yap, Vigneswaran Nallathamby","doi":"10.21037/atm-24-44","DOIUrl":"10.21037/atm-24-44","url":null,"abstract":"<p><strong>Background: </strong>Since dermal matrices (DMs) were first described in surgery, they have become an integral part of the reconstructive ladder, providing plastic surgeons with new approaches to wound reconstruction. While they have been used in reconstruction of a wide range of wounds, there has been limited or no literature on their effects when used in conjunction with fully absorbable antibiotic beads. Therefore, the aim of this study was to analyze the effects of using Matriderm^® dermal matrix concurrently with Stimulan^® absorbable antibiotic beads on wound healing and readiness for skin grafting.</p><p><strong>Case description: </strong>In this manuscript, we report the case of an adult ethnic Chinese male patient with recalcitrant infected right lower limb fasciotomy wounds managed using Matriderm^® dermal matrix in conjunction with Stimulan^® absorbable antibiotic beads prior to split-thickness skin graft reconstruction. The patient was a non-smoker with no known comorbid medical conditions and had initially presented with right lower limb compartment syndrome and rhabdomyolysis following a fall with long lie. He subsequently underwent an emergency fasciotomy with resulting medial and lateral right lower limb fasciotomy wounds. In this case report, wound revascularization, granulation formation and readiness for skin grafting were observed after one week of concurrent application of Matriderm^® and Stimulan^®. The patient's post-operative recovery was uneventful and he was discharged eleven days post skin grafting. There was at least 97% graft uptake and the graft donor site had healed well and was left exposed.</p><p><strong>Conclusions: </strong>The application of DMs in conjunction with absorbable antibiotic beads may shorten time to readiness for definitive wound coverage. Further randomized controlled trials are required to evaluate this potentially synergistic relationship.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing endovascular thrombectomy timing and thrombolysis use for ischemic stroke: insights from the SELECT2 and TIMELESS trials.","authors":"Gauthier Nendumba, Julien Moury, Michael Van Nieuwenhove, Arnaud Robert, Benedicte Hauqiert, Ovidiu Vornicu, Sydney Blackman, Emily Perriens, Ryma Ghorayeb, Sofia Belhoussine Drissi, Patrick El Nawar, Alexis Philippot, Anne-Sophie Dincq, Patrick Evrard, Pierre Bulpa, Isabelle Michaux, Patrick M Honore","doi":"10.21037/atm-24-64","DOIUrl":"10.21037/atm-24-64","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}