Ramon Martins Barbosa, Alan Carlos Nery Dos Santos, Marvyn de Santana do Sacramento, Clarcson Plácido Conceição Dos Santos, Pedro Elias Santos Souza, Uilma Sacramento Santana, Jefferson Petto
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引用次数: 0
Abstract
Background: Isometric resistance exercise (IRE), characterized by static muscle contractions, has demonstrated potential in reducing blood pressure (BP). A meta-analysis revealed significant reductions in systolic (SBP) (6 mmHg), diastolic (DBP) (3 mmHg) and mean (3 mmHg) blood pressure. Although the effects of IRE in hypertensive individuals are known, its impact in normotensive adults is still poorly studied. This study evaluates IRE as a preventive strategy for hypertension. The objective of this study is to describe the effect of IRE on BP in normotensive adults.
Methods: A systematic review registered with PROSPERO (CRD42024496749) was carried out using the PubMed, Virtual Health Library (VHL), Web of Science, Scopus, and Physiotherapy Evidence Database (PEDro). The descriptors "Resistance Training", "Isometric Exercise" and "Blood Pressure" were used. Randomized clinical trials investigating IRE in normotensive adult individuals were included, assessing the outcomes of SBP, DBP and/or mean arterial pressure (MAP). There were no restrictions on the period of publication. The risk of bias was assessed using the PEDro scale.
Results: A total of 3,195 articles were identified, but only 5 were included in the review. The included studies, published between 2000 and 2022, had a parallel design and involved 142 normotensive, sedentary or regularly active volunteers aged between 19 and 34 years old. The exercise protocols for the experimental group consisted of IRE at an intensity of 20% to 34% of maximum voluntary contraction, 4 sets of 2 to 3 minutes each, with rest intervals of 2 to 3 minutes, performed 2 to 5 times a week for 3 to 8 weeks. IRE led to a significant reduction in SBP, DBP and MAP. The main mechanisms associated with this reduction were the release of vasodilator substances, a reduction in oxidative stress and an improvement in autonomic balance. All the studies included had moderate to high methodological quality.
Conclusions: IRE reduces systolic, diastolic and MAP in normotensive individuals.
背景：以静态肌肉收缩为特征的等长阻力运动（IRE）已被证明具有降低血压（BP）的潜力。一项荟萃分析显示收缩压（SBP） （6mmhg）、舒张压（DBP） （3mmhg）和平均血压（3mmhg）显著降低。虽然IRE对高血压个体的影响是已知的，但其对正常血压成人的影响研究仍然很少。本研究评估IRE作为高血压的预防策略。本研究的目的是描述IRE对正常血压成人血压的影响。方法：使用PubMed、虚拟健康图书馆（VHL）、Web of Science、Scopus和物理治疗证据数据库（PEDro），在PROSPERO注册（CRD42024496749）进行系统评价。使用了“阻力训练”、“等长运动”和“血压”描述符。纳入了调查正常血压成人IRE的随机临床试验，评估收缩压、舒张压和/或平均动脉压（MAP）的结果。对出版期限没有限制。偏倚风险采用PEDro量表进行评估。结果：共纳入3195篇文献，其中仅有5篇被纳入综述。纳入的研究发表于2000年至2022年之间，采用平行设计，涉及142名血压正常、久坐或经常运动的志愿者，年龄在19至34岁之间。实验组的运动方案包括IRE，强度为最大自愿收缩的20%至34%，4组，每组2至3分钟，休息时间为2至3分钟，每周进行2至5次，持续3至8周。IRE导致收缩压、舒张压和MAP显著降低。与这种减少相关的主要机制是血管舒张物质的释放，氧化应激的减少和自主神经平衡的改善。所有纳入的研究都具有中等到高的方法学质量。结论：IRE降低正常血压个体的收缩压、舒张压和MAP。
期刊介绍：
The Annals of Translational Medicine (Ann Transl Med; ATM; Print ISSN 2305-5839; Online ISSN 2305-5847) is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research, aiming to provide practical up-to-date information in significant research from all subspecialties of medicine and to broaden the readers’ vision and horizon from bench to bed and bed to bench. It is published quarterly (April 2013- Dec. 2013), monthly (Jan. 2014 - Feb. 2015), biweekly (March 2015-) and openly distributed worldwide. Annals of Translational Medicine is indexed in PubMed in Sept 2014 and in SCIE in 2018. Specific areas of interest include, but not limited to, multimodality therapy, epidemiology, biomarkers, imaging, biology, pathology, and technical advances related to medicine. Submissions describing preclinical research with potential for application to human disease, and studies describing research obtained from preliminary human experimentation with potential to further the understanding of biological mechanism underlying disease are encouraged. Also warmly welcome are studies describing public health research pertinent to clinic, disease diagnosis and prevention, or healthcare policy. With a focus on interdisciplinary academic cooperation, ATM aims to expedite the translation of scientific discovery into new or improved standards of management and health outcomes practice.
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