Annals of translational medicine最新文献

{"title":"Artificial intelligence-driven diagnosis of acute thoracic aortic dissection: integrating imaging, biomarkers, and clinical workflows-a narrative review.","authors":"Eunice Man Ki Lo, Sisi Chen, Randolph Hung Leung Wong","doi":"10.21037/atm-25-82","DOIUrl":"10.21037/atm-25-82","url":null,"abstract":"<p><strong>Background and objective: </strong>Patients presenting to the emergency department with acute thoracic aortic dissection (ATAD) often experience chest pain that requires urgent intervention. However, other chest pain-related emergencies, such as acute coronary syndrome (ACS) and acute pulmonary embolism (PE), are far more common and frequently overshadow ATAD. This disparity leads to a high rate of ATAD misdiagnosis. Recent advancements in artificial intelligence (AI) have led to the development of various models utilizing imaging modalities and biomarkers to enable rapid triage and diagnosis of ATAD in emergency settings. This article aims to evaluate the performance and clinical significance of these AI models within the context of clinical workflows.</p><p><strong>Methods: </strong>We performed literature searches in PubMed, Scopus, and Web of Science to identify relevant studies published between 2015 and 2025, with the focus of the differentiation of ATAD patients from other chest pain-related conditions in emergency settings, with the application of AI.</p><p><strong>Key content and findings: </strong>Eighteen studies were retrieved from the past ten years, highlighting a significant knowledge gap in the field of translational medicine. The discussion included an overview of AI-powered models for ATAD diagnosis, as well as guidelines on current clinical workflows and the application of AI in clinical settings.</p><p><strong>Conclusions: </strong>This article offers a detailed review of AI models developed for the screening and diagnosis of ATAD. It highlights not only the performance of these technologies but also their clinical importance in facilitating timely interventions for high-risk patients. Looking forward, we anticipate a future where AI and deep learning (DL)-driven ATAD diagnostic models will play a pivotal role in optimizing ATAD clinical management.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphangiography and preliminary evaluation of N-butyl cyanoacrylate, Lipiodol, and ethanol mixtures; sodium tetradecyl sulphate with Lipiodol and air; and ethanol with Lipiodol in rats.","authors":"Atsushi Saiga, Kentaro Yamada, Yadong Shi, Kenkichi Michimoto, Takeshi Suzuki, Maofeng Gong, Todd Graham, Khashayar Farsad","doi":"10.21037/atm-25-25","DOIUrl":"10.21037/atm-25-25","url":null,"abstract":"<p><strong>Background: </strong>Lymphatic interventional radiology is expanding in scope, with N-butyl 2-cyanoacrylate (NBCA) being one of the only embolic materials currently in use. However, it has drawbacks such as catheter adhesion and non-target embolization. Although alternative agents are needed for lymphatic interventions, optimal substitutes remain unclear. This study aimed to develop a rat model to evaluate the efficacy of NBCA combined with Lipiodol and ethanol (NLE), sodium tetradecyl sulphate (STS) combined with Lipiodol and air, and ethanol and Lipiodol (EL) in lymphatic interventions.</p><p><strong>Methods: </strong>Twelve Lewis and six Sprague-Dawley male rats were included in this study. Two lymphatic approaches were evaluated: (I) percutaneous transabdominal cisterna chyli/retroperitoneal lymphatic duct puncture at the level of 2nd-3rd lumbar vertebrae using a 25-G needle, as performed in humans (6 rats); and (II) puncture of iliolumbar lymph node (12 rats). For the latter, isosulfan blue was injected subcutaneously into the left and/or right rear foot pad to stain the popliteal lymph nodes, which were then exposed for additional dye injection. A 5.0-cm midline incision was made to expose the blue-stained iliolumbar lymph node. Once lymphangiography was achieved using either approach, embolization was subsequently performed. Two NLE ratios [2:2:1 (NLE221) and 1:5:1 (NLE151)], STS foam (with a ratio of 3:2:3 for air, STS and Lipiodol) and EL (ethanol:Lipiodol =2:1) were used as embolic materials. Their effects were assessed by measuring the travel distance of the embolic mixture.</p><p><strong>Results: </strong>Using the first approach, lymphangiography was successfully performed in 4 of 6 rats, but embolization could not be achieved due to poor needle stability. Using the second approach, the popliteal and iliolumbar lymph node were visualized in all 12 and 11 rats, respectively. Among the 11 rats with iliolumbar lymph node access, lymphangiography using Lipiodol was performed in one rat, and embolization under fluoroscopy was performed in 10 rats. The thoracic duct was visualized following lymphangiography, and embolization was carried out using NLE221 (n=3), NLE151 (n=2), STS (n=3) and EL (n=2). Lymphatic flow cessation was observed in all 10 cases. The average travel distances were 1.2 cm for NLE221, 3.5 cm for NLE151, 4.3 cm for STS and 4.0 cm for EL21.</p><p><strong>Conclusions: </strong>The lymph node puncture approach was more technically feasible for conducting preliminary evaluation of NLE, STS and EL in lymphatic embolization. This model may help optimize the development of ideal agents for lymphatic embolization.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable devices in neurological disorders: a narrative review of status quo and perspectives.","authors":"Heting Cai, Jianian Hu, Chongbo Zhao, Jie Lin","doi":"10.21037/atm-25-46","DOIUrl":"10.21037/atm-25-46","url":null,"abstract":"<p><strong>Background and objective: </strong>Neurological disorders are a group of diseases involving motor, sensory, cognitive, and autonomic functions, among which stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are prevalent. Their management, especially in conditions with chronic courses or long-term sequelae, remains a substantial unmet need. With the growing comprehension of neuroscience, the development of digital technology, and the rising demand for quality of life, wearable devices offer a promising solution for disease management. The review aimed to evaluate the application and prospect of wearable devices in neurological disorders.</p><p><strong>Methods: </strong>We conducted the review by searching papers on the application of wearable devices and wearable technology in neurology and neurological disorders using multiple databases. We summarized the present development status of wearable devices, and outlined the potential value and future direction for further research.</p><p><strong>Key content and findings: </strong>Existing wearable devices for neurological diseases can be applied to diagnosis and follow-up, as an electronic biomarker detector capturing subtle and objective changes in motor, sensory, and cognitive function. The devices can also be utilized for treatment and rehabilitation, mainly through exoskeletons and brain-computer interface. The application of wearable devices in neurology currently faces several critical limitations, including technical bottlenecks in the detection of fine motor and sensory functions, a lack of industry standards, and a limited sample size.</p><p><strong>Conclusions: </strong>This review demonstrates the potential of wearable technology in people with neurological disorders, enabling disease management and clinical trials outside clinical settings in the future. Nevertheless, further research is required to develop lighter, more user-friendly devices with various functions. It is believed that with increasing demand and technical support, wearable devices would have a promising range of applications.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to Prostaglandin F2α protects against pericyte apoptosis by inhibiting the PI3K/Akt/GSK3β/β-catenin signaling pathway.","authors":"","doi":"10.21037/atm-2024-10","DOIUrl":"10.21037/atm-2024-10","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-2717.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future of critical care: a blueprint for building sustainable cardiac critical care capacity.","authors":"Lynze Franko, Ivana Nikolic, Jean Kwo, Aranya Bagchi, David D'Alessandro, Thor Sundt, Kenneth T Shelton","doi":"10.21037/atm-25-67","DOIUrl":"10.21037/atm-25-67","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: The ciliary protein Spef2 stimulates acinar Ampkα/Sirt1 signaling and ameliorates acute pancreatitis and associated lung injury.","authors":"Chun Zhang, Deng-Fang Guo, Gui-Fang Lv, Dai-Chang Zhang, Feng Lin, Jia-Bin Liu, Jian-Yuan Lin, De-Xian Xiao","doi":"10.21037/atm-2024-38","DOIUrl":"10.21037/atm-2024-38","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/atm-22-3118.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to downregulation of miR-182-5p inhibits the proliferation and invasion of triple-negative breast cancer cells through regulating TLR4/NF-κB pathway activity by targeting FBXW7.","authors":"","doi":"10.21037/atm-2024-22","DOIUrl":"10.21037/atm-2024-22","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-20-5192.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"49"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired face identity discrimination in individuals with cerebral visual impairment: a pilot study.","authors":"Kerri Walter, Claire E Manley, Lotfi B Merabet, Peter J Bex","doi":"10.21037/atm-25-53","DOIUrl":"10.21037/atm-25-53","url":null,"abstract":"<p><strong>Background: </strong>Cerebral visual impairment (CVI) is the leading cause of pediatric visual impairment and results from brain-related injury or maldevelopment. Higher-order visual processing deficits are commonly reported and can include difficulties recognizing faces, which can adversely affect the development of communication and socialization skills. In this study, we aimed to measure face discrimination ability in CVI compared to controls using a rapid, self-administered, remote paradigm.</p><p><strong>Methods: </strong>We quantified face discrimination ability with a Foraging Interactive D-prime (FInD) paradigm that measured the threshold distance between Basel Model Faces required for participants to report whether faces were of the same or different people. We measured face discrimination thresholds in 8 control and 8 CVI participants viewing forward-facing and tilted faces.</p><p><strong>Results: </strong>Face discrimination thresholds were significantly higher for CVI than control participants [t(13)=-3.439, P=0.004]. Contrary to controls, CVI participants showed no significant difference between forward-facing and tilted faces [t₍₇₎=-1.355, P=0.22]. Importantly, visual acuity did not correlate with face discrimination performance in the CVI group for forward-facing (r=0.040, R²=0.002, P=0.93) or tilted faces (r=-0.100, R²=0.010, P=0.813). A follow-up experiment with control participants (N=23) manipulating digital blur confirmed that face discrimination ability is resilient to visual acuity differences [t₍₂₂₎=-11.291; P<0.001, d=4.152].</p><p><strong>Conclusions: </strong>These findings quantify a face processing deficit in individuals with CVI and show that this impairment is independent of visual acuity. We hypothesize that while control participants can exploit point-wise comparisons between identical images, individuals with CVI possibly do not utilize this additional source of information.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lyn, a Src kinase family member, is a promising therapeutic target for sepsis-associated acute kidney injury.","authors":"Takahiro Uchida, Takashi Oda","doi":"10.21037/atm-23-1932","DOIUrl":"10.21037/atm-23-1932","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis and risk of gallstone disease: a nation-wide population-based study.","authors":"Jiho Park, Yeonghee Eun, Kyungdo Han, Jin Hyung Jung, Seonyoung Kang, Seonghye Kim, Jong Jin Hyun, Hyungjin Kim, Dong Wook Shin","doi":"10.21037/atm-25-12","DOIUrl":"10.21037/atm-25-12","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and various comorbidities, including potential gallbladder disease. However, evidence linking RA to gallstones or cholecystectomy remains limited and inconsistent. This study assesses whether patients with RA are at higher risk of developing gallstones and undergoing cholecystectomy than individuals without RA.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, we identified 54,910 individuals diagnosed with RA between 2010 and 2017. After applying separate exclusion criteria for the analyses of developing gallstones and undergoing cholecystectomy, we matched those patients in a 1:3 ratio based on age and sex to derive a control population without RA. The study participants were followed from 1 year after their RA diagnosis or corresponding index date (lag period) to Dec. 31, 2020. Cox regression analyses were performed to estimate hazard ratios of developing gallstones and undergoing cholecystectomy compared with the matched controls.</p><p><strong>Results: </strong>We analyzed 46,523 patients with RA and 139,569 matched controls, with a follow-up period ranging from 3.5 to 7.3 years. During the follow-up, gallstone disease developed in 8.33% of patients with RA and 5.51% of the matched controls, corresponding to incidence rates of 15.69 and 10.09 per 1,000 person-years, respectively. The risk of incident gallstones was higher in the RA cohort than in the matched control group [adjusted hazard ratio (aHR) 1.58; 95% confidence interval (CI): 1.52-1.65, P<0.001]. During the same period, 1.24 % of patients with RA and 1.1% of the matched control group underwent cholecystectomy, for incidence rates of 2.27 and 2.0 per 1,000 person-years, respectively. Patients with RA appear to have a marginally elevated risk of undergoing cholecystectomy, compared with matched controls (aHR 1.15, 95% CI 1.05-1.27, P=0.04).</p><p><strong>Conclusions: </strong>The risk of gallstone disease is higher in individuals with RA than in matched controls.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}