Jiho Park, Yeonghee Eun, Kyungdo Han, Jin Hyung Jung, Seonyoung Kang, Seonghye Kim, Jong Jin Hyun, Hyungjin Kim, Dong Wook Shin
{"title":"类风湿性关节炎和胆结石疾病的风险：一项基于全国人群的研究","authors":"Jiho Park, Yeonghee Eun, Kyungdo Han, Jin Hyung Jung, Seonyoung Kang, Seonghye Kim, Jong Jin Hyun, Hyungjin Kim, Dong Wook Shin","doi":"10.21037/atm-25-12","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and various comorbidities, including potential gallbladder disease. However, evidence linking RA to gallstones or cholecystectomy remains limited and inconsistent. This study assesses whether patients with RA are at higher risk of developing gallstones and undergoing cholecystectomy than individuals without RA.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, we identified 54,910 individuals diagnosed with RA between 2010 and 2017. After applying separate exclusion criteria for the analyses of developing gallstones and undergoing cholecystectomy, we matched those patients in a 1:3 ratio based on age and sex to derive a control population without RA. The study participants were followed from 1 year after their RA diagnosis or corresponding index date (lag period) to Dec. 31, 2020. Cox regression analyses were performed to estimate hazard ratios of developing gallstones and undergoing cholecystectomy compared with the matched controls.</p><p><strong>Results: </strong>We analyzed 46,523 patients with RA and 139,569 matched controls, with a follow-up period ranging from 3.5 to 7.3 years. During the follow-up, gallstone disease developed in 8.33% of patients with RA and 5.51% of the matched controls, corresponding to incidence rates of 15.69 and 10.09 per 1,000 person-years, respectively. The risk of incident gallstones was higher in the RA cohort than in the matched control group [adjusted hazard ratio (aHR) 1.58; 95% confidence interval (CI): 1.52-1.65, P<0.001]. During the same period, 1.24 % of patients with RA and 1.1% of the matched control group underwent cholecystectomy, for incidence rates of 2.27 and 2.0 per 1,000 person-years, respectively. Patients with RA appear to have a marginally elevated risk of undergoing cholecystectomy, compared with matched controls (aHR 1.15, 95% CI 1.05-1.27, P=0.04).</p><p><strong>Conclusions: </strong>The risk of gallstone disease is higher in individuals with RA than in matched controls.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 4","pages":"42"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432628/pdf/","citationCount":"0","resultStr":"{\"title\":\"Rheumatoid arthritis and risk of gallstone disease: a nation-wide population-based study.\",\"authors\":\"Jiho Park, Yeonghee Eun, Kyungdo Han, Jin Hyung Jung, Seonyoung Kang, Seonghye Kim, Jong Jin Hyun, Hyungjin Kim, Dong Wook Shin\",\"doi\":\"10.21037/atm-25-12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and various comorbidities, including potential gallbladder disease. However, evidence linking RA to gallstones or cholecystectomy remains limited and inconsistent. This study assesses whether patients with RA are at higher risk of developing gallstones and undergoing cholecystectomy than individuals without RA.</p><p><strong>Methods: </strong>Using data from the Korean National Health Insurance Service, we identified 54,910 individuals diagnosed with RA between 2010 and 2017. After applying separate exclusion criteria for the analyses of developing gallstones and undergoing cholecystectomy, we matched those patients in a 1:3 ratio based on age and sex to derive a control population without RA. The study participants were followed from 1 year after their RA diagnosis or corresponding index date (lag period) to Dec. 31, 2020. Cox regression analyses were performed to estimate hazard ratios of developing gallstones and undergoing cholecystectomy compared with the matched controls.</p><p><strong>Results: </strong>We analyzed 46,523 patients with RA and 139,569 matched controls, with a follow-up period ranging from 3.5 to 7.3 years. During the follow-up, gallstone disease developed in 8.33% of patients with RA and 5.51% of the matched controls, corresponding to incidence rates of 15.69 and 10.09 per 1,000 person-years, respectively. The risk of incident gallstones was higher in the RA cohort than in the matched control group [adjusted hazard ratio (aHR) 1.58; 95% confidence interval (CI): 1.52-1.65, P<0.001]. During the same period, 1.24 % of patients with RA and 1.1% of the matched control group underwent cholecystectomy, for incidence rates of 2.27 and 2.0 per 1,000 person-years, respectively. Patients with RA appear to have a marginally elevated risk of undergoing cholecystectomy, compared with matched controls (aHR 1.15, 95% CI 1.05-1.27, P=0.04).</p><p><strong>Conclusions: </strong>The risk of gallstone disease is higher in individuals with RA than in matched controls.</p>\",\"PeriodicalId\":8216,\"journal\":{\"name\":\"Annals of translational medicine\",\"volume\":\"13 4\",\"pages\":\"42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432628/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of translational medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/atm-25-12\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of translational medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/atm-25-12","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Rheumatoid arthritis and risk of gallstone disease: a nation-wide population-based study.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and various comorbidities, including potential gallbladder disease. However, evidence linking RA to gallstones or cholecystectomy remains limited and inconsistent. This study assesses whether patients with RA are at higher risk of developing gallstones and undergoing cholecystectomy than individuals without RA.
Methods: Using data from the Korean National Health Insurance Service, we identified 54,910 individuals diagnosed with RA between 2010 and 2017. After applying separate exclusion criteria for the analyses of developing gallstones and undergoing cholecystectomy, we matched those patients in a 1:3 ratio based on age and sex to derive a control population without RA. The study participants were followed from 1 year after their RA diagnosis or corresponding index date (lag period) to Dec. 31, 2020. Cox regression analyses were performed to estimate hazard ratios of developing gallstones and undergoing cholecystectomy compared with the matched controls.
Results: We analyzed 46,523 patients with RA and 139,569 matched controls, with a follow-up period ranging from 3.5 to 7.3 years. During the follow-up, gallstone disease developed in 8.33% of patients with RA and 5.51% of the matched controls, corresponding to incidence rates of 15.69 and 10.09 per 1,000 person-years, respectively. The risk of incident gallstones was higher in the RA cohort than in the matched control group [adjusted hazard ratio (aHR) 1.58; 95% confidence interval (CI): 1.52-1.65, P<0.001]. During the same period, 1.24 % of patients with RA and 1.1% of the matched control group underwent cholecystectomy, for incidence rates of 2.27 and 2.0 per 1,000 person-years, respectively. Patients with RA appear to have a marginally elevated risk of undergoing cholecystectomy, compared with matched controls (aHR 1.15, 95% CI 1.05-1.27, P=0.04).
Conclusions: The risk of gallstone disease is higher in individuals with RA than in matched controls.
期刊介绍：
The Annals of Translational Medicine (Ann Transl Med; ATM; Print ISSN 2305-5839; Online ISSN 2305-5847) is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research, aiming to provide practical up-to-date information in significant research from all subspecialties of medicine and to broaden the readers’ vision and horizon from bench to bed and bed to bench. It is published quarterly (April 2013- Dec. 2013), monthly (Jan. 2014 - Feb. 2015), biweekly (March 2015-) and openly distributed worldwide. Annals of Translational Medicine is indexed in PubMed in Sept 2014 and in SCIE in 2018. Specific areas of interest include, but not limited to, multimodality therapy, epidemiology, biomarkers, imaging, biology, pathology, and technical advances related to medicine. Submissions describing preclinical research with potential for application to human disease, and studies describing research obtained from preliminary human experimentation with potential to further the understanding of biological mechanism underlying disease are encouraged. Also warmly welcome are studies describing public health research pertinent to clinic, disease diagnosis and prevention, or healthcare policy. With a focus on interdisciplinary academic cooperation, ATM aims to expedite the translation of scientific discovery into new or improved standards of management and health outcomes practice.
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