Annals of translational medicine最新文献

{"title":"Erratum: Myostatin is involved in skeletal muscle dysfunction in chronic obstructive pulmonary disease via Drp-1 mediated abnormal mitochondrial division.","authors":"","doi":"10.21037/atm-2024b-56","DOIUrl":"10.21037/atm-2024b-56","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-377.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in sepsis in the Emergency Department: a narrative review.","authors":"Mui Teng Chua, Yuru Boon, Zi Yao Lee, Jian Hao Jaryl Kok, Clement Kee Woon Lim, Nicole Mun Teng Cheung, Lorraine Pei Xian Yong, Win Sen Kuan","doi":"10.21037/atm-24-150","DOIUrl":"10.21037/atm-24-150","url":null,"abstract":"<p><strong>Background and objective: </strong>Early recognition and treatment of sepsis in the emergency department (ED) is important. Traditional predictive analytics and clinical decision rules lack accuracy in identifying patients with sepsis. Artificial intelligence (AI) is increasingly prevalent in healthcare and offers application potential in the care of patients with sepsis. This review examines the evidence of AI in diagnosing, managing and prognosticating sepsis in the ED.</p><p><strong>Methods: </strong>We performed literature search in PubMed, Embase, Google Scholar and Scopus databases for studies published between 1 January 2010 and 30 June 2024 that evaluated the use of AI in adult patients with sepsis in ED, using the following search terms: (\"artificial intelligence\" OR \"machine learning\" OR \"neural networks, computer\" OR \"deep learning\" OR \"natural language processing\"), AND (\"sepsis\" OR \"septic shock\", AND \"emergency services\" OR \"emergency department\"). Independent searches were conducted in duplicate with discrepancies adjudicated by a third member.</p><p><strong>Key content and findings: </strong>Incorporating multiple variables such as vital signs, free text input, laboratory tests and electrocardiogram was possible with AI compared to traditional models leading to improvement in diagnostic performance. Machine learning (ML) models outperformed traditional scoring tools in both diagnosis and prognosis of sepsis. ML models were able to analyze trends over time and showed utility in predicting mortality, severe sepsis and septic shock. Additionally, real-time ML-assisted alert systems are effective in improving time-to-antibiotic administration and ML algorithms can differentiate sepsis patients into distinct phenotypes to tailor management (especially fluid therapy and critical care interventions), potentially improving outcomes. Existing AI tools for sepsis currently lack generalizability and user acceptance. This is risk of automation bias with loss of clinicians' skills if over-reliance develops.</p><p><strong>Conclusions: </strong>Overall, AI holds great promise in revolutionizing management of patients with sepsis in the ED as a clinical support tool. However, its application is currently still constrained by inherent limitations. Balanced integration of AI technology with clinician input is essential to harness its full potential and ensure optimal patient outcomes.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic fluid stem cell conditioned medium's role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions.","authors":"Chukwuweike Gwam, Nequesha Mohamed, Ayobami S Ogunsola, Marcel G Brown, Kaitlin A Henry, Xue Ma","doi":"10.21037/atm-24-107","DOIUrl":"10.21037/atm-24-107","url":null,"abstract":"<p><strong>Background: </strong>Peripheral nerve injuries present a major clinical challenge due to their high morbidity and often incomplete recovery of function. While autografts remain the gold standard for nerve repair, their use is constrained by limited donor availability and donor site complications. Alternative strategies, such as allografts and tissue-engineered grafts, have been developed but are still associated with suboptimal outcomes, including chronic pain and sensory disturbances. Thus, there is a need for novel therapies that can enhance nerve regeneration. Amniotic fluid stem cell conditioned medium (AFS-CM) houses regenerative properties that may be useful in peripheral nerve injury. This study aims to assess the role of AFS-CM on Schwann cell survival and proliferation under normative and oxidative stress conditions, preventing oxidative stress-induced premature senescence of Schwann cells <i>in vitro</i> and maintaining cellular redox homeostasis.</p><p><strong>Methods: </strong>Primary Schwann cells were treated with various concentrations of AFS-CM. Cell proliferation was assessed using the Cell Counting Kit-8 (CCK-8) assay, and viability under oxidative stress was measured after exposing cells to hydrogen peroxide (H₂O₂). Reactive oxygen species (ROS) levels and both catalase and superoxide dismutase (SOD) levels were evaluated. Cellular senescence markers were also assessed to determine AFS-CM's protective effects.</p><p><strong>Results: </strong>AFS-CM treatment resulted in a dose-dependent increase in Schwann cell proliferation (P<0.05). Under oxidative stress conditions, AFS-CM significantly improved cell viability compared to controls (P<0.05). ROS levels were markedly reduced in AFS-CM-treated cells (P<0.05), and this was accompanied by upregulation of catalase and SOD expression (P<0.05). Moreover, AFS-CM reduced stress-induced cellular senescence, as indicated by decreased senescence-associated β-galactosidase activity and lower expression of senescence markers (P<0.05).</p><p><strong>Conclusions: </strong>AFS-CM enhances Schwann cell proliferation, viability, and resistance to oxidative stress, while reducing cellular senescence. These findings suggest that AFS-CM could be a promising adjunctive therapy for peripheral nerve injuries by promoting Schwann cell resilience and regenerative capacity. Future studies are needed to validate these <i>in vitro</i> results <i>in vivo</i> and explore their potential clinical application for improving functional recovery in patients with peripheral nerve damage.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: MicroRNA-30/Cx43 axis contributes to podocyte injury by regulating ER stress in diabetic nephropathy.","authors":"","doi":"10.21037/atm-2024b-60","DOIUrl":"10.21037/atm-2024b-60","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-20-6989.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: VEGF gene transfection restores the angiogenesis of oral submucous fibrosis in mice.","authors":"Ying Sun, Tao Wang, Qi-Tao Wen, Da-Hai Yu, Jing-Xin Chen","doi":"10.21037/atm-2024b-62","DOIUrl":"10.21037/atm-2024b-62","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/atm-21-2213.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"e6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A woman with a pleural mesothelioma and an inherited <i>ATM</i> mutation-a case report.","authors":"Marta Seca, B C John Cho, Angelina Tryon, Steven A Narod","doi":"10.21037/atm-24-138","DOIUrl":"10.21037/atm-24-138","url":null,"abstract":"<p><strong>Background: </strong>Pleural mesothelioma (PM) is a rare and aggressive malignancy primarily linked to asbestos exposure. Up to 80% of patients have a history of such exposure. Several studies have investigated the possibility of a genetic predisposition for a subgroup of PM patients, but the data remains inconsistent. The ataxia-telangiectasia mutated (<i>ATM</i>) gene, crucial for DNA repair, is implicated in cancer susceptibility, with heterozygous mutations increasing risks, notably in breast and pancreatic cancers.</p><p><strong>Case description: </strong>We present a case of a 42-year-old woman, with no asbestos exposure history, diagnosed with metastatic PM. Initial treatment with immunotherapy showed limited efficacy. Given the rarity in young females, she opted for genetic testing via \"The Screen Project\", revealing a pathogenic <i>ATM</i> mutation. Due to enhanced radiosensitivity in <i>ATM</i> mutation carriers, to reduce adverse events conventional palliative radiotherapy (RT) was chosen over stereotactic hypofractionated RT. A follow-up computed tomography (CT) scan after 4 weeks indicated disease burden reduction.</p><p><strong>Conclusions: </strong>This case highlights the importance of genetic testing in atypical PM cases, guiding treatment decisions tailored to individual genetic profiles. Awareness of <i>ATM</i> mutations can optimize therapeutic strategies, particularly regarding RT choices, in managing this challenging malignancy. Integrating genetic insights into clinical practice holds promise for enhancing treatment outcomes and refining management strategies in PM and related conditions.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review of robotics technology in spinal surgery with highlights of the Annual Seattle Science Foundation Course.","authors":"Nicholas Dietz, Victoria Alkin, Isador Lieberman, Andrew Manista, Terrence Kim, J Patrick Johnson, Doniel Drazin","doi":"10.21037/atm-24-100","DOIUrl":"https://doi.org/10.21037/atm-24-100","url":null,"abstract":"<p><strong>Background: </strong>Robotic assistance has become increasingly prevalent in spinal surgery in recent years, emerging as a tool to increase accuracy and precision and lower complication rates and radiation exposure. The 7^th and 8^th Annual Seattle Science Foundation (SSF) Robotics Courses showcased presentations and demonstrations from some of the field's most experiences leaders on latest topics in robotics and spinal surgery, including cutting-edge preoperative planning technologies, augmented reality (AR) in the operating room, cervical fusion with transpedicular screws, and neuro-oncologic management. We provide a scoping review of the use of robotics technology in spinal surgery featuring highlights from the 7^th and 8^th Annual SSF Robotics Courses.</p><p><strong>Methods: </strong>A scoping review of the literature was conducted (last search conducted in July 2024). Key search terms included \"robotic assistance\", \"spine surgery\", and \"robotic technology\" on the PubMed database. Additionally, highlights are included from the 7^th and 8^th Annual SSF Robotics Courses.</p><p><strong>Results: </strong>Applications of navigation robotics span subspecialties of spine surgery including deformity correction, minimally invasive approaches, lateral single position operations, spinal oncology, and cervical fusion. Tips on overcoming traditional obstacles of robotics integration such as streamlining staff workflow and adoption while financing robotic-assisted technology are shared. Future directions of robotics enhanced with AR may further guide surgeon decision-making, assist in more practical fashion intraoperatively, and optimize patient outcomes.</p><p><strong>Conclusions: </strong>While improved precision and accuracy, less radiation, and standardization of procedures represent current advantages of robotic-assistance across spine surgery, robotics in spine surgery will usher more transformative changes to patient care and operative skill in coming years.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles' retraction during the pandemic: COVID-19 is not the pacemaker.","authors":"Giuseppe Lippi, Camilla Mattiuzzi","doi":"10.21037/atm-24-144","DOIUrl":"https://doi.org/10.21037/atm-24-144","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Protective effects of muscone on traumatic spinal cord injury in rats.","authors":"","doi":"10.21037/atm-2024-46","DOIUrl":"https://doi.org/10.21037/atm-2024-46","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-2672.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"125"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of liposuction techniques for management of lipedema: a case series and narrative review.","authors":"Pedro Ciudad, Valeria P Bustos, Joseph M Escandón, Emily G Flaherty, Horacio F Mayer, Oscar J Manrique","doi":"10.21037/atm-24-165","DOIUrl":"10.21037/atm-24-165","url":null,"abstract":"<p><strong>Background and objective: </strong>Lipedema is a commonly underdiagnosed chronic condition. This study aimed to evaluate liposuction techniques for lipedema by conducting a systematic review and presenting our experience. A case series study and a comprehensive review were conducted.</p><p><strong>Methods: </strong>We assessed surgical outcomes among patients with lipedema who underwent liposuction. Descriptive and inferential statistics were implemented. In our case series, we used tumescent liposuction, vibration amplification of sound energy at resonance (VASER) liposuction, and waterjet-assisted liposuction (WAL). We also performed a literature review of current concepts and state-of-the-art treatment for lipedema.</p><p><strong>Key content and findings: </strong>Twenty-four female patients were included in this study with a median age of 37 years [interquartile range (IQR), 10 years]. A statistically significant difference between preoperative (29.65 kg/m²) and postoperative body mass index (BMI) (26.95 kg/m²; P<0.05) of patients was evidenced. The amount of total fat removal between surgical techniques was statistically different (P<0.001). A statistically significant difference in the amount of total fat removal between surgical techniques was found (P=0.0015). Post-hoc analysis with Dunn's test evidenced a significant difference only between tumescent suction-assisted lipectomy and WAL (P<0.001). Nineteen studies were included in this review. Low complication rates, improvement in patient-reported outcomes, and reduction in conservative therapy requirements were found when evaluating multiple studies in this review.</p><p><strong>Conclusions: </strong>Liposuction has been shown to be a safe and effective alternative in patients with lipedema. It positively impacts clinical and patient-reported outcomes.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}