Annals of translational medicine最新文献

{"title":"Propofol curtails survival in perioperative and critically ill patients by a relative reduction of 10%: should propofol be abandoned?","authors":"Benedicte Hauquiert, Sydney Blackman, Emily Perriens, Maha Bendoumou, Ileana Ene, Aicha Van Engelgem, Anaïs Carrasco Sanchez, Maya Ramos Prieto, Ovidiu Vornicu, Arnaud Robert, Gauthier Nendumba, Julien Moury, Anne-Sophie Dincq, Patrick Evrard, Pierre Bulpa, Isabelle Michaux, Patrick M Honore","doi":"10.21037/atm-24-52","DOIUrl":"10.21037/atm-24-52","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production.","authors":"","doi":"10.21037/atm-2024-11","DOIUrl":"10.21037/atm-2024-11","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm.2020.02.37.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"103"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel technique to identify and thermally ablate the greater occipital nerve for patients with occipital neuralgia: a retrospective study with cadaveric and <i>ex-vivo</i> validation.","authors":"Sayed E Wahezi, Safwan Zar, Devin Oakes, Tahereh Naeimi, Sandeep Yerra, Sherry A Downie, Salahadin Abdi, Leili Shahgholi, Alaa Abd Elsayed","doi":"10.21037/atm-24-72","DOIUrl":"10.21037/atm-24-72","url":null,"abstract":"<p><strong>Background: </strong>This manuscript presents the challenges of treating various forms of headaches and the potential of interventional techniques targeting the greater occipital nerve (GON) to alleviate the burden on patients. Occipital neuralgia, characterized by stabbing or shooting pain in the base of the skull, is often associated with primary, cervicogenic, or migraine headaches. While occipital nerve blocks offer temporary relief, durable treatment options are limited. Pulsed radiofrequency (PRF) and thermal radiofrequency ablation (TRFA) have shown promise as minimally invasive procedures for long-term treatment. However, GON is not easily identified using ultrasound or fluoroscopic analysis; thereby, minimizing success of proper ablation. Here, the authors provide a percutaneous strategy to localize the GON and maximize lesion performance. We intend to provide an <i>ex-vivo</i> description of staggered bipolar radiofrequency (RF) lesioning and include the use of staggered bipolar lesioning of the GON and stimulation of the semispinalis capitis. We also analyzed the effectiveness and side effects from this ablation, retrospectively.</p><p><strong>Methods: </strong>Patients with chronic refractory GON neuralgia were selected for GON TRFA. A novel double needle technique of sequential electrical stimulation was used to localize the GON and approximate needle to nerve distance. Once the needles were positioned adjacent to the GON, TRFA was performed using a bipolar staggered technique.</p><p><strong>Results: </strong>Twenty-two patients with GON were treated with TRFA using a novel double needle technique. Seventy-two percent of these patients reported greater than 50% pain relief at both 1 and 6 months following the procedure. The results of our <i>ex-vivo</i> study demonstrate that performing TRFA using the parallel needle bipolar approach separated 8 mm apart produced the most desirable lesion dimensions that may correlate with effective ablation of the GON.</p><p><strong>Conclusions: </strong>This study demonstrates a new localization and ablation technique to treat refractory headaches. However, larger studies are needed to confirm our findings.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to hyperglycemia-induced increasing of <i>RELB</i>/circ_0008590 in NF-κB pathway is repressed by miR-1243 in human retinal microvascular endothelial cells.","authors":"","doi":"10.21037/atm-2024-12","DOIUrl":"10.21037/atm-2024-12","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-5562.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 5","pages":"102"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in lung cancer.","authors":"Claudia Bardoni, Lorenzo Spaggiari, Luca Bertolaccini","doi":"10.21037/atm-22-2918","DOIUrl":"10.21037/atm-22-2918","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"79"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis.","authors":"","doi":"10.21037/atm-2023-22","DOIUrl":"10.21037/atm-2023-22","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-1215.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of osteotomy depth and hinge axis orientation on biplanar surgical accuracy in medial opening-wedge high tibial osteotomy-a deeper understanding by 3D simulations.","authors":"Wouter Van Genechten, Annemieke Van Haver, Jozef Michielsen, Steven Claes, Peter Verdonk","doi":"10.21037/atm-23-1870","DOIUrl":"10.21037/atm-23-1870","url":null,"abstract":"<p><strong>Background: </strong>Not all surgical osteotomy steps have been properly investigated for their potential impact on surgical accuracy. The main study objective was to investigate the osteotomy parameters that have respectively major and minor impact on coronal and sagittal bony accuracy in medial opening-wedge high tibial osteotomy (MOWHTO).</p><p><strong>Methods: </strong>Three tibias from an existing 3D MOWHTO osteotomy database were chronologically selected based on segmentation quality, tibial plateau size and the presence of tibial varus. The study consisted of three parts: (I) translating the hinge axis in the coronal plane and switching the osteotomy starting point (30-40 mm) and depth, (II) the hinge axis was rotated stepwise by 10° to perform five simulations, (III) the hinge axis was rotated in the axial plane stepwise by 10° towards anterolateral to perform four simulations (0°, +10°, +20°, +30°). The medial proximal tibial angle (MPTA) and lateral tibial slope were the primary outcomes. Simulations were performed with 5, 10 and 15 mm gap distraction.</p><p><strong>Results: </strong>In the coronal plane, maximum difference in osteotomy depth was 10 mm which represented an MPTA difference of 0.8°-1.1° in 10 mm gap distraction and 1.2°-2.0° in 15 mm gap distraction. Tibial slope remained unchanged. Rotating the hinge axis in the sagittal plane delivered minor changes on both MPTA (<0.5°) and tibial slope (<1.5°) at 10 mm gap distraction. Per 10° of axial rotation of the hinge axis towards anterolateral, the tibial slope increased by 1.0°-1.3° in 10 mm gap distraction while the MPTA remains nearly unchanged.</p><p><strong>Conclusions: </strong>The study showed that the medio-lateral osteotomy length is the main parameter for obtaining bony accuracy in the coronal plane and maintaining a strict perpendicular axial hinge axis position is crucial in preserving the native tibial slope. Correct axial alignment of the hinge axis can be obtained by creating an equal osteotomy depth of the anterior and posterior tibial cortices in the lateral metaphyseal area.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of everolimus in metastatic breast cancer and possibilities of moving forward-a narrative review.","authors":"Gabor Rubovszky","doi":"10.21037/atm-23-1583","DOIUrl":"10.21037/atm-23-1583","url":null,"abstract":"<p><strong>Background and objective: </strong>In hormone-receptor-positive (HR⁺) and human epidermal growth factor receptor 2-negative (HER2^-) metastatic breast cancer endocrine-based therapies are preferred over chemotherapy. One of the treatment options is the combination of everolimus with exemestane or other endocrine drug in later lines mainly based on progression-free survival (PFS) results of the phase 3 BOLERO-2 trial. Altogether, clinical trials did not prove an overall survival (OS) benefit and considerable side effects hampered its application in the day-by-day practice. In recent years CDK4/6-inhibitors became a first-choice combination partner to the endocrine treatment, everolimus still has a place within the treatment armamentarium. Although everolimus is a targeted drug, there is no accepted predictive biomarker and further patient selection is not possible. However, several directions can be defined how to optimally use everolimus. For update information on everolimus treatment in breast cancer I have performed a literature search.</p><p><strong>Methods: </strong>I used the keywords \"breast cancer\" and \"everolimus\" and extended the search in PubMed from 01/01/2014 to 10/02/2023. I considered all phase 3 trials, the phase 1-2 trials with not repetitive information, studies with biomarker results and I also checked review articles to identify potential relevant other clinical trial reports. I also have made a search in clinicaltrials.gov for recently completed and ongoing trials.</p><p><strong>Key content and findings: </strong>I summarized the search results in this concise and brief report focusing on main trial results and ongoing research with everolimus.</p><p><strong>Conclusions: </strong>The most promising research directions seem to be further investigations for useable predictive biomarkers, for combinations with other targeted drugs (even in a triple combination) and for the feasibility of pharmacologically guided dosing method.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"68"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of short-chain fatty acids in the pathogenesis and management of acute lymphocytic leukemia.","authors":"Yajing Song, Peter Gyarmati","doi":"10.21037/atm-23-1806","DOIUrl":"10.21037/atm-23-1806","url":null,"abstract":"<p><p>Acute lymphocytic leukemia (ALL) is an aggressive hematological malignancy of highly proliferative lymphoblasts. ALL is the most common cancer in children, and is typically treated with combination chemotherapy. The 5-year survival of ALL improved significantly in recent decades with this treatment approach. However, certain age groups (below 2 and over 10 years of age) have much worse prognosis, and over 50% of patients with ALL experience long-term side effects proportional to the dosage of anticancer drugs. Therefore, different treatment strategies are required to improve survival in ALL and to reduce side effects of chemotherapy. Since epigenetic modifications are dominantly reversible, \"epidrugs\" (drugs targeting epigenetic markers) are considered for feasibility in the treatment of ALL as epigenetic modifications, and acetylation of histones was demonstrated to play a critical role in the pathogenesis of ALL. Histone deacetylases (HDACs) have been shown to be differentially expressed in several hematological malignancies, including ALL. HDAC inhibitors (HDACis) have been shown to express selective toxicity for ALL cells, but they showed limited efficacy and higher than expected toxicity in mouse models or clinical trials in ALL. The aim of this review is to examine the role of the microbiota and microbial metabolites in the mechanisms of HDAC functions, and explore the utilization of the microbiota and microbial metabolites in improving the efficacy of HDACi in ALL. HDAC regulators and natural HDACi are depleted in ALL due to microbiota change leading to a decrease in butyrate and propionate, and HDACi treatment is not effective in ALL due to their short half-life. We propose that HDACi released by the microbiota may be necessary in HDAC regulation and this process is impaired in ALL. Furthermore, the review will also consider the role of restoration of the microbiota or supplementation of natural HDACi in potentially restoring HDAC and HDACi functions.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential use of stem cell therapies for treating osteoarthritis and rheumatoid arthritis.","authors":"Diana Esquivel, Rangnath Mishra, Anand Srivastava","doi":"10.21037/atm-23-1951","DOIUrl":"10.21037/atm-23-1951","url":null,"abstract":"<p><p>Arthritis, defined as a chronic inflammation often accompanied by swelling of one or more joints, encompasses more than 100 conditions that affect the joints, tissues around them as well as other connective tissues. This condition causes severe discomfort compromising the quality of life drastically, and thereby inflicts severe financial and social impact on the people affected. The incidence rate of arthritis is increasing all around the globe including the United States every year. In general, osteoarthritis (OA) affects more people in comparison to rheumatoid arthritis (RA). In the USA itself, more than 14 million people are affected by OA in comparison to 1.4 million people suffering from RA. In both conditions, elevated levels of proinflammatory cytokines have been recorded, this incidence generally precedes the cartilage degradation observed in the patients. The use of mesenchymal stem cells (MSCs) has proven to be a safe and efficient therapeutic option for treating many inflammation-rooted pathological conditions. Evidence suggests that MSCs down-regulate the effects of proinflammatory cytokines including tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1B, IL-2, and IL-17, and help restore the functions of immune cells. In addition, these cells promote the polarization of M2 phenotype macrophages, thus contributing to the suppression of the inflammatory process and consequentially to cartilage regeneration. Preclinical and clinical trials have proven the safety and effectiveness of this therapy, supported by the fact that these do not provoke any host immune response, and their influence on the cytokine profiles. An attempt to survey the results of stem cell therapy for treating arthritis has been carried out in this review.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 4","pages":"72"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}