The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.

4区 医学
Annals of translational medicine Pub Date : 2025-04-30 Epub Date: 2025-04-29 DOI:10.21037/atm-24-218
Ho Geol Woo, Ju-Young Park, Moo-Seok Park, Tae-Jin Song
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Abstract

Background: Studies evaluating the association between hemorrhoids and heart failure (HF) have been limited. We aimed to evaluate the association between increased incidence of HF and the presence of hemorrhoids using a population-based longitudinal cohort.

Methods: We included 356,033 participants in this study, derived from health screening data collected between 2003 and 2007 from the South Korean health screening cohort database. Hemorrhoid presence was identified as having a minimum of two claims based on the International Classification of Diseases, Tenth Revision (ICD-10) code I84. Propensity score matching (PSM) was used to assign participants to two groups according to the presence and treatment of hemorrhoids. The primary outcome was the incidence of HF, defined as having two or more claims based on the ICD-10 code I50.

Results: Among the participants, the presence of hemorrhoids was observed in 24,363 (6.8%) individuals. Over a median follow-up period of 13.33 years (interquartile range, 10.4-16.26), 55,167 cumulative cases of HF (15.5%) occurred. In multivariate analysis, the group with hemorrhoids consistently showed a higher incidence of HF compared to those without hemorrhoids, both before [hazard ratio (HR): 1.073; 95% confidence interval (CI): 1.028-1.121] and after PSM (HR: 1.073; 95% CI: 1.018-1.131). Regarding surgical procedures/treatments for hemorrhoids, participants who underwent surgical procedures or treatment for hemorrhoids showed a lower incidence of HF before PSM (HR, 0.919; 95% CI: 0.845-1.001) and after PSM (HR, 0.941; 95% CI: 0.880-1.001).

Conclusions: Our study revealed a significantly increased incidence of HF among participants with hemorrhoids. Therefore, it should be noted that when hemorrhoids are present, the risk of developing HF in the future may be increased.

痔疮与心力衰竭发病率的关系:一项全国性队列研究。
背景:评估痔疮和心力衰竭(HF)之间关系的研究有限。我们旨在通过一项基于人群的纵向队列研究来评估心衰发病率增加与痔疮存在之间的关系。方法:我们在这项研究中纳入了356,033名参与者,这些参与者来自2003年至2007年间从韩国健康筛查队列数据库收集的健康筛查数据。根据《国际疾病分类第十版》(ICD-10)代码I84,痔疮被确定为至少有两种索赔要求。使用倾向评分匹配(PSM)将参与者根据痔疮的存在和治疗分为两组。主要结果是HF的发生率,定义为根据ICD-10代码I50有两项或两项以上的索赔。结果:在参与者中,有24,363人(6.8%)存在痔疮。在13.33年的中位随访期间(四分位数范围10.4-16.26),累计发生了55,167例HF(15.5%)。在多因素分析中,有痔疮组的HF发生率始终高于无痔疮组,两者之前的风险比(HR): 1.073;95%置信区间(CI): 1.028-1.121]和PSM后(HR: 1.073;95% ci: 1.018-1.131)。关于痔疮手术/治疗,接受过痔疮手术或治疗的参与者在PSM前HF的发病率较低(HR, 0.919;95% CI: 0.845-1.001)和PSM后(HR, 0.941;95% ci: 0.880-1.001)。结论:我们的研究显示,患有痔疮的参与者心衰发生率显著增加。因此,需要注意的是,当存在痔疮时,将来发生HF的风险可能会增加。
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来源期刊
自引率
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期刊介绍: The Annals of Translational Medicine (Ann Transl Med; ATM; Print ISSN 2305-5839; Online ISSN 2305-5847) is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research, aiming to provide practical up-to-date information in significant research from all subspecialties of medicine and to broaden the readers’ vision and horizon from bench to bed and bed to bench. It is published quarterly (April 2013- Dec. 2013), monthly (Jan. 2014 - Feb. 2015), biweekly (March 2015-) and openly distributed worldwide. Annals of Translational Medicine is indexed in PubMed in Sept 2014 and in SCIE in 2018. Specific areas of interest include, but not limited to, multimodality therapy, epidemiology, biomarkers, imaging, biology, pathology, and technical advances related to medicine. Submissions describing preclinical research with potential for application to human disease, and studies describing research obtained from preliminary human experimentation with potential to further the understanding of biological mechanism underlying disease are encouraged. Also warmly welcome are studies describing public health research pertinent to clinic, disease diagnosis and prevention, or healthcare policy.
 With a focus on interdisciplinary academic cooperation, ATM aims to expedite the translation of scientific discovery into new or improved standards of management and health outcomes practice.
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