Annals of translational medicine最新文献

{"title":"Erratum: MicroRNA-30/Cx43 axis contributes to podocyte injury by regulating ER stress in diabetic nephropathy.","authors":"","doi":"10.21037/atm-2024b-60","DOIUrl":"10.21037/atm-2024b-60","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-20-6989.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A woman with a pleural mesothelioma and an inherited <i>ATM</i> mutation-a case report.","authors":"Marta Seca, B C John Cho, Angelina Tryon, Steven A Narod","doi":"10.21037/atm-24-138","DOIUrl":"10.21037/atm-24-138","url":null,"abstract":"<p><strong>Background: </strong>Pleural mesothelioma (PM) is a rare and aggressive malignancy primarily linked to asbestos exposure. Up to 80% of patients have a history of such exposure. Several studies have investigated the possibility of a genetic predisposition for a subgroup of PM patients, but the data remains inconsistent. The ataxia-telangiectasia mutated (<i>ATM</i>) gene, crucial for DNA repair, is implicated in cancer susceptibility, with heterozygous mutations increasing risks, notably in breast and pancreatic cancers.</p><p><strong>Case description: </strong>We present a case of a 42-year-old woman, with no asbestos exposure history, diagnosed with metastatic PM. Initial treatment with immunotherapy showed limited efficacy. Given the rarity in young females, she opted for genetic testing via \"The Screen Project\", revealing a pathogenic <i>ATM</i> mutation. Due to enhanced radiosensitivity in <i>ATM</i> mutation carriers, to reduce adverse events conventional palliative radiotherapy (RT) was chosen over stereotactic hypofractionated RT. A follow-up computed tomography (CT) scan after 4 weeks indicated disease burden reduction.</p><p><strong>Conclusions: </strong>This case highlights the importance of genetic testing in atypical PM cases, guiding treatment decisions tailored to individual genetic profiles. Awareness of <i>ATM</i> mutations can optimize therapeutic strategies, particularly regarding RT choices, in managing this challenging malignancy. Integrating genetic insights into clinical practice holds promise for enhancing treatment outcomes and refining management strategies in PM and related conditions.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review of robotics technology in spinal surgery with highlights of the Annual Seattle Science Foundation Course.","authors":"Nicholas Dietz, Victoria Alkin, Isador Lieberman, Andrew Manista, Terrence Kim, J Patrick Johnson, Doniel Drazin","doi":"10.21037/atm-24-100","DOIUrl":"https://doi.org/10.21037/atm-24-100","url":null,"abstract":"<p><strong>Background: </strong>Robotic assistance has become increasingly prevalent in spinal surgery in recent years, emerging as a tool to increase accuracy and precision and lower complication rates and radiation exposure. The 7^th and 8^th Annual Seattle Science Foundation (SSF) Robotics Courses showcased presentations and demonstrations from some of the field's most experiences leaders on latest topics in robotics and spinal surgery, including cutting-edge preoperative planning technologies, augmented reality (AR) in the operating room, cervical fusion with transpedicular screws, and neuro-oncologic management. We provide a scoping review of the use of robotics technology in spinal surgery featuring highlights from the 7^th and 8^th Annual SSF Robotics Courses.</p><p><strong>Methods: </strong>A scoping review of the literature was conducted (last search conducted in July 2024). Key search terms included \"robotic assistance\", \"spine surgery\", and \"robotic technology\" on the PubMed database. Additionally, highlights are included from the 7^th and 8^th Annual SSF Robotics Courses.</p><p><strong>Results: </strong>Applications of navigation robotics span subspecialties of spine surgery including deformity correction, minimally invasive approaches, lateral single position operations, spinal oncology, and cervical fusion. Tips on overcoming traditional obstacles of robotics integration such as streamlining staff workflow and adoption while financing robotic-assisted technology are shared. Future directions of robotics enhanced with AR may further guide surgeon decision-making, assist in more practical fashion intraoperatively, and optimize patient outcomes.</p><p><strong>Conclusions: </strong>While improved precision and accuracy, less radiation, and standardization of procedures represent current advantages of robotic-assistance across spine surgery, robotics in spine surgery will usher more transformative changes to patient care and operative skill in coming years.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles' retraction during the pandemic: COVID-19 is not the pacemaker.","authors":"Giuseppe Lippi, Camilla Mattiuzzi","doi":"10.21037/atm-24-144","DOIUrl":"https://doi.org/10.21037/atm-24-144","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Huperzine A lowers intraocular pressure via the M3 mAChR and provides retinal neuroprotection via the M1 mAChR: a promising agent for the treatment of glaucoma.","authors":"","doi":"10.21037/atm-2024-41","DOIUrl":"https://doi.org/10.21037/atm-2024-41","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-20-8093.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"126"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Protective effects of muscone on traumatic spinal cord injury in rats.","authors":"","doi":"10.21037/atm-2024-46","DOIUrl":"https://doi.org/10.21037/atm-2024-46","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-2672.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"125"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of liposuction techniques for management of lipedema: a case series and narrative review.","authors":"Pedro Ciudad, Valeria P Bustos, Joseph M Escandón, Emily G Flaherty, Horacio F Mayer, Oscar J Manrique","doi":"10.21037/atm-24-165","DOIUrl":"10.21037/atm-24-165","url":null,"abstract":"<p><strong>Background and objective: </strong>Lipedema is a commonly underdiagnosed chronic condition. This study aimed to evaluate liposuction techniques for lipedema by conducting a systematic review and presenting our experience. A case series study and a comprehensive review were conducted.</p><p><strong>Methods: </strong>We assessed surgical outcomes among patients with lipedema who underwent liposuction. Descriptive and inferential statistics were implemented. In our case series, we used tumescent liposuction, vibration amplification of sound energy at resonance (VASER) liposuction, and waterjet-assisted liposuction (WAL). We also performed a literature review of current concepts and state-of-the-art treatment for lipedema.</p><p><strong>Key content and findings: </strong>Twenty-four female patients were included in this study with a median age of 37 years [interquartile range (IQR), 10 years]. A statistically significant difference between preoperative (29.65 kg/m²) and postoperative body mass index (BMI) (26.95 kg/m²; P<0.05) of patients was evidenced. The amount of total fat removal between surgical techniques was statistically different (P<0.001). A statistically significant difference in the amount of total fat removal between surgical techniques was found (P=0.0015). Post-hoc analysis with Dunn's test evidenced a significant difference only between tumescent suction-assisted lipectomy and WAL (P<0.001). Nineteen studies were included in this review. Low complication rates, improvement in patient-reported outcomes, and reduction in conservative therapy requirements were found when evaluating multiple studies in this review.</p><p><strong>Conclusions: </strong>Liposuction has been shown to be a safe and effective alternative in patients with lipedema. It positively impacts clinical and patient-reported outcomes.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and progression of frontotemporal dementia in carriers of the TMEM106B protective genotype and its relationship with TDP-43 pathology.","authors":"Karina Braga Gomes","doi":"10.21037/atm-24-104","DOIUrl":"10.21037/atm-24-104","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"119"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: The effects of dexmedetomidine on the cognitive function of mild cognitive impairment (MCI) rats.","authors":"","doi":"10.21037/atm-2024-47","DOIUrl":"https://doi.org/10.21037/atm-2024-47","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-2043.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between pro-inflammatory mediators and sarcopenia in cancer patients through different diagnostic tools: a narrative review.","authors":"Juliana Aparecida Braga Cruz, Leani Souza Maximo Pereira, Daniel Steffens, Ariane Vieira Carvalho, Ana Paula Drummond-Lage","doi":"10.21037/atm-24-128","DOIUrl":"https://doi.org/10.21037/atm-24-128","url":null,"abstract":"<p><strong>Background and objective: </strong>Sarcopenia, characterized by the progressive loss of skeletal muscle mass (MM) and muscle function, is a common and debilitating condition in cancer patients, significantly impacting their quality of life, treatment outcomes, and overall survival. The pathophysiology of sarcopenia is multifactorial, involving metabolic, hormonal, and inflammatory changes. Recent research highlights the role of chronic inflammation in the development and progression of sarcopenia, with pro-inflammatory cytokines being key mediators of muscle catabolism. The primary objective of this study was to assess the role of pro-inflammatory cytokines in identifying sarcopenia among cancer patients. As a secondary objective, we aim to investigate whether the methods used for assessing sarcopenia, both imaging and functional, align with established guidelines.</p><p><strong>Methods: </strong>A search of the Web of Science was conducted for English-language articles published since 2005, with the following terms: \"Cancer\" AND \"Sarcopenia\" AND \"Pro-inflammatory cytokine*\" OR \"Interleukin*\". Inclusion criteria included peer-reviewed controlled trials, observational studies, case reports, and case series. To avoid redundancy, articles with results which were included in systematic reviews, narrative reviews, or scoping reviews were excluded from this review.</p><p><strong>Key content and findings: </strong>The analysis of 10 selected papers, including 1,138 cancer patients, revealed a lack of assessment of muscle strength (MS) and muscle functional performance in most of the studies on sarcopenia, contradicting the comprehensive nature of sarcopenia that includes MM, MS, and muscle functionality. There is no standardization of pro-inflammatory mediators for sarcopenia identification.</p><p><strong>Conclusions: </strong>Future research should focus on establishing cutoff points for inflammatory mediators and identifying which cytokines are linked to sarcopenia. Given the complexity of sarcopenia in different cancers, new projects should investigate whether cytokine expression depends on the tumor type. Moreover, considering that the majority of the study population comprised elderly individuals with primary sarcopenia, it is crucial to discern the extent to which the findings are influenced by age versus cancer-related factors.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 6","pages":"114"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}