Annals of translational medicine最新文献

{"title":"A standardised and reproducible method for <i>en bloc</i> multi-visceral organ retrieval in a porcine model.","authors":"Dylan R Barnett, Rohan Bhattacharjya, Jake Bastian, Akshay Kanhere, David Daniel, Shantanu Bhattacharjya","doi":"10.21037/atm-2025-1-168","DOIUrl":"10.21037/atm-2025-1-168","url":null,"abstract":"<p><strong>Background: </strong>The rapidly changing landscape of abdominal transplantation including regional normothermic perfusion of abdominal organs during procurement, broadening indications for multi-visceral transplantation (MVT) in both benign and malignant pathology and the ever increasing gap between organ supply and demand have necessitated the normalisation of expanded criteria donors (ECD). Key to mitigating the increased risk of delayed or non-function of ECD organs is the development of suitable preclinical animal models that allow for the development of reliable viability assessment as well as reconditioning and repair protocols that can thereafter be translated to humans. Due to physiological and anatomical similarities to humans, pigs make ideal pre-clinical animal models. Our group has recently concluded a study assessing the feasibility of machine perfusion and reanimation in a porcine model. In this paper, the authors describe a reproducible <i>en bloc</i> surgical technique to retrieve a composite organ block containing the liver, pancreas, small bowel, and kidneys that can be used for preclinical translational studies on organ preservation, viability assessment and preconditioning with specific reference to pertinent porcine anatomy.</p><p><strong>Methods: </strong>Twenty-six adult female Large White pigs (<i>Sus scrofa domestica</i>) were procured to obtain a multi-visceral organ block to evaluate the functionality of a novel machine perfusion rig. The average weight of the pigs was 63.05 kg. Each organ block was excised consistently by the same surgical team. The block was re-animated using <i>ex vivo</i> normothermic perfusion to simulate transplant and confirm viability.</p><p><strong>Results: </strong>We describe the stepwise surgical technique of multi-organ retrieval as a combined organ block. The average procedure time was 108.3 (range, 57-179) min.</p><p><strong>Conclusions: </strong>This surgical technique facilitated retrieval of all twenty-six organ blocks for experiments in MVT. The warm ischemia duration is minimal and closely replicates donation following brain death (DBD) in humans. With minor modifications, a donation following circulatory death (DCD) model would also be achievable. This technique is reproducible and safe and can be used to retrieve abdominal organs collectively for <i>en bloc</i> testing or to be divided subsequently on the back table, with each organ used for a distinct purpose or project.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is pulmonary hypertension still a contraindication for lung volume reduction?-a narrative review of contemporary evidence.","authors":"Munir Adamu Bala, Henry O'Connor, Ra'fat Tawalbeh, Vasileios Kouritas","doi":"10.21037/atm-2026-1-0028","DOIUrl":"10.21037/atm-2026-1-0028","url":null,"abstract":"<p><strong>Background and objective: </strong>Severe emphysema in chronic obstructive pulmonary disease causes lung hyperinflation, increased intrathoracic pressure and loss of pulmonary vasculature, which together contribute to pulmonary hypertension (PH) and right heart dysfunction. Historically, PH was considered an absolute contraindication to lung volume reduction surgery (LVRS) because clinicians feared that removing lung tissue and pulmonary vessels would raise pulmonary artery pressures and provoke right-heart failure. The objective of this narrative review is to synthesize recent evidence on the safety, feasibility and haemodynamic impact of LVRS and bronchoscopic lung volume reduction (BLVR) in patients with emphysema-associated PH and to propose practical recommendations for future research and clinical practice.</p><p><strong>Methods: </strong>We searched PubMed, MEDLINE and Web of Science from January 1990 to January 2026 using combinations of related to lung volume reduction (LVR) and PH. Reference lists of key articles were manually screened. Both surgical and bronchoscopic interventions were considered, and study designs ranging from randomized trials to observational cohorts and case series were eligible due to limited randomized data. Hemodynamic and clinical endpoints were extracted and narratively synthesized.</p><p><strong>Key content and findings: </strong>Lung hyperinflation compresses the heart and pulmonary vessels, raising pulmonary artery pressures and reducing venous return and cardiac output. LVR decreases intrathoracic pressure and improves ventilation-perfusion matching; endobronchial valves improve lung function, exercise capacity and survival. A total of 21 studies were included, comprising one randomised control trial [the National Emphysema Treatment Trial (NETT) cardiovascular substudy], 15 observational cohort studies, and 5 case series. Overall, the literature consistently indicates that the benefits of LVR on respiratory mechanics may offset the theoretical risk of losing pulmonary vasculature, provided PH is mild to moderate and patients are carefully assessed.</p><p><strong>Conclusions: </strong>Current evidence challenges the dogma that PH is an absolute contraindication to LVR. In selected emphysema patients with heterogeneous disease and mild-to-moderate PH, LVRS and BLVR can be performed safely and may reduce pulmonary artery pressures and improve right-ventricular function. Right heart catheterisation should be strongly considered for haemodynamic phenotyping before intervention and multidisciplinary selection protocols are recommended. Severe PH or decompensated right-heart failure remains a relative contraindication, and bronchoscopic procedures should be reserved for carefully selected cases.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?","authors":"Ying Qiu Zhou, Rodney A Gabriel","doi":"10.21037/atm-2026-1-0037","DOIUrl":"10.21037/atm-2026-1-0037","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Candesartan induces tumor vascular normalization to improve the efficacy of radiotherapy in the therapeutic window.","authors":"","doi":"10.21037/atm-2024-35","DOIUrl":"10.21037/atm-2024-35","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-2108.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.","authors":"Mitchell K Ng, David Jacofsky, Wael Barsoum, Michael A Mont","doi":"10.21037/atm-25-143","DOIUrl":"10.21037/atm-25-143","url":null,"abstract":"<p><p>Calcium montmorillonite (CMM) clay, a naturally occurring mineral-rich volcanic clay has garnered scientific attention for its detoxification properties, gastrointestinal (GI) support, skin benefits, and potential metabolic modulation. Recent advances in pharmaceutical-grade formulation and mechanistic understanding have renewed clinical interest in CMM as a low-risk, non-systemic adjunct in modern medical practice. General practitioners and surgeons may find it particularly useful as a safe adjunct in gut health, topical recovery, and inflammatory modulation. With supporting data from preclinical and clinical research, including studies on aflatoxin binding, microbiome modulation, and treatment of radiation enteritis and pediatric diarrhea, CMM represents a promising natural therapeutic mineral for integration into modern health protocols. This narrative review summarizes the biological properties, clinical safety, indications, and emerging efficacy data surrounding CMM, with a focus on potential perioperative and wellness applications.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to Panax notoginseng attenuates hypoxia-induced glycolysis in colonic mucosal epithelial cells in DSS-induced colitis.","authors":"","doi":"10.21037/atm-2024-33","DOIUrl":"10.21037/atm-2024-33","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-22-566.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards haplotypes of blood group genes: the impact of long-read sequencing in molecular immunohematology.","authors":"Lea Wörner, Peter Bugert","doi":"10.21037/atm-2026-1-0022","DOIUrl":"10.21037/atm-2026-1-0022","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation in young women with breast cancer: a narrative review of effectiveness, oncologic safety, and clinical practice implications.","authors":"Renata Arruda Cerqueira, Daniel Steffens, Maria Eduarda Alves Pimenta Rosa, Ariane Vieira Carvalho, Ana Paula Drummond-Lage","doi":"10.21037/atm-2026-1-0016","DOIUrl":"10.21037/atm-2026-1-0016","url":null,"abstract":"<p><strong>Background and objective: </strong>Breast cancer is the most frequently diagnosed malignancy among women of reproductive age, and advances in cancer survival have increased the relevance of fertility preservation (FP) as a component of comprehensive oncologic care. Concerns regarding treatment-related gonadotoxicity, potential delays in chemotherapy initiation, and long-term oncologic safety continue to influence clinical decision-making. This narrative review of systematic reviews aimed to synthesize contemporary evidence on FP methods in young women with breast cancer, focusing on effectiveness, timing, and oncologic safety.</p><p><strong>Methods: </strong>A structured narrative review of systematic reviews and meta-analyses was conducted using PubMed/MEDLINE and Web of Science from database inception through December 2025. Eligible articles were English-language systematic reviews evaluating FP strategies in premenopausal or perimenopausal women with breast cancer and reporting reproductive and/or oncologic outcomes. Data were extracted using a predefined framework, and findings were integrated through qualitative synthesis.</p><p><strong>Key content and findings: </strong>Sixteen systematic reviews were included. FP strategies evaluated included temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy, controlled ovarian stimulation (COS) with oocyte or embryo cryopreservation, and alternative approaches such as ovarian tissue cryopreservation (OTC) and in vitro maturation (IVM). COS followed by embryo cryopreservation demonstrated the highest rates of clinical pregnancy and live birth. GnRHa use was consistently associated with improved ovarian function recovery, reduced premature ovarian insufficiency, and increased post-treatment pregnancy rates. Across studies, FP interventions were not associated with increased risks of disease recurrence or compromised survival outcomes.</p><p><strong>Conclusions: </strong>Current evidence supports the effectiveness and oncologic safety of established FP preservation strategies in young women with breast cancer. Importantly, the integration of structured oncofertility pathways into routine oncology practice requires early referral systems, multidisciplinary coordination, and individualized risk assessment. Translating these findings into practice is essential to ensure equitable access to FP within comprehensive cancer care.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Induction of osteoclast formation by LOX mutant (LOXG473A) through regulation of autophagy.","authors":"","doi":"10.21037/atm-2024-36","DOIUrl":"10.21037/atm-2024-36","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/atm-21-4474.].</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction in primary angle closure suspects: current perspectives.","authors":"Teresa Laborda-Guirao, Antonio Hidalgo-Torres, José María Sánchez-González, Timoteo González-Cruces","doi":"10.21037/atm-2026-1-0023","DOIUrl":"10.21037/atm-2026-1-0023","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"14 2","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}