Annals of translational medicine最新文献

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Vismodegib as an adjuvant treatment for periorbital basal cell carcinoma: a case report and review of literature 将 Vismodegib 作为眶周基底细胞癌的辅助治疗:病例报告和文献综述
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-1589
S. Jabbehdari, Manasa Veluvolu, Tom Kornhauser, Thomas A. Jennings, John D. Pemberton
{"title":"Vismodegib as an adjuvant treatment for periorbital basal cell carcinoma: a case report and review of literature","authors":"S. Jabbehdari, Manasa Veluvolu, Tom Kornhauser, Thomas A. Jennings, John D. Pemberton","doi":"10.21037/atm-23-1589","DOIUrl":"https://doi.org/10.21037/atm-23-1589","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A HIF-2α-dependent KMT2E-AS1/KMT2E axis orchestrates endothelial epigenetic and metabolic dysfunction in pulmonary hypertension 依赖于 HIF-2α 的 KMT2E-AS1/KMT2E 轴协调肺动脉高压的内皮表观遗传和代谢功能障碍
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-24-54
Sarah-Eve Lemay, S. Provencher, S. Bonnet, F. Potus, O. Boucherat
{"title":"A HIF-2α-dependent KMT2E-AS1/KMT2E axis orchestrates endothelial epigenetic and metabolic dysfunction in pulmonary hypertension","authors":"Sarah-Eve Lemay, S. Provencher, S. Bonnet, F. Potus, O. Boucherat","doi":"10.21037/atm-24-54","DOIUrl":"https://doi.org/10.21037/atm-24-54","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"29 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A two-phased study on the use of remote photoplethysmography (rPPG) in paediatric care 关于在儿科护理中使用远程照相血压计(rPPG)的两阶段研究
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-1896
Nur Adila Binte Ahmad Hatib, Jan Hau Lee, Shu-Ling Chong, Q. Sng, V. Tan, G. Ong, Alicia May Lim, B. H. Quek, Mee See How, Joel Meng Fai Chan, S. Saffari, Kee Chong Ng
{"title":"A two-phased study on the use of remote photoplethysmography (rPPG) in paediatric care","authors":"Nur Adila Binte Ahmad Hatib, Jan Hau Lee, Shu-Ling Chong, Q. Sng, V. Tan, G. Ong, Alicia May Lim, B. H. Quek, Mee See How, Joel Meng Fai Chan, S. Saffari, Kee Chong Ng","doi":"10.21037/atm-23-1896","DOIUrl":"https://doi.org/10.21037/atm-23-1896","url":null,"abstract":"aged 5 to 16 years were recruited for Phase 1 (765 datapoints). All patients were haemodynamically stable and normothermic. Patients and caregivers showed high acceptability to rPPG. rPPG values were clinically discrepant for children <10 years. For those ≥ 10 years, moderate correlation was observed for HR, with Spearman’s correlation coefficient (Rs) of 0.50 [95% confidence intervals (CI): 0.42, 0.57]. We performed Phase 2 on 23 patients aged 12 to 16 years (559 datapoints). Strong correlation was observed for HR with Rs=0.82 (95% CI: 0.78, 0.85). There was weak correlation for SpO 2 and RR (Rs=−0.25 and −0.02, respectively).","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival outcomes of Zo-NAnTAx: a five-year analysis of zoledronic acid added to a neoadjuvant regimen for HER2-positive breast cancer Zo-NAnTAx的生存结果:对唑来膦酸加入HER2阳性乳腺癌新辅助治疗方案的五年分析
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-1880
Bruno de Paula, Eliana Abdelhay, Carlos Augusto Moreira de Sousa, S. Crocamo
{"title":"Survival outcomes of Zo-NAnTAx: a five-year analysis of zoledronic acid added to a neoadjuvant regimen for HER2-positive breast cancer","authors":"Bruno de Paula, Eliana Abdelhay, Carlos Augusto Moreira de Sousa, S. Crocamo","doi":"10.21037/atm-23-1880","DOIUrl":"https://doi.org/10.21037/atm-23-1880","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"121 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical delay in abdominal based flap surgery: a scoping review 腹部皮瓣手术中的手术延迟:范围界定综述
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-306
Warren M Rozen, Vikash Yogaraj, Mustafa Siddiqui, Evania Lok, D. Hunter-Smith
{"title":"Surgical delay in abdominal based flap surgery: a scoping review","authors":"Warren M Rozen, Vikash Yogaraj, Mustafa Siddiqui, Evania Lok, D. Hunter-Smith","doi":"10.21037/atm-23-306","DOIUrl":"https://doi.org/10.21037/atm-23-306","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"45 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of carbon dots from Lycium barbarum in radiation-induced bone injury 枸杞碳点对辐射诱导骨损伤的治疗潜力
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-24-10
D. K. Khajuria, David Karasik
{"title":"Therapeutic potential of carbon dots from Lycium barbarum in radiation-induced bone injury","authors":"D. K. Khajuria, David Karasik","doi":"10.21037/atm-24-10","DOIUrl":"https://doi.org/10.21037/atm-24-10","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141403722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of phosphatemia at admission to the intensive care unit to predict mechanical ventilation among patients with acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study 评估重症监护病房入院时的磷酸盐血症以预测慢性阻塞性肺病急性加重患者的机械通气情况:一项回顾性队列研究
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-1650
Sylvain Diop, Stéphane Legriel, Alexis Ferré
{"title":"Assessment of phosphatemia at admission to the intensive care unit to predict mechanical ventilation among patients with acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study","authors":"Sylvain Diop, Stéphane Legriel, Alexis Ferré","doi":"10.21037/atm-23-1650","DOIUrl":"https://doi.org/10.21037/atm-23-1650","url":null,"abstract":"Background: Hypophosphatemia has been reported to impair diaphragmatic function in patients with chronic obstructive pulmonary disease (COPD). However, little is known about the role of dysphosphatemia at admission [plasmatic phosphate concentration at intensive care unit (ICU) admission (T0-Ph)] to the ICU and respiratory outcomes among patients with severe acute COPD exacerbation. We aimed to assess the value of T0-Ph as a predictive factor of invasive mechanical ventilation (MV) during ICU stay. Methods: We retrospectively included consecutive patients admitted to the ICU for a severe acute exacerbation of COPD between May 2015 and December 2018. Logistic multivariate regression analysis was performed to identify association between T0-Ph and the need for invasive MV during the ICU stay. Results: We included 198 patients of whom 132 (67%) were male. The median age was 70 [interquartile range (IQR), 61–77] years. Nine (4.5%) patients died in the ICU. Median T0-Ph was significantly higher among patients requiring invasive MV as compared to non-intubated patients [1.23 (IQR, 1.07–1.41) and 1.09 (IQR, 0.91–1.27) mmol/L; P=0.005]. By multivariate analysis, pneumonia [odds ratio (OR) =6.42; 95% confidence interval (CI): 2.78–15.96; P<0.0001) and a history of intubation (OR =3.33; 95% CI: 0.97–11.19; P=0.05) were independently associated with the need for invasive MV, whereas T0-Ph was not (OR =1.75; 95% CI: 0.72–4.44; P=0.22). Conclusions: T0-Ph was significantly higher in patients requiring invasive MV. However, T0-Ph was not associated with the need for invasive MV in multivariate analysis.","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foot and ankle surgery: new frontiers for translational advancements 足踝外科:转化进步的新领域
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-2023-28
A. Anastasio
{"title":"Foot and ankle surgery: new frontiers for translational advancements","authors":"A. Anastasio","doi":"10.21037/atm-2023-28","DOIUrl":"https://doi.org/10.21037/atm-2023-28","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FLT3 inhibitor maintenance after allogeneic stem cell transplantation in FLT3-mutated acute myeloid leukemia (AML) patients FLT3突变急性髓性白血病(AML)患者异基因干细胞移植后的FLT3抑制剂维持治疗
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-1941
Gong He, Erika Belmont, Theodore G. Karrison, Wendy Stock, James L. LaBelle, S. Kosuri, R. A. Larson, Justin P. Kline, P. Riedell, Mariam T. Nawas, Michael R Bishop, Hongtao Liu
{"title":"FLT3 inhibitor maintenance after allogeneic stem cell transplantation in FLT3-mutated acute myeloid leukemia (AML) patients","authors":"Gong He, Erika Belmont, Theodore G. Karrison, Wendy Stock, James L. LaBelle, S. Kosuri, R. A. Larson, Justin P. Kline, P. Riedell, Mariam T. Nawas, Michael R Bishop, Hongtao Liu","doi":"10.21037/atm-23-1941","DOIUrl":"https://doi.org/10.21037/atm-23-1941","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"39 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twenty-five years with HER2 targeted therapy 使用HER2靶向疗法25年
4区 医学
Annals of translational medicine Pub Date : 2024-06-01 DOI: 10.21037/atm-23-153
Jan Trøst Jørgensen
{"title":"Twenty-five years with HER2 targeted therapy","authors":"Jan Trøst Jørgensen","doi":"10.21037/atm-23-153","DOIUrl":"https://doi.org/10.21037/atm-23-153","url":null,"abstract":"","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141403144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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