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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society最新文献

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Angiogenesis and vascular remodeling by intussusception: from form to function. 肠套叠引起的血管生成和血管重构:从形态到功能。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01417.2002
Haymo Kurz, Peter H Burri, Valentin G Djonov
{"title":"Angiogenesis and vascular remodeling by intussusception: from form to function.","authors":"Haymo Kurz,&nbsp;Peter H Burri,&nbsp;Valentin G Djonov","doi":"10.1152/nips.01417.2002","DOIUrl":"https://doi.org/10.1152/nips.01417.2002","url":null,"abstract":"<p><p>During most instances of angiogenesis, not only are the capillaries or terminal vessels generated and modified, but the supplying vascular system is subjected to remodeling as well. Intussusception, i.e., transluminal pillar formation, is one essential mechanism for growth, arborization, bifurcation remodeling, and pruning. Complex and efficient vascular beds can thus be generated by local interactions between vascular cells and hemodynamic conditions.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01417.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 184
Dysfunction of wild-type huntingtin in Huntington disease. 野生型亨廷顿蛋白在亨廷顿病中的功能障碍。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01410.2002
Elena Cattaneo
{"title":"Dysfunction of wild-type huntingtin in Huntington disease.","authors":"Elena Cattaneo","doi":"10.1152/nips.01410.2002","DOIUrl":"10.1152/nips.01410.2002","url":null,"abstract":"<p><p>Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The renal pelvis: machinery that concentrates urine in the papilla. 肾盂:将尿液集中于乳头的器官。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.1416.2002
Terry M Dwyer, Bodil Schmidt-Nielsen
{"title":"The renal pelvis: machinery that concentrates urine in the papilla.","authors":"Terry M Dwyer,&nbsp;Bodil Schmidt-Nielsen","doi":"10.1152/nips.1416.2002","DOIUrl":"https://doi.org/10.1152/nips.1416.2002","url":null,"abstract":"<p><p>Two decades ago, Bodil Schmidt-Nielsen and Bruce Graves documented the rhythmic contractions of the renal pelvis in a remarkable video, visually demonstrating how peristaltic waves empty the papilla and how the subsequent elastic recoil draws water from the collecting duct and into the tethered-open ascending vasa recta. Thus a periodic hydrostatic gradient generates an axial osmotic gradient. This review recapitulates the video and offers a link to figures and scenes digitized from the original tape.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.1416.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22200027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 83
Genesis and control of the respiratory rhythm in adult mammals. 成年哺乳动物呼吸节律的发生与控制。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01406.2002
Gérard Hilaire, Rosario Pásaro
{"title":"Genesis and control of the respiratory rhythm in adult mammals.","authors":"Gérard Hilaire,&nbsp;Rosario Pásaro","doi":"10.1152/nips.01406.2002","DOIUrl":"https://doi.org/10.1152/nips.01406.2002","url":null,"abstract":"<p><p>The neural mechanisms responsible for respiratory rhythmogenesis in mammals were studied first in vivo in adults and subsequently in vitro in neonates. In vitro data have suggested that the pacemaker neurons are the kernel of the respiratory network. These data are reviewed, and their relevance to adults is discussed.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"23-8"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01406.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
ATP as a signaling molecule: the exocrine focus. 作为信号分子的ATP:外分泌焦点。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01409.2002
Ivana Novak
{"title":"ATP as a signaling molecule: the exocrine focus.","authors":"Ivana Novak","doi":"10.1152/nips.01409.2002","DOIUrl":"https://doi.org/10.1152/nips.01409.2002","url":null,"abstract":"<p><p>Why and how do cells release ATP? It is not spilled energy. ATP becomes an extracellular regulator. Various cellular responses are initiated by purinergic receptors and signaling processes and are terminated by breakdown of ATP by ectonucleotidases. In epithelia, ATP regulates salt and water transport; other effects may be longer lasting.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"12-7"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01409.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 185
Ubiquitin-dependent proteolysis in neurons. 神经元中泛素依赖性蛋白水解。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01408.2002
Lars Klimaschewski
{"title":"Ubiquitin-dependent proteolysis in neurons.","authors":"Lars Klimaschewski","doi":"10.1152/nips.01408.2002","DOIUrl":"https://doi.org/10.1152/nips.01408.2002","url":null,"abstract":"<p><p>Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01408.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
From the nucleus toward the cell periphery: a guided tour for mRNAs. 从细胞核到细胞外围:mrna的向导之旅。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01413.2002
Brigitte M Jockusch, Stefan Hüttelmaier, Susanne Illenberger
{"title":"From the nucleus toward the cell periphery: a guided tour for mRNAs.","authors":"Brigitte M Jockusch,&nbsp;Stefan Hüttelmaier,&nbsp;Susanne Illenberger","doi":"10.1152/nips.01413.2002","DOIUrl":"https://doi.org/10.1152/nips.01413.2002","url":null,"abstract":"<p><p>RNA processing, directed transport along cytoskeletal tracks, and site-specific translation of mRNA at the cell periphery are considered discrete steps in the generation of microfilament-membrane adhesion complexes. A recently identified member of the heterogeneous nuclear ribonucleoprotein family, raver1, may couple these steps and contribute to the assembly and maintenance of these structures.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01413.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22200028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Small G proteins as novel therapeutic targets in cardiovascular medicine. 小G蛋白作为心血管医学新的治疗靶点。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01407.2002
Christine Barandier, Xiu-Fen Ming, Zhihong Yang
{"title":"Small G proteins as novel therapeutic targets in cardiovascular medicine.","authors":"Christine Barandier,&nbsp;Xiu-Fen Ming,&nbsp;Zhihong Yang","doi":"10.1152/nips.01407.2002","DOIUrl":"https://doi.org/10.1152/nips.01407.2002","url":null,"abstract":"<p><p>Small G proteins are implicated in regulation of endothelial function, smooth muscle cell contraction, proliferation, and migration, as well as cardiomyocyte hypertrophy. Targeting small G proteins and their downstream signaling could constitute promising therapeutic approaches in cardiovascular disorders such as atherosclerosis, restenosis, hypertension, vasospasm, and cardiac hypertrophy.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01407.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
CFTR and bicarbonate secretion by [correction of to] epithelial cells. [校正]上皮细胞分泌CFTR和碳酸氢盐。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI: 10.1152/nips.01412.2002
Martin J Hug, Tsutomu Tamada, Robert J Bridges
{"title":"CFTR and bicarbonate secretion by [correction of to] epithelial cells.","authors":"Martin J Hug,&nbsp;Tsutomu Tamada,&nbsp;Robert J Bridges","doi":"10.1152/nips.01412.2002","DOIUrl":"https://doi.org/10.1152/nips.01412.2002","url":null,"abstract":"<p><p>Defective HCO(3)(-) and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO(3)(-) secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO(3)(-).</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01412.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22199375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 80
Transport of xenobiotics across the blood-brain barrier. 通过血脑屏障的外源性药物运输。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-12-01 DOI: 10.1152/nips.01402.2002
Bruno Hagenbuch, Bo Gao, Peter J Meier
{"title":"Transport of xenobiotics across the blood-brain barrier.","authors":"Bruno Hagenbuch,&nbsp;Bo Gao,&nbsp;Peter J Meier","doi":"10.1152/nips.01402.2002","DOIUrl":"https://doi.org/10.1152/nips.01402.2002","url":null,"abstract":"<p><p>Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"231-4"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01402.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22114085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
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