野生型亨廷顿蛋白在亨廷顿病中的功能障碍。

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-02-01 DOI:10.1152/nips.01410.2002

Elena Cattaneo

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摘要

亨廷顿蛋白与亨廷顿病（一种遗传性神经退行性疾病）有关。研究活动主要集中在突变型亨廷顿蛋白的异常功能上。然而，最近的研究结果表明，野生型亨廷顿蛋白在大脑神经元中具有重要的活性，这表明这些活性的丧失可能在HD中起作用。

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Dysfunction of wild-type huntingtin in Huntington disease.

Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD.

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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

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