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Central nervous system processing of human visceral pain in health and disease. 中枢神经系统处理人体内脏疼痛在健康和疾病中的作用。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-06-01 DOI: 10.1152/nips.01428.2002
Anthony R Hobson, Qasim Aziz
{"title":"Central nervous system processing of human visceral pain in health and disease.","authors":"Anthony R Hobson,&nbsp;Qasim Aziz","doi":"10.1152/nips.01428.2002","DOIUrl":"https://doi.org/10.1152/nips.01428.2002","url":null,"abstract":"<p><p>To understand the pathophysiology of anomalous pain in functional gastrointestinal disorders, we must increase our understanding of how the central nervous system processes visceral pain. Over the past decade, novel application of functional brain imaging and electrophysiological techniques has given us the opportunity to study these processes in humans, and this review summarizes the current body of knowledge.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"109-14"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01428.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22388758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Pathophysiological basis of smoke inhalation injury. 烟雾吸入性损伤的病理生理基础。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-06-01 DOI: 10.1152/nips.01427.2002
Kazunori Murakami, Daniel L Traber
{"title":"Pathophysiological basis of smoke inhalation injury.","authors":"Kazunori Murakami,&nbsp;Daniel L Traber","doi":"10.1152/nips.01427.2002","DOIUrl":"https://doi.org/10.1152/nips.01427.2002","url":null,"abstract":"<p><p>Smoke inhalation injury results in serious respiratory failure. When smoke inhalation injury is combined with burn injury or pneumonia, the physiological responses are different and more severe than those of smoke inhalation injury alone. Treatment strategies should be planned based on these pathophysiological aspects.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"125-9"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01427.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22388761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 95
Chemotropic molecules: guides for axonal pathfinding and cell migration during CNS development. 趋化分子:中枢神经系统发育过程中轴突寻路和细胞迁移的向导。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-06-01 DOI: 10.1152/nips.01414.2002
Fernando de Castro
{"title":"Chemotropic molecules: guides for axonal pathfinding and cell migration during CNS development.","authors":"Fernando de Castro","doi":"10.1152/nips.01414.2002","DOIUrl":"https://doi.org/10.1152/nips.01414.2002","url":null,"abstract":"<p><p>Different molecules (netrins, semaphorins, slits) with chemotropic functions and their receptors (neogenin, DCC, neuropilins, plexins, robos) have been identified that guide axons during development of the nervous system to establish the complex pattern of connections among a large number of neurons. These molecules have been recently identified to play a role in cell migration of the central nervous system during development.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"130-6"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01414.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22388762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Annexin 1: an endogenous anti-inflammatory protein. 膜联蛋白1:一种内源性抗炎蛋白。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01424.2002
Mauro Perretti, Felicity N E Gavins
{"title":"Annexin 1: an endogenous anti-inflammatory protein.","authors":"Mauro Perretti,&nbsp;Felicity N E Gavins","doi":"10.1152/nips.01424.2002","DOIUrl":"https://doi.org/10.1152/nips.01424.2002","url":null,"abstract":"<p><p>A hallmark of inflammation is the mobilization of blood-borne leukocytes across microvessels to kill and remove the invading pathogen. For its damaging potential, leukocyte movement is finely regulated, and endogenous pathways exist to ensure the time dependency of this process. Annexin 1 and its receptor(s) are one example of these pathways.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"60-4"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01424.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 147
Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes. 自身鞘糖脂:由自身反应性T淋巴细胞识别的新抗原。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01418.2002
Gennaro De Libero, Lucia Mori
{"title":"Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes.","authors":"Gennaro De Libero,&nbsp;Lucia Mori","doi":"10.1152/nips.01418.2002","DOIUrl":"https://doi.org/10.1152/nips.01418.2002","url":null,"abstract":"<p><p>T cells may recognize glycolipids and lipids of bacterial and self origin associated with the CD1 antigen-presenting molecules. Understanding the mechanisms governing CD1-self glycolipid interaction will provide information on the molecular rules of glycolipid presentation and suggest new approaches to immunotherapy.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01418.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Alveolar flooding at high altitude: failure of reabsorption? 高海拔肺泡泛洪:重吸收失败?
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01421.2002
Sabine Höschele, Heimo Mairbäurl
{"title":"Alveolar flooding at high altitude: failure of reabsorption?","authors":"Sabine Höschele,&nbsp;Heimo Mairbäurl","doi":"10.1152/nips.01421.2002","DOIUrl":"https://doi.org/10.1152/nips.01421.2002","url":null,"abstract":"<p><p>Na-driven fluid reabsorption prevents alveolar fluid accumulation. Hypoxia augments fluid filtration by hemodynamic effects and inhibits Na reabsorption in cultured cells. A combination of both effects in vivo causes alveolar flooding, edema, thickening of the diffusion barrier for oxygen, and hypoxemia, a life-threatening situation for mountaineers in remote high-altitude mountain ranges.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"55-9"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01421.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Fish or chips? 鱼还是薯条?
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01419.2002
Axel R Heller, Hermann J Theilen, Thea Koch
{"title":"Fish or chips?","authors":"Axel R Heller,&nbsp;Hermann J Theilen,&nbsp;Thea Koch","doi":"10.1152/nips.01419.2002","DOIUrl":"https://doi.org/10.1152/nips.01419.2002","url":null,"abstract":"<p><p>Cell membranes are not simply barriers separating intracellular from extracellular space. Rather, they represent a dynamic high-turnover system that adapts to current demands. During inflammation, prostaglandins and leukotrienes are formed from membrane-derived phospholipids. Encouraging improvements in critically ill patients were observed after nutritional replacement of long-chain omega-6 fatty acids with long-chain omega-3-fatty acids, contained in fish oil.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"50-4"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01419.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Arteriovenous pairing: a determinant of capillary exchange. 动静脉配对:毛细血管交换的决定因素。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01423.2002
Norman R Harris
{"title":"Arteriovenous pairing: a determinant of capillary exchange.","authors":"Norman R Harris","doi":"10.1152/nips.01423.2002","DOIUrl":"https://doi.org/10.1152/nips.01423.2002","url":null,"abstract":"<p><p>Venuloarteriolar signaling helps mediate microvascular function and dysfunction. Mediators produced at venular sites of inflammation appear to constrict arterioles and increase capillary permeability. In contrast, venules beneficially dilate arterioles to enhance capillary flow according to metabolic demand. These mechanisms are altered with cardiovascular risk factors, contributing to microvascular complications.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"83-7"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01423.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Hypoxia, hormones, and red blood cell function in chick embryos. 鸡胚胎中的缺氧、激素和红细胞功能。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01426.2002
Stefanie Dragon, Rosemarie Baumann
{"title":"Hypoxia, hormones, and red blood cell function in chick embryos.","authors":"Stefanie Dragon,&nbsp;Rosemarie Baumann","doi":"10.1152/nips.01426.2002","DOIUrl":"https://doi.org/10.1152/nips.01426.2002","url":null,"abstract":"The red blood cell function of avian embryos is regulated by cAMP. Adenosine A(2A) and beta-adrenergic receptor activation during hypoxic conditions cause changes in the hemoglobin oxygen affinity and CO(2) transport. Furthermore, experimental evidence suggests a general involvement of cAMP in terminal differentiation of avian erythroblasts.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01426.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
"The force be with you": ATP in gut mechanosensory transduction. “力与你同在”:肠机械感觉传导中的ATP。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-04-01 DOI: 10.1152/nips.01411.2002
Helen J Cooke, Jacqueline Wunderlich, Fievos L Christofi
{"title":"\"The force be with you\": ATP in gut mechanosensory transduction.","authors":"Helen J Cooke,&nbsp;Jacqueline Wunderlich,&nbsp;Fievos L Christofi","doi":"10.1152/nips.01411.2002","DOIUrl":"https://doi.org/10.1152/nips.01411.2002","url":null,"abstract":"<p><p>Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01411.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22296754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
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