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Angioadaptation: keeping the vascular system in shape. 血管适应:保持血管系统的形状。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-10-01 DOI: 10.1152/nips.01395.2001
Andreas Zakrzewicz, Timothy W Secomb, Axel R Pries
{"title":"Angioadaptation: keeping the vascular system in shape.","authors":"Andreas Zakrzewicz,&nbsp;Timothy W Secomb,&nbsp;Axel R Pries","doi":"10.1152/nips.01395.2001","DOIUrl":"https://doi.org/10.1152/nips.01395.2001","url":null,"abstract":"<p><p>The development and maintenance of the vascular system requires not only the formation of new vessels (vasculogenesis, angiogenesis) but also the continuous adjustment of vessel and network structures in response to functional needs. This \"angioadaptation\" depends on the interplay of vascular responses to growth factors, to the metabolic status of the tissue, and to hemodynamic forces exerted by the flowing blood.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01395.2001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22009194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 121
Agrin in the developing CNS: new roles for a synapse organizer. 发育中的中枢神经系统:突触组织者的新角色。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-10-01 DOI: 10.1152/nips.01390.2002
Stephan Kröger, Jörn E Schröder
{"title":"Agrin in the developing CNS: new roles for a synapse organizer.","authors":"Stephan Kröger,&nbsp;Jörn E Schröder","doi":"10.1152/nips.01390.2002","DOIUrl":"https://doi.org/10.1152/nips.01390.2002","url":null,"abstract":"<p><p>The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01390.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22009196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Who discovered the Frank-Starling mechanism? 谁发现了弗兰克-斯特林机制?
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-10-01 DOI: 10.1152/nips.01383.2002
Heinz-Gerd Zimmer
{"title":"Who discovered the Frank-Starling mechanism?","authors":"Heinz-Gerd Zimmer","doi":"10.1152/nips.01383.2002","DOIUrl":"https://doi.org/10.1152/nips.01383.2002","url":null,"abstract":"<p><p>In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"181-4"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01383.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22009191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 62
Cholinergic control of heart rate by nitric oxide is site specific. 一氧化氮对心率的胆碱能控制是部位特异性的。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-10-01 DOI: 10.1152/nips.01386.2002
Neil Herring, Edward J F Danson, David J Paterson
{"title":"Cholinergic control of heart rate by nitric oxide is site specific.","authors":"Neil Herring,&nbsp;Edward J F Danson,&nbsp;David J Paterson","doi":"10.1152/nips.01386.2002","DOIUrl":"https://doi.org/10.1152/nips.01386.2002","url":null,"abstract":"<p><p>Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"202-6"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01386.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22009195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 65
Molecular motors: force and movement generated by single myosin II molecules. 分子马达:由单个肌球蛋白II分子产生的力和运动。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-10-01 DOI: 10.1152/nips.01389.2002
Caspar Rüegg, Claudia Veigel, Justin E Molloy, Stephan Schmitz, John C Sparrow, Rainer H A Fink
{"title":"Molecular motors: force and movement generated by single myosin II molecules.","authors":"Caspar Rüegg,&nbsp;Claudia Veigel,&nbsp;Justin E Molloy,&nbsp;Stephan Schmitz,&nbsp;John C Sparrow,&nbsp;Rainer H A Fink","doi":"10.1152/nips.01389.2002","DOIUrl":"https://doi.org/10.1152/nips.01389.2002","url":null,"abstract":"<p><p>Muscle myosin II is an ATP-driven, actin-based molecular motor. Recent developments in optical tweezers technology have made it possible to study movement and force production on the single-molecule level and to find out how different myosin isoforms may have adapted to their specific physiological roles.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"17 ","pages":"213-8"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01389.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22009197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Laminin binding conveys mechanosensing in endothelial cells. 层粘连蛋白结合传递内皮细胞的机械感应。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI: 10.1152/NIPS.01381.2001
T. Gloe, U. Pohl
{"title":"Laminin binding conveys mechanosensing in endothelial cells.","authors":"T. Gloe, U. Pohl","doi":"10.1152/NIPS.01381.2001","DOIUrl":"https://doi.org/10.1152/NIPS.01381.2001","url":null,"abstract":"In endothelial cells, forces like shear stress are transferred to focal adhesion sites and activate in concert with matrix receptor kinases, leading to an initiation of signaling cascades. The laminin binding protein is one of these matrix receptors and is critically involved in sensing and quantification of shear stress.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"16 1","pages":"166-9"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83001394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Central synaptic integration: linear after all? 中枢突触整合:到底是线性的吗?
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI: 10.1152/NIPS.01379.2001
C. Stricker
{"title":"Central synaptic integration: linear after all?","authors":"C. Stricker","doi":"10.1152/NIPS.01379.2001","DOIUrl":"https://doi.org/10.1152/NIPS.01379.2001","url":null,"abstract":"Unitary synaptic currents in hippocampus show small variability. Experimental evidence suggests that the neuron is endowed with mechanisms to reduce location-dependent differences in amplitude and time course of synaptic events, contributing to small variability. These mechanisms may allow the neuron to count individual quanta and thereby linearize integration of unitary events.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"7 1","pages":"138-43"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88713882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. 缺氧肺血管收缩的机制:钾通道、氧化还原O(2)传感器和争议。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI: 10.1152/NIPS.01388.2002
S. Archer, E. Michelakis
{"title":"The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies.","authors":"S. Archer, E. Michelakis","doi":"10.1152/NIPS.01388.2002","DOIUrl":"https://doi.org/10.1152/NIPS.01388.2002","url":null,"abstract":"Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in PO(2) are sensed by a vascular redox O(2) sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K(+) channels, thereby controlling membrane potential, Ca(2+) entry, and tone.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"30 1","pages":"131-7"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85102059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 165
Cardiac Ca(2+) regulation and the tuna fish sandwich. 心脏Ca(2+)调节和金枪鱼三明治。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI: 10.1152/NIPS.01375.2001
S. O'Neill
{"title":"Cardiac Ca(2+) regulation and the tuna fish sandwich.","authors":"S. O'Neill","doi":"10.1152/NIPS.01375.2001","DOIUrl":"https://doi.org/10.1152/NIPS.01375.2001","url":null,"abstract":"Following myocardial ischemia and reperfusion, there is a risk of fatal arrhythmias that result from damage to cellular Ca(2+) homeostasis mechanisms. n-3 Polyunsaturated fatty acids seem to protect against these arrhythmias by mechanisms involving the sarcoplasmic reticulum and the sarcolemma.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"34 1","pages":"162-5"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82702983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Early life stress: long-term physiological impact in rodents and primates. 早期生活压力:啮齿动物和灵长类动物的长期生理影响。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI: 10.1152/NIPS.01367.2001
C. Pryce, D. Rüedi-Bettschen, A. Dettling, J. Feldon,
{"title":"Early life stress: long-term physiological impact in rodents and primates.","authors":"C. Pryce, D. Rüedi-Bettschen, A. Dettling, J. Feldon,","doi":"10.1152/NIPS.01367.2001","DOIUrl":"https://doi.org/10.1152/NIPS.01367.2001","url":null,"abstract":"Rat, monkey, and human infants have evolved to expect certain patterns of care. Spontaneous or experimental deviations of care from the norm result in infant stress responses. Hyperactivity of immature stress systems such as the limbic-hypothalamic-pituitary-adrenal axis and the limbic-sympatho-adrenomedullary axis can alter their subsequent reactivity across the life span.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"2008 1","pages":"150-5"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88201711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
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