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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society最新文献

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Aldosterone: refreshing a slow hormone by swift action. 醛固酮:一种快速作用的缓慢激素。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01596.2003
Brigitte Boldyreff, Martin Wehling
{"title":"Aldosterone: refreshing a slow hormone by swift action.","authors":"Brigitte Boldyreff, Martin Wehling","doi":"10.1152/nips.01596.2003","DOIUrl":"https://doi.org/10.1152/nips.01596.2003","url":null,"abstract":"Aldosterone elicits not only genomic effects with physiological consequences within hours or days but also elicits rapid nongenomic effects, such as activation of sodium transport in target cells, within seconds or minutes. Rapid aldosterone effects, which have also been shown in several in vivo studies in humans (e.g., increase in peripheral vascular resistance and blood pressure), are of potential clinical importance.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01596.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Use of recombinant congenic strains in mapping disease-modifying genes. 利用重组同源菌株定位疾病修饰基因。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01512.2003
Jana Müllerová, Pavel Hozák
{"title":"Use of recombinant congenic strains in mapping disease-modifying genes.","authors":"Jana Müllerová,&nbsp;Pavel Hozák","doi":"10.1152/nips.01512.2003","DOIUrl":"https://doi.org/10.1152/nips.01512.2003","url":null,"abstract":"<p><p>Previous research studies have established much information about single-gene diseases. However, other genes also influencing the outcome of a disease and genes involved in complex disease remain largely unknown. Here we report on recombinant congenic strains of mice, a powerful tool for genetic dissection of a complex trait.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"105-9"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01512.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Role of superoxide as a signaling molecule. 超氧化物作为信号分子的作用。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01514.2003
Timo M Buetler, Alexandra Krauskopf, Urs T Ruegg
{"title":"Role of superoxide as a signaling molecule.","authors":"Timo M Buetler,&nbsp;Alexandra Krauskopf,&nbsp;Urs T Ruegg","doi":"10.1152/nips.01514.2003","DOIUrl":"https://doi.org/10.1152/nips.01514.2003","url":null,"abstract":"<p><p>Superoxide is known to affect vascular physiology in several ways and has also been recognized to contribute significantly to vascular physiopathology. Here we discuss the emerging role of superoxide as an essential signaling molecule in normal physiology.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"120-3"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01514.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 196
How free fatty acids inhibit glucose utilization in human skeletal muscle. 游离脂肪酸如何抑制人体骨骼肌对葡萄糖的利用。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01459.2003
Michael Roden
{"title":"How free fatty acids inhibit glucose utilization in human skeletal muscle.","authors":"Michael Roden","doi":"10.1152/nips.01459.2003","DOIUrl":"https://doi.org/10.1152/nips.01459.2003","url":null,"abstract":"<p><p>Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"92-6"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01459.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 183
Morphological features of cell death. 细胞死亡的形态学特征。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01519.2004
U Ziegler, P Groscurth
{"title":"Morphological features of cell death.","authors":"U Ziegler,&nbsp;P Groscurth","doi":"10.1152/nips.01519.2004","DOIUrl":"https://doi.org/10.1152/nips.01519.2004","url":null,"abstract":"<p><p>Cell death is discriminated into two main forms: apoptosis and necrosis. In contrast to necrosis, apoptosis is a regulated, energy-dependent form of cell death leading to phagocytosis of cellular remnants by neighboring cells. Characteristic morphological features of these two forms of cell death will be discussed and correlated to underlying molecular mechanisms.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"124-8"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01519.2004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 542
Activity-dependent synaptic competition at mammalian neuromuscular junctions. 哺乳动物神经肌肉连接处活动依赖性突触竞争。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01464.2003
Mario Buffelli, Giuseppe Busetto, Carlo Bidoia, Morgana Favero, Alberto Cangiano
{"title":"Activity-dependent synaptic competition at mammalian neuromuscular junctions.","authors":"Mario Buffelli, Giuseppe Busetto, Carlo Bidoia, Morgana Favero, Alberto Cangiano","doi":"10.1152/nips.01464.2003","DOIUrl":"10.1152/nips.01464.2003","url":null,"abstract":"<p><p>Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Vision" in single-celled algae. 单细胞藻类的“视觉”。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01517.2004
Suneel Kateriya, Georg Nagel, Ernst Bamberg, Peter Hegemann
{"title":"\"Vision\" in single-celled algae.","authors":"Suneel Kateriya,&nbsp;Georg Nagel,&nbsp;Ernst Bamberg,&nbsp;Peter Hegemann","doi":"10.1152/nips.01517.2004","DOIUrl":"https://doi.org/10.1152/nips.01517.2004","url":null,"abstract":"<p><p>Photosynthetic unicellular algae have a unique visual system. In Chlamydomonas reinhardtii, the pigmented eye comprises the optical system and at least five different rhodopsin photoreceptors. Two of them, the channelrhodopsins, are rhodopsin-ion channel hybrids switched between closed and open states by photoisomerization of the attached retinal chromophore. They promise to become a useful tool for noninvasive control of membrane potential and intracellular ion concentrations.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"133-7"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01517.2004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 116
Cellular and gene therapy for major histocompatibility complex class II deficiency. 主要组织相容性复合体II类缺乏的细胞和基因治疗。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01462.2003
Franck Matheux, Jean Villard
{"title":"Cellular and gene therapy for major histocompatibility complex class II deficiency.","authors":"Franck Matheux,&nbsp;Jean Villard","doi":"10.1152/nips.01462.2003","DOIUrl":"https://doi.org/10.1152/nips.01462.2003","url":null,"abstract":"<p><p>Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency. Lentiviral vectors are used for gene therapy in a mouse model of this disease. In addition, by a direct genetic correction approach, a diagnostic test to determine which of the four MHC II genes is defective in new MHC II-deficiency patients has been optimized.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"154-8"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01462.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Olfaction: from odorant molecules to the olfactory cortex. 嗅觉:从气味分子到嗅觉皮层。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.1507.2003
Anna Menini, Laura Lagostena, Anna Boccaccio
{"title":"Olfaction: from odorant molecules to the olfactory cortex.","authors":"Anna Menini,&nbsp;Laura Lagostena,&nbsp;Anna Boccaccio","doi":"10.1152/nips.1507.2003","DOIUrl":"https://doi.org/10.1152/nips.1507.2003","url":null,"abstract":"<p><p>How do we smell? Our knowledge of how odor information from the environment is perceived has greatly advanced since the discovery of approximately 1,000 genes for odorant receptors in the mammalian genome. From the combination of molecular-genetic, electrophysiological, and optical imaging studies a better understanding of how we smell is emerging.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"101-4"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.1507.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 72
The airway compartment: chambers of secrets. 气道隔室:密室。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01508.2003
B Beck-Schimmer, R C Schimmer, T Pasch
{"title":"The airway compartment: chambers of secrets.","authors":"B Beck-Schimmer,&nbsp;R C Schimmer,&nbsp;T Pasch","doi":"10.1152/nips.01508.2003","DOIUrl":"https://doi.org/10.1152/nips.01508.2003","url":null,"abstract":"<p><p>The adhesion molecule intercellular adhesion molecule-1 (ICAM-1) is known to play a crucial role in lung inflammation such as endotoxin-induced injury. Although ICAM-1 has been characterized on endothelial cells, limited information is available regarding its expression in the epithelial compartment. The present review provides novel views on this aspect.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"129-32"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01508.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
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