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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society最新文献

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Proteomic strategies and their application in studies of renal function. 蛋白质组学策略及其在肾功能研究中的应用。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01515.2003
Pedro Cutillas, Alma Burlingame, Robert Unwin
{"title":"Proteomic strategies and their application in studies of renal function.","authors":"Pedro Cutillas,&nbsp;Alma Burlingame,&nbsp;Robert Unwin","doi":"10.1152/nips.01515.2003","DOIUrl":"https://doi.org/10.1152/nips.01515.2003","url":null,"abstract":"<p><p>Proteomics is a promising new tool for functional genomics. In addition to two-dimensional gel electrophoresis, other methods that are based on liquid chromatography and mass spectrometry are now available to study proteins. In this brief article, we review the strengths and limitations of the proteomic approaches currently available to the researcher, and we provide examples of how proteomics has been, and can in the future be, used to study the kidney.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"114-9"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01515.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Connexins pave the way for vascular communication. 连接蛋白为血管通讯铺平了道路。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01520.2004
Cor De Wit
{"title":"Connexins pave the way for vascular communication.","authors":"Cor De Wit","doi":"10.1152/nips.01520.2004","DOIUrl":"https://doi.org/10.1152/nips.01520.2004","url":null,"abstract":"<p><p>Coordinated behavior within arterioles is necessary for large resistance changes to occur and is reflected as a conduction of dilations/constrictions along arterioles. These responses arise from locally initiated hyper- or depolarizations that propagate via transmembrane channels formed by connexins (gap junctions). Mounting evidence indicates that gap-junctional communication contributes to the control of vascular tone.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"148-53"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01520.2004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 71
Neuroglobin: a respiratory protein of the nervous system. 神经球蛋白:一种神经系统的呼吸蛋白。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01513.2003
Thorsten Burmester, Thomas Hankeln
{"title":"Neuroglobin: a respiratory protein of the nervous system.","authors":"Thorsten Burmester,&nbsp;Thomas Hankeln","doi":"10.1152/nips.01513.2003","DOIUrl":"https://doi.org/10.1152/nips.01513.2003","url":null,"abstract":"<p><p>Nerve tissues exhibit some of the highest oxygen consumption rates found in the body. Neuroglobin, a heme protein distantly related to hemoglobin, is thought to enhance the supply of oxygen to the neurons, the eye, and some endocrine tissues. Neuroglobin may promote neuronal survival under hypoxic conditions as they occur, for example, in stroke.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"110-3"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01513.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 126
The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle. 肌浆网、Ca2+捕获和平滑肌波动机制。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI: 10.1152/nips.01518.2004
John G McCarron, Karen N Bradley, Debbi MacMillan, Susan Chalmers, Thomas C Muir
{"title":"The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle.","authors":"John G McCarron,&nbsp;Karen N Bradley,&nbsp;Debbi MacMillan,&nbsp;Susan Chalmers,&nbsp;Thomas C Muir","doi":"10.1152/nips.01518.2004","DOIUrl":"https://doi.org/10.1152/nips.01518.2004","url":null,"abstract":"<p><p>The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When \"leaky,\" the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"138-47"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01518.2004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24518923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Central pathways controlling brown adipose tissue thermogenesis. 控制棕色脂肪组织产热的中枢通路。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01502.2003
Shaun F Morrison
{"title":"Central pathways controlling brown adipose tissue thermogenesis.","authors":"Shaun F Morrison","doi":"10.1152/nips.01502.2003","DOIUrl":"https://doi.org/10.1152/nips.01502.2003","url":null,"abstract":"Heat production in brown adipose tissue contributes to cold defense, to stress-induced increases in body temperature, and to energy balance. Elucidating the functional organization of the central network controlling the sympathetic outflow to brown adipose tissue could provide a framework for understanding how dysregulation of thermogenesis contributes to hyperthermia and to obesity.","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01502.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 191
Electrophysiological insights into the mechanism of ion-coupled cotransporters. 离子偶联共转运体机制的电生理学见解。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01504.2003
Antonio Peres, Stefano Giovannardi, Elena Bossi, Riccardo Fesce
{"title":"Electrophysiological insights into the mechanism of ion-coupled cotransporters.","authors":"Antonio Peres,&nbsp;Stefano Giovannardi,&nbsp;Elena Bossi,&nbsp;Riccardo Fesce","doi":"10.1152/nips.01504.2003","DOIUrl":"https://doi.org/10.1152/nips.01504.2003","url":null,"abstract":"<p><p>Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"80-4"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01504.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Comparative physiology of lung complexity: implications for gas exchange. 肺复杂性的比较生理学:对气体交换的影响。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01469.2003
Frank L Powell, Susan R Hopkins
{"title":"Comparative physiology of lung complexity: implications for gas exchange.","authors":"Frank L Powell,&nbsp;Susan R Hopkins","doi":"10.1152/nips.01469.2003","DOIUrl":"https://doi.org/10.1152/nips.01469.2003","url":null,"abstract":"<p><p>Lungs evolved to increase diffusing capacity by compartmentalizing and reducing the size of individual gas exchange units. This increased the potential for gas exchange limitations from ventilation-perfusion heterogeneity. However, comparative studies on reptiles, birds, and mammals show that heterogeneity is independent of lung complexity.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01469.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Lipid rafts: feeling is believing. 脂筏:感觉就是相信。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01505.2003
Robert M Henderson, J Michael Edwardson, Nicholas A Geisse, David E Saslowsky
{"title":"Lipid rafts: feeling is believing.","authors":"Robert M Henderson,&nbsp;J Michael Edwardson,&nbsp;Nicholas A Geisse,&nbsp;David E Saslowsky","doi":"10.1152/nips.01505.2003","DOIUrl":"https://doi.org/10.1152/nips.01505.2003","url":null,"abstract":"<p><p>In the late 1990s, accumulated evidence led to the proposal that biological membranes are composed of microdomains of different lipids, which form functional \"rafts.\" Recent work using atomic force microscopy has given us new insights into the factors influencing the formation and behavior of these physiological microenvironments</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"39-43"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01505.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 66
Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. 肺血管平滑肌细胞增殖中的钙和TRP通道。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01457.2003
Judd W Landsberg, Jason X-J Yuan
{"title":"Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.","authors":"Judd W Landsberg,&nbsp;Jason X-J Yuan","doi":"10.1152/nips.01457.2003","DOIUrl":"https://doi.org/10.1152/nips.01457.2003","url":null,"abstract":"<p><p>Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"44-50"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01457.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40839000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 107
A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice. 对皮肤中离子通量的非常规观察:来自转基因小鼠的经验教训。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01503.2003
Marjorie Guitard, Celine Leyvraz, Edith Hummler
{"title":"A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice.","authors":"Marjorie Guitard,&nbsp;Celine Leyvraz,&nbsp;Edith Hummler","doi":"10.1152/nips.01503.2003","DOIUrl":"https://doi.org/10.1152/nips.01503.2003","url":null,"abstract":"<p><p>The mammalian, highly amiloride-sensitive epithelial sodium channel (ENaC) is member of the degenerin/ENaC superfamily of ion channels known to be implicated in sodium homeostasis, mechanosensation, and mechanoperception. A novel role for ENaC implicated in differentiation processes in skin reshapes our current view of this ancient transmembrane channel protein.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"75-9"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01503.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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