John G McCarron, Karen N Bradley, Debbi MacMillan, Susan Chalmers, Thomas C Muir
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The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle.
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.
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