The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-06-01 DOI:10.1152/nips.01518.2004

John G McCarron, Karen N Bradley, Debbi MacMillan, Susan Chalmers, Thomas C Muir

引用次数: 21

Abstract

The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.

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肌浆网、Ca2+捕获和平滑肌波动机制。

肌浆网(SR)和肌膜的对应区域被动地捕获进入细胞的Ca2+，以限制胞浆Ca2+浓度的上升，而不需要SR泵的参与。当“渗漏”时，SR促进Ca2+进入细胞质。SR Ca2+释放通过肌醇1,4,5-三磷酸受体(IP(3)Rs)作为钙波传播;单独的IP(3)Rs说明了波的传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

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