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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society最新文献

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Unorthodox sites and modes of aldosterone action. 醛固酮作用的非正统位点和模式。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01463.2003
Hans Oberleithner
{"title":"Unorthodox sites and modes of aldosterone action.","authors":"Hans Oberleithner","doi":"10.1152/nips.01463.2003","DOIUrl":"https://doi.org/10.1152/nips.01463.2003","url":null,"abstract":"<p><p>Aldosterone controls electrolyte balance by acting on the renal epithelium. However, there is strong evidence that vascular endothelium is another target for mineralocorticoids. Endothelial cells gain sensitivity to diuretics when exposed to aldosterone. Atomic force microscopy detects such phenomena. It is speculated that endothelium and kidney join forces in the regulation of body fluids.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"51-4"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40839001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Molecular mechanisms of epithelial polarity: about shapes, forces, and orientation problems. 上皮极性的分子机制:关于形状、力和取向问题。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-04-01 DOI: 10.1152/nips.01501.2003
Ruth Kroschewski
{"title":"Molecular mechanisms of epithelial polarity: about shapes, forces, and orientation problems.","authors":"Ruth Kroschewski","doi":"10.1152/nips.01501.2003","DOIUrl":"https://doi.org/10.1152/nips.01501.2003","url":null,"abstract":"<p><p>In a variety of organs, epithelial cells assemble into networks of cysts and tubules. Such structures can be reproduced in vitro. Here the importance of plasma membrane compartmentalization and forces that drive morphogenetic events during cystogenesis are discussed.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":" ","pages":"61-6"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01501.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40838298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The physiological regulation of thirst and fluid intake. 口渴和液体摄入的生理调节。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01470.2003
Michael J McKinley, Alan Kim Johnson
{"title":"The physiological regulation of thirst and fluid intake.","authors":"Michael J McKinley,&nbsp;Alan Kim Johnson","doi":"10.1152/nips.01470.2003","DOIUrl":"https://doi.org/10.1152/nips.01470.2003","url":null,"abstract":"<p><p>Thirst is important for maintaining body fluid homeostasis and may arise from deficits in either intracellular or extracellular fluid volume. Neural signals arising from osmotic and hormonal influences on the lamina terminalis may be integrated within the brain, with afferent information relayed from intrathoracic baroreceptors via the hindbrain to generate thirst.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01470.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 353
Tracking the moveable feast: sonomicrometry and gastrointestinal motility. 追踪移动盛宴:声速测量和胃肠运动。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01439.2003
David W Adelson, Mulugeta Million
{"title":"Tracking the moveable feast: sonomicrometry and gastrointestinal motility.","authors":"David W Adelson,&nbsp;Mulugeta Million","doi":"10.1152/nips.01439.2003","DOIUrl":"https://doi.org/10.1152/nips.01439.2003","url":null,"abstract":"<p><p>Ultrasonomicrometry measures distance between piezoelectric crystals based on transmission time of ultrasound bursts. It allows monitoring of coordinated motion of small and delicate tissues, including gastrointestinal sphincters. Its suitability for motility studies in small animals such as mice suggests that its use in gastrointestinal studies will increase in coming years.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01439.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Proteoglycans and brain repair. 蛋白聚糖与大脑修复。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01449.2003
Francesca Properzi, James W Fawcett
{"title":"Proteoglycans and brain repair.","authors":"Francesca Properzi,&nbsp;James W Fawcett","doi":"10.1152/nips.01449.2003","DOIUrl":"https://doi.org/10.1152/nips.01449.2003","url":null,"abstract":"<p><p>Proteoglycans are complex molecules composed of long, unbranched sugar chains attached to a protein core. In the mammalian central nervous system, they are a major component of the extracellular matrix and of the cellular surface. After a central nervous system injury, their expression in the lesion area changes strongly and contributes to the inhibition of axon regrowth and brain repair.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01449.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
On heat and cells and proteins. 关于热量，细胞和蛋白质。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01403.2002
Dörthe M Katschinski
{"title":"On heat and cells and proteins.","authors":"Dörthe M Katschinski","doi":"10.1152/nips.01403.2002","DOIUrl":"https://doi.org/10.1152/nips.01403.2002","url":null,"abstract":"<p><p>Two principal forms of temperature-control strategies have evolved, i.e., poikilothermic and homeothermic life. Even in homeothermic animals, the temperature field of the body is not homogeneous. These observed temperature differences can affect cellular function directly or via the expression of heat shock or cold shock proteins.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"11-5"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01403.2002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 80
Selectins facilitate carcinoma metastasis and heparin can prevent them. 选择素促进癌转移，肝素可预防癌转移。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01450.2003
Lubor Borsig
{"title":"Selectins facilitate carcinoma metastasis and heparin can prevent them.","authors":"Lubor Borsig","doi":"10.1152/nips.01450.2003","DOIUrl":"https://doi.org/10.1152/nips.01450.2003","url":null,"abstract":"<p><p>Selectins are cell adhesion molecules mediating attachment of leukocytes to activated endothelium as well as the adhesion reaction of tumors during malignancy. Heparin, which is known to attenuate metastasis, is a potent blocker of selectins. Here, the role of selectins in metastasis and the potential of heparin to modulate malignancy are discussed.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01450.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 81
Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier. 为什么不是所有人都有蛋白尿?我们目前对肾小球屏障理解的更新。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01461.2003
Börje Haraldsson, Jenny Sörensson
{"title":"Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier.","authors":"Börje Haraldsson,&nbsp;Jenny Sörensson","doi":"10.1152/nips.01461.2003","DOIUrl":"https://doi.org/10.1152/nips.01461.2003","url":null,"abstract":"<p><p>The key question is not why some patients have proteinuria but rather why not all people have it. In the present review, we will present an update on the glomerular barrier after the recent breakthroughs in podocyte biology. In particular, we will discuss the role of the endothelium, which seems to be a neglected part of the glomerular membrane.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01461.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 125
Hypothalamic and midbrain circuitry that distinguishes between escapable and inescapable pain. 下丘脑和中脑回路区分可逃避和不可逃避的疼痛。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2004-02-01 DOI: 10.1152/nips.01467.2003
Bridget M Lumb
{"title":"Hypothalamic and midbrain circuitry that distinguishes between escapable and inescapable pain.","authors":"Bridget M Lumb","doi":"10.1152/nips.01467.2003","DOIUrl":"https://doi.org/10.1152/nips.01467.2003","url":null,"abstract":"<p><p>Characteristics of emotional, behavioral, and physiological responses to pain are determined to a large extent by the behavioral significance of the pain, in particular to the degree to which the pain can be escaped. This review presents evidence that these different patterns of response depend on the activation of distinct pathways within the brain.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"19 ","pages":"22-6"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01467.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24177315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Role of calcium sensitivity modulation in skeletal muscle performance. 钙敏感性调节在骨骼肌性能中的作用。
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2003-12-01 DOI: 10.1152/nips.01456.2003
Brian R MacIntosh
{"title":"Role of calcium sensitivity modulation in skeletal muscle performance.","authors":"Brian R MacIntosh","doi":"10.1152/nips.01456.2003","DOIUrl":"https://doi.org/10.1152/nips.01456.2003","url":null,"abstract":"<p><p>A common mechanism affecting Ca(2+) sensitivity in skeletal muscle is the proximity of myosin heads with actin filaments, a function of myofilament lattice spacing and myosin head mobility with respect to the myosin filament. This is an important mechanism of pCa(2+)(50) modulation by length, pH, regulatory light-chain phosphorylation, and temperature.</p>","PeriodicalId":82140,"journal":{"name":"News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society","volume":"18 ","pages":"222-5"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/nips.01456.2003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24072780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
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