Role of calcium sensitivity modulation in skeletal muscle performance.

Abstract

A common mechanism affecting Ca(2+) sensitivity in skeletal muscle is the proximity of myosin heads with actin filaments, a function of myofilament lattice spacing and myosin head mobility with respect to the myosin filament. This is an important mechanism of pCa(2+)(50) modulation by length, pH, regulatory light-chain phosphorylation, and temperature.