层粘连蛋白结合传递内皮细胞的机械感应。

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society Pub Date : 2002-08-01 DOI:10.1152/NIPS.01381.2001

T. Gloe, U. Pohl

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引用次数: 33

摘要

在内皮细胞中，剪切应力等力被转移到黏附点，并与基质受体激酶一起激活，导致信号级联反应的启动。层粘连蛋白结合蛋白是这些基质受体之一，在剪切应力的传感和定量中起关键作用。

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Laminin binding conveys mechanosensing in endothelial cells.

In endothelial cells, forces like shear stress are transferred to focal adhesion sites and activate in concert with matrix receptor kinases, leading to an initiation of signaling cascades. The laminin binding protein is one of these matrix receptors and is critically involved in sensing and quantification of shear stress.

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News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

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