Helen J Cooke, Jacqueline Wunderlich, Fievos L Christofi
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"The force be with you": ATP in gut mechanosensory transduction.
Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.
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