Archives of Dermatological Research最新文献

{"title":"Adherence to oral and topical medications among dermatology patients","authors":"Rania Mounir Abdel Hay,&nbsp;Leila Z. Gad,&nbsp;Layla W. Ebeid,&nbsp;Youssef A. Elsherbini,&nbsp;Ahmed A. Elmetwally,&nbsp;Marwa Fathy Hussein,&nbsp;Mohammad Yasine Beeharry,&nbsp;Aya M. AlOrbani","doi":"10.1007/s00403-025-03952-2","DOIUrl":"10.1007/s00403-025-03952-2","url":null,"abstract":"<div><p>Poor adherence contributes to worsening of medical conditions, increased medical costs, comorbidities and mortalities. Many factors may influence adherence in dermatology. Our aim was to study the degree of adherence of dermatology patients to topical and systemic medications and to identify the relationship of adherence to patient, disease, and treatment characteristics, as well as the influence of health care providers. Seven hundred and eighteen patients of both sexes with various dermatological complaints were included. They were all subjected to Morisky 8-item Medication Adherence Scale. Topical therapy was associated with a significantly lower adherence when compared to systemic therapy (<i>P</i> &lt; 0.001). Adherence to systemic medication was superior for acute compared to chronic skin diseases (<i>P</i> = 0.008). Reduced adherence was also observed among uneducated patients, those facing financial difficulties, individuals prescribed complex topical regimens, and those using ointments Additional factors included insufficient instructions from physicians, perceived treatment effectiveness, and the experience of side effects. Patients with psoriasis and eczema showed the lowest adherence levels to both topical and systemic treatment. Overall, adherence of dermatology patients to treatment, particularly to topical treatment, was found to be unsatisfactory. Dermatologists should assess each patient’s individual adherence barriers, and the management plan should be tailored according to many factors including the patient’s financial status and educational level.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Kangfuxin liquid for eczema: a systematic review and meta-analysis","authors":"Yi-ran Chen,&nbsp;Xiao-fan Yang,&nbsp;Xiao-jie Ding,&nbsp;Ying Luo,&nbsp;Le Kuai,&nbsp;Bin Li,&nbsp;Mi Zhou,&nbsp;Yue Luo,&nbsp;Xiao-ya Fei","doi":"10.1007/s00403-025-03983-9","DOIUrl":"10.1007/s00403-025-03983-9","url":null,"abstract":"<div><p>Eczema is a chronic, recurrent dermatosis with the skin repeated inflammation, itching, red and swollen. Such experience often take a physical and mental double burden on patients and their caregivers and family member. At present, the existing treatment methods have different limitations. In China, Kangfuxin liquid has been clinically used to treat eczema, and has shown good therapeutic effect. In order to conduct a more comprehensive analysis of clinical data and bring more references for clinicians and experts, this paper adopted a systematic review and meta-analysis to evaluate the effectiveness of Kangfuxin liquid in the treatment of eczema. We conducted a search in several databases, including EMBASE, PubMed, and the Cochrane Library, to identify suitable randomized controlled trials (RCTs). Following this, we gathered data from the RCTs which compared conventional therapies to Kangfuxin liquid alone or in combination with conventional therapies. We utilized RevMan 5.4 software to compute 95% confidence intervals (CIs) and risk ratios (RRs), and to carry out the meta-analysis. 17 meta-analyses involving 1725 patients were included. A meta-analysis showed that standalone Kangfuxin liquid therapy significantly improved the overall effective rate compared to nonglucocorticoid ointment therapy (Kangfuxin liquid vs nonglucocorticoid ointment: RR, 1.24; 95% CI, 1.09–1.42; P = 0.001). The total effective rate for standalone Kangfuxin liquid therapy was consistent with that of glucocorticoid ointment therapy (Kangfuxin liquid vs glucocorticoid ointment: RR, 1.09; 95% CI, 0.88–1.36; P = 0.41). In addition, the results were significantly improved when Kangfuxin liquid combined with conventional western medicine (Kangfuxin liquid + conventional Western medicine vs conventional Western medicine: RR, 1.12; 95% CI, 1.03–1.22; P = 0.009). Kangfuxin liquid can effectively treat eczema. However, further scale-up, involving more rigorous, precise, and inclusive meta-analyses are needed to make a significant difference in the treatment of eczema.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of acne vulgaris predicts maladaptive psychosocial perceptions and neuropsychiatric disorders: a case-control study","authors":"Brad R. Woodie,&nbsp;Isaiah N. Holt,&nbsp;Justin A. Freking,&nbsp;Heather C. W. Harrison,&nbsp;Gabrielle M. Rivin,&nbsp;Alan B. Fleischer Jr","doi":"10.1007/s00403-025-04123-z","DOIUrl":"10.1007/s00403-025-04123-z","url":null,"abstract":"<div><p>Acne vulgaris can negatively impact a patient’s quality of life. This study evaluated the psychological and interpersonal perceptions of patients who had received acne treatment. Using data from the National Institutes of Health’s <i>All of Us</i> Research Program, we analyzed survey responses from 1,843 participants treated with systemic therapies for acne (reflecting more severe disease) and 1,843 matched participants treated with topical therapies alone. Outcomes included surveys assessing both mental and social health and the prevalence of neuropsychiatric conditions between groups. Compared with those who used only topical therapies, participants treated with systemic therapies for acne experience greater personal and relational difficulties in addition to having higher rates of obsessive-compulsive disorder, personality disorders, anxiety, and depression. These findings were robust in a sensitivity analysis excluding isotretinoin-treated participants. The subset of people with acne who receive systemic therapy comprise a high-risk group for adverse psychological outcomes. We aim to bring greater awareness and sensitivity to these issues among dermatologists and other clinicians managing acne. We also aim to highlight the potential need for neuropsychiatric support in patients with more severe acne.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04123-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinico-epidemiological study on acne vulgaris with an assessment of its treatment strategies and drug prescribing practices in a tertiary care hospital - an observational study","authors":"Ramalingam Kothai,&nbsp;Gopalan Kannan,&nbsp;Balasubramanian Arul,&nbsp;Muthukumaran Venkatesan,&nbsp;Gnanavel Ambiga Vidyashaagaran,&nbsp;Andiappan Nagappan","doi":"10.1007/s00403-025-04105-1","DOIUrl":"10.1007/s00403-025-04105-1","url":null,"abstract":"<div><h3>Background</h3><p>Acne vulgaris is a widespread dermatological condition, particularly prevalent among adolescents and young adults. Despite their commonality, the variability in treatment practices has made it essential to reassess current prescribing practices and treatment strategies.</p><h3>Aim</h3><p>Relating the clinico-epidemiological features of acne vulgaris and evaluating the treatment strategies and drug prescribing practices in a tertiary care hospital.</p><h3>Materials and methods</h3><p>A prospective observational study was conducted with 100 patients in the dermatology department of a tertiary care hospital from January to June 2024. Sociodemographic data were collected through patient interviews, and detailed dermatological assessments were performed by dermatologists to categorize acne severity and identify common triggers.</p><h3>Results</h3><p>Statistical analysis of the results was expressed in percentages. The majority of patients were aged between 18 and 27 years, with a higher prevalence among females. Most patients were students, residing in urban areas, with moderate to severe acne. The most common treatment regimen involved a combination of topical retinoids, antibiotics, and isotretinoin prescribed for severe cases.</p><h3>Conclusion</h3><p>This study highlights the importance of improving acne treatment strategies, focusing on personalized approaches to improve patient outcomes. There is a critical need for continuous education among healthcare providers regarding emerging treatment options and best clinical practices in acne management.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorogenic acid targets SIRT6 to relieve UVB - induced UV damage","authors":"Simin Wu,&nbsp;Qixing Zhou,&nbsp;Ziqi Gao,&nbsp;Jiaxu Man,&nbsp;Wei He,&nbsp;Jingying Feng,&nbsp;Xiaoyong Li,&nbsp;Dongying Zhang","doi":"10.1007/s00403-025-04134-w","DOIUrl":"10.1007/s00403-025-04134-w","url":null,"abstract":"<div><p>Skin photoaging, one of the most critical types of exogenous skin aging, occurs when the skin is exposed to excessive ultraviolet radiation, leading to a series of skin-aging problems. The objective of this study was to utilize keratinocytes (HaCaT) treated with medium wave ultraviolet (UVB) as a photoaging model to investigate the anti-photoaging activity of chlorogenic acid (CGA) and preliminarily elucidate its underlying mechanism. The crystal violet assay shows that both 100 and 150 µM of CGA can significantly suppress the cell damage induced by 21.6 mJ/cm² UVB. Furthermore, the results of comet electrophoresis and Western Blot (WB) experiments demonstrate that CGA and OSS-128,167 (SIRT6 inhibitor) can effectively inhibit DNA damage caused by UVB, thereby alleviating cell apoptosis. The co-immunoprecipitation (CO-IP) and WB results suggest that CGA and OSS-128,167 can effectively suppress the activity and expression of the deacetylase of SIRT6, thus enhancing the expression of DDB2 and activating the nucleotide excision repair (NER) of cells to achieve the anti-photoaging effect. The aforementioned results imply that CGA activates NER repair and protects cells from UVB-induced damage by inhibiting the deacetylation activity of SIRT6 and subsequently decreasing the deacetylation modification of DDB2. The study elucidates the molecular mechanisms underlying the beneficial effects of CGA on skin photoaging and establishes a theoretical basis for the development of CGA based sunscreen formulations.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of surgical margins and reoperation in basal cell carcinoma recurrence: a study of 3036 cases","authors":"Martin Iurilli,&nbsp;Vito Cazzato,&nbsp;Vittorio Ramella,&nbsp;Giovanni Papa","doi":"10.1007/s00403-025-04084-3","DOIUrl":"10.1007/s00403-025-04084-3","url":null,"abstract":"<div><p>Introduction: Basal cell carcinoma (BCC) is the most common type of skin cancer globally, with its prevalence increasing due to chronic ultraviolet (UV) radiation exposure. Although surgical excision remains the cornerstone of treatment, achieving optimal outcomes requires a careful balance between complete tumor removal and the preservation of cosmetic appearance. Objective: This study aims to investigate the relationship between excision margins, reoperation rates, and BCC recurrence through a retrospective analysis of 3036 surgical excisions. Methods: Conducted at the Department of Plastic Surgery in Trieste, Italy, this study includes data from 2037 patients treated between 2014 and 2018. Excision procedures adhered to standardized hospital protocols. Tumor characteristics, excision margins, and involved anatomical sites were analyzed. Results: The study demonstrated an equal gender distribution (51.02% women), with the nodular subtype (45.85%) being the most common. The head was the most frequently affected site (54.74%). A complete excision rate of 93.3% was achieved, but incomplete excisions were more common in head and neck locations and certain histological subtypes. Surgical reinterventions were primarily performed for high-risk BCCs, significantly reducing recurrence rates (0.52%). Conclusion: Reoperation, especially for high-risk BCCs, should be prioritized over conservative management to minimize recurrence. Narrow excision margins were associated with higher recurrence rates, highlighting the importance of adequate margin clearance. This study enhances understanding of the complex interplay between excision techniques, reoperation, and long-term outcomes in BCC management.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04084-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragalin inhibits fibroblast proliferation, motion, and ECM synthesis and regulates the MAPK pathway in keloid","authors":"Bin Niu,&nbsp;Liang Zhang,&nbsp;Anchen Chen","doi":"10.1007/s00403-025-04092-3","DOIUrl":"10.1007/s00403-025-04092-3","url":null,"abstract":"<div><p>Keloid is a fibroproliferative skin disorder characterized by fibroblast hyperproliferation and excessive extracellular matrix (ECM) deposition. Astragalin (AST) is a bioactive natural flavonoid with multiple pharmacological properties. This study aims to investigate the effect of AST on keloid formation in vitro. Primary keloid fibroblasts (KFs) and normal fibroblasts (NFs) were isolated from human keloid tissues and normal skin tissues, respectively, and treated with or without AST. MTT, colony formation, and Transwell assays were utilized to evaluate AST’s effect on fibroblast proliferation, migration, and invasiveness. Western blotting was implemented for detecting protein levels of ECM components and mitogen-activated protein kinases (MAPKs). The results showed that AST treatment hindered the proliferative, migratory, and invasive capacities of KFs and NFs, and KFs were more sensitive to AST than NFs. AST restrained ECM deposition and inactivated the MAPK signaling pathway in KFs and NFs. In conclusion, AST suppresses the invasive growth of keloid fibroblasts probably by inactivating MAPK signaling.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous psoriasis and current treatments: a review of the literature","authors":"S. Minhaj Rahman,&nbsp;Omar Alani,&nbsp;Aasheen Qadri,&nbsp;Fahad Ahmed,&nbsp;Adel Haque","doi":"10.1007/s00403-025-04085-2","DOIUrl":"10.1007/s00403-025-04085-2","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04085-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedling with autologous platelet rich fibrin versus microneedling with autologous platelet rich plasma in treatment of abdominal stretch marks: a randomized comparative study","authors":"Asmaa Ehab Mohamed Ahmed,&nbsp;Wafaa Afify Mahmoud,&nbsp;Fatma Badr Youssef El-Komy","doi":"10.1007/s00403-025-04135-9","DOIUrl":"10.1007/s00403-025-04135-9","url":null,"abstract":"<div><p>Striae distensae (SD), commonly known as stretch marks, are a common dermatological condition with challenging therapeutic interventions and varying outcomes. The current study aims to compare the clinical response, efficacy, side effects, and safety of microneedling (MN) with autologous platelet-rich fibrin (PRF) versus MN with autologous platelet-rich plasma (PRP) in treating abdominal stretch marks. Thirty patients (27 females and 3 males) with bilateral abdominal SD were underwent both MN with PRP and MN with PRF in a randomized split-abdomen design, with session performed every month for a total of three sessions. Clinical efficacy was assessed by two independent dermatologists using the Davey score, the Global Aesthetic Improvement Scale (GAIS), measurement of the width of widest striae, and patient satisfaction score. Blinded evaluation was conducted by comparing pre- and post-treatment photographs. 3-mm punch biopsy specimens were taken from the same lesion sites pre-treatment and one month after the last session and were stained by hematoxylin and eosin (H&amp;E) to subjectively assess histopathological changes and treatment efficacy. Both treatment modalities induced significant clinical improvement with PRF sides demonstrating superior results. However, when comparing both methods, no statistically significant difference was observed between them regarding Davey score, width of the widest striae, GAIS, and patient satisfaction. In conclusion: The combination of MN with PRF appears to be a promising therapeutic modality with better patient satisfaction compared to MN with PRP in the treatment of SD. Moreover, PRF is inexpensive, simple to produce and is made naturally without the need of biochemical additives.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and experimental aspects of tirbanibulin treatments","authors":"Annabel Shen,&nbsp;Rebecca A. Simonette,&nbsp;Peter L. Rady,&nbsp;Stephen K. Tyring","doi":"10.1007/s00403-025-04119-9","DOIUrl":"10.1007/s00403-025-04119-9","url":null,"abstract":"<div><p>Tirbanibulin is a topical medication approved in 2020 as a 5 day topical treatment for actinic keratosis, a precancerous skin lesion characterized by the hyperproliferation of atypical keratinocytes. Tirbanibulin exerts its effects through dual mechanisms: microtubule inhibition, which disrupts cell division, and Src kinase inhibition, which interferes with cancer-associated signaling pathways. Although its primary use is in AK, these mechanisms suggested potential therapeutic applications in a broader range of epithelial cancers. In this literature review, we explored tirbanibulin’s application in not only actinic keratosis, but also in squamous cell carcinoma and basal cell carcinoma. We addressed the relevant findings obtained in recent papers to evaluate tirbanibulin’s safety, efficacy, side effects, real-life clinical experiences, and its potential in anti-aging and skin lightening therapies on patients. In summary, we highlighted the preclinical and clinical evidence on the use of tirbanibulin as an effective and safe treatment option beyond AK.</p><div><figure><div><div><picture><source><img></source></picture></div><div><p>Graphical Abstract</p></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}