Archives of Dermatological Research最新文献

{"title":"Development and preliminary validation of the skin checking and avoidance behaviors scale in pemphigus vulgaris","authors":"Marney A. White,&nbsp;Donna A. Culton,&nbsp;Kristina Seiffert-Sinha,&nbsp;Animesh A. Sinha,&nbsp;Mary M. Tomayko","doi":"10.1007/s00403-026-04969-x","DOIUrl":"10.1007/s00403-026-04969-x","url":null,"abstract":"<div><p>Patients with the autoimmune blistering disease pemphigus vulgaris (PV) often experience significant health anxiety about the disease recurring or worsening. We theorized that anxiety about PV manifests with cognitive and behavioral pathologies, including skin checking and avoidance behaviors. To assess maladaptive checking and avoidance in PV patients, we developed and validated the Skin Checking and Avoidance Behavior Scale (SCABS). Items were generated with input from patients and specialist physicians. A sample of 160 participants with PV completed the SCABS and measures of depression, anxiety, and fear of disease recurrence. Psychometric analyses included exploratory factor analysis, interitem reliability analyses, correlations, and analysis of variance to evaluate the scale construct validity. Face and content validity were established through participant and expert ratings for each item. Exploratory factor analysis identified three subscales (Checking and Worrying, Contact Avoidance, and Ingested and Situational Avoidance). All subscales demonstrated strong interitem reliability. The subscale and total scores were associated with remission status, depression, anxiety, fear of recurrence, and occupational impairment, supporting the construct validity of the scale. The Skin Checking and Avoidance Behaviors Scale was developed to measure clinically significant psychological distress in PV patients. Our comprehensive review of the extant literature indicated that regular mental health screening is recommended for patients with PV, yet few disease-specific tools exist. The SCABS may be used to identify impairing checking and avoidance behaviors, and to determine when psychosocial intervention is most likely to benefit patients living with PV.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding access to biologics: a pilot ECHO program for primary care providers","authors":"Matthew Helm,&nbsp;Jordan Willis,&nbsp;Thomas N. Helm,&nbsp;Kelly Gerard,&nbsp;Galen Foulke","doi":"10.1007/s00403-026-04976-y","DOIUrl":"10.1007/s00403-026-04976-y","url":null,"abstract":"<div><p>The Extension for Community Healthcare Outcomes (ECHO) program is a teleteaching model connecting academic medical centers with primary care providers (PCPs) in underserved areas through virtual learning. This pilot study aimed to assess whether ECHO could effectively train rural PCPs on dermatologic biologic indications, management, side effects, and prescription assistance programs and serve as a method to increase access to care. A pre-recruitment survey was used to determine feasibility of the program. Eight PCPs were recruited via flyers and email to participate in an eight-session, continuing medical education (CME)-accredited series. Sessions featured 20-minute talks on topics like biologic classes, indications, and prior authorization strategies, followed by case-based discussions. Post-session surveys assessed changes in PCPs’ self-reported knowledge, patient care ability, plans to make changes in their practice, and sense of professional isolation regarding biologic use and feedback on the sessions. Post-session self-reported responses showed increase in knowledge of biologics, improvement of patient care ability, plans to make changes in their practice, and a decreased sense of professional isolation. This pilot study shows that the ECHO model could be utilized to educate PCPs on dermatologic biologics and may increase access to specialty medications in underserved communities.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation characteristics, safety, and accessibility of conditioners for textured hair","authors":"Aaliyah Bourne,&nbsp;Victoria Palmer,&nbsp;Amy McMichael","doi":"10.1007/s00403-026-04949-1","DOIUrl":"10.1007/s00403-026-04949-1","url":null,"abstract":"<div><p>Textured hair, characterized by curved follicular architecture and increased mechanical fragility, requires tailored conditioning strategies to maintain hair and scalp health. Hair conditioners are widely used among individuals with textured hair; however, systematic evaluation of their formulation characteristics, safety profiles, and accessibility remains limited. This cross-sectional analysis evaluated the ingredient composition, functional chemistry, safety considerations, and retail accessibility of 31 conditioners marketed for textured hair. Products were drawn from the 20 conditioner brands most frequently mentioned by Black consumers in Mintel’s <i>Black Haircare–US–2024</i> report and comprised 13 deep and 18 leave-in products. Ingredients were classified using the European Commission Cosmetic Ingredient Database and International Nomenclature of Cosmetic Ingredients frameworks. Safety evaluation used the 2020 American Contact Dermatitis Society (ACDS) Core Allergen Series and published chemical-of-concern lists addressing endocrine disruption, asthma, and carcinogenicity. Compared with leave-in products, deep conditioners contained higher densities of quaternary ammonium conditioning agents (mean 2.6 vs. 2.3 ingredients per product) and culturally relevant emollients (5.3 vs. 3.3). Leave-in conditioners more frequently incorporated silicones (66.7% vs. 53.8%), while film-forming agents and hydrolyzed proteins were uncommon in both categories. Every product contained at least two label-declared chemicals of concern or allergens, with a mean of 5.9 per formulation. Fragrance (93.5%), cetearyl alcohol (87.1%), phenoxyethanol (58.1%), and benzyl alcohol (41.9%) were most prevalent, but these are relatively infrequent causes of allergic contact dermatitis. Of greater clinical relevance, stearamidopropyl dimethylamine—the amidoamine included in the ACDS series—was identified in 38.7% of products, and methylisothiazolinone and methylchloroisothiazolinone in 12.9% each. Over 80% of products were priced more than 50% above the national per-ounce average, and 51.6% showed limited retail accessibility. Because labels do not disclose concentrations, these findings constitute hazard identification rather than risk estimation; within that constraint, conditioners marketed for textured hair frequently contain potential sensitizers and show formulation characteristics that do not consistently align with marketed function. Ingredient-level counseling accounting for composition, cumulative exposure, and accessibility is essential when guiding patients with textured hair.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04949-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome‑based interventions for treatment of atopic dermatitis—a mini review","authors":"Xiaoqian Cui,&nbsp;Chaofan Li,&nbsp;Hailong Zhang,&nbsp;Xingxing Yuan","doi":"10.1007/s00403-026-04926-8","DOIUrl":"10.1007/s00403-026-04926-8","url":null,"abstract":"<div><p>The gut microbiome has emerged as a central regulator of immune homeostasis and skin health through the gut–skin axis, a communication network linking intestinal microbes with distant organs. In atopic dermatitis (AD), a chronic inflammatory skin disease affecting millions worldwide, accumulating evidence implicates gut dysbiosis in disease pathogenesis and severity. This mini-review provides a comprehensive and critical synthesis of current knowledge regarding the role of the gut microbiome in AD, with a focus on mechanistic pathways, clinical evidence for microbiome-targeted interventions, and future research priorities. A systematic literature search was conducted in PubMed, Web of Science, and Scopus for studies published between January 2016 and March 2025; 1,247 unique records were identified, and 69 studies met inclusion criteria. Key mechanisms by which gut microbial composition influences AD include the production of immunomodulatory metabolites such as short-chain fatty acids (SCFAs) and tryptophan derivatives, regulation of regulatory T cell (Treg) differentiation and Th1/Th2 balance, maintenance of intestinal and skin epithelial barrier integrity, and modulation of neuroimmune interactions underlying pruritus. Clinical studies of probiotics, prebiotics, synbiotics, postbiotics, dietary modifications, and fecal microbiota transplantation are reviewed with particular attention to study design, sample size, effect sizes, risk of bias, and reproducibility. High-quality randomized controlled trials support the adjunctive use of specific probiotic strains; notably <i>Lacticaseibacillus rhamnosus</i> GG (1 × 10^10 CFU/day) and <i>Bifidobacterium bifidum</i>, in pediatric AD, with modest but statistically significant improvements in SCORAD scores and quality of life. However, evidence for other strains and for prebiotics, synbiotics, and dietary interventions remains limited, heterogeneous, and often preliminary. Important knowledge gaps include optimal strain selection, dosing, treatment duration, long-term safety, and mechanistic biomarkers of response. The review concludes with expert recommendations for future research, emphasizing the need for well-powered, long-term randomized controlled trials with standardized outcomes, multi-omics integration, and personalized approaches based on age, genetics, and baseline microbial composition. While gut microbiome modulation is not yet ready to replace conventional AD therapies, it represents a promising complementary strategy that warrants continued rigorous investigation.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of five large language models on board-style dermatology questions from the American Board of Dermatology","authors":"Rose Rasty,&nbsp;Elyse Mackenzie,&nbsp;Shaunt Mehdikhani,&nbsp;Babar Rao","doi":"10.1007/s00403-026-04894-z","DOIUrl":"10.1007/s00403-026-04894-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidradenocarcinoma: a narrative review of treatment with Mohs micrographic surgery","authors":"Abhinav Janappareddi,&nbsp;Deepika P. Kamineni,&nbsp;Parveer Kaur,&nbsp;Courtney L. Collins,&nbsp;Lanah Almatroud,&nbsp;Miguel Skyler Verzosa,&nbsp;Andrew Oh,&nbsp;Sai Anusha Sanka,&nbsp;Amritpal Kooner,&nbsp;Leo Wan,&nbsp;Nihal Bondugula,&nbsp;Eli Engledow","doi":"10.1007/s00403-026-04955-3","DOIUrl":"10.1007/s00403-026-04955-3","url":null,"abstract":"<div><p>Wide local excision (WLE) is the most commonly reported treatment for hidradenocarcinoma (HAC). Recurrence rates of HAC treated with WLE range from 10 to 50%. A limited number of cases have reported on Mohs micrographic surgery (MMS) as an alternative treatment modality. We conducted a narrative review of the literature using PubMed and Scopus to identify seven studies published from 2004 to 2021 that reported outcomes of HAC treated with MMS. Among 18 documented MMS-treated HAC cases, no recurrences or metastases were reported. However, the generalizability of current findings is limited by the existing literature. These findings highlight the need for larger, controlled studies to better define the role of MMS in the management of HAC, either as a sole treatment modality or in combination with adjunct therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional analysis of the distribution of dermatologists in the appalachian region using the national plan and provider enumeration system national provider identifier registry","authors":"Jacob Fay,&nbsp;Natasha Salmen,&nbsp;Victor Lufi,&nbsp;Sanjana Nallapaneni,&nbsp;Eliot Mostow","doi":"10.1007/s00403-026-04903-1","DOIUrl":"10.1007/s00403-026-04903-1","url":null,"abstract":"<div><p>Appalachian communities face health disparities due to geographic, socioeconomic, and physician access limitations. Limited dermatologic care in these areas may contribute to poor health outcomes. The primary objective of this study was to assess the distribution of dermatologists across Appalachia using the National Plan and Provider Enumeration System (NPPES) National Provider Identifier Registry and the Appalachian Regional Commission’s (ARC) interactive mapping tool. Secondary objectives included identifying barriers to dermatologic care and suggesting potential solutions. Dermatologists were identified by taxonomy and zip code and mapped to 423 Appalachian counties across 13 states. A total of 870 dermatologists were identified. The ARC divides Appalachia into five subregions: North, North Central, South, South Central, and Central. Pennsylvania reported the highest number (n=238), and Mississippi the lowest (n=10) across 24 counties. Overall, 277 counties (65.5%) lacked any dermatologists. County dermatologist density was median 0.00 per 100,000 (IQR 0.00–2.01). Aggregated subregional density ranged from 4.27 per 100,000 in South Central Appalachia to 1.41 per 100,000 in Central Appalachia. The 10 counties with the most dermatologists contained 409/870 (47.0%). Distressed counties were more likely to have no dermatologist (70/77 [90.9%]) than competitive (4/14 [28.6%]) or attainment counties (0/3 [0%]). Data were based on primary addresses from the NPPES registry, which may not reflect actual practice locations. The study’s design limits assessment of workforce changes over time. Appalachia faces a significant shortage and uneven distribution of dermatologists, with most counties lacking access to care. Expanded service models (e.g., teledermatology and outreach) and targeted workforce planning in persistently underserved counties may improve access to dermatologic care in Appalachia.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory skin disorders in polycystic ovary syndrome: a retrospective cohort study","authors":"Amit Singal,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-026-04962-4","DOIUrl":"10.1007/s00403-026-04962-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum and tissue levels of pigment epithelium-derived factor (PEDF) in patients with psoriasis vulgaris","authors":"Amr Abdelhamed,&nbsp;Sahar M. Gebril,&nbsp;Soheir Abdel-Hamid,&nbsp;Omnia A. Abdel Hafez,&nbsp;Ramadan Saleh","doi":"10.1007/s00403-026-04887-y","DOIUrl":"10.1007/s00403-026-04887-y","url":null,"abstract":"<div><p>Psoriasis is a chronic inflammatory condition that is linked to increased interaction between inflammatory mediators. Additionally, pigment epithelium-derived factor (PEDF), a neurotrophic factor that inhibits angiogenesis, has been found in higher concentrations in the sera of psoriasis patients. This study aimed to evaluate serum and tissue PEDF levels in patients with psoriasis vulgaris and to assess the relationships between PEDF levels and the Psoriasis Area and Severity Index (PASI) score and Metabolic Syndrome (MetS). This cross-sectional study included 26 psoriasis vulgaris patients and 26 healthy controls. Patients were evaluated for the PASI score and MetS. In addition, ELISA and immunohistochemical analyses were performed to assess PEDF levels in blood and tissue. Psoriatic cases showed a non-significant decrease in median (range) serum PEDF level of 21.5 (13–162) compared with the control group of 22.2 (7-193) (<i>p</i> = 0.261). There was a significant reduction in the tissue expression of PEDF in lesional skin 1.4 (0.5–2.2) as compared to\"peri-lesional skin” 5 (2-5.5) in the psoriatic group (<i>p</i> &lt; 0.001) and the control group 5.8 (5.7–7.3) (<i>p</i> &lt; 0.001). Serum/tissue levels of PEDF expression in patients with psoriasis vulgaris were neither correlated with PASI score nor with MetS (<i>p</i> &gt; 0.05). Psoriasis tissue has lower median PEDF expression than “peri-lesional skin” and control skin. However, there was no relationship between serum or tissue PEDF levels and PASI score or the presence or absence of MetS in psoriatic patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding access and education: the Rural Access to Dermatology Society (RADS) Virtual Symposium showcasing student research in rural dermatology","authors":"Natasha L. Salmen,&nbsp;Mary E. Logue","doi":"10.1007/s00403-026-04959-z","DOIUrl":"10.1007/s00403-026-04959-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}