Archives of Dermatological Research最新文献

{"title":"Microfluidic preparation of porous polycaprolactone microspheres as dermal fillers with enhanced collagen secretion","authors":"Jintao Zhang,&nbsp;Yijing Li,&nbsp;Jiacheng Ye,&nbsp;Lian Cen","doi":"10.1007/s00403-026-04944-6","DOIUrl":"10.1007/s00403-026-04944-6","url":null,"abstract":"<div><p>Microsphere-based dermal fillers were emerged as effective therapeutic agents for dermal volume restoration. This study aimed to develop a microfluidic technology to prepare poly(ε-caprolactone) (PCL) microspheres with porous morphology, and to investigate how the surface porosity of microspheres as dermal fillers rendered regulatory effects on collagen regeneration and inflammatory response of human skin fibroblasts (HSFs). Droplet-based microfluidic technology was employed to fabricate PCL microspheres and tridecane was used as a porogen to construct the porous architecture. The effect of flow rate ratios on particle size was investigated. The impacts of microspheres with porous and compact surface morphology (PM and SM) on HSF’s proliferation, type I collagen (COL-I) and type Ⅲ collagen (COL-III) secretion, interleukin-6 expression were evaluated. It was shown that monodisperse PM and SM of around 49 μm were successfully fabricated via droplet-based microfluidic technology. Their size could be precisely controlled by flow rate ratios. Porosity of PM was 78.19%. Both PM and SM exhibited excellent biocompatibility with HSFs and effectively promoted their proliferation and collagen synthesis in vitro, with PM significantly outperforming SM at a same concentration. The optimal microsphere concentration for promoting collagen secretion was identified as 0.5 mg/mL. Additionally, interleukin-6 (IL-6) expression in HSFs was progressively upregulated with the treatment of PM and SM, and minor enhancement of PM over SM on IL-6 expression was noticed. This study not only explained why the incorporation of microspheres promoted volume restoration of skin to delay aging, but also provided PM of superior functionality as a dermal filler as well as detailed microfluidic manufacturing technology.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adult red blood cell width to albumin ratio (RAR) and psoriasis: a retrospective cross-sectional study","authors":"Ao Gao,&nbsp;Zongyan Wei,&nbsp;Xueying Ye,&nbsp;Wenming Shao,&nbsp;Yunfeng Hu","doi":"10.1007/s00403-026-04922-y","DOIUrl":"10.1007/s00403-026-04922-y","url":null,"abstract":"<div><p>This study aims to investigate the association between the red blood cell distribution width-to-albumin ratio (RAR), a biomarker reflecting systemic inflammation and nutritional status, and psoriasis prevalence in a nationally representative U.S. population. Cross-sectional data from 11,668 adults in the National Health and Nutrition Examination Survey (NHANES) (2003–2006 and 2009–2014) were analyzed. Psoriasis was defined by self-reported clinician diagnosis. RAR was calculated as red cell distribution width (RDW) (%) divided by serum albumin (g/dL). Multivariable logistic regression models were used, and Restricted Cubic Spline (RCS) analysis was performed to assess the potential linear relationship. Additionally, subgroup and sensitivity analyses were conducted to evaluate the robustness of the findings. Of the 11,668 adults included in the study, 280 were diagnosed with psoriasis. Elevated Ln-transformed RAR (ln-RAR) was independently associated with higher psoriasis prevalence (fully adjusted Odds ratios, OR = 3.57, 95% CI: 1.37–8.92, <i>P</i> = 0.003). A linear dose-response relationship was confirmed (<i>P</i> for non-linearity &gt; 0.05) in RCS. In the subgroup analysis, effect size of RAR on the presence of psoriasis in subgroups was stable (all <i>P</i> values &gt; 0.05). The sensitivity analysis was consistent with the main results, further supporting the stability of our conclusion. RAR is a potential biomarker that shows positive correlation with the prevalence of psoriasis, with a linear association. Further prospective studies are needed to confirm these findings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse kinetics of actinic keratoses after field treatments with adjuvant cryosurgery: a retrospective study of cases with variable follow-up times","authors":"Despina Exadaktylou,&nbsp;Panagiota Chroni,&nbsp;Sotiria Stefaniotou,&nbsp;Panagiota Spyridonos,&nbsp;Georgios Gaitanis,&nbsp;Ioannis D. Bassukas","doi":"10.1007/s00403-026-04931-x","DOIUrl":"10.1007/s00403-026-04931-x","url":null,"abstract":"<div><p>To date all treatments for cutaneous field cancerization (CFC) offer only transient improvement; hence. time-to-relapse is crucial for planning CFC treatment. Yet, respective data is scarce in the literature. This retrospective chart-review study exploited the unintentional prolongation of the follow up time of patients treated for CFC during the COVID-19 pandemic to compare relapse kinetics after cryosurgery only (cryo) or cryosurgery combined with either daylight-PDT (cryoPDT) or topical imiquimod (cryoIMQ). Only data of the first-after-treatment evaluation per therapy cycle is eligible for analysis. Follow up times were calculated from the day of the cryosurgery session (treatment initiation). Modified AKASI scores, constrained to the treated head subregions, were applied to measure disease burden and AKASI change-from-baseline to quantify the therapeutic effect. Wilcoxon and Kruskal-Wallis tests were calculated for continuous data and Kaplan-Meier and Cox methods for time-to-event data analysis at two-tailed probability level <i>p</i> &lt; 0.05 to indicate statistical significance. <i>N</i> = 116 treatment cycles of head-located CFC regions (83 scalp, 26 forehead, 7 cheek) from <i>N</i> = 30 patients (27 men; median age: 81 years) were included. Forty treatment cycles were cryosurgery monotherapy, 27 cryoPDT and 49 cryoIMQ. The lockdowns resulted into a prominent, modality-independent, variation of the times to first follow-up (range: 28–1379 days). There was an initial significant CFC improvement only with the field modalities (<i>p</i> = 0.001 and <i>p</i> = 0.012 for cryoPDT and cryoIMQ, respectively), which, however, vanished with increasing follow-up time. Moreover, both combinational modalities were significantly superior to monomodal cryosurgery. The mean duration of the therapeutic effect (months [95% confidence intervals], ) was with 14.15 [9.94–18.37] significantly longer for the cryoIMQ compared to cryosurgery monotherapy (8.34 [5.21, 11.48], <i>p</i> = 0.007) and to cryoPDT (8.53 [4.16, 12.90]; <i>p</i> = 0.032; Kaplan-Meier). Main limitations of our study are the small number of patients/treatment cycles, and that the data is collected from a single setting. In conclusion, CFC treatment with the combination of four weeks imiquimod after mild cryosurgery seems to confer a significantly longer lasting therapeutic effect, compared to a corresponding combination of cryosurgery with daylight-PDT.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current impact and future outlook of artificial intelligence among American College of Mohs Surgery members","authors":"Omeed Modiri,&nbsp;Olivia McGeough,&nbsp;Alexandra Elder,&nbsp;Courtney Ensslin,&nbsp;Jesse M. Lewin","doi":"10.1007/s00403-026-04791-5","DOIUrl":"10.1007/s00403-026-04791-5","url":null,"abstract":"<div><p>Artificial intelligence (AI) is increasingly prevalent in healthcare and is becoming integrated into various aspects of clinical practice. However, its current utilization in dermatologic surgery remains unclear. Understanding the role and perceptions of AI is important for its safe and effective implementation. This study assesses the current scope of AI use among Mohs surgeons and explores perceptions regarding its benefits, risks, and potential role in dermatologic surgery. An anonymous 12-question survey was distributed to members of the American College of Mohs Surgery (ACMS). Statistical analysis was performed using Fisher’s exact tests, with <i>p</i> &lt; 0.05 considered statistically significant. Thirty-six surveys were completed. Overall, 42% reported prior use of AI tools and 67% of all participants indicated they were likely to incorporate AI into their clinical practice within two years. ChatGPT was the most frequently used platform (96%), followed by OpenEvidence (30%), and Gemini (22%), with limited use of custom AI models. Mohs surgeons with fewer than five years in practice were 2.83 times more likely to report having used AI tools compared with those with more than five years in practice, although this difference was not statistically significant (<i>p</i>=0.21). The most frequently perceived benefits of AI in dermatologic surgery were increased efficiency (76%) and reduced administrative burden (62%). Primary concerns related to AI use were centered around the potential for inaccurate or unreliable information (86%), patient safety and liability (54%), and dehumanization of care (49%). While 72% of participants believed AI will change the practice of dermatologic surgery over the next 5–10 years, only 39% reported feeling any degree of comfort with the use of AI-assisted tools to guide surgical margins or repairs. Regarding the impact of AI on patient outcomes in dermatologic surgery, 50% believed AI would lead to improvement, 19% expected a neutral effect, 25% were unsure, and 6% anticipated harm. Our study demonstrates dermatologic surgeons’ growing interest in integrating AI into clinical practice, particularly for workflow support, yet they express concern about its limitations and potential risks in surgical decision-making. Study limitations include a low response rate, sampling bias, and recall bias, which are inherent to survey-based studies. Larger studies are needed to validate these findings. Further research and standardized guidelines evaluating responsible AI use are important for its safe and effective implementation in healthcare.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical and follow-up data in patients with mycosis fungoides: a 10-year single-centre experience","authors":"Burhan Engin,&nbsp;Gurbuz Yildirim,&nbsp;Yusuf Can Erkoc","doi":"10.1007/s00403-026-04943-7","DOIUrl":"10.1007/s00403-026-04943-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in fee-for-service medicaid participation in Mohs micrographic surgery","authors":"Ross O’Hagan,&nbsp;Olivia McGeough,&nbsp;Jesse M. Lewin","doi":"10.1007/s00403-026-04876-1","DOIUrl":"10.1007/s00403-026-04876-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Hailey–Hailey disease: Short report","authors":"Olivia Katamanin,&nbsp;Julia M. Riley,&nbsp;Kelsey S. Flood","doi":"10.1007/s00403-026-04961-5","DOIUrl":"10.1007/s00403-026-04961-5","url":null,"abstract":"<div><p>Hailey–Hailey disease (HHD) is a rare autosomal dominant disease caused by mutations in <i>ATP2C1</i>. Features include recurrent vesicles and erosions involving intertriginous areas. HHD commonly presents in adulthood; early onset cases, i.e. those occurring before 13 years of age, remain poorly characterized. The objective of this brief report is to synthesize the literature on pediatric-onset HHD, focusing on clinical presentation, histologic findings, and management. A scoping review was conducted using PubMed and Google Scholar including the search terms “Hailey–Hailey disease,” “familial benign chronic pemphigus,” “pediatric,” and “child.” Eligible studies included case reports, case series, and clinical studies. Variables collected included age, gender, clinical and histopathologic features, anatomic distribution, and treatments. Eight published reports describing nine pediatric patients were included. The mean age at symptom onset was 2.6 years (median: 6 months) and mean age at presentation was 4.7 years (median: 4.5 years). Patients presented with recurrent vesiculobullous or erosive eruptions with pruritus, irritation, and pain. Histopathology revealed intraepidermal acantholysis with a “dilapidated brick wall\" appearance. Management strategies included topical corticosteroids, topical antifungals, topical and systemic antibiotics, and topical calcineurin inhibitors, with mixed outcomes. Some cases reported spontaneous resolution or symptomatic improvement with conservative management. In summary, pediatric onset of HHD is a rare acantholytic dermatosis with features similar to that of adult-onset disease. Challenges include delays in diagnosis and the lack of definitive treatment guidelines for the pediatric population.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound and shear-wave elastography as a tool for evaluating response to treatment of morphea: a preliminary report of a prospective study","authors":"Faezeh Khorasanizadeh,&nbsp;Mohamad Amin Sharifi,&nbsp;Seyed Mohammad Vahabi,&nbsp;Mahshid Sadat Ansari,&nbsp;Narges Ghandi,&nbsp;Fatemeh Hosseini,&nbsp;Ifa Etesami,&nbsp;Ximena Wortsman","doi":"10.1007/s00403-026-04919-7","DOIUrl":"10.1007/s00403-026-04919-7","url":null,"abstract":"<div><p>Morphea is an autoimmune connective tissue disorder with no established objective biomarkers for treatment monitoring. Due to the subjectivity of current clinical scoring systems, this study investigates the efficacy of grayscale ultrasound, color Doppler, and shear-wave elastography (SWE) in assessing treatment response and correlating with clinical scores. In this prospective cohort study newly biopsy-confirmed patients with at least one clinically active plaque were followed for 6 months by Color Doppler ultrasound, shear wave elastography, and clinical scoring. The most clinically probable active lesion in each patient was marked and compared to adjacent or contralateral normal skin as control. Eighteen patients with Plaque-type/linear morphea were examined. After six months, dermal thickness as well as mean clinical scores decreased significantly (<i>p</i> &lt; 0.05), while hypodermal thickness decreased and elasticity slightly increased, but it was not significant (<i>p</i> &gt; 0.05). Localized Scleroderma Activity Index (LoSAI) and Localized Scleroderma Damage Index (LoSDI) decreased from 4.28 ± 3.28 to 1.44 ± 1.75 and 11.39 ± 7.38 to 9.56 ± 6.77, respectively. Hypodermal thickness correlated negatively with Physician Global Assessment of Damage (PGA-D) (<span>(:rho:)</span>=-0.410, <i>p</i> = 0.027) and positively with LoSAI (<span>(:rho:)</span> =0.513, <i>p</i> = 0.004). Additionally, hypodermis thickness was positively correlated with PGA-A before treatment. Furthermore, hypodermal stiffness after treatment was positively correlated with LoSDI. In terms of disease activity assessments, SWE and color Doppler showed poor inter-rater agreement between radiologists and dermatologists (kappa = 0.053). In this preliminary study (<i>N</i> = 18), dermal thickness measured via high-frequency ultrasound may serve as an objective marker for treatment response in morphea. While color Doppler and shear wave elastography (SWE) demonstrated potential as adjunctive tools, their clinical utility remains exploratory and requires validation in larger cohorts.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of autoimmune thyroid disorders in vitiligo patients: a large-scale multi-center retrospective cohort study using a national database","authors":"Rahib K. Islam,&nbsp;Andrew J. Malek,&nbsp;Kazi N. Islam,&nbsp;Collins T. Langley,&nbsp;Christopher J. Haas","doi":"10.1007/s00403-026-04960-6","DOIUrl":"10.1007/s00403-026-04960-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A geospatial investigation of travel-time access inequities to medicare-participating dermatologists among U.S. adults aged 65+","authors":"Clayton Frazier,&nbsp;Congcong Miao,&nbsp;Megan S. Evans,&nbsp;Nathaniel Gonzales,&nbsp;Emily Frazier","doi":"10.1007/s00403-026-04920-0","DOIUrl":"10.1007/s00403-026-04920-0","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}