Archives of Dermatological Research最新文献

{"title":"Increase in utilization of 5-fluorouracil and imiquimod for actinic keratoses: analysis of US visits from 1995-2019","authors":"Brad R. Woodie, Muayad M. Shahin, Alan B. Fleischer Jr","doi":"10.1007/s00403-025-04186-y","DOIUrl":"10.1007/s00403-025-04186-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of fungal infection in psoriasis patients treated with IL-17 and IL-23 inhibitors: a multi-cohort study using real-world data","authors":"Rahib K. Islam, Alexander Maltese, Shari R. Lipner","doi":"10.1007/s00403-025-04188-w","DOIUrl":"10.1007/s00403-025-04188-w","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of cutaneous microvascular complications in patients with diabetic kidney disease: a retrospective TriNetX analysis","authors":"Katherine Benandi, Kristin Wolf","doi":"10.1007/s00403-025-04199-7","DOIUrl":"10.1007/s00403-025-04199-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium–glucose cotransporter 2 inhibitors and bullous pemphigoid risk in US and global population: real world evidences","authors":"Hui-Chin Chang, Tsu-Man Chiu, Yi-Sheng Jhang, Shiu-Jau Chen, Yu-Jung Su, Meng-Che Wu, Shuo-Yan Gau","doi":"10.1007/s00403-025-04213-y","DOIUrl":"10.1007/s00403-025-04213-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-coding RNAs (miRNAs – circRNAs - lncRNAs) and genes interact with the regulation of vitiligo","authors":"Ahmed Ibrahim AbdElneam,&nbsp;Ghada Farouk Mohammed","doi":"10.1007/s00403-025-04113-1","DOIUrl":"10.1007/s00403-025-04113-1","url":null,"abstract":"<div><p>Vitiligo is a chronic skin disorder characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The molecular mechanisms underlying vitiligo remain incompletely understood, with recent studies highlighting the role of non-coding RNAs in disease pathogenesis. To identify and analyze the roles of miRNAs, (circular RNAs) circRNAs, and (long non-coding RNAs) lncRNAs in the pathogenesis of vitiligo, focusing on their interactions with key coding genes and pathways. We utilized Microarray data from the GSE65127 and GSE75819 datasets in the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) related to Vitiligo. The analysis was conducted using GEO2R for identifying upregulated and downregulated genes. Protein-protein interaction (PPI) networks were constructed using STRING and further analyzed with Cytoscape and CytoHubba. Gene Ontology (GO), disease pathways, Disease gene associations, and phenotypes are determined by many online software. miRNAs and cirRNas, lncRNAs were predicted using bioinformatics tools. The constructed network identified AKT1 as a central hub, hsa-miR-140-3p assumes a critical role by interacting with both AKT1 and CTSD, while circRNAs such as hsa_circ_0020776, hsa_circ_0033552, and hsa_circ_0020773 significantly modulate these interactions. Also, hsa-miR-921 is highly effective in binding to AKT1, as well as to hsa_circ_0033546 and hsa_circ_0033547. lncRNAs, including AFAP1-AS1 and MALAT1, contribute to the network by establishing connections with the mRNA of target genes. we determined two genes, two miRNAs, and 5 circRNAs may serve as potential biomarkers or therapeutic targets for vitiligo.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topical tacrolimus 0.03% ointment in combination with microneedling versus topical phenytoin 2% cream in combination with microneedling for the treatment of non-segmental facial vitiligo","authors":"Rabab Khaled Abdelaziz,&nbsp;Hassan Abou Khodair Mohammed,&nbsp;Ibrahim Fouda","doi":"10.1007/s00403-025-04070-9","DOIUrl":"10.1007/s00403-025-04070-9","url":null,"abstract":"<div><h3>Aim of the study</h3><p>To evaluate the efficacy and safety of microneedling combined with tacrolimus 0.03% ointment versus microneedling combined with phenytoin 2% cream in the treatment of non-segmental facial vitiligo.</p><h3>Materials and methods</h3><p>This was a prospective single-blinded randomized clinical trial conducted on a total of 40 patients with non-segmental facial vitiligo, who were distributed into two groups (each of 20 patients); group I (<i>n</i> = 20) were treated with microneedling combined with tacrolimus 0.03% ointment and group II (<i>n</i> = 20) treated with microneedling combined with phenytoin 2% cream. The approach was conducted for another time every 14 days for all cases for over a period of 6 months, then the cases were followed up for three months following the termination of the treatment sessions.</p><h3>Results</h3><p>There were no statistically significant differences recorded between both groups in regard to all demographic data and disease characteristics (<i>P</i> &gt; 0.05). As regards to clinical improvement, microneedling combined with tacrolimus 0.03% ointment was associated with a superior improvement compared to microneedling combined with phenytoin 2% cream, nevertheless, this improvement was not statistically significant. Also, microneedling combined with tacrolimus was associated with a higher patient satisfaction compared to microneedling combined with phenytoin 2% cream, however, this improvement was not associated with statistical significance.</p><h3>Conclusion</h3><p>Our results provide additional evidence for the potential positive role of phenytoin as a therapeutic option in patients with non segmental vitiligo. However, tacrolimus 0.03% ointment combined with microneedling was associated with a better response than phenytoin 2% cream combined with microneedling.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the treatment compliance of patients with androgenetic alopecia and its influencing factors: based on the comparison between microneedle therapy and drug therapy","authors":"Xiaojin Wu,&nbsp;Yanli Tang,&nbsp;Ningning Shen,&nbsp;Zhongyun Wang","doi":"10.1007/s00403-025-04211-0","DOIUrl":"10.1007/s00403-025-04211-0","url":null,"abstract":"&lt;div&gt;&lt;p&gt;The aim of this study is to analyze treatment adherence and its influencing factors in patients with androgenetic alopecia (AGA). Clinical data from 156 AGA patients, including 89 males and 67 females, were collected. The patients were assigned to either medication group (&lt;i&gt;n&lt;/i&gt; = 86) or microneedling group (&lt;i&gt;n&lt;/i&gt; = 70). Treatment adherence was assessed using the Morisky Medication Adherence Scale (MGL). Additional data on the patients’ basic information, annual income, education level, side effects, treatment efficacy, disease severity, and mental health (anxiety and depression) were also recorded. Univariate and multivariate analyses were used to identify factors associated with treatment adherence. The results showed that patients in the microneedling group demonstrated significantly higher treatment adherence compared to those in the medication group (&lt;i&gt;P&lt;/i&gt; = 0.032). Within the microneedling group, adherence was significantly associated with age, education level, annual income, treatment duration, and side effects (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Specifically, patients over the age of 30, those with higher incomes, higher educational levels, and those with treatment durations of less than 3 months exhibited better adherence. Additionally, both treatment efficacy improvement and reduced anxiety were strongly correlated with better adherence (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, &lt;i&gt;P&lt;/i&gt; = 0.010). In the medication group, side effects and treatment efficacy were significant factors influencing adherence (&lt;i&gt;P&lt;/i&gt; = 0.001, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Logistic regression analysis revealed that, within the microneedling group, patients with at least a middle school education or higher (OR = 0.031, &lt;i&gt;P&lt;/i&gt; = 0.035; OR = 0.016, &lt;i&gt;P&lt;/i&gt; = 0.041) and those who experienced improved treatment outcomes (OR = 0.002, &lt;i&gt;P&lt;/i&gt; = 0.006) were more likely to adhere to treatment. On the other hand, the occurrence of side effects significantly increased the likelihood of non-adherence (OR = 92.358, &lt;i&gt;P&lt;/i&gt; = 0.019). Patients with more severe conditions were more likely to adhere to treatment (OR = 0.035, &lt;i&gt;P&lt;/i&gt; = 0.038). In the medication group, those with stable or improved treatment outcomes showed better adherence (OR = 0.004, &lt;i&gt;P&lt;/i&gt; = 0.010; OR = 0.005, &lt;i&gt;P&lt;/i&gt; = 0.012). However, patients with more severe conditions were more likely to discontinue treatment (OR = 204.058, &lt;i&gt;P&lt;/i&gt; = 0.029), and depression was identified as a significant risk factor for non-adherence (OR = 586.074, &lt;i&gt;P&lt;/i&gt; = 0.004). Microneedling therapy demonstrates significant advantages in improving patient adherence, particularly by reducing side effects, enhancing perceived treatment efficacy, and improving mental health. Treatment efficacy and side effects are key determinants of treatment adherence, with patient age, education level, and income also playing an important role. Future studies should further explore the long-term efficacy and safety of microneedling therapy across different patie","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of DNA methylation pattern in the etiology of basal cell carcinoma","authors":"Bita Faam,&nbsp;Sahar Dadkhahfar,&nbsp;Zahra Razzaghi,&nbsp;Mostafa Rezaei Tavirani,&nbsp;Reza M. Robati","doi":"10.1007/s00403-025-04205-y","DOIUrl":"10.1007/s00403-025-04205-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of tumor upstaging following partial biopsy and scouting biopsy in the treatment of melanoma in situ and invasive melanoma with Mohs micrographic surgery: a retrospective cohort study","authors":"Rachael S. Chacko,&nbsp;Payal C. Shah,&nbsp;James X. Feng,&nbsp;Matthew J. Davis,&nbsp;Matthew LeBoeuf","doi":"10.1007/s00403-025-04079-0","DOIUrl":"10.1007/s00403-025-04079-0","url":null,"abstract":"<div><p>Understanding the impact of diagnostic and preoperative biopsy techniques on upstaging risk during treatment of melanoma in situ and invasive melanoma (MIS/IM) with Mohs micrographic surgery (MMS) is important for preoperative counseling and surgical planning. To determine the risk of tumor upstaging associated with partial biopsy and scouting biopsy techniques during MMS treatment of MIS/IM. A retrospective cohort study of 327 patients who underwent MMS for MIS/IM treatment at Dartmouth between March 2020 through January 2024. Binary logistic regression was used to assess the association of diagnostic and scouting biopsy with risk of upstaging. Seven (<i>n</i> = 7/327, 2.1%) patients upstaged during MMS, and four newly qualified for SLNB. Punch biopsy and partial biopsy were significantly associated with tumor upstaging. Upstaged tumors had greater number of MMS stages. Scouting biopsy use led to a 14.0% relative risk reduction in upstaging. A low overall risk of upstaging and SLNB following MMS validates recent data in the literature and supports use of MMS for MIS/IM treatment. As partial and punch biopsy contribute to upstaging risk, dermatologists should consider broad shave biopsies when sampling suspicious pigmented lesions. Preoperative scouting biopsies may be useful in reducing upstaging risk, number of MMS stages, and associated patient morbidity.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of LINC00114 in atopic dermatitis: modulating inflammation and epidermal barrier dysfunction","authors":"Yifeng Sun,&nbsp;Xin Li,&nbsp;Ningning Deng,&nbsp;Tingqi Zhao,&nbsp;Juan Lv,&nbsp;Jinyu Chu","doi":"10.1007/s00403-025-04168-0","DOIUrl":"10.1007/s00403-025-04168-0","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by a dysregulated immune response and impaired epidermal barrier function. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression in various diseases, yet their specific roles in AD remain poorly understood. This study investigates the role of LINC00114, an lncRNA identified as significantly upregulated in lesional skin of AD patients. Using RNA sequencing, quantitative real-time PCR, and in vitro experiments, we demonstrate that LINC00114 is induced by Th2 cytokines IL-4 and IL-13, correlating with clinical severity scores. Notably, the observed 2–3 fold changes in LINC00114 expression indicate a substantial biological impact; as such alterations can significantly influence inflammatory pathways and epidermal barrier integrity. Mechanistically, LINC00114 functions as a molecular sponge for miR-128, inhibiting its regulatory effects on pro-inflammatory targets. Furthermore, LINC00114 enhances the JAK/STAT signaling pathway, promoting Th2-driven inflammation. Our findings also reveal that LINC00114 impairs epidermal barrier function by downregulating key proteins such as filaggrin and involucrin. In a murine model of AD, targeting LINC00114 with siRNA significantly reduced skin inflammation and improved barrier integrity. These results highlight LINC00114 as a novel therapeutic target for AD, offering potential avenues for more effective treatments aimed at restoring immune balance and skin barrier function.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}