Archives of Dermatological Research最新文献

{"title":"METTL3-modified exosomes from adipose-derived stem cells enhance the proliferation and migration of dermal fibroblasts by mediating m6A modification of CCNB1 mRNA","authors":"Xiaolong Zhou,&nbsp;Hongde Li,&nbsp;Zijing Xie","doi":"10.1007/s00403-025-03896-7","DOIUrl":"10.1007/s00403-025-03896-7","url":null,"abstract":"<div><p>Skin scalded injury is a devastating condition. Exosomes derived from adipose-derived mesenchymal stem cells (ASC-exos) have been shown encouraging therapeutic potential in wound healing. Here, we explored the activity and mechanism of methyltransferase-like 3 (METTL3)-modified ASC-exos in the migration and proliferation of dermal fibroblasts. ASC-exos were isolated from mouse ASCs, characterized, and used to incubate mouse dermal fibroblasts. Fluorescence microscopy was used to analyze the transfer of ASC-exos into fibroblasts. Cell migration, invasion, proliferation, and viability were assessed by wound healing, transwell, 5-Ethynyl-2ʹ-deoxyuridine (EdU), and Cell Counting Kit-8 (CCK-8) assays, respectively. Protein expression was tested by western blotting. The influence of METTL3 in cyclin B1 (CCNB1) was evaluated by methylated RNA immunoprecipitation (MeRIP), actinomycin D treatment and quantitative PCR assays. ASC-exos significantly increased the proliferative, invasive, and migratory potentials of dermal fibroblasts. Overexpression of METTL3 resulted in elevated proliferation, invasiveness, and migratory capacity in dermal fibroblasts. Furthermore, METTL3-modified ASC-exos derived from METTL3-increased ASCs exerted more significantly promoting effects on fibroblast proliferation and migration than ASC-exos. Mechanistically, METTL3 upregulated CCNB1 by affecting its mRNA m6A modification. Additionally, reduction of CCNB1 had a counteracting impact on the effects of METTL3-modified ASC-exos in dermal fibroblasts. Our study shows that METTL3-modified ASC-exos enhance the migration and invasion of dermal fibroblasts by mediating CCNB1 mRNA m6A modification, raising hopes that these exosomes might serve as a therapeutic option for scalded skin wound repair.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of comorbidities and thromboembolic events in individuals with Autoimmune Bullous diseases","authors":"Sierra Thomas,&nbsp;Kevin Truong-Balderas,&nbsp;Joseph McGrath,&nbsp;Joe Jackson,&nbsp;Tanner Sanberg,&nbsp;Erin X. Wei","doi":"10.1007/s00403-025-03856-1","DOIUrl":"10.1007/s00403-025-03856-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case-control comparison of alopecia areata and inflammatory bowel disease","authors":"Amritpal Kooner,&nbsp;Rawle A. Sekhon,&nbsp;Beniamin Zeka,&nbsp;Aditya Dutt,&nbsp;Mohammad Fardos","doi":"10.1007/s00403-025-03976-8","DOIUrl":"10.1007/s00403-025-03976-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of disease severity with C-reactive protein/albumin ratio and hematological parameters in patients with rosacea","authors":"Huriye Aybüke Koç,&nbsp;Cansu Altınöz Güney,&nbsp;Akın Aktaş","doi":"10.1007/s00403-025-03861-4","DOIUrl":"10.1007/s00403-025-03861-4","url":null,"abstract":"<div><p>This study aims to investigate the effectiveness of the C-reactive protein/albumin ratio (CAR) and parameters derived from complete blood counts as indicators of inflammatory activity in patients with rosacea and to evaluate their association with disease severity. This retrospective cross-sectional study included 90 rosacea patients classified into three groups based on the Investigator Global Assessment (IGA) score: 30 with mild, 30 with moderate, and 30 with severe disease, along with 30 healthy controls. There were no significant differences between the patient and control groups in terms of gender (%31.1 vs. %30 male) and age (41.92 ± 10.70 years vs. 41.07 ± 11.92 years). In rosacea patients, neutrophil (<i>P</i> = 0.0004), lymphocyte (<i>P</i> = 0.031), platelet (<i>P</i> = 0.041), monocyte (<i>P</i> = 0.003), CRP (<i>P</i> &lt; 0.0001), and CAR (<i>P</i> &lt; 0.0001) levels were significantly higher. The AUC value for CAR was 0.83, with a cut-off value of 0.91; sensitivity was 66.67%, and specificity was 96.67%. Significant differences were observed among the three patient groups classified by rosacea severity for neutrophil (<i>P</i> &lt; 0.0001), lymphocyte (<i>P</i> = 0.011), monocyte (<i>P</i> = 0.0001), CRP (<i>P</i> &lt; 0.0001), albumin (<i>P</i> &lt; 0.0001), CAR (<i>P</i> &lt; 0.0001), neutrophil/lymphocyte ratio (NLR) (<i>P</i> = 0.004), and lymphocyte/monocyte ratio (LMR) (<i>P</i> = 0.021). Patients with rhinophyma had higher neutrophil (<i>P</i> = 0.005) and NLR (<i>P</i> = 0.019) levels. Those with ocular involvement had higher CRP (<i>P</i> = 0.003) and CAR (<i>P</i> = 0.002) levels, while albumin (<i>P</i> = 0.024) levels were lower. This study is the first to examine the relationship between CAR, rosacea severity, and different clinical types. Based on our findings, we believe that CAR and other hematological parameters can be used to assess the severity of rosacea and monitor various clinical types.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel biomarkers associated with immune infiltration in major depression disorder and atopic dermatitis","authors":"Han Jiang,&nbsp;Bizhen Gong,&nbsp;Zhaoxian Yan,&nbsp;Peng Wang,&nbsp;Jing Hong","doi":"10.1007/s00403-025-03907-7","DOIUrl":"10.1007/s00403-025-03907-7","url":null,"abstract":"<div><p>Major depression disorder (MDD) and atopic dermatitis (AD) are distinct disorders involving immune inflammatory responses. This study aimed to investigate the comorbid relationship between AD and MDD and to identify possible common mechanisms. We obtained AD and MDD data from the Gene Expression Omnibus (GEO) database. Differential expression analysis and the Genecard database were employed to identify shared genes associated with inflammatory diseases. These shared genes were then subjected to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Hub genes were selected based on the protein–protein interactions using CytoHubba, and key regulatory genes were identified through enrichment analysis. Subsequently, we conducted immune infiltration and correlation analyses of the shared genes in AD. Finally, we employed three machine learning models to predict the significance of shared genes. A total of 17 shared genes were identified in the AD_Inflammatory_MDD dataset (S100A9, PTGER2, PI3, SNCA, DAB2, PDGFA, FSTL1, CALD1, XK, UTS2, DHRS9, PARD3, NFIB, TMEM158, LIPH, RAB27B, and SH3BRL2). These genes were associated with biological processes such as the regulation of mesenchymal cell proliferation, cellular ketone metabolic processes, and glial cell differentiation. The neuroactive ligand-receptor interaction, IL-17 signaling, and Rap1 signaling pathways were significantly enriched in KEGG analysis. SNCA, S100A9, SH3BGRL2, RAB27B, TMEM158, DAB2, FSTL1, CALD1, and XK were identified as hub genes contributing to comorbid AD and MDD development. The three machine learning models consistently identified SNCA and PARD3 as important biomarkers.SNCA, S100A9, SH3BGRL2, RAB27B, TMEM158, DAB2, FSTL1, CALD1, and XK were identified as significant genes contributing to the development of AD and MDD comorbidities. Immune infiltration analysis showed a notable increase in the infiltration of various subtypes of CD4 + T cells, suggesting a potential association between the development of skin inflammation and the immune response. Across different machine learning models, SNCA and PARD3 consistently emerged as important biomarkers, providing a new direction for clinical diagnosis and treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of microneedle combined with 5% Minoxidil solution and finasteride in the treatment of androgenetic alopecia in males","authors":"Yan Chang,&nbsp;Wenxia Zhang,&nbsp;Jianping Zhou,&nbsp;Linna Lv,&nbsp;Qi He,&nbsp;Yan Chen,&nbsp;Ping Wang,&nbsp;Qing Zhai","doi":"10.1007/s00403-025-03891-y","DOIUrl":"10.1007/s00403-025-03891-y","url":null,"abstract":"<div><p>Androgenetic alopecia in males is associated with genetic predisposition and increased androgen secretion. This work was to investigate the clinical therapeutic effects of microneedling plus5% Minoxidil and Finasteride in treating male androgenetic alopecia. 45 male patients with androgenetic alopecia were recruited and rolled into control group 1 (Group A) received monotherapy with 5% Minoxidil; control group 2 (Group B) received 5% Minoxidil and Finasteride; and the experimental group (Group C) received combination therapy with microneedling, 5% Minoxidil, and Finasteride. Each group consisted of 15 patients. Comparison was made on trace element levels, testosterone levels, hair microscopy indicators, Norwood Hamilton hair loss (HL) classification, self-rating of hair growth and Ars (ARs). After treatment, the contents of trace elements and hormone levels in the three groups did not change considerably(<i>P</i> &gt; 0.05). After treatment, the ratio of villi to single hair follicle in the three groups decreased markedly. The decline degree of group B and group C was superior to group A (<i>P</i> &lt; 0.05), while that of group C was superior to group B (<i>P</i> &gt; 0.05). After treatment, the hair density and hair shaft diameter of the three groups of patients increased markedly. The increase of group B and group C was superior to group A (<i>P</i> &lt; 0.05), while that of group C was superior to group B (<i>P</i> &gt; 0.05). After treatment, the Norwood-Hamilton alopecia scale in group C was better than that in group A (<i>P</i> &lt; 0.01). A total of 80% patients in group C scored ≥ 3, which was better than the other two groups in general. The incidence of ARs differed slightly among the three groups (<i>P</i> &gt; 0.05). Relative to the use of Minoxidil or combination therapy with Finasteride alone, microneedling combined therapy greatly improved hair loss in patients, promoted new hair growth, and holds clinical value.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pharmacovigilance analysis of abrocitinib-related skin adverse events based on the FDA Adverse Event Reporting System (FAERS)","authors":"Min Huang,&nbsp;Peng Li","doi":"10.1007/s00403-025-03959-9","DOIUrl":"10.1007/s00403-025-03959-9","url":null,"abstract":"<div><p>In January 2022, the U.S. Food and Drug Administration (FDA) approved the marketing of abrocitinib, an oral small molecule selectively inhibiting Janus kinase, for the treatment of patients with recurrent moderate to severe atopic dermatitis. Despite the lack of long-term post-marketing safety studies, this drug was cited with a black box warning by the FDA for potentially increasing the risk of several severe adverse events (AEs). This retrospective pharmacovigilance disproportionality analysis study used data from the FDA Adverse Event Reporting System (FAERS) from the first quarter of 2022 to the first quarter of 2024, aiming to analyze the potential association between abrocitinib and skin AEs. Three disproportionality measurement were performed for data mining, including the reporting odd ratio method, the proportional reporting ratio method and the Medicines and Healthcare products Regulatory Agency method. Out of 3,269,835 AE reports extracted from the database, 699 cases of skin-related AEs were identified, where abrocitinib was implicated as the primary suspect drug. The patient demographic information, outcomes and report sources were analyzed. 34 kinds of positive risk signals were detected, many of which were unexpected safety signals. This study provided a scientific reference to understand the safety of abrocitinib in practical applications.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing AI and human interaction in aesthetic dermatology","authors":"Marina Landau,&nbsp;George Kroumpouzos,&nbsp;Mohamad Goldust","doi":"10.1007/s00403-025-03997-3","DOIUrl":"10.1007/s00403-025-03997-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing patterns for treatment of acne vulgaris: A retrospective chart review at an urban public and private hospital","authors":"Nicole C. Syder,&nbsp;Arielle Carolina Mora Hurtado,&nbsp;Autumn Saizan,&nbsp;Melissa Gonzalez,&nbsp;Jack Rodman,&nbsp;Nada Elbuluk","doi":"10.1007/s00403-025-03900-0","DOIUrl":"10.1007/s00403-025-03900-0","url":null,"abstract":"<div><h3>Background</h3><p>Studies have found demographic differences in prescribing patterns for certain inflammatory conditions, including acne.</p><h3>Objective</h3><p>To investigate acne prescription patterns among patients seen in the private system (PS) and safety-net health care system (SNS) of the University of Southern California (USC).</p><h3>Methods</h3><p>This was a multisite, retrospective study of patients obtaining acne care at PS and SNS outpatient dermatology facilities in Los Angeles over a one-year period.</p><h3>Results</h3><p>Despite similar acne severity, SNS patients were less often prescribed azelaic acid, benzoyl peroxide/clindamycin, benzoyl peroxide/adapalene, sulfacetamide, topical dapsone, and salicylic acid than PS patients (<i>p</i> &lt; 0.001). SNS patients received fewer prescriptions for oral medications including spironolactone, antibiotics, and isotretinoin (<i>p</i> &lt; 0.001). Despite similar acne severity, non-White patients were less frequently prescribed topical retinoids (<i>p</i> = 0.003), benzoyl peroxide/clindamycin (<i>p</i> = 0.003), isotretinoin (<i>p</i> &lt; 0.001) and spironolactone (<i>p</i> &lt; 0.001) than White patients. Despite higher acne severity among Hispanics/Latinos, they were less often prescribed spironolactone and oral antibiotics than their non-Hispanic/Latino counterparts (<i>p</i> = 0.023).</p><h3>Conclusions</h3><p>Findings from this study highlight differences in acne prescribing patterns by race/ethnicity and hospital system, which can impact the ability of patients to have successful treatment of their acne and its sequelae.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-03900-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of 21 common dermatology smartphone applications: evaluating socioeconomic and geographical barriers","authors":"Justin Lyon,&nbsp;Annabelle Huntsman,&nbsp;Adriene Pavek,&nbsp;Dekker C. Deacon,&nbsp;Tammy K. Stump","doi":"10.1007/s00403-025-03956-y","DOIUrl":"10.1007/s00403-025-03956-y","url":null,"abstract":"<div><p>The objective of the study was to identify areas for improvement in cost, geographical accessibility, and language diversity in current dermatologic education smartphone applications (apps). Education is a critical component of improving patient health outcomes. Smartphone apps offer accessible tools for managing and monitoring dermatological health, helping to reduce educational and geographical barriers that patients may face. By providing easily accessible information and tracking capabilities, these apps may empower patients to take an active role in their health care. Apps were selected based on purpose, included features, and user demographics (specifically patient-directed). Apps were divided into categories related to dermatological health, including patient education, skin-care regimens, and tracking chronic condition progression. Selected apps were assessed by the following: cost, languages offered, educational content, diagnostic/special features, country based in, the country provided in, advertisements, and incentives. Of the 21 apps analyzed, 65% are only available in English, 17% offer 2–3 languages, and 18% offer 4 + languages, although these apps are available in multiple countries. Chronic condition management apps were predominantly free, 40% of patient education apps were free, and 55% of diagnostic apps were free. 67% of apps provided an educational component, with five including incentives for use. Utilizing mobile applications is a promising and innovative avenue for patient education. However, there is a vast imbalance in the number of languages offered and cost, highlighting the need to create smartphone apps available in multiple languages at a low price.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}