Archives of Dermatological Research最新文献_第10页

The effectiveness of fractional laser-assisted photodynamic therapy utilizing methylene blue for the treatment of keloids

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04058-5

Nada M. El-Tayeb, Nermeen S. A. Abdel Fattah, Nafissa El-Badawy, May H. El-Samahy

{"title":"The effectiveness of fractional laser-assisted photodynamic therapy utilizing methylene blue for the treatment of keloids","authors":"Nada M. El-Tayeb, Nermeen S. A. Abdel Fattah, Nafissa El-Badawy, May H. El-Samahy","doi":"10.1007/s00403-025-04058-5","DOIUrl":"10.1007/s00403-025-04058-5","url":null,"abstract":"<div><p>Keloids represent a therapeutic challenge due to lack of satisfactory treatment and high rate of recurrence. Various treatment modalities exist, including intralesional steroids, photodynamic therapy (PDT), lasers and different combinations have been used to reach better results. This study assessed the efficacy and safety of fractional carbon dioxide-assisted delivery of Methylene blue in treatment of keloids to provide an additional treatment option for keloids. A total of 20 previously-untreated keloids have been treated with 3 monthly sessions of fractional carbon dioxide (CO<sub>2</sub>) laser and methylene blue PDT using intense pulsed light (IPL). In the first session debulking of the keloid’s height by at least 50% with ablative CO2 was performed. Patients were photographed and assessed before treatment and 2 months after the last session, clinically using patient and observer scar assessment scale (POSAS), histopathologically by H&E and Masson trichrome. The follow up showed significant reduction in total POSAS scores. Histopathologically, collagen improved from 3.45 ± 1.05to 2.65 ± 0.875. Side effects were tolerable & included pain, burning sensation, erythema, desquamation, slight edema, slight exudation, and hyperpigmentation. Clinical and histopathological improvements were seen after methylene blue-PDT, and it could be a potential treatment option for keloids. However, further controlled studies are needed to compare its effectiveness with other established modalities along with determination of ideal parameters of IPL & fractional CO2.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysplastic nevi and malignant melanoma: insights into pre-biopsy diagnostic accuracy and the critical role of dermatology consultation

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04089-y

Cansu Altınöz Güney, Sertaç Şener, Huban Sibel Orhun, Fadime Kılınç, Ayşe Akbaş, Akın Aktaş

{"title":"Dysplastic nevi and malignant melanoma: insights into pre-biopsy diagnostic accuracy and the critical role of dermatology consultation","authors":"Cansu Altınöz Güney, Sertaç Şener, Huban Sibel Orhun, Fadime Kılınç, Ayşe Akbaş, Akın Aktaş","doi":"10.1007/s00403-025-04089-y","DOIUrl":"10.1007/s00403-025-04089-y","url":null,"abstract":"<div><p>A dysplastic nevus (DN) is an acquired melanocytic nevus that displays clinical and histological features similar to malign melanoma (MM). This study aims to evaluate the demographic and clinical characteristics of DN and primary cutaneous MM, as well as assess the accuracy of pre-biopsy diagnoses. We retrospectively analyzed 206 histopathologically confirmed cases of DN (<i>n</i> = 185) and MM (<i>n</i> = 21) from 159 patients at a tertiary care center. The biopsy samples had been sent from both dermatology and other surgical departments. The study included 21 patients with MM and 139 with DN; one patient had both conditions. The mean age was 60.6 ± 15.9 years for MM patients and 34.7 ± 14.9 years for DN patients, both with a slight male predominance. Melanomas were predominantly on the face (42.9%), whereas DN lesions were mostly on the trunk (76.8%). Breslow thickness analysis showed 33.3% of MM tumors were < 1 mm and 28.6% were > 4 mm. In 90.5% of MM cases and 71.4% of DN cases, preliminary diagnoses of MM and/or DN were noted on pathology request forms. Overall, pre-biopsy diagnoses were consistent with final diagnoses in 73.3% of the 206 lesions. Diagnostic accuracy was higher in dermatology compared to other surgical departments (85.8% vs. 50%, <i>p</i> <.00001) and was better for trunk and feet locations compared to unspecified areas (<i>p</i> = .023 and <i>p</i> = .044, respectively). The study highlights the need for dermatology consultation before excising nevi or suspicious lesions and emphasizes early melanoma detection. Despite the small sample size, it underscores the importance of enhanced screening methods and awareness campaigns.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04031-2

Şeyhmus Kaya, Ramazan Oğuz Yüceer, Mustafa Tosun, Reikhan Mustafaeva

{"title":"The role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study","authors":"Şeyhmus Kaya, Ramazan Oğuz Yüceer, Mustafa Tosun, Reikhan Mustafaeva","doi":"10.1007/s00403-025-04031-2","DOIUrl":"10.1007/s00403-025-04031-2","url":null,"abstract":"<div><p>Inflammatory processes play a crucial role in both autoimmune and non-autoimmune skin diseases. The complement system contributes to these processes, with both well-established and yet-to-be-confirmed effects. The relationship between C4d, an intermediate product of the complement system, and skin diseases remains an area of ongoing investigation. While the presence and role of C4d in autoimmune and non-autoimmune skin diseases have been explored using immunohistochemical methods, the topic remains inconclusive. Bullous pemphigoid is an autoimmune skin disorder characterized by subepidermal blistering, predominantly affecting the elderly population. This study aims to evaluate the potential of C4d as an alternative immunohistochemical marker to the gold-standard diagnostic method, direct immunofluorescence, in diagnosing Bullous pemphigoid. Additionally, C4d staining patterns were analyzed in correlation with clinical data to assess its prognostic significance. In this retrospective study, the histomorphological, clinical, and demographic data of 43 patients diagnosed with Bullous pemphigoid were analyzed. Immunohistochemical assessment of C4d expression and staining patterns was conducted. The findings suggest that C4d may serve as a potential diagnostic and prognostic marker. C4d expression was significantly more frequent in lesions located on the upper extremities and in patients with higher eosinophil scores. Furthermore, patients with high eosinophil scores were more likely to receive systemic treatment. This study demonstrates that C4d could contribute significantly to the diagnostic process, particularly in cases where immunofluorescence studies are limited.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional study of skin diseases in Iranians using the global burden of disease database

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04115-z

Dev Patel, Atef Fayed, Naeha Pathak, Omar Alani, Dany Alkurdi, Shari R. Lipner

引用次数: 0

Mapping access to care: a powerful medium to visualize barriers to care

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04122-0

Ashima Agarwal, Alaina J. James

引用次数: 0

Vitiligo treatment trends in underrepresented groups

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04116-y

Sara D. Ragi, Megan M. Tran, Megan Hoang, Zachary Lin, Mayra BC Maymone, John Kawaoka, Neelam A. Vashi

引用次数: 0

The regulatory effects of vitamins on immunity and skin health

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04086-1

Agatha Ngukuran Jikah, Great Iruoghene Edo, Ali B. M. Ali, Patrick Othuke Akpoghelie, Emad Yousif, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Khalid Zainulabdeen, Joseph Oghenewogaga Owheruo, Arthur Efeoghene Athan Essaghah, Huzaifa Umar, Dina S. Ahmed, Ahmed A. Alamiery

引用次数: 0

Phenotype-endotype relationship in elderly atopic dermatitis and effects of dupilumab therapy: prospective study

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04090-5

Giuseppina Caiazzo, Maddalena Napolitano, Maria Quaranta, Vincenzo Picone, Gabriella Fabbrocini, Cataldo Patruno

{"title":"Phenotype-endotype relationship in elderly atopic dermatitis and effects of dupilumab therapy: prospective study","authors":"Giuseppina Caiazzo, Maddalena Napolitano, Maria Quaranta, Vincenzo Picone, Gabriella Fabbrocini, Cataldo Patruno","doi":"10.1007/s00403-025-04090-5","DOIUrl":"10.1007/s00403-025-04090-5","url":null,"abstract":"<div><p>Atopic dermatitis is a chronic inflammatory systemic disease that can persist or start in adulthood, even in elderly age, with several clinical phenotypes. The aim of this study was to evaluate the relationship between phenotype and endotype in elderly patients, and the long-term effects of dupilumab on molecular signature in these patients. A total of 50 elderly patients had been treated with dupilumab during the follow up period. Regarding effectiveness parameters, mean EASI score at Week 0 was 25.12 ± 4.23 and significantly reduced to 2.42 ± 3.15 at Week 52 (<i>p</i> < 0.05). Regarding safety, none of the registered adverse events led to the discontinuation of dupilumab therapy. Moreover, after 52 weeks of dupilumab treatment, Th2 cytokines expression was decreased, with IL-13 and IL-31 downregulated in both patient groups at Week 52, at both gene and protein levels when compared with Week 0. Our data also revealed a significant increase in both IL-4 gene expression and protein production at Week 52 when compared with Week 0. Unexpectedly, our results also revealed that IL-22 cutaneous expression was significantly increased, while circulating levels were decreased at Week 52 when compared to Week 0. In conclusion, our results highlight the effectiveness of dupilumab at a late time point as Week 52. Of note, a dumping of the Th2- and Th17- immune response at both systemic and in situ level and a possible remodelling role of IL-22 in the skin is suggested.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04090-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous viral infection comorbidities in patients with basal cell carcinoma

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04124-y

Amritpal Kooner, Rawle. A Sekhon, Justin Chen, Aditya Dutt

引用次数: 0

Key considerations of injectable minoxidil for alopecia

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04068-3

Carli D. Needle, Anna L. Brinks, Caitlin A. Kearney, Jerry Shapiro, Kristen I. Lo Sicco

{"title":"Key considerations of injectable minoxidil for alopecia","authors":"Carli D. Needle, Anna L. Brinks, Caitlin A. Kearney, Jerry Shapiro, Kristen I. Lo Sicco","doi":"10.1007/s00403-025-04068-3","DOIUrl":"10.1007/s00403-025-04068-3","url":null,"abstract":"<div><p>Minoxidil has become an increasingly popular treatment option for hair loss disorders including androgenetic alopecia, cicatricial alopecia, and alopecia areata. There are various minoxidil formulations available including topical, oral, and injectable minoxidil. While injectable minoxidil may offer certain advantages, potential risks and costs should also be considered. First, we explore the enhanced bioavailability of injectable minoxidil in comparison to topical and oral formulations, as well as the variability in sulfotransferase enzyme levels and its role in the activation of minoxidil at hair follicles. Furthermore, we expand upon the potential adverse effects associated with injectable minoxidil given its widespread systemic distribution. We also highlight the importance of considering cost, access, and availability of injectable minoxidil given that injections are significantly more expensive than oral minoxidil tablets and involve the additional obstacle of frequent dermatology visits. Depending on geographic region and socioeconomic status, many patients may not live in sufficiently close proximity to a dermatologist for this level of care. Finally, we emphasize the need for ongoing research efforts to compare the efficacy, access, and tolerability of injectable minoxidil, alternative minoxidil formulations, and other alopecia medications.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0