Archives of Dermatological Research最新文献

{"title":"Intralesional corticosteroids for keloids in patients with skin of color: a systematic review and meta-analysis","authors":"Jia Qi Adam Bai, Sana Gupta, Ryan S. Q. Geng, Carly Kirshen","doi":"10.1007/s00403-026-04619-2","DOIUrl":"10.1007/s00403-026-04619-2","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologic treatment for cutaneous immune-related adverse events in cancer patients undergoing immune-checkpoint therapy: a retrospective review","authors":"Juna Khang,&nbsp;Elif Karatas,&nbsp;Rebeca Martinez,&nbsp;Jean S. McGee,&nbsp;Katherine Brag","doi":"10.1007/s00403-026-04609-4","DOIUrl":"10.1007/s00403-026-04609-4","url":null,"abstract":"<div><p> Cutaneous immune-related adverse events (cirAEs) from immune checkpoint inhibitor (ICI) therapy can disrupt the course of oncology treatment. Data guiding the safety and effectiveness of biologics for cirAEs remain limited. We therefore aimed to evaluate the efficacy and oncologic safety of biologic therapy for ICI-associated cirAEs. We conducted a retrospective review of adult patients at Beth Israel Deaconess Medical Center from January 1st 2015 to July 31st 2025 who received biologic therapy from a dermatologist for a cirAE in the setting of immunotherapy for a malignancy. We collected demographics, cirAE phenotype, biologic used, cirAE outcomes, ICI treatment course, and cancer status before and after biologic initiation. We included twenty-two patients with 30 discrete cirAEs. The most common cirAE phenotypes were psoriasiform (36%), immunobullous (29%), and eczematous (26%) eruptions. Overall, 19/22 patients (86%) achieved complete resolution of their cirAE on biologic therapy. Among patients whose ICIs were held or discontinued, 6/18 (33%) successfully resumed immunotherapy after cutaneous improvement on biologic therapy. No patient experienced a change in cancer status from before to after biologic treatment. Our findings suggest that biologics are highly effective for treating a range of ICI-induced cirAE and appear safe in this population, with no adverse impact on cancer status. Biologic therapy may allow for salvage of ICI treatment in a subset of patients, potentially improving overall cancer outcomes.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating mind and skin: a pragmatic framework for psychodermatology in clinical practice","authors":"Sophia A. Mense,&nbsp;Olga Gomeniouk,&nbsp;Hanna A. Aronovich,&nbsp;Parul K. Goyal","doi":"10.1007/s00403-026-04611-w","DOIUrl":"10.1007/s00403-026-04611-w","url":null,"abstract":"<div><p>Psychodermatology, an emerging subspecialty at the intersection of dermatology, psychiatry, and psychology, addresses the bidirectional relationship between skin disease and mental health. Psychological stress, anxiety, and trauma can exacerbate dermatologic conditions, while chronic skin diseases often precipitate significant psychological distress, reduced quality of life, and psychiatric comorbidities. Despite mounting evidence of this burden, psychodermatologic care remains underrepresented in dermatology training, leading to underdiagnosis, suboptimal management, and fragmented care. This narrative review proposes a pragmatic, scalable framework for integrating mental health into dermatologic practice within the U.S. healthcare system, comprising three core components: routine psychological screening with defined score thresholds, standardized referral pathways, and tiered follow-up actions. This framework is intended to guide, rather than replace, clinical judgment and specialty psychiatric care. We outline validated screening tools, practical referral models adaptable to diverse settings, and strategies for maintaining interdisciplinary communication, including telehealth integration. The framework emphasizes cultural sensitivity, acknowledging global disparities, stigma, and variations in symptom expression that affect care delivery. Implementation considerations include the need for enhanced psychodermatology training in medical education, systemic and financial barriers to integrated care, and the potential cost-effectiveness of collaborative models. The proposed approach aims to normalize mental health screening in dermatology, reduce stigma, and improve patient outcomes through early identification, timely intervention, and coordinated management of psychocutaneous disorders. By offering a flexible yet structured model, this review provides a foundation for both immediate clinical adoption and future research into sustainable, equitable psychodermatologic care.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous cell carcinoma in situ treatment practices amongst the American College of Mohs Surgery","authors":"Jay R. Patel,&nbsp;Mariana Chrispim Gimenez,&nbsp;Lilyveth Mesa,&nbsp;Marc D. Brown,&nbsp;Franki Lambert Smith","doi":"10.1007/s00403-026-04612-9","DOIUrl":"10.1007/s00403-026-04612-9","url":null,"abstract":"<div><p>Squamous cell carcinoma in situ (SCCIS) is a common precursor to invasive squamous cell carcinoma. While Mohs micrographic surgery (MMS) is frequently used in the treatment of this condition, emerging evidence highlights the effectiveness of non-surgical methods, underscoring the need to understand current practice patterns. Our objective was to identify current preferences amongst members of the American College of Mohs Surgery (ACMS) when treating SCCIS to reassess the need for targeted studies and updated guidelines. An online survey was distributed to ACMS members in July 2024, with responses collected through February 2025. Demographics and first-line treatment preferences were analyzed using descriptive statistics and chi-square testing (<i>p</i> &lt; 0.05). 100 Mohs surgeons completed the required portion of the survey, with 72 completing supplemental items. MMS was consistently the preferred first-line treatment across most anatomic sites and lesion characteristics, except for lesions in area L, for which malignant destruction and excision were most often preferred, and actinic keratosis with focal SCCIS in areas M and H, for which topical 5-fluorouracil was preferred. Treatment of SCCIS varies substantially by lesion and patient characteristics. While MMS remains the predominant approach, findings highlight opportunities to refine guidelines and better integrate non-surgical modalities for select low-risk cases.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rubber accelerators in medical examination and surgical gloves in the United States: a post-COVID-19 manufacturer/company survey","authors":"Mahnoor Mukarram,&nbsp;Brailyn Weber,&nbsp;Samuel F. Ekstein,&nbsp;Dathan Hamann","doi":"10.1007/s00403-026-04615-6","DOIUrl":"10.1007/s00403-026-04615-6","url":null,"abstract":"<div><p>Rubber accelerator contact allergy is a common cause of glove-related contact dermatitis, especially in occupational settings. While previous studies have reported accelerator presence in medical gloves, discontinuation of gloves due to COVID-19 pandemic-associated supply chain challenges are a current barrier to patient education. The objective of this study was to provide an updated post-COVID-19 guide for medical exam and surgical glove accelerator content in the United States for accelerator-allergic patients based on a manufacturer/company survey. In August 2024, an internet-based search was conducted to compile a list of commercially-available medical examination and surgical gloves. Accelerator ingredients are reported. Nine glove manufacturers were included in the survey, including 142 gloves. 76 gloves were discontinued since the previous analysis, primarily natural rubber latex (NRL) gloves. Dithiocarbamates were the most common accelerator (83.1%), with mercaptobenzothiazole (MBT, 21.8%), and other accelerators present at lower frequencies. The number of gloves labeled as accelerator-free has increased 3-fold since 2016. Altogether, medical examination and surgical glove availability and associated allergen information have changed significantly in the post COVID-19 pandemic supply chain. Accelerators remain common in most medical rubber gloves; however, accelerator-free options are available and patients with these contact allergies should be counseled appropriately.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of JAK inhibitors in older adults with alopecia areata: a real-world analysis using TriNetX","authors":"Hong Ye,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-026-04616-5","DOIUrl":"10.1007/s00403-026-04616-5","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of narrowband ultraviolet B phototherapy on serum folate levels: a systematic review and meta-analysis","authors":"Chang-Jie Du,&nbsp;Yuan-Chen Zhao,&nbsp;Jian-Wen Ye,&nbsp;Zhong-Wei Hong,&nbsp;Guang-Ru Zhao,&nbsp;Dong-Sheng Di,&nbsp;Rui-Xue Leng","doi":"10.1007/s00403-026-04606-7","DOIUrl":"10.1007/s00403-026-04606-7","url":null,"abstract":"<div>\u0000 \u0000 <p>This systematic review and meta-analysis evaluated whether narrowband ultraviolet B (NB-UVB) phototherapy affects serum folate levels. A systematic search of PubMed, Web of Science, and Embase, supplemented by manual searching, identified self-controlled clinical trials that examined the impact of NB-UVB phototherapy on serum folate levels. Nine studies met the inclusion criteria, all of which underwent rigorous screening and quality assessment. Using random-effects models, we calculated standardized mean differences (SMDs) and 95% confidence intervals (CIs), and further performed subgroup analyses, meta-regression, sensitivity analyses, and publication bias assessments with funnel plots and Egger’s test. The pooled analysis indicated that NB-UVB phototherapy was associated with decreased serum folate levels, although the reduction was not statistically significant (SMD = -0.56, 95% CI: -1.19 to 0.06, <i>P</i> = 0.077). Similar non-significant decreases were observed in psoriasis subgroup (SMD = -0.79, 95% CI: -1.63 to 0.05, <i>P</i> = 0.065) and the vitiligo subgroup (SMD = -0.72, 95% CI: -1.56 to 0.11, <i>P</i> = 0.089). Meta-regression analyses did not identify any significant moderators contributing to between-study heterogeneity. Sensitivity analyses confirmed the robustness of the overall pooled result, while exclusion of certain studies in the psoriasis and vitiligo subgroups led to significant decreases in serum folate levels and substantially reduced heterogeneity. No substantial publication bias was detected. Further well-designed studies with larger sample sizes and higher methodological quality are still needed to validate these findings.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigmatization attitudes toward patients living with psoriasis in Thailand: a cross-sectional survey","authors":"Korakot Leelathanakorn,&nbsp;Leena Chularojanamontri,&nbsp;Chayada Chaiyabutr,&nbsp;Narumol Silpa-archa,&nbsp;Chanisada Wongpraparut,&nbsp;Woraphat Ratta-apha,&nbsp;Orawan Supapueng","doi":"10.1007/s00403-026-04613-8","DOIUrl":"10.1007/s00403-026-04613-8","url":null,"abstract":"<div>\u0000 \u0000 <p>Data on stigmatizing attitudes toward people living with psoriasis (PLWP) in the general population are scarce. This study aimed to determine the prevalence and predictors of stigmatizing attitudes toward PLWP among three Thai groups: medical students (MS), nonmedical students (NMS), and laypeople. A standardized online questionnaire was completed by 1200 Thais. The Thai lay sample was recruited using power calculations and demographic quotas based on national census data to ensure representativeness of the general population. The incorrect belief that psoriasis is contagious was most common among NMS (37.3%), followed by laypeople (25.3%) and MS (11.3%). The MS had the highest proportion (66.8%) of participants who believed that PLWP were disadvantaged, stigmatized, or discriminated against. Among the 1200 Thai participants, 577 (48.1%) considered psoriasis to be a societal burden. Shaking or touching lesional areas and sharing a swimming pool caused the greatest discomfort. Greater psoriasis knowledge and awareness of “World Psoriasis Day” were significantly associated with fewer stigmatizing attitudes and reduced stigma. These findings underscore the urgent need for public health interventions and educational campaigns to improve societal attitudes toward PLWP, particularly within Thai society.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04613-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined microneedling and platelet-rich plasma for atrophic acne scars: a systematic review, meta-analysis and trial sequential analysis","authors":"Sabia Afreen,&nbsp;Shwetha Shenod,&nbsp;Revathi Thirumushi Sairaj,&nbsp;Amshag Khalil,&nbsp;Shahd Khalil,&nbsp;Lara Nazzal,&nbsp;Stephani Carolina Salvatierra Moreno,&nbsp;Rupalakshmi Vijayan,&nbsp;Victor Sebastian Arruarana,&nbsp;Ajay Kumar,&nbsp;Camila Sanchez-Cruz,&nbsp;Ernesto Calderon Martinez","doi":"10.1007/s00403-026-04547-1","DOIUrl":"10.1007/s00403-026-04547-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Atrophic acne scars remain a challenging concern. Microneedling and platelet-rich plasma (PRP) have demonstrated promising results. However, evidence supporting their combined use is limited. This study aims to compare the effectiveness of combined microneedling and platelet-rich plasma (PRP) therapy with microneedling or PRP monotherapy for the treatment of atrophic acne scars. A systematic search of electronic databases was conducted to identify relevant studies published up to July 2025. Primary outcomes included changes in the Goodman and Baron’s quantitative score, proportions of patients achieving good or excellent response, and patient satisfaction. Meta-analysis was performed using R version 3.4.3. Trial Sequential Analysis (TSA) was applied to assess the conclusiveness of statistically significant outcomes. Seventeen studies with 1111 participants were included. Combined microneedling and PRP therapy resulted in significantly greater improvement in acne scars compared to microneedling alone (MD = − 2.91; 95% CI: − 4.16 to − 1.65; <i>p</i> &lt; 0.01; I² = 43.5%). The odds of achieving excellent outcomes (&gt; 2-grade improvement) were higher with combination therapy (RR = 3.05; 95% CI: 1.68–5.51; <i>p</i> &lt; 0.01). Similarly, combination therapy was associated with greater odds of achieving &gt; 75% improvement (MD = 2.39; 95% CI: 1.25–4.59; <i>p</i> &lt; 0.01; I² = 0%); with TSA confirming that the required information size was reached. For &gt; 50% improvement, the effect remained significant (RR = 2.01; 95% CI: 1.16–3.48; <i>p</i> = 0.01), although the accumulated sample size was insufficient. Adverse events including erythema, edema, pain, and hyperpigmentation were comparable between groups, with no significant differences. In conclusion, combined microneedling and PRP therapy provides clinically meaningful improvement in atrophic acne scars compared with monotherapy, without additional safety concerns. However, standardized treatment protocols and larger, well-designed randomized controlled trails with longer follow-up are required to strengthen the current evidence.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04547-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in NIH dermatology principal investigator grants: men receive higher quantity and average grant amounts compared to women (2009–2023)","authors":"Matthew D. Viveiros,&nbsp;Emily Bogdanski,&nbsp;Michelle Huynh,&nbsp;Hayley Zimbric,&nbsp;Kelly Tyler,&nbsp;Jessica Kaffenberger","doi":"10.1007/s00403-026-04605-8","DOIUrl":"10.1007/s00403-026-04605-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}