Archives of Dermatological Research最新文献

{"title":"Dynamic changes in some facial muscles after superficial versus deep hyaluronic acid injection: an electromyographic study","authors":"Yehia Farouk Elgarem, Yasmeen Mohamed Elsayed Mahmoud, Sarah Sayed Eltawab, Marwa Elsaeed Eldeeb","doi":"10.1007/s00403-025-03914-8","DOIUrl":"10.1007/s00403-025-03914-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of combining histaglobulin with antihistamines in patients with chronic spontaneous urticaria in a tertiary care hospital setting- a randomized trial","authors":"Kalpana Mali Ramanna,&nbsp;Thota Sai Sumanth,&nbsp;Deepthi Konda,&nbsp;Madhavi Eerike,&nbsp;Soundarya Priyadarsini Kalaiselvan MD,&nbsp;Chandru Elangovan,&nbsp;Venu Goapala Rao Konda,&nbsp;Siddharam S. Janti","doi":"10.1007/s00403-025-04045-w","DOIUrl":"10.1007/s00403-025-04045-w","url":null,"abstract":"<div><p>Chronic Spontaneous Urticaria (CSU) significantly affects quality of life. This study evaluates the efficacy of histaglobulin combined with antihistamine (bilastine) versus antihistamine alone in CSU management. A single-center, open-label, randomized trial was conducted in the dermatology OPD of a tertiary care hospital from September 2023 to August 2024. Fifty-seven eligible participants aged &gt; 18 years with symptoms persisting &gt; 6 weeks were randomized into test -histaglobulin plus bilastine group(<i>n</i> = 27) or bilastine alone (<i>n</i> = 30) groups. The test group received weekly histaglobulin injections and daily bilastine (20 mg), while the bilastine alone group received bilastine 20 mg only. Baseline data, including demographics, CSU characteristics, and Urticaria Activity Score (UAS), were recorded. Investigations included blood counts, renal/liver/thyroid function tests, serum IgE, absolute eosinophil count (AEC), vitamin B12 levels, and Autologous Serum Skin Test (ASST). UAS7 scores were recorded weekly for 6 weeks. The primary outcome was the change in UAS, with secondary outcomes assessing symptom control, and adverse events. A total 57 participants were recruited, with 27 and 30 in the test and bilastine alone group respectively. The combination of Histaglobulin with bilastine demonstrated significantly greater efficacy compared to bilastine alone. By Week 6, the Histaglobulin group achieved an 89.9% reduction in UAS versus 59.4% in the bilastine alone group (<i>p</i> &lt; 0.01), with faster symptom resolution observed from Week 2. Laboratory findings showed notable reductions in serum IgE and AEC in the Histaglobulin group, suggesting enhanced modulation of allergic responses. No adverse effects were reported, highlighting the therapy’s safety. The addition of Histaglobulin to bilastine provides a superior and well-tolerated treatment option for CSU, delivering faster symptom relief and better disease control. These findings support its use as an effective adjunctive therapy, warranting further investigation in larger sample size studies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGFR influences the resistance to targeted therapy in BRAF V600E melanomas by regulating the ferroptosis process","authors":"Yuexin Sun,&nbsp;Haoyue Yu,&nbsp;Ying Zhou,&nbsp;Jun Bao,&nbsp;Xiaoping Qian","doi":"10.1007/s00403-025-03895-8","DOIUrl":"10.1007/s00403-025-03895-8","url":null,"abstract":"<div><p>To identify genes differentially expressed between resistant and sensitive BRAF V600E melanoma cell lines using bioinformatics tools applied to GEO data. We retrieved and downloaded the target gene set (GSE45558) from the GEO database and used R software to filter differentially expressed genes (DEGs) between BRAF V600E melanoma cell lines resistant. The identified DEGs were subjected to GO functional enrichment analysis (including biological processes, molecular functions, and cellular components) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, utilizing R software. Protein-protein interaction networks for the DEGs were generated using the STRING online database. Top hub genes were cross-referenced with genes related to ferroptosis from the FerrDb database to identify DEGs linked to ferroptosis in resistant melanoma cells. From the GEO database analysis, we identified the top 100 DEGs between BRAF V600E melanoma cell lines, including 50 downregulated and 50 upregulated DEGs. Using STRING and Cytoscape, we identified the top 10 hub genes: IL6, IL1B, CCL2, MMP2, TGFB2, EGFR, POSTN, SERPINE1, COL1A2, and MITF. Cross-referencing with the FerrDb database, we found that IL6 and EGFR are differentially expressed genes related to ferroptosis in resistant melanoma cells. Validation through clinical samples and in vitro experiments confirmed the high expression of the ferroptosis-related gene EGFR as a potential biomarker for resistance to targeted therapy in BRAF^V600E melanoma. Bioinformatics analysis identified key resistance genes in BRAF^V600E melanoma targeted therapy, demonstrating the impact of ferroptosis-related gene EGFR on the resistance of BRAF^V600E melanoma.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-03895-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair regeneration in androgenetic alopecia using secretome of adipose-derived stem cells (ADSC) and minoxidil: a comparative study of three groups","authors":"Lili Legiawati,&nbsp;Irma Bernadette S. Sitohang,&nbsp;Shannaz Nadia Yusharyahya,&nbsp;Sondang P. Sirait,&nbsp;Endi Novianto,&nbsp;Isabella Kurnia Liem,&nbsp;Trie Kurniawati,&nbsp;Ines Soepinarko Putri,&nbsp;Faizal Dzaky Rahmadika,&nbsp;Nadhira Permata Hakiki,&nbsp;Brigitta Cindy Lauren","doi":"10.1007/s00403-025-04006-3","DOIUrl":"10.1007/s00403-025-04006-3","url":null,"abstract":"<div><p>Androgenetic alopecia is one of the most common cause of hair loss disorder. This hereditary and androgen-dependent disorder tends to progress into partial or even complete baldness Several therapeutic options are now available for AGA, including conventional medications such as finasteride, dutasteride, and minoxidil. However, side effects of these medications are also commonly reported. The use of adipose derived stem cells and their secreted bioactive molecules, “secretome” has gained attention which could produce many effects for hair growth promotion and has been proven in clinical trials. This study aims to compare the effectiveness and safety of with minoxidil in androgenetic alopecia cases. 60 subjects were divided into three treatment groups (minoxidil only, secretome only, and combination of both) and were given intervention on week 0, 4, and 8. All subjects were evaluated by physical examination, photography, trichoscopy, and trichoscan until week 12. All groups showed a statistically significant improvement (<i>p</i> &lt; 0.05) on hair growth parameters with the best improvement observed on week 12. The combination group had the best improvement substantially on hair growth parameters. Side effects are minimum and reported by the subjects in minoxidil group. Clinicaltrials.gov, NCT06066827. Registered 05 October 2023, Retrospectively. https://register.clinicaltrials.gov/prs/app/template/Home.vm?uid=U0004ES6_ts=7_sid=S000DOK9_cx=-igh2d.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights into genodermatoses: Genetic findings from 43 patients","authors":"Arzu Deniz Sama,&nbsp;Enise Avci Durmusalioglu,&nbsp;Esra Isik,&nbsp;Turkan Turkut Tan,&nbsp;Mehmet Mert Topaloglu,&nbsp;Yusuf Can Dogan,&nbsp;Ayda Acar,&nbsp;Nilay Duman,&nbsp;Tahir Atik","doi":"10.1007/s00403-025-04056-7","DOIUrl":"10.1007/s00403-025-04056-7","url":null,"abstract":"<div><p>Genodermatoses, a group of inherited skin disorders, are characterized by significant genetic heterogeneity and clinical variability, often posing diagnostic and therapeutic challenges. Advances in next-generation sequencing (NGS) technologies, such as whole exome sequencing (WES) and clinical exome sequencing (CES), have transformed the diagnostic landscape by enabling comprehensive genetic analysis. This study aimed to investigate the molecular spectrum and clinical relevance of genetic findings in 43 patients diagnosed with genodermatoses. Demographic, clinical, and molecular data were collected, and genetic testing was performed using the MGI-Seq platform. Variants were analyzed for pathogenicity, zygosity, and novelty. Neurofibromatosis Type 1 (27.9%) and Epidermolysis Bullosa (23.2%) were the most common diagnoses, followed by Ichthyosis (16.2%) and Oculocutaneous Albinism (13.9%). Less frequent conditions included Ectodermal Dysplasia (6.9%) and single cases of Palmoplantar Keratoderma, PTEN Hamartoma Syndrome, Rothmund-Thomson Syndrome, Xeroderma Pigmentosum, and Megaconial Congenital Muscular Dystrophy (each 2.3%). Molecular findings underscored the genetic complexity of genodermatoses, with 42 distinct variants identified across 19 genes. Of these, 13 variants (31%) were novel, expanding the known molecular spectrum. The novel variants were detected in genes including <i>NF1</i>,<i> COL7A1</i>,<i> ITGB4</i>,<i> COL17A1</i>,<i> NIPAL4</i>,<i> ALOX12B</i>,<i> KRT10</i>,<i> ST14</i>,<i> OCA2</i>, and <i>PTEN</i>, highlighting the diagnostic value of comprehensive genetic analysis. The mean age at diagnosis varied significantly among conditions, reflecting the diagnostic challenges and clinical variability of genodermatoses. This study emphasizes the critical role of WES and CES in diagnosing genodermatoses and understanding their molecular basis, which enhances diagnostic accuracy and supports personalized management strategies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between multiple myeloma and melanoma: a cross-sectional study of the NIH All of Us Research Program","authors":"Kailyn Valido,&nbsp;Michael J. Murphy,&nbsp;Jason W. Langway,&nbsp;Jeffrey M. Cohen,&nbsp;Jonathan S. Leventhal,&nbsp;Sandhya C. Deverapalli","doi":"10.1007/s00403-025-04024-1","DOIUrl":"10.1007/s00403-025-04024-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of patch test results in 716 pediatric patients with type IV hypersensitivity dermatosis","authors":"Jian-Rong Niu,&nbsp;Hui Zhou,&nbsp;Xiao Xia,&nbsp;Rong Tian","doi":"10.1007/s00403-024-03685-8","DOIUrl":"10.1007/s00403-024-03685-8","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;This study presents a comprehensive analysis of patch test results in a cohort of 716 pediatric patients diagnosed with type IV hypersensitivity dermatosis. The aim is to provide valuable insights for the prevention and treatment of type IV hypersensitivity dermatosis in the pediatric population.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;A prospective study was conducted from August 2021 to October 2023, enrolling pediatric patients with type IV hypersensitivity dermatosis attending the Department of Dermatology at the prestigious Air Force Medical Center. The patients were categorized into four distinct age groups based on World Health Organization guidelines: infants and young children (under 3 years), preschoolers (ages 3 to 5), school-age children (ages 6 to 11), and adolescents (ages 12 to 14). Patch testing was performed using a pediatric series of allergens, and the distribution patterns of allergens were meticulously analyzed based on the test results. Furthermore, variations in patch test positivity rates and allergen positivity rates were evaluated across different genders and age groups.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Out of the 716 patients included in the study, the overall patch test positivity rate was found to be 86.87%. The top five allergens identified were textile dye mix, limonene hydroperoxide, nickel sulfate, cobalt chloride, and benzoyl peroxide. A comparative analysis of patch test positivity rates between males and females revealed no significant difference (87.85% vs. 86.19%, χ2 = 0.439, &lt;i&gt;P&lt;/i&gt; &gt; 0.05). Similarly, there was no statistically significant variation observed in the patch test positivity rates among the top three dermatoses, including eczema, facial dermatitis, and allergic contact dermatitis (ACD) (χ2 = 6.39, &lt;i&gt;P&lt;/i&gt; &gt; 0.05). Notably, within the top 10 allergens, textile dye mix, benzoyl peroxide, disperse blue 106/124, and potassium dichromate exhibited higher positivity rates in males (38.14%, 25.99%, 25.14%, and 13.56%, respectively) compared to females (29.56%, 18.23%, 17.40%, and 7.18%, respectively). Conversely, the positivity rate of cobalt chloride was higher in females (28.18%) than in males (19.49%). These gender-based differences were statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In terms of age groups, there was no significant disparity observed in the overall patch test positivity rates (χ2 = 3.26, &lt;i&gt;P&lt;/i&gt; &gt; 0.05). However, when analyzing the top five allergens, namely textile dye mix, nickel sulfate, and cobalt chloride, distinct variations in positivity rates were discerned among different age groups (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). For the specific case of ACD, sensitivity: 82.6%, specificity: 57.1%, false positive rate (FPR): 42.9% .&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;This study elucidates the primary allergens implicated in type IV hypersensitivity dermatosis among pediatric patients visiting our dermatology outpatient clinic, namely textile dye mix, limonene hydroperoxide, nickel sulfate, cobalt ch","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding fibrosing alopecia in a pattern distribution: a retrospective study with histological challenges in the diagnosis of diffuse central alopecia","authors":"Betina Werner,&nbsp;Vanessa Cristina Soares,&nbsp;Fabiane Mulinari-Brenner,&nbsp;Stanislav N. Tolkachjov","doi":"10.1007/s00403-025-04014-3","DOIUrl":"10.1007/s00403-025-04014-3","url":null,"abstract":"<div><p>Fibrosing alopecia in a pattern distribution (FAPD) has been described as a diffuse alopecia in the central region of the scalp with clinical and histopathological features of both androgenetic alopecia (AGA) and lichen planopilaris (LPP). Review cases that met clinical and microscopic criteria for FAPD with a minimum follow-up period of 18 months. We evaluated 28 histopathologic criteria in 35 scalp biopsies from 22 patients. The cases were separated into two groups according to the presence or absence of cicatricial fibrous tract (CFT). Low terminal to vellus hair ratio was seen in 45% of samples and 55% of biopsies presented lichenoid inflammation. Among 9 patients with CFT, four developed well-defined areas of alopecia in the follow-up. A wide range of histological features were observed and very few cases showed alterations of both AGA an LPP simultaneously. FAPD is a term that could be used either when diagnostic signs of LPP are not present or perifollicular fibrosis and higher terminal to vellus hair ratio forbid an undisputed AGA diagnosis. The presence of CFT and lichenoid inflammation may be a warning sign for actual LPP with initially diffuse distribution on the scalp and potentially scarring outcome.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous T-cell lymphoma epidemiology: perspectives and updated prevalence data","authors":"Kritin K. Verma,&nbsp;Jean E. Pizano,&nbsp;Justin Pizano,&nbsp;Rishabh Lohary,&nbsp;Daniel P. Friedmann,&nbsp;Cameron E. West,&nbsp;Michelle B. Tarbox","doi":"10.1007/s00403-025-04042-z","DOIUrl":"10.1007/s00403-025-04042-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: factors associated with comorbidity development in atopic dermatitis: a cross-sectional study","authors":"Saad Khan,&nbsp;Fatima Naveed,&nbsp;Faraz Arshad,&nbsp;Ayesha Khan,&nbsp;Rizwan Ahmad","doi":"10.1007/s00403-025-04013-4","DOIUrl":"10.1007/s00403-025-04013-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}