Archives of Dermatological Research最新文献

{"title":"Decreased physical activity in lupus patients, an analysis of biometric data from the all of us database","authors":"Evelyn F. Fagan, Christopher Reagen, Joseph T. McGrath, Meera Kattapuram, Sarah Lonowski, Erin X. Wei","doi":"10.1007/s00403-025-04011-6","DOIUrl":"10.1007/s00403-025-04011-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01711 modulates proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by targeting miR-34a-5p","authors":"Lun Pan,&nbsp;Chengshuai Sun,&nbsp;Hua Jin,&nbsp;Shaocong Lv","doi":"10.1007/s00403-025-04200-3","DOIUrl":"10.1007/s00403-025-04200-3","url":null,"abstract":"<div><p>Hypertrophic scar (HS) is a proliferative disorder that occurs after skin injury and generally leads to disfigurement and impaired skin function in patients. This study aims to delve into the biological role of long intergenic non-protein coding RNA 1711 (LINC01711) in HS, thereby identifying novel therapeutic approaches for HS. HS tissues and corresponding normal tissues were obtained from 35 patients. The expression of LINC01711 was evaluated by qRT-PCR. The effect of LINC01711 knockdown on HS fibroblasts (HSFs) was measured by CCK-8 assay, migration assay, and apoptosis assay. The molecular mechanisms were investigated through bioinformatics analysis and dual-luciferase reporter assay. The impact of LINC01711 on the expression of extracellular matrix (ECM) deposition markers was measured using ELISA assay. LINC01711 was upregulated in HS tissues and positively correlated with disease severity. The silencing of LINC01711 induced the suppression of cell viability, migration, and the promotion of apoptosis in HSFs. LINC01711 negatively modulated microRNA-34a-5p (miR-34a-5p) expression. Suppression of miR-34a-5p reversed the biological function of LINC01711 knockdown in HSFs. Furthermore, LINC01711 modulated collagen type I alpha 1 chain (COL1A1), tissue inhibitor of metalloprotease-1 (TIMP1), and actin alpha 2 (Acta2) expression in HSFs mediated by miR-34a-5p. The results demonstrated that LINC01711 functioned as a regulatory factor in the proliferation, migration, apoptosis, and ECM deposition of HSFs mediated by miR-34a-5p.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of adverse outcomes between oral tranexamic acid and topical triple combination therapy for treatment of melasma","authors":"Aashish Batheja,&nbsp;Sara Lamb","doi":"10.1007/s00403-025-04246-3","DOIUrl":"10.1007/s00403-025-04246-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expression of NLR family pyrin domain containing receptor 1 in psoriatic patients: correspondence","authors":"Amnuay Kleebayoon,&nbsp;Viroj Wiwanitkit","doi":"10.1007/s00403-025-04245-4","DOIUrl":"10.1007/s00403-025-04245-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic stem cell translation for relapse of psoriasis. Systematic review","authors":"Wenqiu Wang,&nbsp;Rui Wang,&nbsp;Chengxin Li","doi":"10.1007/s00403-025-04191-1","DOIUrl":"10.1007/s00403-025-04191-1","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Psoriasis is a chronic, systemic, autoimmune disease with a high rate of progression and relapse, making treatment a challenge and requiring new therapeutic options. Hematopoietic stem cell transplantation (HSCT) is a promising therapeutic modality for hematological malignancies. Several clinical cases have found that psoriasis in patients with hematological tumor was effectively controlled after HSCT and did not have experienced recurrence during follow-up. HSCT shows considerable promise in the treatment of psoriasis and prevention of its recurrence because of its potential immunomodulatory activity. Therefore, we evaluated the efficacy of HSCT in patients with psoriasis through a systematic literature review (SLR). We systematically searched the PubMed, the Cochrane Library, Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and Wanfang databases to identify studies published before May 31, 2023. All types of clinical studies were considered: patients ≥ 12 years old with hematologic malignancies and psoriasis undergoing HSCT therapy. We included studies if they reported on the outcomes of interest. Exclusion criteria: animal models, human mesenchymal stem cells (hMSC) transplants, narrative reviews, letters to the editor. MeSH and “Key word” terms were used. The level of evidence and the quality rating were rated Joanna Briggs Institute (JBI) lists. We initially identified 90 articles, of which 20 were finally included (1 case series and 19 case reports). These twenty articles included 41 patients (33 male and 8 female, age range 12–67 years). The level of evidence was mostly 4 (JBI); the quality of evidence was met (≥ 50% of JBI items). The primary outcome indicator was psoriasis recurrence in patients during the follow-up time of each study. We performed subgroup analyses of the resulting data according to type of HSCT (autologous or allogeneic transplantation), and whether or not treatment for GVHD was administered after transplantation. Synthesis without meta-analysis items (SWiM) showed that recurrence of psoriasis (and/or psoriatic arthritis) during follow-up was the primary outcome of interest. Overall, a total of 31 (75.6%) of the 41 patients included in our review did not experience recurrence during follow-up period, with a maximum follow-up of 264 months (22 years) and a minimum of 5 months. The remaining 10 patients (24.4%) experienced recurrence of psoriasis during post-transplantation follow-up, with the earliest recurrence of skin lesions occurring at 1.4 months after transplantation but the lesions disappearing at 3.5 months; and the latest recurrence occurred up to 60 months post-transplant, while the patient experienced a flare-up of psoriatic arthritis at 156 mouths, but the severity and duration of psoriasis and arthritis improved compared to pretransplant. HSCT is expected to be an effective treatment for psoriasis as well as recurrence for a wide range of psoriasis patients. Future better epidemi","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cepharantine prevents hypertrophic scarring by regulating the TGF-β/SMAD pathway","authors":"Chenhuan Liu,&nbsp;Qin Yu,&nbsp;Lingyan Shen,&nbsp;Xiaoyan Wen,&nbsp;Juan lian,&nbsp;Jiani Wang,&nbsp;Jin Yang,&nbsp;Lin Chen","doi":"10.1007/s00403-025-04120-2","DOIUrl":"10.1007/s00403-025-04120-2","url":null,"abstract":"<div><p>Hypertrophic scarring (HS) is a fibrotic skin disorder characterized by excessive deposition of extracellular matrix (ECM), leading to symptoms such as pain, itching, and skin contraction. HS can also result in restricted joint mobility and cosmetic deformities, imposing psychological and economic burdens on patients. Additionally, it increases wound care costs, and currently, no ideal treatment options exist. Therefore, HS is not only a clinical care issue but also a societal problem, with significant challenges related to its management and prevention. In this study, a custom-made cepharanthine ointment was applied to a rabbit ear scar model to investigate its effects on morphology, histology, and protein expression in HS. Additionally, the mechanism underlying the effect of cepharanthine on affected fibroblasts and the expression of ECM proteins was explored in vitro models of fibrosis. Animal experiments demonstrated that cepharanthine significantly reduced the tissue scar hypertrophy index and collagen content, improved the arrangement of fibroblasts, and inhibited ECM production. Cellular experiments indicated that cepharanthine effectively downregulated key proteins in the TGF-β/SMAD pathway, decreased ECM protein expression, and suppressed fibroblast proliferation and migration. Cepharanthine can prevent HS by reducing ECM deposition through the TGF-β/SMAD signalling pathway.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of plasma exosomal microRNA- 148a- 3p on the CD4+ T cell function and its mechanism in the pathogenesis of psoriasis","authors":"Ling Lin,&nbsp;Wei Li,&nbsp;Xinjing Gao,&nbsp;Qian Li,&nbsp;Xin Zhou,&nbsp;Weiyu Liu,&nbsp;Xuelian Zhong,&nbsp;Yunqing Yang,&nbsp;Xibao Zhang,&nbsp;Quan Luo","doi":"10.1007/s00403-025-04197-9","DOIUrl":"10.1007/s00403-025-04197-9","url":null,"abstract":"<div><p>Psoriasis represents a chronic inflammatory skin disease occurring globally. We investigated the role of plasma exosomal microRNA (miR)- 148a- 3p and its target gene Bim in psoriasis. Plasma exosomes (Exos) and CD4⁺ T cells were extracted from psoriatic patients. miR- 148a- 3p expression in Exos and CD4⁺ T cells of psoriatic patients, the proportions of CD4⁺ T cell subsets, and the contents of anti-inflammatory/pro-inflammatory factors were determined by RT-qPCR, flow cytometry and ELISA. The correlation between plasma exosomal miR- 148a- 3p and CD4⁺ T cell subsets in psoriatic patients was analyzed by Pearson’s analysis. The psoriatic mouse was treated with Exos/antagomir miR- 148a- 3p. Histopathological changes in the skin were observed. The CD4⁺ T cell subset levels, serum cytokine contents and miR- 148a- 3p expression in the blood were measured. The miR- 148a- 3p-Bim targeted binding relationship was predicted and verified by Starbase database and dual-luciferase assay. The Bim expression in psoriatic mice was determined. Psoriatic patients had highly-expressed miR- 148a- 3p in both Exos and CD4⁺ T cells, and abnormal CD4⁺ T cell subsets and cytokine levels. Plasma exosomal miR- 148a- 3p was correlated with the CD4⁺ T cell subsets in psoriatic patients. Exos caused down-regulated miR- 148a- 3p level in skin tissues of mouse, regulated CD4⁺ T cell function and aggravated the symptoms in psoriatic mice. miR- 148a- 3p repression partially reversed the role of Exos in CD4⁺ T cell function and psoriasis-like symptoms. Exos-carried miR- 148a- 3p targeted Bim in CD4⁺ T cells of psoriatic mice. Plasma exosomal miR- 148a- 3p targeted Bim to affect the dysfunction of CD4⁺ T cells in psoriatic mice, thereby aggravating the psoriasis-like symptoms.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pruritus biomarkers expression in chronic spontaneous urticaria","authors":"Gabriel Paschoaleto Rodrigues Lopes,&nbsp;Yasmim Álefe Leuzzi Ramos,&nbsp;Naiura Vieira Pereira,&nbsp;Mírian Nacagami Sotto,&nbsp;Joyce Tiyeko Kawakami,&nbsp;Marcella Soares Pincelli,&nbsp;Maria Notomi Sato,&nbsp;Maira Pedreschi Marques Baldassin,&nbsp;Alessandra Dellavance,&nbsp;Luis Eduardo Coelho Andrade,&nbsp;Raquel Leão Orfali,&nbsp;Celina Wakisaka Maruta","doi":"10.1007/s00403-025-04170-6","DOIUrl":"10.1007/s00403-025-04170-6","url":null,"abstract":"<div><p>Chronic urticaria (CU) is a skin disease characterized by recurrent episodes of urticaria and/or angioedema, persisting for more than six weeks. Chronic urticaria is classified as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). Histamine, released by mast cells and basophils, is the central mediator in the development of signs and symptoms, especially pruritus. IL-31 activates pruritus via IL-31RA. Th2 cytokines also contributes to the inflammatory environment, releasing further IL-31. We aimed to investigate the quantification of mast cells, expression of pro-inflammatory cytokines in skin samples from individuals with CU and cell activation by the basophil activation test. Thirteen patients with CSU, 11 patients with CIndU and 10 healthy controls (HC) were enrolled in the study. We performed histologic quantification of the mast cells, metachromatic stained with toluidine blue, in CSU and CIndU lesional samples; IL-31, IL-31RA, IL-4 and IFN-γ expression by immunohistochemistry; and basophil activation test (BAT) by flow cytometry. The main findings were increased mast cell quantification in CSU; increased epidermal and dermal expression of IL-31 in CSU lesional samples and increased dermal expression in CIndU samples; augmented IL-31RA expression at epidermis and dermis of CSU group; augmented expression IL-4 at epidermis of CSU patients. We also found enhanced BAT positivity in CSU, reinforcing the autoimmune profile of our CSU patients. The analysis of the proinflammatory cytokines related to pruritus, showed increased expression of the evaluated components. These remarkable findings in CSU emphasize their relevance as potential disease biomarkers and targets for immunomodulatory interventions.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis vulgaris and circulating metabolic biomarkers: a mendelian randomization analysis","authors":"Dezhao Bi,&nbsp;Jianxin Shi,&nbsp;Yunyao Hu,&nbsp;Jin Tong Tey,&nbsp;Dan Yao,&nbsp;Songmao Hua,&nbsp;Xiaochen Zhu,&nbsp;Jia Liu,&nbsp;Shun Guo","doi":"10.1007/s00403-025-04232-9","DOIUrl":"10.1007/s00403-025-04232-9","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the use of population descriptors in dermatology trials and beyond: disentangling race and ethnicity from skin color","authors":"Valerie M. Harvey,&nbsp;Jenna C. Lester,&nbsp;Tarannum Jaleel,&nbsp;Junko Takeshita,&nbsp;Amy J. McMichael,&nbsp;Yvette Miller-Monthrope,&nbsp;Nina G. Jablonski,&nbsp;Jade Lewis,&nbsp;Andrew F. Alexis,&nbsp;Stafford G. Brown,&nbsp;Cheryl M. Burgess,&nbsp;Angel S. Byrd,&nbsp;Suephy C. Chen,&nbsp;Caryn Cobb,&nbsp;Roxana Daneshjou,&nbsp;Seemal R. Desai,&nbsp;Candrice R. Heath,&nbsp;Chidubem A.V. Okeke,&nbsp;Hema Sundaram,&nbsp;Susan C. Taylor,&nbsp;Jonathan S. Weiss,&nbsp;Jane Y. Yoo,&nbsp;Valerie D. Callender","doi":"10.1007/s00403-025-04219-6","DOIUrl":"10.1007/s00403-025-04219-6","url":null,"abstract":"<div><p><b>Importance</b>: Race and ethnicity as population descriptors in research and clinical practice have often been a subject of debate, drawing heightened scrutiny in recent years. Criticism focuses on their oversimplification and misapplication, which fail to capture the complexity of human health and genetic diversity. There is growing recognition that these categories, rooted in outdated social constructs, do not accurately reflect biological differences. <b>Observations</b>: Historically, race and ethnicity have been used as proxies for genetic variation and skin color, despite the understanding that these constructs are not biologically defined. The Skin of Color Society’s second <i>Meeting the Challenge</i> Summit, attended by over 100 U.S. and international participants, highlighted several key themes: (1) the need for transparency in the rationale behind using population descriptors and decision-making processes; (2) recognizing the role of race and racism in dermatology; (3) exploring the intersection of dermatology, skin color, and cultural influences; (4) understanding the context of population descriptor usage; (5) developing improved, objective tools for classifying skin color; and (6) advancing research and creating guidelines. <b>Conclusions and Relevance</b>: There is an urgent need to reconsider the use of race and ethnicity as population descriptors in dermatology research. Current systems, which conflate social identity with biological markers, perpetuate health disparities and limit the accuracy of clinical data. Moving forward, more specific descriptors such as skin color, alongside socially determined factors, will be crucial in achieving meaningful diversity and inclusivity in clinical research.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}