Archives of Dermatological Research最新文献

Study of cathelicidin (LL-37) immunoexpression in the skin of vitiligo patients.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-025-03801-2

Lamia Hamouda Elgarhy, Basma Ramadan Refaey Ramadan, Fersan Abd Allah Sallam, Dalya Ayman Iskandarani, El-Sayed Shaaban Hewedy

{"title":"Study of cathelicidin (LL-37) immunoexpression in the skin of vitiligo patients.","authors":"Lamia Hamouda Elgarhy, Basma Ramadan Refaey Ramadan, Fersan Abd Allah Sallam, Dalya Ayman Iskandarani, El-Sayed Shaaban Hewedy","doi":"10.1007/s00403-025-03801-2","DOIUrl":"https://doi.org/10.1007/s00403-025-03801-2","url":null,"abstract":"Vitiligo is a pigmentary disorder acquired and caused by the loss or destruction of melanocytes from the epidermis. There is strong proof that vitiligo is mainly an autoimmune disease. Cathelicidin (LL37), an antimicrobial polypeptide, is an important part of the innate immune system and has a role in different skin autoimmune diseases. The present work aimed to study the immunoexpression of cathelicidin in the vitiligo patients' skin to elucidate its possible role in vitiligo pathogenesis. Twenty vitiligo patients and 20 controls of matched sex and age were included. A 3 mm punch biopsy was taken from the non-lesional and lesional skin of each patient and controlled subjects. Each was stained with hematoxylin and eosin (H&E) and subjected to cathelicidin immunostaining detection. A significant difference was detected between the two studied groups regarding cathelicidin immunohistochemical expression (Pvalue < 0.001). The lesional immunohistochemical expression of cathelicidin showed a mean of 2.85 ± 0.67. The non-lesional immunohistochemical expression of cathelicidin showed a mean of 2.05 ± 0.51 with a statistically significant higher mean value in the patients' group than the controls (P < 0.001) which recommends that cathelicidin may play a role in the vitiligo pathogenesis. The immunohistochemical scores of the lesional and non-lesional cathelicidin levels were significantly related to the VIDA score (p < 0.001 and = 0.016, respectively) which suggests a role of cathelicidin in vitiligo activity. A significant elevation was indicated in the non-lesional cathelicidin expression, indicating that cathelicidin may be able to predict the appearance of future lesions in non-lesional skin, this requires further longitudinal studies to be confirmed.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"316"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying care gaps and referral patterns in acute dermatology at urgent care centers.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03662-1

S Minhaj Rahman, Amanda Rodriguez Orengo, Acacia Bowden, Clayton B Green, Alice P Pentland, Christopher T Richardson, Anna De Benedetto, Molly Plovanich, Julie Ryan Wolf

{"title":"Identifying care gaps and referral patterns in acute dermatology at urgent care centers.","authors":"S Minhaj Rahman, Amanda Rodriguez Orengo, Acacia Bowden, Clayton B Green, Alice P Pentland, Christopher T Richardson, Anna De Benedetto, Molly Plovanich, Julie Ryan Wolf","doi":"10.1007/s00403-024-03662-1","DOIUrl":"https://doi.org/10.1007/s00403-024-03662-1","url":null,"abstract":"Limited urgent access to board-certified dermatologists drives patients to seek dermatologic care at urgent care centers (UCC). UCC are staffed by clinicians with comparatively limited dermatology training, often resulting in lower quality care for acute dermatology conditions. Using a retrospective cohort of 839 referrals, this study investigates health care referral outcomes for patients seeking dermatologic care at UCC. We further surveyed five dermatologists on the appropriateness of UCC referral and UCC treatment plans in a subset of 40 referrals, as well as the feasibility of referral management by dermatology e-consultation (eConsult). Most patients referred by UCC did not complete an in-person dermatology evaluation (56.5%). Of those that completed an in-person dermatology evaluation, only 29.1% of UCC diagnoses were concordant. While our surveyed dermatologists (≥3/5 consensus) determined only 20% of UCC referrals had appropriate treatment plans, they found most referrals (92.5%) could have been managed with an eConsult with only 5.0% requiring an urgent in-person dermatology evaluation. These data reveal several practice gaps in dermatological care delivery in UCC and inefficiencies in the urgent referral process.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"315"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural anti-aging strategies: mechanisms and role of phytoextracts in combating skin aging.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-025-03807-w

Vishakha Saini, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma, Kumar Guarve

引用次数: 0

The effect of the antibody-mediated immune responses on hidradenitis suppurativa: a mendelian randomization study.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-025-03831-w

Yuzhe Cheng, Jun Niu

引用次数: 0

Skin cancer knowledge, attitudes, beliefs, and prevention practices among beachgoers: a narrative review.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03547-3

Amanda H Wilkerson, Judy Yau, Ross L Pearlman, Emily K Cobb, Isabella Aldana, Natalie Garcia, Raj H Patel, Arjun Pandya, Alexis Hilts, Jenna C Benge, Thy Huynh, Allison R Cruse, Vinayak K Nahar

{"title":"Skin cancer knowledge, attitudes, beliefs, and prevention practices among beachgoers: a narrative review.","authors":"Amanda H Wilkerson, Judy Yau, Ross L Pearlman, Emily K Cobb, Isabella Aldana, Natalie Garcia, Raj H Patel, Arjun Pandya, Alexis Hilts, Jenna C Benge, Thy Huynh, Allison R Cruse, Vinayak K Nahar","doi":"10.1007/s00403-024-03547-3","DOIUrl":"https://doi.org/10.1007/s00403-024-03547-3","url":null,"abstract":"People who spend time at the beach at increased risk for ultraviolet light (UV) exposure. This review assessed skin cancer-related knowledge, attitudes, beliefs, and prevention practices among beachgoers and sunbathers at the beach. Relevant articles were search in the following electronic databases: PubMed (Medline), Cumulative Index to Nursing and Allied Health (CINAHL), ERIC, and PsycINFO. A narrative analysis of pertinent study findings was conducted. A total of 24 studies were included in this narrative review. Findings included moderate to high knowledge of sun protection as well as knowledge-based deficiencies around the type of UV light that causes sun damage, risk factors, prevention of lip damage and cancer, length of sun exposure, and risk of photoaging with increased sun protection factor value. Beachgoers and sunbathers perceive their own risk of skin cancer and skin aging as less than that of the general population. Variable sun protection behaviors were observed in this population including use of sunscreen, sunglasses, shade, hats, and protective clothing. Amongst all beachgoers and sunbathers, 21-22.8% do not use sun protection and 62% have experienced a blistering sunburn in their lives. Beachgoers would benefit from increased education on skin cancer susceptibility and the importance of sun protection strategies. Healthcare providers should provide counseling on sun protection to reduce the morbidity and mortality associated with skin cancer. Disseminating information through the media may help bring more awareness of healthy skin practices at the beach and prevent skin cancers.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"314"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world switching patterns and associated characteristics in patients with psoriasis treated with biologics.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03746-y

Elizabeth Lazaridou, Zoe Apalla, Stylianos Ravanidis, Garyfallia Stefanou, Katerina Vellopoulou, Anastasios Tsolakidis, Konstantinos Mathioudakis, Georgia Kourlaba

{"title":"Real-world switching patterns and associated characteristics in patients with psoriasis treated with biologics.","authors":"Elizabeth Lazaridou, Zoe Apalla, Stylianos Ravanidis, Garyfallia Stefanou, Katerina Vellopoulou, Anastasios Tsolakidis, Konstantinos Mathioudakis, Georgia Kourlaba","doi":"10.1007/s00403-024-03746-y","DOIUrl":"https://doi.org/10.1007/s00403-024-03746-y","url":null,"abstract":"Multiple parameters define the treatment course with biologics for a psoriatic patient while treatment switches are often associated with worse prognosis. The purpose of this study was to describe the switching patterns of biologics for psoriasis in the Greek market landscape and to detect associated factors that may impact the evolvement of selected therapy. This is a retrospective cohort study using data recorded in the nationwide digital prescription database of Greece. Patients with a diagnosis for psoriasis, with or without concomitant psoriatic arthritis (PsA), who had initiated a biologic treatment between January 1st 2016 and December 31st 2020 were included. Overall, 6,772 biologic-naïve patients were included. Patients treated with infliximab demonstrated the highest switching rates while those treated with ustekinumab and secukinumab the lowest. Secukinumab and brodalumab had the lowest rates of switch or re-initiation 12 months after initiation. Switches from secukinumab to brodalumab and ustekinumab and from adalimumab to secukinumab and ustekinumab were more frequently observed. The risk was significantly higher for patients with concurrent PsA and for women, while patients treated with brodalumab, secukinumab and ustekinumab demonstrated a lower risk compared to adalimumab. Antibodies against interleukins have lower switching rates compared to more traditional biologics. The time to switch is longer for the first transition highlighting the necessity to establish long term therapeutic options early in the treatment course. Concurrent PsA or gender may have a significant impact in outcome, thus they need to be considered before the launch of a selected therapy.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"310"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized nanostructured lipid carriers from aceh traditional coconut (Pliek) oil: a promising topical formulations for atopic dermatitis.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-025-03824-9

Rima Hayati, Endang Lukitaningsih, Teuku Nanda Saifullah Sulaiman, Nanda Earlia, Rinaldi Idroes

{"title":"Optimized nanostructured lipid carriers from aceh traditional coconut (Pliek) oil: a promising topical formulations for atopic dermatitis.","authors":"Rima Hayati, Endang Lukitaningsih, Teuku Nanda Saifullah Sulaiman, Nanda Earlia, Rinaldi Idroes","doi":"10.1007/s00403-025-03824-9","DOIUrl":"https://doi.org/10.1007/s00403-025-03824-9","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by dry skin, severe itching, redness, and inflammation. Its complex etiology, involving genetic, immunological, and environmental factors, necessitates innovative therapeutic approaches. This study investigates nanostructured lipid carriers (NLCs) formulated with traditional fermented coconut (Cocos nucifera L.) oil from Aceh (pliek oil). The NLC was optimized using Box-Behnken Design and prepared through high shear homogenization and ultrasonication. The optimized formula consisted of 8% w/w lipid phase, 2 min sonication time, and 6% Tween 80, resulting in a particle size of 207.1 ± 0.93 nm, a polydispersity index of 0.275 ± 0.005, and a zeta potential of - 30.2 ± 0.78 mV. A 1:1 ratio of Tween 80 and Span 20 ensured stable NLC. The NLC of Pliek oil (NLC-PL) gel met EuroGuiDerm standards for AD treatment, with a pH of 5.62 ± 0.06, indicating skin compatibility. Histological analysis demonstrated that the NLC-PL gel (2.5% w/w pliek oil) significantly reduced MC903-induced ear thickness and inflammation compared to the negative control (p < 0.05), and suppressed mast cell numbers, comparable to the positive control (p > 0.05). Enzyme-Linked Immunosorbent Assay (ELISA) confirmed its role as a c-jun N-terminal kinase 1 (JNK1) inhibitor, supporting its potential as targeted topical therapy for AD. This study aligns with the study's objective to develop innovative treatments for AD.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"313"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The paradoxical activity of BRAF inhibitors: potential use in wound healing.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03785-5

Sonali Karhana, Mohd Samim, Nidhi, Mohd Ashif Khan

{"title":"The paradoxical activity of BRAF inhibitors: potential use in wound healing.","authors":"Sonali Karhana, Mohd Samim, Nidhi, Mohd Ashif Khan","doi":"10.1007/s00403-024-03785-5","DOIUrl":"https://doi.org/10.1007/s00403-024-03785-5","url":null,"abstract":"The area of wound healing presents a promising field of interest for clinicians as well as the scientific community. A major concern for physicians is the rising number of elderly people suffering from diabetes, leprosy, tuberculosis and the associated chronic wounds. While traditional therapies target basic wound care, innovative strategies that accelerate wound healing are needed. V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors are anti-cancer drugs used primarily for melanoma. They also exhibit paradoxical activity, a phenomenon characterized by unintended activation of the Mitogen-Activated Protein Kinase (MAPK) signalling pathway leading to skin hyperproliferation. Studies have demonstrated that BRAF inhibitors can be repurposed to accelerate the healing of acute and chronic wounds by exploiting their paradoxical activity. This review evaluates studies on BRAF inhibitors by employing a systematic search strategy using databases such as PubMed, Scopus, Google Scholar, and Web of Science. Articles were screened based on relevance to the paradoxical activity of BRAF inhibitors, their mechanisms, and applications in wound healing. Evidence from in vitro, in vivo, and clinical studies demonstrates that BRAF inhibitors can enhance processes such as epithelialization and angiogenesis, essential for wound repair. This review summarizes the reports on the paradoxical activity of BRAF inhibitors, the predicted mechanisms behind the paradoxical activity, and their potential use in wound healing.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"311"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of combined low-level nd: YAG laser with mesenchymal stem cells in the healing of diabetic wounds: an experimental study.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03714-6

Ali TizMaghz, Shahrokh Shojaei, Pedram Tehrani

{"title":"The effect of combined low-level nd: YAG laser with mesenchymal stem cells in the healing of diabetic wounds: an experimental study.","authors":"Ali TizMaghz, Shahrokh Shojaei, Pedram Tehrani","doi":"10.1007/s00403-024-03714-6","DOIUrl":"https://doi.org/10.1007/s00403-024-03714-6","url":null,"abstract":"Although the role of low-level laser therapy (LLLT) and human adipose-derived stem cells (hADSC) in accelerating diabetic wound healing has been proven, their synergistic effect is still debated. This study aimed to evaluate the individual and combined effects of LLLT and hADSC on wound healing and on biomechanical parameters in type 2 diabetic rabbits. In this experimental study, 40 rabbits with type 2 diabetes (induced by streptozotocin (STZ)) were included. Rabbits were randomly assigned with equal ratios to 4 groups, including the control group (group A), hADSCs alone (group B), the laser alone (group C), and the combined group of hADSCs cells with laser (group D). 30 days after diabetes, two wounds were created on the back of each rabbit. Immediately after creating a wound, hADSC was injected into two parts of the wound. In the laser groups, the wound site was treated with a low-power 660 nm laser for 4 weeks daily for 20-30 s. The number of closed wounds in the treatment group was evaluated 7, 15 and 30 days after the treatment. On the 15th and 30th days, a standard sample of each healing wound was sent for biomechanical evaluation. Thirty days after treatment, the combined effect of LLLT + hADSCs was superior to their individual effects on wound healing and biomechanical parameters (mean bending stiffness, maximum force, high-stress load, and energy absorption), while their individual effects were similar. Fifteen days after treatment, the effect of LLLT alone was superior to hADSCs alone for wound healing and improvement of biomechanical parameters. LLLT and hADSCs, individually and in combination, were superior in diabetic wound healing and biomechanical parameters compared to the control group in type 2 diabetic rabbits. The combined effect of LLLT with hADSCs was superior to their individual effects.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"317"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatologists' knowledge, attitudes, and practices regarding omalizumab therapy for chronic urticaria.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-28 DOI: 10.1007/s00403-024-03749-9

Shaofang Wu, Xin Ye, Xinyang Liu, Luyi Dai, Huan Chen

{"title":"Dermatologists' knowledge, attitudes, and practices regarding omalizumab therapy for chronic urticaria.","authors":"Shaofang Wu, Xin Ye, Xinyang Liu, Luyi Dai, Huan Chen","doi":"10.1007/s00403-024-03749-9","DOIUrl":"https://doi.org/10.1007/s00403-024-03749-9","url":null,"abstract":"The purpose of this study was to evaluate dermatologists' knowledge, attitudes, and practices (KAP) concerning omalizumab therapy for chronic urticaria. We conducted a cross-sectional study in several hospitals in China, mainly in hospitals in Zhejiang Province, during August 1, 2024 - August 15, 2024 using a self-administered KAP questionnaire. Wilcoxon-Mann-Whitney tests and Kruskal-Wallis analysis of variance were performed to compare differences across groups Factors influencing practice were determined through multivariable logistic regression. The study analyzed 354 valid questionnaires. Among the respondents, 248 (70.06%) were aged between 31 and 35 years, and 269 (75.99%) had 5-10 years of experience. The mean scores for knowledge, attitudes, and practices were 5.71 ± 1.39 (possible range: 0-9), 21.39 ± 2.25 (possible range: 5-25), and 19.84 ± 2.53 (possible range: 5-25), respectively. Multivariate logistic regression indicated that a higher attitude score (OR = 1.929, 95% CI: [1.511-2.462], P < 0.001), being male (OR = 3.262, 95% CI: [1.507-7.059], P = 0.003), and awareness of omalizumab (OR = 4.966, 95% CI: [1.466-16.830], P = 0.010) were significantly associated with proactive practice. Dermatologists demonstrated insufficient knowledge, positive attitudes, and proactive practices towards omalizumab therapy for chronic urticaria. Given the identified knowledge gap, there is a pressing need for targeted educational interventions to enhance dermatologists' understanding of omalizumab therapy for chronic urticaria, aiming to improve patient care and outcomes in clinical practice.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"309"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0