Archives of Dermatological Research最新文献

Wound treatment with curcumin prevents hypertrophic scarring and promotes remodeling by inhibiting fibroblast activation and regulating collagen deposition 伤口治疗用姜黄素防止增生性疤痕和促进重塑通过抑制成纤维细胞活化和调节胶原沉积

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-17 DOI: 10.1007/s00403-025-04271-2

Wang Wei, Yansheng Zhang, Yao Qian, Tianyun Pan, Qiuhua Ma

{"title":"Wound treatment with curcumin prevents hypertrophic scarring and promotes remodeling by inhibiting fibroblast activation and regulating collagen deposition","authors":"Wang Wei, Yansheng Zhang, Yao Qian, Tianyun Pan, Qiuhua Ma","doi":"10.1007/s00403-025-04271-2","DOIUrl":"10.1007/s00403-025-04271-2","url":null,"abstract":"<div><p>More and more attention is paid to the prevention of hypertrophic scars (HS). This study aimed to investigate the mechanisms of topical curcumin application in alleviating HS secondary to wounds. Human dermal fibroblasts (HDFs) were cultured with transforming growth factor-β1 and varying concentrations of curcumin for 48 h. The proliferation activity, apoptosis and migration of HDFs were detected by CCK-8 assay, EdU assay, flow cytometry and wound healing assay, respectively. The expression of proteins implicated in fibroblast activation and collagen deposition was determined by Western blotting (WB). Curcumin (25 μmol/L, 28 days) was applied to rabbit ear wounds, and hypertrophic scarring was evaluated grossly and microscopically. We found that curcumin inhibited the proliferation and migration of HDFs and promoted cell apoptosis in a concentration-dependent manner. Curcumin at 10 and 25 μmol/L concentrations reduced the expression of Ki-67 and α-smooth muscle actin and increased cleaved caspase-3 expression and Bax/Bcl-2 ratio. Although the protein levels of collagen-I (COL-I), COL-III, matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were down-regulated, COL-III/COL-I and MMP-2/TIMP-1 ratios were maintained. Curcumin decreased the Manchester scar scale score, scar elevation index and collagen volume fraction of rabbit ear scars. Immunohistochemical results were generally consistent with the WB data. Unlike suppression of TIMP-1 in the entire region of the scar, curcumin reduced MMP-2 expression only in the edge part, which might be related to the alteration of cell polarity and orientation of fibroblasts. In conclusion, curcumin facilitates high-quality scars after wound healing by regulating fibroblast activation and collagen deposition.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital ichthyosis is associated with cutaneous malignancies in a case-control study 先天性鱼鳞病与皮肤恶性肿瘤相关的病例对照研究

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04259-y

Kaya L. Curtis, Steven Zeldin, Shari R. Lipner

{"title":"Congenital ichthyosis is associated with cutaneous malignancies in a case-control study","authors":"Kaya L. Curtis, Steven Zeldin, Shari R. Lipner","doi":"10.1007/s00403-025-04259-y","DOIUrl":"10.1007/s00403-025-04259-y","url":null,"abstract":"<div><h3>Background</h3><p>Congenital ichthyoses are a heterogeneous group of keratinization disorders. Though there are case reports describing skin cancer development in congenital ichthyosis patients, the risk of skin cancer in congenital ichthyosis patients compared to the general population is unknown.</p><h3>Objective</h3><p>We aimed to evaluate the association of congenital ichthyosis with cutaneous malignancies using a large national database.</p><h3>Methods</h3><p>A nested case-control study using the National Institutes of Health <i>All of Us</i> database was conducted analyzing participants ≥ 18 years with CI and controls matched 1:12 by age, sex, and race/ethnicity. Multivariate logistic regression assessed odds ratios for CI and skin cancer associations (<i>P</i> < 0.05).</p><h3>Key results</h3><p>A total of 198 CI participants and 2,376 controls were included in the final analysis. Mean age of CI participants was 67.2 years, with 56.1% female and 67.7% white, similar to controls (<i>P</i> = 0.97, <i>P</i> = 1, <i>P</i> = 0.99, respectively). After controlling for smoking, alcohol, obesity, and mobility, congenital ichthyosis was associated with actinic keratosis (AK) (OR = 3.65; 95% CI 1.00-5.51; <i>P</i> < 0.001), melanoma (OR = 2.39; 95% CI 1.05–5.45; <i>P</i> = 0.04), and basal cell carcinoma (BCC) (OR = 1.90; 95% CI 1.03–3.39; <i>P</i> = 0.03), but not squamous cell carcinoma (SCC) (<i>P</i> = 0.50).</p><h3>Conclusion</h3><p>We found that CI was associated with cutaneous malignancies. Larger scale studies are needed to confirm these findings with narrower confidence intervals. We recommend routine skin cancer surveillance in CI patients pending additional studies clarifying risk of cutaneous malignancy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mohs Micrographic Surgery (MMS) in immunosuppressed patients: a review of outcomes and prognosis 莫氏显微摄影手术（MMS）在免疫抑制患者：结果和预后的回顾

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04274-z

Maira A. Bhatty, Micah Belzberg, Allison T. Vidimos, Christine Poblete-Lopez

引用次数: 0

The causal relationship between celiac disease and psoriasis: evidence from Mendelian randomization and meta-analysis 乳糜泻和牛皮癣之间的因果关系：来自孟德尔随机化和荟萃分析的证据

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04253-4

Ruixuan Wang, Suad Ali Hassan Fodei, Xinquan Wang, Wangqing Chen, Wu Zhu

引用次数: 0

Systematic review of Flegel disease: clinical presentations, associations, diagnostic pitfalls, and management challenges 弗雷格尔病的系统综述：临床表现、关联、诊断缺陷和管理挑战

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04268-x

Lanah Almatroud, Leo Wan, Aileen Park, Amor Khachemoune

{"title":"Systematic review of Flegel disease: clinical presentations, associations, diagnostic pitfalls, and management challenges","authors":"Lanah Almatroud, Leo Wan, Aileen Park, Amor Khachemoune","doi":"10.1007/s00403-025-04268-x","DOIUrl":"10.1007/s00403-025-04268-x","url":null,"abstract":"<div><p>Flegel’s disease (FD), also known as hyperkeratosis lenticularis perstans, is a rare benign hyperkeratotic dermatosis primarily affecting middle-aged individuals, with a slight female predominance. It presents as small, keratotic papules, often on the lower extremities. The pathogenesis of FD remains uncertain, with proposed mechanisms including genetic predisposition and primary keratinization disorders. Histopathologically, FD is characterized by discrete hyperkeratosis, parakeratosis, thinning or absence of the stratum granulosum, and lichenoid infiltrates in the papillary dermis. Dermoscopic findings such as scaly white and brownish structureless areas can assist in diagnosis. A key point of discussion is the potential overlap between FD and Kyrle disease (KD), as both conditions share similar clinical features, though distinctions exist. FD remains challenging to treat, with no standardized or evidence-based therapeutic guidelines. Various treatment modalities have been attempted, including emollients, topical corticosteroids, retinoids, vitamin D analogs, 5-fluorouracil (5-FU), phototherapy, and ablative techniques like laser therapy and cryotherapy. This systematic review consolidates current knowledge on FD, emphasizing the need for further research to clarify the pathogenesis, genetic underpinnings, and effective management strategies. Understanding FD’s distinct features and treatment challenges will aid dermatologists in accurate diagnosis and patient-centered care.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical metformin in wound healing: a comprehensive systematic review of therapeutic outcomes 局部二甲双胍在伤口愈合：治疗结果的全面系统回顾

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04277-w

Dorian Maghsoodloo, Hamed Zartab, Milad Alipour, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Abolfazl Parsi-Moud, Alireza Firooz

{"title":"Topical metformin in wound healing: a comprehensive systematic review of therapeutic outcomes","authors":"Dorian Maghsoodloo, Hamed Zartab, Milad Alipour, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Abolfazl Parsi-Moud, Alireza Firooz","doi":"10.1007/s00403-025-04277-w","DOIUrl":"10.1007/s00403-025-04277-w","url":null,"abstract":"<div><p>Metformin’s topical application has proven to be a therapeutic wound healing dressing via pro-angiogenic, anti-inflammatory, autophagy-promoting, and antibacterial effects. The systematic review article aimed to evaluate the available evidence (from both preclinical and clinical studies), in order to better understand its therapeutic potential in wound care. We performed a systematic literature search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases till January 2025. A total of 26 studies included in final analysis according to inclusion criteria. The majority of preclinical investigations demonstrated accelerated wound healing with characterized of increased wound closure and collagen deposition, elevated pro-angiogenic markers (e.g., VEGF, CD31, and α-SMA), suppression of pro-inflammatory cytokines, and induction of autophagy signaling. Notably, biomaterial-based delivery platform applications such as hydrogels and nanofibers greatly magnified these therapeutic effects. While encouraging results in in-vitro, in-vivo and animal models have been documented, clinical studies remain limited in scope. In fact, this large disparity between preclinical results and limited clinical evidences obviously highlights the urgent need for properly designed human trials to determine safety, efficacy, and best delivery modalities of topical metformin. Collectively, topical metformin is a novel and potentially valuable addition to wound treatment cares, which could be subjected to further clinical study.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The lip flip: a systematic review of botulinum toxin lip augmentation 翻唇：肉毒杆菌毒素丰唇的系统回顾

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04265-0

Chase A. Pitchford, Andrew S. Desrosiers, Stanislav N. Tolkachjov

引用次数: 0

SKIN: a four step method for navigating difficult conversations in dermatology 皮肤：在皮肤病学中导航困难对话的四步方法

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-16 DOI: 10.1007/s00403-025-04257-0

Emily R. Gordon, Megan H. Trager, Cindy Nelson, Rosie Balk, Jeff Miller, Brigit A. Lapolla, Oluwaseyi Adeuyan, Celine M. Schreidah, Faramarz H. Samie, Cori Salvit, Douglas J. Koo, Larisa J. Geskin

{"title":"SKIN: a four step method for navigating difficult conversations in dermatology","authors":"Emily R. Gordon, Megan H. Trager, Cindy Nelson, Rosie Balk, Jeff Miller, Brigit A. Lapolla, Oluwaseyi Adeuyan, Celine M. Schreidah, Faramarz H. Samie, Cori Salvit, Douglas J. Koo, Larisa J. Geskin","doi":"10.1007/s00403-025-04257-0","DOIUrl":"10.1007/s00403-025-04257-0","url":null,"abstract":"<div><p>Diagnostic disclosure in the world of new technologies presents unique challenges. Studies investigating the role of dermatologists in breaking bad news and standard practices do not exist. To evaluate dermatologists’ perceptions, frequency, and attitudes towards breaking bad news and to create a practical guide for diagnostic disclosure. A national survey of 223 dermatologists (via the American Academy of Dermatology) assessed their comfort and training in breaking bad news. The responses were analyzed for patterns and gaps in preparedness. All dermatologists felt breaking bad news was an important daily task. However, many (40%) did not feel completely comfortable with diagnostic disclosure and often learned during practice (61%) or lacked any training in the task (17%). Dermatologists highlighted the need for additional resources; thus we created a guide for breaking bad news in dermatology which we called the SKIN (Set the stage, Knowledge, Inform, Next steps) approach. The SKIN approach offers a structured framework to improve dermatologists’ confidence and effectiveness in diagnostic disclosure. Incorporating formal training into medical education and residency programs could further enhance preparedness for this task.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of serum interleukin-19 (IL-19) levels in acne vulgaris: a comprehensive case control study 血清白细胞介素-19 （IL-19）水平在寻常痤疮中的作用：一项全面的病例对照研究

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-15 DOI: 10.1007/s00403-025-04263-2

M. K. Mrunalini Rayi, Rochelle Cheryl Monteiro, Shivashankara Ramachandrayya

{"title":"Role of serum interleukin-19 (IL-19) levels in acne vulgaris: a comprehensive case control study","authors":"M. K. Mrunalini Rayi, Rochelle Cheryl Monteiro, Shivashankara Ramachandrayya","doi":"10.1007/s00403-025-04263-2","DOIUrl":"10.1007/s00403-025-04263-2","url":null,"abstract":"<div><p>Acne vulgaris (AV) has a multifactorial pathogenesis, with inflammation being a key factor. The pro-inflammatory role of interleukin (IL)-19 has been explored in several systemic and some dermatological conditions. This study aimed to analyse serum levels of IL-19 in cases as well as healthy controls and to assess its correlation with the disease severity. A cross sectional, observational, analytical study was performed over a time period of 18 months at a tertiary care hospital. The study included 37 clinically diagnosed cases of acne aged between 16 to 30 years and 37 age and sex matched controls. Severity of the lesions was calculated using the Global Acne Grading System (GAGS). IL-19 levels of all the participants were measured with the help of quantitative Enzyme Linked Immunosorbent Assay (ELISA). The Spearman's rank correlation coefficient was used to evaluate the relationship between serum levels of IL-19 and the severity of AV, and a p-value of less than 0.05 was considered statistically significant. In this study, serum IL-19 levels showed a positive correlation with both the patients’ age and the duration of their symptoms, with p values of 0.04 for each. The median serum IL-19 levels were observed to be higher in the cases (80.89 ng//L) as compared to controls (44.82 ng/L), although this difference was not statistically significant (p = 0.095). Additionally, no significant correlation was found between IL-19 levels and the severity of acne (p = 0.45). Unlike prior work, our study found no link between IL-19 and severity of AV. Thus, we conclude that IL-19 may not be a reliable marker of the disease severity as previously stated and further research, preferably in larger sample size is warranted to confirm the same.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sun protection behaviors and knowledge among Riyadh residents: a snapshot 利雅得居民的防晒行为和知识：快照

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-05-14 DOI: 10.1007/s00403-025-04252-5

Rasha Elzeny, Faten A. AlRadini, Mai M. Albuqmi, Mohamed A.S. Amer, Sarah F. Almuqati, Rawabi Bandar Alsenan, Muhammad Liaquat Raza, Samar A. Amer

引用次数: 0