Archives of Dermatological Research最新文献

{"title":"Hemophagocytic lymphohistiocytosis in children with drug reaction with eosinophilia and systemic symptoms (DReSS): a systematic review","authors":"Yousef Alabdeen, Nicole Cherepacha, Frances St George-Hyslop, Luis Fernando Sanchez-Espino, Bindiya Chugani, Quenby Mahood, Elizaveta Limenis, Cathryn Sibbald, Ruud H.J. Verstegen","doi":"10.1007/s00403-025-04407-4","DOIUrl":"10.1007/s00403-025-04407-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panniculitis in newborns after ice therapy for supraventricular tachycardia: a systematic review","authors":"Abdul Aziz Abdul Ghafoor, Hediyeh Vaseli, Arveen Shokravi, Nafeel Arshad, Mohammad Shokravi","doi":"10.1007/s00403-025-04409-2","DOIUrl":"10.1007/s00403-025-04409-2","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of intestinal parasites in patients with pemphigus vulgaris","authors":"Maksut Şahin,&nbsp;Hatice Uce Özkol,&nbsp;Milad Afşar,&nbsp;Selahattin Aydemir,&nbsp;Abdurrahman Ekici","doi":"10.1007/s00403-025-04380-y","DOIUrl":"10.1007/s00403-025-04380-y","url":null,"abstract":"<div><p>It is known that opportunistic parasites are more effective in immunocompromised individuals, infections are more severe and treatment is negatively affected. There is a limited number of studies on the relationship between parasitosis and Pemphigus Vulgaris (PV), most of which are case reports. The aim of this study was to investigate the prevalence of intestinal parasites in patients with PV. Thirty patients with PV and 30 healthy individuals without any chronic disease as a control group were included in the study. Stool samples taken from the patients were evaluated by the native-Lugol method. Then, nested PCR was used to determine <i>G. intestinalis</i> and <i>Cryptosporidium</i> spp. positivity in stool samples, conventional PCR was used to determine <i>Blastocystis</i> and microsporidia positivity, and ELISA was used to determine <i>E. histolytica</i> positivity. One or more parasite species were detected in 23 (76.7%) of 30 PV patients and 10 (33.3%) of 30 healthy individuals in the control group (<i>P</i> = 0.0001). More than one parasite was seen in 12 patients (40%) in the patient group and in 5 individuals (16.7%) in the control group (<i>P</i> = 0.038). In the patient group, <i>Blastocystis</i> and <i>G. intestinalis</i> were detected in 8 (26.7%) individuals each, microsporidia in 12 (40%) individuals, <i>Cryptosporidium</i> spp. in 5 (16.7%) individuals, <i>E. histolytica</i> in 4 (13.3%) individuals, <i> E. coli</i> in 1 (3.33%) individual and <i>Taenia</i> spp. in 1 (3.33%) individual. Microsporidia were detected in 5 (16.7%) of the individuals in the control group, <i>Blastocystis</i> in 3 (10%), <i>E. histolytica</i> in 3 (10%), <i>G. intestinalis</i> in 2 (6.7%), <i>Cryptosporidium</i> spp. in 2 (6.7%) and <i> E. coli</i> in 1 (3.33%). Statistical significance was found between the patient and control groups in terms of microsporidia and <i>G. intestinalis</i> positivity. The parasite rate was higher in individuals aged 40 years and over in the control group (<i>P</i> = 0.024). The results obtained in the study show that parasitic infections are an important risk factor for patients with PV due to the characteristics of the disease and the treatment applied. Therefore, we believe that all patients with PV should be evaluated for intestinal parasites for early diagnosis of intestinal parasites in PV patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cutaneous innervation following bleomycin administration","authors":"Ying-Yi Lu,&nbsp;Chun-Ching Lu,&nbsp;Hung-Pei Tsai,&nbsp;Chieh-Hsin Wu","doi":"10.1007/s00403-025-04410-9","DOIUrl":"10.1007/s00403-025-04410-9","url":null,"abstract":"<div><p>Keloid patients always suffer stressful physical and psychological burdens due to intense pain. During wound healing, abnormal nerve fiber density results in altered skin sensation. However, the characteristics of cutaneous innervation in keloids and the underlying mechanisms remain unclear. Therefore, this study aims to determine whether cutaneous innervation occurs in a bleomycin-induced mouse model. Wild-type mice received intradermal bleomycin administration, a well-established model, to mimic keloids. Skin biopsies were analyzed for dermal thickness and intradermal nerve density using immunohistochemistry and immunofluorescence assays. Cutaneous neuroinflammation was evaluated using western blot analysis. Compared with phosphate-buffered saline-treated mice (saline), bleomycin-treated mice (BLM) exhibited increased dermal nerve fiber density and nociceptor expression. In addition, protein levels of NOD-like receptor family pyrin domain containing 3 (NLRP3), and apoptosis-associated speck-like protein containing a CARD (ASC) were elevated in bleomycin-treated mice, along with an increased ratio of c-caspase-1 to caspase-1. These findings suggest that the augmented cutaneous neuroinflammation potentially contributes to the enhanced cutaneous innervation in a bleomycin mouse model. Targeting the NLRP3 inflammasome in a bleomycin mouse model may reduce cutaneous reinnervation in mice.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum level of apelin-12 in acne patients: is it a marker of disease severity?","authors":"Eman M. K. Youssef,&nbsp;Marwa A. Gaber,&nbsp;Amira A. H. Mohammed,&nbsp;Doaa A. E. Abou-Taleb","doi":"10.1007/s00403-025-04375-9","DOIUrl":"10.1007/s00403-025-04375-9","url":null,"abstract":"<div><p>Acne vulgaris (AV) is a common multifactorial chronic inflammatory skin disease which is often associated with metabolic and hormonal factors. Our aim was to detect the level of serum apelin-12 in acne cases and to assess its correlation with body mass index (BMI), insulin resistance (IR) and acne severity. Ninety individuals were included in this case-control study, comprising 60 acne patients and 30 age-and sex-matched healthy controls. Clinical evaluation included BMI, waist circumference, and evaluation of the severity of acne by using the Global Acne Grading Scale (GAGS). Laboratory tests included serum apelin-12, serum fasting blood glucose (FBG), fasting insulin, and complete lipid profile (cholesterol, triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). IR was assessed by using Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR). Serum levels of apelin-12 in acne patients was found to be significantly higher than in healthy controls (<i>P</i> = 0.000*). Apelin-12 level increased with acne severity assessed by GAGS and was positively correlated with BMI, FBG, fasting insulin level and HOMA-IR. TG, cholesterol and LDL levels were also higher in acne patients compared to controls, while HDL levels were lower. A significant association was found between acne severity and IR, suggesting that IR plays a crucial role in the pathogenesis of AV. Serum apelin-12 can be utilized as a probable indicator for severity of acne. Its level is associated with IR, BMI and the inflammatory status of acne. The significant association among acne severity and IR highlighted that detection and management of IR may contribute positively to acne treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical practices among Mohs surgeons for medically complex and high-risk patients: a survey of American College of Mohs surgery members","authors":"Jay Patel,&nbsp;Olivia McGeough,&nbsp;Jaclyn Rosenthal Himeles,&nbsp;Jesse M. Lewin","doi":"10.1007/s00403-025-04404-7","DOIUrl":"10.1007/s00403-025-04404-7","url":null,"abstract":"<div><p>Mohs micrographic surgery (MMS) offers high cure rates and low complication risk for skin cancer. No formal guidelines exist for preoperative clearance or perioperative management of medically complex patients. We aimed to assess current practice patterns of Mohs micrographic surgeons with membership in the American College of Mohs Surgeons (ACMS) to identify practice gaps and inform future directions for expanding best practice guidelines in MMS. A 30-question survey was distributed to American College of Mohs Surgery (ACMS) members to evaluate preoperative clearance and perioperative management of high-risk patients. Descriptive statistics and chi-squared analyses were performed. Sixty-eight surgeons responded (52% single-specialty, 20% academic, 48% suburban, 40% urban). Practice characteristics did not affect responses. Although 43% responded that they do obtain preoperative clearance, 77% of those only obtain clearance 1–5 times per year, demonstrating the infrequent use of preoperative clearance in general. When utilized, preoperative clearance was most often for severe cardiovascular disease (50%), bleeding disorders (47%), or surgical complexity (40%). Primary care (71%) and cardiology (68%) were the main consultants. For patients with implantable cardiac devices, 47% used monopolar hyfrecators over bipolar forceps (32%) and electrocautery (21%). Cardiovascular disease did not affect lidocaine with epinephrine use (90%), and 54% used plain lidocaine in pregnancy, regardless of trimester. Anxiolytics were prescribed by 67% at least a few times per year, with 63% not monitoring perioperative vital signs after giving anxiolytics. Most surgeons avoided prophylactic antibiotics in solid organ transplant recipients (13% preoperative, 34% postoperative). HIV and hepatitis C testing and viral load monitoring were rarely performed. Bloodborne pathogen precautions included verbal (77%) or written (64%) communication and double gloves (40%). This survey identifies key comorbidities and approaches to management of medically complex patients, revealing variability in practice patterns among the cohort surveyed. Few sought clearances overall, reflecting the low complication rates and overall safety of MMS. Despite this, substantial heterogeneity exists for preoperative clearance and perioperative management. The findings highlight the need for further evaluation of practices and outcomes among Mohs surgeons, along with formal guidelines to standardize care in medically complex patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing in the assessment of skin changes through validated measurement scales: a systematic review","authors":"Thaís Pinto Nascimento,&nbsp;Bárbara Juliana Carvalho Costa,&nbsp;Elisangela Aparecida da Silva,&nbsp;Alexandre Vilhena da Silva Neto,&nbsp;Joao Ricardo Nickenig Vissoci,&nbsp;Felipe Leão Murta,&nbsp;Wuelton Marcelo Monteiro,&nbsp;Jacqueline de Almeida Gonçalves Sachett","doi":"10.1007/s00403-025-04368-8","DOIUrl":"10.1007/s00403-025-04368-8","url":null,"abstract":"<div>\u0000 \u0000 <p>Traditional clinical observations are the gold standard for early diagnosis and treatment of wounds. However, the exclusive use of clinical inspection increases the changes of diagnostic inaccuracies due to the subjectivity of the evaluator. The application of scales in the evaluation of skin changes can more reliably and effectively guide patient management. The objective of this study is to conduct an integrative literature review of studies that involve the validation of measurement scales for the evaluation of skin changes in various pathologies. The PUBMED, MEDLINE, and LILACS databases were used for the literature search on the subject. The review prioritized the selection of studies that address validated scales for the assessment of skin changes in different pathological conditions. A brief evolution in the scientific field on the topic was observed, particularly between the years 2012 and 2016. The most significant publications were concentrated in the United States and Brazil, suggesting a greater interest in studies on validated measurement scales for wounds. The types of studies selected in the articles were distributed among retrospective, prospective, cross-sectional cohorts, randomized, and combined research with both prospective and retrospective elements. The most evaluated characteristics by the scales included erythema, abscess, dryness, papules, redness, desquamation, cellulitis, and irritation. The diversity of the structures of the scales validated by the studies and the different types of scores for wound evaluation were also highlighted. The scales were notably applied in various clinical aspects, including skin integrity and discomfort, inflammatory aspects, eruptions, pruritus, infections, pigmentation, and healing. The skin, as a protective barrier of the body, can be compromised by the occurrence of severe pathological conditions. The skin, as a protective barrier of the body, can be compromised by the occurrence of severe pathological conditions. The use of measurement tools, combined with clinical observation commonly performed by professionals, implies potential improvement in patient management. As seen, several scales have potential validity, depending on the pathology studied. Thus, they also serve as a basis for the development of new scales for other diseases.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between IRAK1 gene polymorphism, gene expression, and non-segmental vitiligo risk in Egyptians","authors":"Fatma Yusif Ali Abd Allah,&nbsp;Azza Gaber Antar Farag,&nbsp;Ahmed E. Abdel-Magied,&nbsp;Ibrahim El-Tantawy El-Sayed,&nbsp;Mona A. Abbas","doi":"10.1007/s00403-025-04383-9","DOIUrl":"10.1007/s00403-025-04383-9","url":null,"abstract":"<div>\u0000 \u0000 <p>Vitiligo is the most prevalent depigmenting skin disorder. Increasing evidence implicates immune dysregulation and inflammatory signaling in its pathogenesis. Interleukin-1 receptor-associated kinase 1 (IRAK1) has been associated with various autoimmune conditions. However, its role in vitiligo remains unexplored. This study investigated the potential relationship between the IRAK1 rs1059703 polymorphism, gene expression, and susceptibility to vitiligo. Genotyping the IRAK1 gene rs1059703 and quantifying its relative expression were assessed using real-time PCR in 123 participants: 53 non-segmental vitiligo patients and 70 healthy volunteers of comparable age and sex. The AA genotype (under the recessive model) was significantly more frequent in vitiligo patients compared to controls (<i>p</i> = 0.032), which increased the risk of vitiligo by an odds ratio of 2.207. Additionally, the A allele demonstrated a notable association with vitiligo risk, with an odds ratio of 1.991. A considerable correlation existed between the AA genotype and a positive family history of vitiligo. IRAK1 expression was markedly more significant in cases versus controls (<i>p</i> &lt; 0.001). Moreover, IRAK1 expression notably correlated with disease duration. The IRAK1 rs1059703 variant, particularly the AA genotype and A allele, along with increased gene expression, may contribute to vitiligo risk. Additional studies with larger cohorts and varied demographics are needed to support these conclusions and elucidate the underlying mechanisms.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional observational study to compare psychosocial impact with stress biomarker level in patients with atopic dermatitis","authors":"Tabinda Sultan,&nbsp;Aakriti Garg,&nbsp;Mukesh Manjhi,&nbsp;Mohd Ashif Khan","doi":"10.1007/s00403-025-04370-0","DOIUrl":"10.1007/s00403-025-04370-0","url":null,"abstract":"<div><p>Atopic Dermatitis (AD), a chronic inflammatory skin condition, affects 10–30% of children and 2–10% of adults in developed countries. This study explored the psychosocial impact of AD, focusing on the relationship between stress biomarkers and disease severity. Sixty participants were included in the current study in which 15 were healthy and 45 had AD which were further equally divided into 3 groups (<i>n</i> = 15), namely, mild, moderate, and severe AD groups using the SCORAD tool. Salivary cortisol levels, depressive symptoms, self-esteem, and quality of life were assessed. A significant positive correlation was found between cortisol levels and SCORAD scores (<i>r</i> = 0.89, <i>p</i> &lt; 0.001), linking increased disease severity with higher stress levels. Greater stress was also associated with more severe depressive symptoms (PHQ9 scores, <i>r</i> = 0.81, <i>p</i> &lt; 0.0001), lower self-esteem, and reduced quality of life (DLQI scores, <i>r</i> = 0.84 for SCORAD and <i>r</i> = 0.88 for cortisol, both <i>p</i> &lt; 0.001). These findings emphasize the heavy psychosocial burden on individuals with severe AD and highlight the need for holistic management. Addressing both physical and psychological aspects, including stress biomarkers like salivary cortisol, may improve treatment outcomes and enhance patients’ overall well-being.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food insecurity is associated with rheumatologic comorbidities in psoriasis patients","authors":"Ajay K. Pandey,&nbsp;Md Hafizur Rahman,&nbsp;Mohammad Rifat Haider,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-025-04403-8","DOIUrl":"10.1007/s00403-025-04403-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}