Archives of Dermatological Research最新文献

{"title":"Rethinking the use of population descriptors in dermatology trials and beyond: disentangling race and ethnicity from skin color","authors":"Valerie M. Harvey,&nbsp;Jenna C. Lester,&nbsp;Tarannum Jaleel,&nbsp;Junko Takeshita,&nbsp;Amy J. McMichael,&nbsp;Yvette Miller-Monthrope,&nbsp;Nina G. Jablonski,&nbsp;Jade Lewis,&nbsp;Andrew F. Alexis,&nbsp;Stafford G. Brown,&nbsp;Cheryl M. Burgess,&nbsp;Angel S. Byrd,&nbsp;Suephy C. Chen,&nbsp;Caryn Cobb,&nbsp;Roxana Daneshjou,&nbsp;Seemal R. Desai,&nbsp;Candrice R. Heath,&nbsp;Chidubem A.V. Okeke,&nbsp;Hema Sundaram,&nbsp;Susan C. Taylor,&nbsp;Jonathan S. Weiss,&nbsp;Jane Y. Yoo,&nbsp;Valerie D. Callender","doi":"10.1007/s00403-025-04219-6","DOIUrl":"10.1007/s00403-025-04219-6","url":null,"abstract":"<div><p><b>Importance</b>: Race and ethnicity as population descriptors in research and clinical practice have often been a subject of debate, drawing heightened scrutiny in recent years. Criticism focuses on their oversimplification and misapplication, which fail to capture the complexity of human health and genetic diversity. There is growing recognition that these categories, rooted in outdated social constructs, do not accurately reflect biological differences. <b>Observations</b>: Historically, race and ethnicity have been used as proxies for genetic variation and skin color, despite the understanding that these constructs are not biologically defined. The Skin of Color Society’s second <i>Meeting the Challenge</i> Summit, attended by over 100 U.S. and international participants, highlighted several key themes: (1) the need for transparency in the rationale behind using population descriptors and decision-making processes; (2) recognizing the role of race and racism in dermatology; (3) exploring the intersection of dermatology, skin color, and cultural influences; (4) understanding the context of population descriptor usage; (5) developing improved, objective tools for classifying skin color; and (6) advancing research and creating guidelines. <b>Conclusions and Relevance</b>: There is an urgent need to reconsider the use of race and ethnicity as population descriptors in dermatology research. Current systems, which conflate social identity with biological markers, perpetuate health disparities and limit the accuracy of clinical data. Moving forward, more specific descriptors such as skin color, alongside socially determined factors, will be crucial in achieving meaningful diversity and inclusivity in clinical research.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined subcision with polydioxanone monofilament (PDO) threads versus polydioxanone monofilament (PDO) threads alone in treatment of atrophic post-acne scars","authors":"Manar Abd-Elbadea Ahmed Mohamed,&nbsp;Hanan Mohamed Ali Darwish,&nbsp;Hala Shawky Abd-Elhafiz","doi":"10.1007/s00403-025-04204-z","DOIUrl":"10.1007/s00403-025-04204-z","url":null,"abstract":"<div><p>Acne scaring negatively impacts life quality. Treatment options vary in clinical effectiveness, side effects, and downtime. Polydioxanone threads (PDO) stimulate neo-collagenesis and create mechanical lift through artificial ligaments, while subcision is an office surgical method for managing atrophic scars. Both methods have their advantages and disadvantages. To assess the clinical efficiency and safety of PDO threads alone against combined subcision in the management of atrophic following-acne scars. Twenty patients with facial atrophic following acne scars were involved. The right side of the face was managed with PDO threads, while the left side was managed with subcision and PDO threads. Patients were assessed after three months using the Goodman and Baron qualitative and quantitative acne scarring grading systems. On the right side, improvement was excellent in two patients (10%), good in fourteen patients (70%), and poor in four patients (20%). On the left side, the improvement was excellent in six patients (30%), good in twelve patients (60%), and poor in two patients (10%). There was a statistically insignificant variance between both sides with a p-value of 0.308. There were no reported serious side effects, and the pain was tolerable. PDO thread insertion, either alone or combined with subcision, is safe and efficient in managing atrophic post-acne scars.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing hair regrowth in Alopecia areata: the power duo of CO2 fractional laser and Bimatoprost","authors":"Ahmed Hassan Nouh,&nbsp;Ayaat Abd Elghany Behairy,&nbsp;Fatma Badr El-Koumy,&nbsp;Ahmed Mohamed Abdel Aal,&nbsp;Maryna S. Zhuravlova","doi":"10.1007/s00403-025-04183-1","DOIUrl":"10.1007/s00403-025-04183-1","url":null,"abstract":"<div><p>Alopecia Areata (AA) is a chronic, immune-mediated inflammatory condition primarily targeting hair follicles, leading to non-scarring hair loss. Traditional therapeutic approaches, including topical and systemic immunosuppressive treatments, often yield inconsistent results and carry significant side effects. Recently, laser therapy has emerged as a promising modality for AA treatment, particularly when combined with adjunctive agents that enhance hair follicle stimulation. This study evaluates the efficacy and safety of a novel therapeutic combination: CO2 fractional laser therapy with Bimatoprost 0.03% solution application. Conducted at Al-Azhar University Hospital between January 2019 and May 2023, the study involved 60 patients with clinically and dermoscopically confirmed AA. Participants were randomly assigned into two groups: Group A (<i>n</i> = 30) received three CO2 fractional laser sessions with subsequent daily application of Bimatoprost 0.03%, while Group B (<i>n</i> = 30) underwent laser therapy alone. Clinical outcomes were assessed using standardized photographic documentation, dermoscopic evaluation, and patient-reported improvement scores. Results demonstrated a significantly higher response rate in Group A compared to Group B (80% vs. 40%, <i>p</i> = 0.025). The combination therapy led to faster and more pronounced hair regrowth, with notable improvements in hair density, pigmentation, and thickness. Minimal adverse effects were reported, limited to transient erythema and mild procedural discomfort. Statistical analysis confirmed a superior treatment response in Group A across all assessment parameters (<i>p</i> &lt; 0.05). These findings suggest that the combination of CO2 fractional laser therapy with Bimatoprost 0.03% offers a safe and effective treatment modality for AA, outperforming laser therapy alone. This study provides a foundation for further research and highlights the potential integration of prostaglandin analogs with laser-based interventions in AA management. Future studies with larger sample sizes and extended follow-up periods are necessary to validate these promising results and assess long-term treatment sustainability.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between vitiligo and allergic diseases: a bidirectional two-sample Mendelian randomization study","authors":"Ri Zhang,&nbsp;Zeqi Shi,&nbsp;Xiaoqi Nie,&nbsp;Yujia Wei,&nbsp;Dong Li","doi":"10.1007/s00403-025-04047-8","DOIUrl":"10.1007/s00403-025-04047-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04047-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy","authors":"Chou-Yi Hsu,&nbsp;Harish C. Chandramoorthy,&nbsp;Jaafaru Sani Mohammed,&nbsp;Shaker Al-Hasnaawei,&nbsp;Mohammed Yaqob,&nbsp;Mayank Kundlas,&nbsp;Krishnakumar Samikan,&nbsp;Samir Sahoo,&nbsp;S. K. Sunori,&nbsp;Zainab Ahmed Abbas","doi":"10.1007/s00403-025-04237-4","DOIUrl":"10.1007/s00403-025-04237-4","url":null,"abstract":"<div><p>Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and disease burden in Chinese patients with prurigo nodularis","authors":"Xinming Mai,&nbsp;Yan Liao,&nbsp;Chener Yang,&nbsp;Lu Wei,&nbsp;Mengting Yin,&nbsp;Xu Yang,&nbsp;Jiaying Chen,&nbsp;Ruimiao Wu,&nbsp;Xia Dou","doi":"10.1007/s00403-025-04229-4","DOIUrl":"10.1007/s00403-025-04229-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin levels in scarring and nonscarring alopecia: a cross-sectional study from the All of Us database","authors":"Shanelle Jackson,&nbsp;Arielle Carolina Mora Hurtado,&nbsp;Kevin Puerta Durango,&nbsp;Charissa Obeng-Nyarko,&nbsp;Jack Rodman,&nbsp;Susan C. Taylor,&nbsp;Nada Elbuluk","doi":"10.1007/s00403-025-04228-5","DOIUrl":"10.1007/s00403-025-04228-5","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast view on the first resistant dermatophyte to terbinafine, Trichophyton rubrum","authors":"Ali Abdul Hussein S. AL-Janabi","doi":"10.1007/s00403-025-04220-z","DOIUrl":"10.1007/s00403-025-04220-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Simvastatin in the treatment of vitiligo: a systematic review and meta-analysis of randomized controlled trials","authors":"Song Zhang,&nbsp;Ibrahim Serag,&nbsp;Shereen Mohamed Olama,&nbsp;Mahmoud G. A. Saleh,&nbsp;E. A. Shaban,&nbsp;Mostafa Hossam El Din Moawad","doi":"10.1007/s00403-025-04234-7","DOIUrl":"10.1007/s00403-025-04234-7","url":null,"abstract":"<div><p>Vitiligo is an autoimmune skin disorder characterized by progressive depigmentation due to melanocyte destruction. Despite various treatment options, achieving complete repigmentation remains challenging. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has demonstrated anti-inflammatory and immunomodulatory effects, making it a promising candidate for vitiligo treatment. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of Simvastatin in vitiligo treatment. A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted following PRISMA guidelines. Only RCTs comparing Simvastatin with a control or pre-post Simvastatin assessments in vitiligo patients were included. Six RCTs with a total of 371 patients met the eligibility criteria. The primary outcomes analyzed were VASI reduction and excellent repigmentation response (≥ 75% repigmentation). Secondary outcomes included changes in total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels. Meta-analyses were performed using a random-effects model, and heterogeneity was assessed using the I² statistic. Simvastatin significantly reduced VASI scores (SMD = −0.30; 95% CI −0.52–−0.07, p = 0.010; I² = 0%). The likelihood of achieving excellent repigmentation (≥ 75%) was significantly higher in the Simvastatin group (OR = 6.54; 95% CI 1.08–38.42, p = 0.04; I² = 0%). Additionally, Simvastatin led to a significant reduction in total cholesterol (−62.1 mg/dL; 95% CI −74.0–−50.2, p &lt; 0.00001; I² = 0%), triglycerides (−65.08 mg/dL; 95% CI −89.81–−40.35, p &lt; 0.00001; I² = 69%), and LDL (−66.13 mg/dL; 95% CI −77.50–−54.76, p &lt; 0.00001; I² = 90%). Simvastatin demonstrates significant efficacy in vitiligo treatment, improving VASI scores and repigmentation while also lowering lipid levels. This is the first meta-analysis on this topic, providing evidence for Simvastatin as a potential adjunct therapy. Further large-scale RCTs are needed to validate these findings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of current dermatopathology training across U.S. residency programs","authors":"Evelyn F. Fagan,&nbsp;Joseph T. McGrath,&nbsp;Divya Sharma,&nbsp;Sierra Thomas,&nbsp;Corey Georgesen,&nbsp;Erin X. Wei","doi":"10.1007/s00403-025-04185-z","DOIUrl":"10.1007/s00403-025-04185-z","url":null,"abstract":"<div><p>Dermatopathology (DP) is integral to dermatology residency training, aiding in accurate diagnoses and clinical interpretations. This study evaluates the current state of DP education and faculty backgrounds in dermatology residency programs, using information available on 142 ACGME-accredited dermatology residency programs. The focus was on DP training, including dedicated rotations, training years, and duration as well as DP faculty and fellowship opportunities. Of the programs analyzed, 53.52% offered distinct DP rotations. Residents in these programs spent an average of 11.37 weeks in DP training, with 70.83% providing DP exposure in the first year. The average number of board-certified dermatopathologists per program was 2.91 (SD = 2.11); however, 23.19% of programs lacked dermatology-trained dermatopathologists. DP fellowships were available in 36.62% of programs and among fellowship directors, 63.46% were board-certified in anatomic pathology and 51.98% in dermatology. While DP training is widely offered, the extent and structure of this training vary across residency programs with many lacking dedicated rotations or first-year exposure. Both dermatology-trained and pathology-trained dermatopathologists contribute to academic settings, although fellowship directors are more commonly trained in pathology. This highlights the need for greater consistency and clarity in DP training across residency programs to ensure comprehensive exposure in this essential field.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}