{"title":"Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis.","authors":"Yihai Wang, Zhengnan Li","doi":"10.1007/s00403-025-04256-1","DOIUrl":"https://doi.org/10.1007/s00403-025-04256-1","url":null,"abstract":"<p><strong>Background: </strong>Osteomyelitis results principally from endo-/exogenous bacterial infections, whose incidence that complicating bone injuries reaches approximately 30%, with the risk of disability and teratogenicity. Skin microbiota has been found to be clinically linked to osteomyelitis, but substantial evidence is lacking.</p><p><strong>Methods: </strong>Mendelian randomization (MR) was applied to unveil the causality between human skin microbiome and osteomyelitis. Genetic data of 1,656 skin microbiota samples were obtained from genome-wide association studies (GWAS), with the outcome of osteomyelitis from UK Biobank (UKB) database.</p><p><strong>Results: </strong>Two sample MR confirmed 12 skin microbiota strains that possessed significant causality strength with osteomyelitis, in which asv013 [S. epidermidis] (β = 0.061, P = 0.027), Genus propionibacterium (β = 0.065, P = 0.021), Family micrococcaceae (β = 0.086, P = 0.004), asv003 [Staphylococcus (unc.)] (β = 0.065, P = 0.027), and asv004 [Corynebacterium (unc.)] (β = 0.070, P = 0.016) were drivers of osteomyelitis, whilst the leaving asv037 [C. Glutamicum] (β = -0.041, P = 0.004), asv021 [Micrococcus (unc.)] (β = -0.059, P = 0.019), asv063 [Finegoldia (unc.)] (β = -0.037, P = 0.038), Order clostridiales (β = -0.043, P = 0.013), Class betaproteobacteria (β = -0.061, P = 0.004), Family clostridiales (β = -0.061, P = 0.002), and Order clostridiales (β = -0.063, P = 0.023) could be perceived as protective factors. No heterogeneity or pleiotropy in sensitivity analyses were observed, hinting the robustness of the MR findings.</p><p><strong>Conclusion: </strong>This study preliminarily clarified the causal effect of skin microbiome on osteomyelitis. Strains that may significantly trigger or suppress the outcome of osteomyelitis were figured out, which may provide promising insights for the genesis and progression of osteomyelitis, thereby benefiting relevant clinical prevention and treatment.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"797"},"PeriodicalIF":1.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitali Alexeev, Leonie Huitema, Taylor Phillips, Paras Patel, Mauricio Salas Garza, Franziska Ringpfeil, Julio Cesar Salas-Alanis, Olga Igoucheva
{"title":"Cross-sectional analysis of wound-associated soluble factors in early, established, and chronic wounds of recessive dystrophic epidermolysis bullosa patients.","authors":"Vitali Alexeev, Leonie Huitema, Taylor Phillips, Paras Patel, Mauricio Salas Garza, Franziska Ringpfeil, Julio Cesar Salas-Alanis, Olga Igoucheva","doi":"10.1007/s00403-025-04293-w","DOIUrl":"10.1007/s00403-025-04293-w","url":null,"abstract":"<p><strong>Background: </strong>Poorly healing wounds represent the primary health-related burden for hereditary recessive dystrophic epidermolysis bullosa (RDEB) patients. Contribution of wound-associated soluble constituents to wound progression remains not well defined.</p><p><strong>Objective: </strong>To conduct cross-sectional analysis of cytokine, chemokine, and growth factor in exudates from RDEB wounds and define changes associated with wound progression.</p><p><strong>Methods: </strong>Concentrations of selected cytokines, chemokines, and growth factors were evaluated by multiplex ELISA in eight blister fluids and 66 exudates from early, established, and chronic RDEB and five chronic venous ulcers (VU). A cross-sectional analysis was performed.</p><p><strong>Results: </strong>Our data demonstrated that proinflammatory CXCL8 and IL-1β tend to accumulate in established RDEB lesions. The levels of several interleukins including IL-17, IL-18, and IL-10 were significantly higher in RDEB chronic wounds than in VU. Contrary to VU and other chronic wounds, high levels of VEGF, G-CSF, and HGF growth factors were detected in RDEB established and chronic skin lesions.</p><p><strong>Conclusion: </strong>Although this study is limited to cross-sectional analysis of wound exudates, detected high levels of specific pro-inflammatory, neutrophil-recruiting, and pro-angiogenic and pro-proliferative factors, such as IL-1β, CXCL8, VEGF, G-CSF, and HGF define RDEB wounds and offer potential pharmacological targets to improve wound healing in the patients.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"796"},"PeriodicalIF":1.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Keloids and hypertrophic scars in individuals with darker Fitzpatrick skin types: a systematic review of treatment efficacy and quality of life outcomes.","authors":"Devaun Reid, Samantha Malak, Monica Khadka, Rana Hanna, Trevor Pharr, W Austin Wyant, Sharon Albers","doi":"10.1007/s00403-025-04292-x","DOIUrl":"10.1007/s00403-025-04292-x","url":null,"abstract":"<p><strong>Importance: </strong>Keloids and hypertrophic scars (HTS) can cause physical discomfort and- psychosocial distress, especially in individuals with darker Fitzpatrick skin types. These scars often recur and may lead to itching, pigmentation changes, pain, and reduced self-esteem.</p><p><strong>Objective: </strong>To examine how keloids and HTS affect quality of life (QoL) in darker-skinned populations and to evaluate treatment strategies that may improve both scar outcomes and QoL.</p><p><strong>Evidence review: </strong>We conducted a systematic review in April 2024 using PubMed, Scopus, and Embase. Two independent reviewers screened studies based on predetermined criteria, with a third resolving discrepancies. The Methodological Index for Non-Randomized Studies (MINORS) scale<sup>1</sup> was used to assess study quality.</p><p><strong>Findings: </strong>From 132 initial publications, 14 studies met the inclusion criteria. Surgical excision followed by brachytherapy showed recurrence rates of about 3.1% for keloids. Combining silicone gel sheeting, intralesional corticosteroids, laser therapy, and pressure therapy was generally more effective for HTS. While only a few studies included formal QoL assessments, improvements in pain, pruritus, and overall patient satisfaction were reported. Notably, darker Fitzpatrick skin types were underrepresented in existing scar severity scales, pointing to a gap in tailored outcome measures.</p><p><strong>Conclusions and relevance: </strong>Treatments such as surgical excision followed by brachytherapy appear promising for keloids, and multimodal approaches may yield better outcomes for HTS. However, potential side effects like hyperpigmentation must be considered. More inclusive research with standardized QoL measures is needed to clarify how these interventions influence both scar resolution and overall well-being in darker-skinned populations.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"795"},"PeriodicalIF":1.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nooshin Bagherani, Reza Shojaei, Abolfazl Jokar, Amir Almasi, Bruce R Smoller, Mahsa Rafiee
{"title":"Assessment of efficacy of carboxytherapy in reducing thickness of abdominal subcutaneous fat through clinical and ultrasonographical studies: a randomized 2-split clinical trial.","authors":"Nooshin Bagherani, Reza Shojaei, Abolfazl Jokar, Amir Almasi, Bruce R Smoller, Mahsa Rafiee","doi":"10.1007/s00403-025-04254-3","DOIUrl":"10.1007/s00403-025-04254-3","url":null,"abstract":"<p><p>The prevalence of overweight/obesity is continuing its relentless global rise. In this condition, the risk of some disorders such as cardiovascular diseases, hypertension, diabetes mellitus, hirsutism, menstrual abnormalities, gallbladder disease, arthritis, and some site-specific cancers is increased. In the current study, we assessed the efficacy of carboxytherapy in reducing thickness of the abdominal subcutaneous fat through clinical and ultrasonographical studies. Our study was a prospective, randomized, single-blind, 2-split clinical trial in which 30 obese subjects with abdominal adiposity were recruited. In each case carboxytherapy was randomly done on the one side of abdomen (interventional group) every 2 weeks for 5 sessions, while the contralateral side was left without therapy (control group). Before every session, data of subjective and objective clinical assessments, body weight, BMI, waist circumference, and waist to hip circumference ratio were collected. Two weeks after the last session, the thickness of different skin layers was measured by ultrasonography in the both study groups. Of 30 subjects, 20 were female (66.67%) and 10 were male (33.33%), with mean age of 39.16 years (± 9.51). The mean weight, BMI, waist circumference, and waist to hip circumference ratio demonstrated significant decrease during the study. The subjective and objective assessments both showed significant improvement. The subcutis thickness revealed a statistically significant decrease in the interventional group, with no significant difference between males and females. No significant complication was reported. Carboxytherapy is a safe and effective modality in the management of local fat deposits.Clinical trial registry code: IRCT20220517054900N1.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"794"},"PeriodicalIF":1.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eman R M Hofny, Ayatollah H Younis, Dalia M Badary, Marwa G Elnaggar, Nermin E Eleraky, Islam M Abdel-Bary, Aya Y Badran
{"title":"Comparative study of different treatment modalities for melasma: introducing a novel nanotechnology-based tranexamic acid microemulsion.","authors":"Eman R M Hofny, Ayatollah H Younis, Dalia M Badary, Marwa G Elnaggar, Nermin E Eleraky, Islam M Abdel-Bary, Aya Y Badran","doi":"10.1007/s00403-025-04294-9","DOIUrl":"https://doi.org/10.1007/s00403-025-04294-9","url":null,"abstract":"<p><p>Melasma therapy remains challenging due to limited effectiveness, side effects, and relapses. Topical tranexamic acid (TXA) is promising but requires further research to optimize its formulation. Alongside the therapeutic benefit of fractional CO2 laser (FCL) in melasma, FCL and microneedling (MN) are recognized methods for transepidermal drug delivery. Nanotechnology-based topicals can enhance drug penetration and reduce side effects. Objectives were to evaluate and compare the effectiveness of combined FCL- or MN-assisted transepidermal delivery of TXA 3% gel and FCL monotherapy versus nanotechnology-based TXA 1% microemulsion monotherapy in melasma treatment. Fifty-two melasma females were divided randomly into three groups (A, B & C) for a five-month treatment. Group A (n = 20), using a split-face design, received FCL on the right side (A1) and MN on the left (A2), both with TXA 3% gel applied post-session and daily. Group B (n = 21), also with a split-face design, received FCL with TXA 3% gel post-session only on the right side (B1), while the left side (B2) received FCL alone. Group C (n = 11) received TXA 1% microemulsion daily for the whole face. Evaluations included clinical, dermoscopic, and immunohistochemical SOX10 assessments, with a three-month follow-up. All groups showed a significant reduction of Hemi Melasma Area and Severity Index (Hemi-MASI), dermoscopic, and SOX10 immunoreactivity scores. Groups A1, A2, and C exhibited greater improvement compared to B1 and B2. No recurrence occurred during follow-up. Concluding that TXA 1% microemulsion is effective and safe, procedure-free monotherapy with outcomes comparable to FCL- and MN-assisted TXA 3% gel delivery for melasma.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"792"},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olamiposi O Akinsooto, Michael R Nock, Jeffrey M Cohen
{"title":"Acne is associated with migraine: a case-control study of US adults.","authors":"Olamiposi O Akinsooto, Michael R Nock, Jeffrey M Cohen","doi":"10.1007/s00403-025-04291-y","DOIUrl":"https://doi.org/10.1007/s00403-025-04291-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"793"},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bianca Y Kang, Saranya P Wyles, Yakir Levin, Rawaa Almukhtar, Stephanie R Jackson Cullison, Jayne S Joo, Sami K Saikaly, Shalinie Mahadeo, Michael Ong, Sophia Salingaros, Maria Hordinsky, Sarah A Ibrahim, Devina Mehta, Shoko Mori, Edit B Olasz Harken, Diana Bolotin, Kira Minkis, Murad Alam
{"title":"Barriers to clinical cosmetic and laser dermatology research in the academic setting by source of funding: a systematic review.","authors":"Bianca Y Kang, Saranya P Wyles, Yakir Levin, Rawaa Almukhtar, Stephanie R Jackson Cullison, Jayne S Joo, Sami K Saikaly, Shalinie Mahadeo, Michael Ong, Sophia Salingaros, Maria Hordinsky, Sarah A Ibrahim, Devina Mehta, Shoko Mori, Edit B Olasz Harken, Diana Bolotin, Kira Minkis, Murad Alam","doi":"10.1007/s00403-025-04241-8","DOIUrl":"10.1007/s00403-025-04241-8","url":null,"abstract":"<p><p>Clinical research is a cornerstone of academic dermatology, including research in cosmetic and laser procedures. However, numerous barriers exist to conducting clinical research in an academic setting as compared to private practice. The objective of this study was to describe the barriers to clinical research in cosmetic and laser dermatology in the academic setting under three common funding scenarios: (1) industry sponsored, (2) unfunded, investigator-initiated, and (3) publicly funded, investigator-initiated. A systematic review of the literature was conducted to identify 17 publications regarding funding of clinical dermatology research. Inductive content analysis was used to extract, categorize, and understand the barriers related to clinical dermatology research, specifically in cosmetic dermatology, based on the type of funding. An expert panel of 11 board-certified dermatologists who practice and conduct research in cosmetic and laser dermatology at academic institutions reviewed these barriers, interpreted each barrier's implications for academic cosmetic and laser dermatology research, and proposed possible approaches to overcoming each. Nine barriers were identified for each funding scenario, and a total of 60 approaches for mitigating these were suggested. Most barriers to industry sponsored research were related either to institutional hurdles or industry preferences. The most cited barrier to unfunded, investigator-initiated research was limited protected academic time. The most frequently cited barriers to publicly funded, investigator-initiated research were grant availability and disproportionate awarding of grants based on investigator demographics. Proposed approaches for overcoming barriers included recruiting the help of trainees, streamlining administrative paperwork, fostering collaboration between industry and academic centers, providing financial incentives, seeking out mentorship from other faculty, and collaborating with other investigators, departments, and institutions.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"791"},"PeriodicalIF":1.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahib K Islam, Ryan Chan, Andrew Gross, Hassan Malik, Humza Pirzadah, Ahmed Abdelmaksoud, Christopher Haas, Manal Fawzy, Eman Toraih, Shari R Lipner
{"title":"Higher incidence of dermatological immune-related adverse events in cancer patients treated with immune checkpoint inhibitors vs. other treatments: a TriNetX research network study.","authors":"Rahib K Islam, Ryan Chan, Andrew Gross, Hassan Malik, Humza Pirzadah, Ahmed Abdelmaksoud, Christopher Haas, Manal Fawzy, Eman Toraih, Shari R Lipner","doi":"10.1007/s00403-025-04288-7","DOIUrl":"https://doi.org/10.1007/s00403-025-04288-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"789"},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the tissue expression of thyroid peroxidase in chronic spontaneous urticaria patients.","authors":"Maryam Khoshkhui, Morteza Safari Tirtashi, Mehraneh Movahedi Aliabadi, Sahar Rastgoo, Masoumeh Gharib","doi":"10.1007/s00403-025-04272-1","DOIUrl":"https://doi.org/10.1007/s00403-025-04272-1","url":null,"abstract":"<p><p>Chronic spontaneous urticaria (CSU) characterized by recurrent wheals and/or angioedema, remains a challenging condition. Autoallergic and autoimmune mechanisms (Type I and IIb) have been recognized for CSU pathogenesis. Studies have demonstrated the association between CSU and serum anti-thyroid peroxidase (TPO) antibodies (Abs). However, the potential for increased TPO expression within affected skin tissue of CSU patients is unclear. Patients diagnosed with CSU were recruited from the UCARE center of Mashhad University of Medical Sciences, the case group. Matched healthy individuals who underwent cosmetic surgery served as the control group. Skin biopsies were obtained from active wheal lesions in the CSU patients. Thyroid function tests (TFTs) and serum anti-TPO Ab levels were measured in both groups. Immunohistochemistry (IHC) staining was used to assess skin biopsy samples. A total of 60 participants were enrolled, including 30 CSU patients and 30 healthy controls. Hypothyroidism was significantly more prevalent in the case group compared to controls (p = 0.007). Additionally, the patients exhibited a significantly higher rate of positive serum anti-TPO Ab compared to the healthy individuals (p = 0.001). Notably, IHC staining revealed no TPO expression in the skin samples of either group. This study demonstrated that elevated serum anti-TPO Ab levels in CSU patients may not directly translate to TPO expression within affected skin tissue. While further research with larger cohorts is warranted, our findings contribute to the understanding of the histopathological underpinnings of CSU in relation to TPO, anti-TPO Ab, and potential autoimmune mechanisms.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"790"},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole Cherepacha, Frances St George-Hyslop, Bindiya Chugani, Yousef Alabdeen, Luis Fernando Sanchez-Espino, Quenby Mahood, Cathryn Sibbald, Ruud H J Verstegen
{"title":"Rapid-onset drug reaction with eosinophilia and systemic symptoms (DReSS) in children: a scoping review.","authors":"Nicole Cherepacha, Frances St George-Hyslop, Bindiya Chugani, Yousef Alabdeen, Luis Fernando Sanchez-Espino, Quenby Mahood, Cathryn Sibbald, Ruud H J Verstegen","doi":"10.1007/s00403-025-04295-8","DOIUrl":"https://doi.org/10.1007/s00403-025-04295-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"787"},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}