Archives of Dermatological Research最新文献

{"title":"The burden of insurance requirements on timely access to biologic therapy for patients with autoimmune blistering diseases: a survey of immunobullous experts in the United States","authors":"Paige E. Adams,&nbsp;Elise K. Brunsgaard,&nbsp;Nikki Rezania,&nbsp;Rebecca A. Strong,&nbsp;Marc Yale,&nbsp;Kyle T. Amber","doi":"10.1007/s00403-025-04376-8","DOIUrl":"10.1007/s00403-025-04376-8","url":null,"abstract":"<div><p>The advancement of biologic therapies has improved outcomes for patients with autoimmune blistering diseases (AIBDs). Despite medical advancements, lack of insurance coverage limits access to these medications. In this observational study, we aimed to describe the burden of prior authorizations (PAs) and insurance delays for biologic therapy in AIBD patients from the physician perspective. Surveys were completed by AIBD experts (<i>n</i> = 18) across the United States, amounting to a response rate of 60%. AIBD experts reported an average 3.1 week wait time for insurance approval of rituximab, with over half reporting that insurance required a change in dosing protocol. Though experts identified a benefit of dupilumab and omalizumab in bullous pemphigoid, expectant insurance denial limited the use of these therapies. Experts spent an average of 1.4 h per week on insurance-related matters for AIBD patients, and half hired additional staff in the last 3 years due to PAs for biologic therapy in AIBD patients. These findings highlight the substantial burden of insurance coverage on the utility of biologic therapy in AIBD and underscore the significant work contributions required by physicians and staff for insurance-related processes.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic lupus erythematosus and mortality in COVID-19 hospitalizations: a multicenter study","authors":"Shiv Patel,&nbsp;Aayush Shah,&nbsp;Shrey Patel,&nbsp;Sareena Shah,&nbsp;Peter A. Lio","doi":"10.1007/s00403-025-04405-6","DOIUrl":"10.1007/s00403-025-04405-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical metformin 15% gel versus dapsone 5% gel in the treatment of acne vulgaris: a split face study","authors":"Mohamed S. Zaky,&nbsp;Zakaria M. Obaid,&nbsp;Shahdan Abdel Rahman Zaafan,&nbsp;Mohamed L. Elsaie","doi":"10.1007/s00403-025-04395-5","DOIUrl":"10.1007/s00403-025-04395-5","url":null,"abstract":"<div><p>Acne vulgaris (AV) is a prevalent dermatological condition with multifactorial pathogenesis, including hormonal, microbial, and inflammatory components. Although topical treatments remain first-line therapy for mild to moderate cases, limitations such as antibiotic resistance and adverse effects necessitate alternative options. This study aimed to evaluate and compare the clinical efficacy and safety of 15% topical metformin gel versus 5% topical dapsone gel in the management of AV using a split-face design. A single-blind, interventional, split-face study was conducted on 50 patients with AV. Each participant applied metformin 15% gel to one side of the face and dapsone 5% gel to the other side twice daily for 12 weeks, with a follow-up at week 16. Acne severity was assessed using the Global Acne Grading System (GAGS) at baseline and at regular intervals. Side effects and demographic correlations were also analyzed. Both agents significantly reduced GAGS scores over time. Dapsone showed superior efficacy at the 16-week follow-up, with a more sustained reduction in acne lesions. Side effects were minimal and comparable between groups. Younger patients showed better response, particularly to dapsone. Topical metformin and dapsone are both effective and well-tolerated treatments for AV. Dapsone demonstrated a slightly greater long-term benefit. Larger, multicenter trials are recommended to confirm these findings and explore combination regimens.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding rural access to pediatric dermatology expertise: an interdisciplinary approach through project ECHO","authors":"Brailyn Weber,&nbsp;Madison Ferris,&nbsp;DeAngela Ivory,&nbsp;Vanessa Trammell,&nbsp;Vinayak K. Nahar,&nbsp;Sarah Asch","doi":"10.1007/s00403-025-04399-1","DOIUrl":"10.1007/s00403-025-04399-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145210758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in skin substitute usage from 2013 to 2023: a national medicare trends analysis","authors":"Guilherme Kuceki,&nbsp;Austin S. Cusick,&nbsp;Michael Goldenberg,&nbsp;Umer Nadir,&nbsp;Mojahed Shalabi,&nbsp;Sino Mehrmal,&nbsp;Stanislav N. Tolkachjov","doi":"10.1007/s00403-025-04397-3","DOIUrl":"10.1007/s00403-025-04397-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum levels and local expression of neutrophil gelatinase-associated lipocalin in generalized pustular psoriasis","authors":"Misaki Kusano,&nbsp;Kinuko Irie,&nbsp;Toshiyuki Yamamoto","doi":"10.1007/s00403-025-04398-2","DOIUrl":"10.1007/s00403-025-04398-2","url":null,"abstract":"<div><p>Generalized pustular psoriasis (GPP) is not solely a skin condition but also a systemic disorder, in which innate immune systems are involved. Neutrophil gelatinase-associated lipocalin (NGAL) is a protein secreted by activated neutrophils, and is expressed in various tissues. In the present study, we investigated the role of NGAL by comparing its serum levels among patients with GPP, psoriasis vulgaris, palmoplantar pustulosis, and healthy controls. Serum NGAL concentration was significantly higher in the patients with active GPP than in the psoriasis vulgaris, palmoplantar pustulosis, and healthy controls. Interestingly, in the patients with GPP, higher serum NGAL levels positively correlated with disease severity. Moreover, GPP patients with liver dysfunction and type 2 diabetes exhibited higher NGAL concentration in the sera. In addition, local expression of NGAL was enhanced in the lesional skin of GPP. These findings suggest that NGAL is a key factor in the pathogenesis of GPP, and may function as a useful clinical biomarker for this systemic inflammatory condition.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted immunoglobulin G N-glycan profiles as risk and protective factors in dermatitis","authors":"Boxiang Wang,&nbsp;Nanchi Ye,&nbsp;Youhan Lu,&nbsp;Yanggang Hong","doi":"10.1007/s00403-025-04401-w","DOIUrl":"10.1007/s00403-025-04401-w","url":null,"abstract":"<div><p>Dermatitis is a common inflammatory skin disorder that includes atopic, contact, infective, and seborrhoeic dermatitis, yet its underlying molecular mechanisms remain unclear. Immunoglobulin G (IgG) N-glycosylation, a post-translational modification influencing immune responses, has been implicated in inflammatory diseases, but its causal role in dermatitis is unknown. This study employed Mendelian randomization (MR) to investigate the relationship between IgG N-glycan profiles and dermatitis subtypes using genome-wide association study (GWAS) data from 8,090 European individuals and dermatitis datasets from the GWAS Catalog and FinnGen consortium. Genetic variants associated with IgG N-glycan traits were selected as instrumental variables (IVs), and causal effects were estimated using inverse variance-weighted (IVW) analysis, supported sensitivity analysis to assess pleiotropy and heterogeneity. The analysis identified GP18, GP2, and GP23 as significantly associated with atopic dermatitis, indicating a role in inflammatory pathways. GP20 was positively associated with infective dermatitis, suggesting involvement in immune defense against microbial infections. Conversely, GP20, GP2, and GP6 showed negative associations with seborrhoeic dermatitis, implying a potential protective role. GP4 was positively linked to contact dermatitis, highlighting IgG glycosylation’s role in allergic sensitization. These results provide the first causal evidence linking IgG N-glycan modifications to dermatitis, reinforcing the importance of glycosylation in immune regulation. Our findings suggest that IgG N-glycans could serve as biomarkers or therapeutic targets for dermatitis, paving the way for glycan-based interventions. Future studies should validate these findings across diverse populations and explore the underlying biological mechanisms driving IgG glycosylation-mediated immune modulation in dermatological diseases.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the role of melanogenesis in melanoma: oncogenic crosstalk and therapeutic prospects","authors":"Aalim Maqsood Bhat,&nbsp;Irshad Ahmad Bhat,&nbsp;Sheikh Tasduq Abdullah","doi":"10.1007/s00403-025-04400-x","DOIUrl":"10.1007/s00403-025-04400-x","url":null,"abstract":"<div><p>Skin is the largest and outermost organ of the human body, composed of diverse tissues and cell types that work in concert to maintain physiological homeostasis. Skin pigment, melanin is synthesized by a physiological process termed as melanogenesis in a highly specialized cell type termed as melanocytes, located in the basal layer of the epidermis. Among the various types of skin cancers melanoma is the most aggressive form of skin cancer, originating from melanocytes due to mutations in cancer-critical genes, leading to uncontrolled proliferation, progression, and metastasis. Although melanoma accounts for about 1% of all skin cancers, but it is the most lethal, accounting for roughly 80% of all skin cancer-related deaths. The global incidence of melanoma is steadily rising, influenced by a combination of environmental and genetic factors. Among environmental contributors, ultraviolet (UV) radiation—particularly UV-B and UV-A—is a significant risk factor, while inherited genetic mutations also play a critical role in melanoma susceptibility and progression. Although several effective systemic therapies for melanoma have been established and resistance mechanisms have been extensively studied, a complete understanding of the molecular processes driving melanoma progression and therapy resistance continues to evolve. In melanoma, hyper-activation of signalling transduction pathways like Mitogen activating protein kinases (MAPK) due to <i>BRAF</i> mutation and Phosphoinositol-3 kinase (PI3K) due to <i>PTEN</i> mutation leads further dysregulation of melanogenesis regulating pathways leading to abnormal synthesis of melanin pigment, which in turn leads the progression of melanoma. The role of melanogenesis and its dysregulation in melanoma has not been fully explored and limited number of studies have been done so far. In this study, we aim to comprehensively summarize current insights of melanogenesis in melanoma pathophysiology, with a particular emphasis on the interplay between oncogenic drivers and melanogenesis-associated signaling pathways. We further provide perspectives, how it might be as explored as therapeutic target in melanoma with/without existing treatment options.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing dermatology with ultrasonography: a review on filler differentiation","authors":"Patricia Cristina de Almeida,&nbsp;Laurentia Fidella Averina Setia Santoso,&nbsp;Nancy Emmanuel,&nbsp;Ivan Rollemberg","doi":"10.1007/s00403-025-04377-7","DOIUrl":"10.1007/s00403-025-04377-7","url":null,"abstract":"<div><p>Dermal fillers play a significant role in nonsurgical facial rejuvenation, including facial contouring and addressing concerns such as volume loss, rhytides, and scars. However, patients often fail to provide precise details about their filler procedures, including the injection site, depth, or the specific type of filler used. Ultrasonography can be a valuable tool in assessing the type of filler, injection site, effectiveness, and the need for extraction in cases of complications. A literature review was conducted by searching the terms “dermal fillers” and “ultrasonography” on PubMed, supplemented by a manual search. A total of 20 articles were included for synthesis in this review along with some references from the included articles. Additionally, we incorporated original ultrasonographic images of various dermal fillers, obtained directly from our patients. This review explores the classification and characteristics of available dermal fillers, the challenges associated with their use, the role of ultrasonography in preventing complications, and the ultrasonographic features of different dermal fillers. Most permanent fillers, including polymethylmethacrylate (PMMA), poly-L-lactic acid (PLLA), polyacrylamide, silicone, silicone oil, and autologous fat, appear hyperechoic on ultrasonography. Due to their non-degradable nature, their size and shape remain constant over time. In contrast, non-permanent fillers typically exhibit hypoechogenicity on ultrasonographic imaging. A distinguishing feature of non-permanent fillers is their gradual decrease in size, which can be observed over time as they degrade. Ultrasonography is a reliable tool for detecting dermal filler injections in patients and assessing the filler type, injection site, effectiveness, and the need for extraction in cases of complications. Sonographic evaluation of dermal fillers is based on various parameters, including echogenicity, texture, shape, quantity, borders, artifacts, diameter, anatomical location, internal characteristics, and changes over time.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TFCP system: a novel framework for evaluating the effectiveness of skin wound treatment","authors":"Bo-Wen Zheng,&nbsp;Chao Lian,&nbsp;Yong-Hong Qin,&nbsp;Jian-Xiong Qiao,&nbsp;Lin Zhong,&nbsp;Jin Zhang,&nbsp;Ying-Jun Su,&nbsp;Xuan-Fen Zhang","doi":"10.1007/s00403-025-04388-4","DOIUrl":"10.1007/s00403-025-04388-4","url":null,"abstract":"<div><p>Acute and chronic skin wounds, including defects and ulcers, represent a prevalent clinical challenge in increasing morbidity. With advancements in treatment technologies such as skin wound care and surgical repair, treatment effectiveness has constantly shown improvement. However, assessments of treatment efficacy have typically relied on measures involving primary or secondary healing and subsequent basic functional evaluations. Unfortunately, the degree of cosmetic improvement and the level of pain during diagnosis and treatment have often been overlooked. So, the current assessment methods and results are far from meeting the assessment needs of the injured in terms of self-care, work ability, and confidence recovery. Consequently, some wounds that should be promptly repaired do not receive timely or optimal treatment, resulting in prolonged total treatment times, painful treatment experiences, residual scarring, or functional and aesthetic impacts from remaining scars or skin grafts (flaps). To address these issues, we propose a new therapeutic effect evaluation system (TFCP system), which encompass treatment duration (T), functional recovery (F) (complete, significant, basic, none), cosmetic outcome (C) (regenerative rejuvenation repair, rejuvenation repair, cosmetic repair, disfiguration), and pain level (P) (none, mild, moderate, severe). The TFCP system can be used to predict and ultimately evaluate the therapeutic effects of various skin wounds, thereby promoting the adoption of concepts and technologies related to cosmetic repair and comfortable diagnosis and treatment. Ultimately, this will help improve the effectiveness of skin wound treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}