Archives of Dermatological Research最新文献

{"title":"The significance of DNA methylation pattern in the etiology of basal cell carcinoma","authors":"Bita Faam, Sahar Dadkhahfar, Zahra Razzaghi, Mostafa Rezaei Tavirani, Reza M. Robati","doi":"10.1007/s00403-025-04205-y","DOIUrl":"10.1007/s00403-025-04205-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of topical cetirizine using microneedling in androgenetic alopecia male patients","authors":"Yasser Mostafa Gohary,&nbsp;Basma Mohamed Mohamed Elkastawy,&nbsp;Hasnaa Osama,&nbsp;Mona Elsayed Ahmed Abdellatif","doi":"10.1007/s00403-025-04108-y","DOIUrl":"10.1007/s00403-025-04108-y","url":null,"abstract":"<div><h3>Background</h3><p>Androgenetic alopecia (AGA) affects both sexes equally and lasts long. AGA is the most common kind of hair loss in men. Gradual, pattern-based hair thinning on the scalp is a hallmark of the disease. The front, back, center, and sides of a man’s head are the most common areas where hair thinning and loss occur.</p><h3>Aim</h3><p>To evaluate the efficacy of microneedling-administered topical cetirizine in treating androgenetic alopecia in men.</p><h3>Methods</h3><p>A total of 80 AGA male patients were randomly assigned to this single-blind, parallel placebo-controlled study conducted at Beni-Suef University Hospital’s Dermatology Outpatient Clinic. Researchers allocated 40 patients to undergo topical cetirizine microneedling (MN) and 40 patients to saline MN for 8 weeks.</p><h3>Results</h3><p>In the 8th week, the cetirizine group demonstrated a greater prevalence of vellus hair (70.0%) than the saline group (30.0%), with a statistically significant difference (<i>p</i>-value = 0.001). The majority of patients administered cetirizine by MN exhibited enhanced hair density (80.0%) in contrast to 25.0% in the saline group, with a statistically significant difference between the two groups (<i>p</i>-value = 0.001). No notable adverse effects linked to the administration of cetirizine by MN were reported.</p><h3>Conclusion</h3><p>The microneedling of 1% topical cetirizine proved efficient in promoting hair growth without problems in the treatment of male androgenetic alopecia.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of tumor upstaging following partial biopsy and scouting biopsy in the treatment of melanoma in situ and invasive melanoma with Mohs micrographic surgery: a retrospective cohort study","authors":"Rachael S. Chacko,&nbsp;Payal C. Shah,&nbsp;James X. Feng,&nbsp;Matthew J. Davis,&nbsp;Matthew LeBoeuf","doi":"10.1007/s00403-025-04079-0","DOIUrl":"10.1007/s00403-025-04079-0","url":null,"abstract":"<div><p>Understanding the impact of diagnostic and preoperative biopsy techniques on upstaging risk during treatment of melanoma in situ and invasive melanoma (MIS/IM) with Mohs micrographic surgery (MMS) is important for preoperative counseling and surgical planning. To determine the risk of tumor upstaging associated with partial biopsy and scouting biopsy techniques during MMS treatment of MIS/IM. A retrospective cohort study of 327 patients who underwent MMS for MIS/IM treatment at Dartmouth between March 2020 through January 2024. Binary logistic regression was used to assess the association of diagnostic and scouting biopsy with risk of upstaging. Seven (<i>n</i> = 7/327, 2.1%) patients upstaged during MMS, and four newly qualified for SLNB. Punch biopsy and partial biopsy were significantly associated with tumor upstaging. Upstaged tumors had greater number of MMS stages. Scouting biopsy use led to a 14.0% relative risk reduction in upstaging. A low overall risk of upstaging and SLNB following MMS validates recent data in the literature and supports use of MMS for MIS/IM treatment. As partial and punch biopsy contribute to upstaging risk, dermatologists should consider broad shave biopsies when sampling suspicious pigmented lesions. Preoperative scouting biopsies may be useful in reducing upstaging risk, number of MMS stages, and associated patient morbidity.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of LINC00114 in atopic dermatitis: modulating inflammation and epidermal barrier dysfunction","authors":"Yifeng Sun,&nbsp;Xin Li,&nbsp;Ningning Deng,&nbsp;Tingqi Zhao,&nbsp;Juan Lv,&nbsp;Jinyu Chu","doi":"10.1007/s00403-025-04168-0","DOIUrl":"10.1007/s00403-025-04168-0","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by a dysregulated immune response and impaired epidermal barrier function. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression in various diseases, yet their specific roles in AD remain poorly understood. This study investigates the role of LINC00114, an lncRNA identified as significantly upregulated in lesional skin of AD patients. Using RNA sequencing, quantitative real-time PCR, and in vitro experiments, we demonstrate that LINC00114 is induced by Th2 cytokines IL-4 and IL-13, correlating with clinical severity scores. Notably, the observed 2–3 fold changes in LINC00114 expression indicate a substantial biological impact; as such alterations can significantly influence inflammatory pathways and epidermal barrier integrity. Mechanistically, LINC00114 functions as a molecular sponge for miR-128, inhibiting its regulatory effects on pro-inflammatory targets. Furthermore, LINC00114 enhances the JAK/STAT signaling pathway, promoting Th2-driven inflammation. Our findings also reveal that LINC00114 impairs epidermal barrier function by downregulating key proteins such as filaggrin and involucrin. In a murine model of AD, targeting LINC00114 with siRNA significantly reduced skin inflammation and improved barrier integrity. These results highlight LINC00114 as a novel therapeutic target for AD, offering potential avenues for more effective treatments aimed at restoring immune balance and skin barrier function.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary and multiple xanthogranulomas in adult patients: a single-center retrospective cohort study","authors":"Michelle Kwan,&nbsp;Christopher S. Yang,&nbsp;Cuong V. Nguyen","doi":"10.1007/s00403-025-04103-3","DOIUrl":"10.1007/s00403-025-04103-3","url":null,"abstract":"<div><p>The systemic associations of adult xanthogranulomas (XGs), the most common subtype of non-Langerhans cell histiocytosis, are poorly understood. In this retrospective cohort analysis, we studied adult patients diagnosed with XGs and investigated the clinical features and systemic associations of adult XGs. Among 138 patients (mean age 43.3 years, 51.4% female, 76.8% white), adult XGs most frequently presented on the trunk (40.6%), differing from the pediatric predilection for the head and neck. Patients presenting with multiple XGs (3.6%) were significantly more likely to have systemic malignancies (<i>p</i> = 0.009), particularly hematologic malignancies (<i>p</i> = 0.001), as well as non-malignant hematologic disorders (<i>p</i> = 0.027). Hyperlipidemia (37%), cardiac disease (51.4%), and endocrine disease (31.2%) were the most prevalent systemic comorbidities. In conclusion, the presentation of multiple XGs in an adult is associated with malignancy (particularly hematologic malignancies) and non-malignant hematologic disorders, suggesting a possible link with immune dysregulation. Molecular testing in one patient with multiple XGs and CMML transformed to AML revealed the same KMT2a deletion in both the XGs and the bone marrow, raising the possibility of clonal relationships in some cases.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes as a risk factor for promoting hypertrophic scar formation after wound healing: a two-sample mendelian randomization study","authors":"Wenlian Zheng,&nbsp;Wenxiu Lai,&nbsp;Yixun Zhang,&nbsp;Xiaoxiang Wang,&nbsp;Kaibo Yang,&nbsp;Xin Zhou,&nbsp;Zheng Chen,&nbsp;Ronghua Yang,&nbsp;Liaoyuan Deng","doi":"10.1007/s00403-025-04101-5","DOIUrl":"10.1007/s00403-025-04101-5","url":null,"abstract":"<div><p>Individuals with type 2 diabetes mellitus (T2DM) not only face the risk of difficult wound healing after trauma or surgery but also struggle with scar formation after wound healing. However, the relationship between T2DM and hypertrophic scars (HS) remains unclear. First, the data sets related to T2DM and HS were downloaded from the OpenGWAS database. Second, the inverse variance-weighted (IVW) technique was employed to assess the causal impact of T2DM on HS utilizing mendelian randomization (MR). Finally, sensitivity analyses and reverse MR analyses were performed to determine the robustness of the findings and to examine the potential for reverse causation. A positive causal relationship between T2DM and HS was observed. Three suitable datasets for T2DM analysis were obtained using the ids ebi-a-GCST006867, ebi-a-GCST007515, and ebi-a-GCST007516 (A total of 206,572 cases and 753,191 controls were included). The HS (finn-b-L12_HYPETROPHICSCAR) dataset comprised 766 cases and 207,482 controls. The IVW model results showed odds ratio (OR) of 1.213 (95% confidence interval (CI): 1.04−1.41, <i>p</i> = 0.0137), 1.300 (95% CI: 1.05−1.61, <i>p</i> = 0.017), and 1.284 (95% CI: 1.03−1.60, <i>p</i> = 0.0276), respectively. The analysis results were stable without any significant bias or reverse causality. This study systematically explored the causal relationship between T2DM and the risk of HS for the first time, and provided a quantitative effect assessment. The results showed consistency, which indicated the potential biological mechanism and clinical intervention direction.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04101-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intradermal tranexamic acid injection following IPL for the treatment of persistent post acne erythema: a split-face, controlled trial","authors":"Mehdi Gheisari,&nbsp;Nushin Golchin,&nbsp;Afsaneh Sadeghzadeh Bazargan,&nbsp;Latif Gachkar,&nbsp;Shirin Zaresharifi","doi":"10.1007/s00403-025-04215-w","DOIUrl":"10.1007/s00403-025-04215-w","url":null,"abstract":"<div><p>Post-acne erythema (PAE) is a common consequence of acne vulgaris, often leading to significant psychological distress and social impairment. While Intense Pulsed Light (IPL) has been proven as a non-invasive option for reducing erythema, the addition of adjunctive therapies may enhance treatment outcomes. To evaluate the effects of intradermal tranexamic acid (TXA) injections on the reduction of persistent PAE following IPL therapy in a split-face controlled trial. 33 patients aged 16 to 45 with persistent PAE were randomly assigned to receive either IPL with intradermal injection of TXA or IPL with placebo (normal saline) on opposite sides of their faces. A total of three treatment sessions were performed three weeks apart. Improvement in PAE was assessed at the follow-up session one month after the third session compared to before treatment. The response to treatment was assessed using the total physician’s score of improvement based on the clinician erythema assessment scale and the patient’s self-assessment based on a rating of 1 to 4. According to physicians’ scores of improvement and patients’ self-assessment of TXA injection, improvement in erythema was observed in most of the patients. Nevertheless, these results were not statistically significant. In addition, IPL treatment (on the control side) effectively improved PAE based on physicians’ scores of improvement and patients’ self-assessments, still, these results were statistically significant only in the physicians’ scores of improvements. Furthermore, 53% of patients did not report adverse reactions on the intervention side. The most commonly mentioned side effect was erythema on the injection side in 27.3% of patients, which was resolved within 24 h in all cases. This study highlights the complexities of treating persistent PAE. While most patients reported mild to moderate improvement with intradermal TXA, the combination of intradermal TXA and IPL did not show significant improvement over IPL treatment. Adverse effects were minimal, with injection site erythema being the most common. These findings warrant further investigation into optimizing treatment protocols for PAE management.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of The efficacy and safety of fractional erbium: YAG laser in combination with Tranexamic acid delivery by different methods versus Tranexamic acid alone: A systematic review and meta-analysis","authors":"Sara Mahfoud Hassan Alghamdi,&nbsp;Ahmed Mohammed Baabdullah,&nbsp;Dareen Bajamaan,&nbsp;Razan Almleaky,&nbsp;Mohammed Alahmadi,&nbsp;Mashael Sharaf,&nbsp;Badr Salem Aljohani,&nbsp;Rayan Alsaqri,&nbsp;Abdulrahman Ayman Alharbi","doi":"10.1007/s00403-025-04178-y","DOIUrl":"10.1007/s00403-025-04178-y","url":null,"abstract":"<div><p>Melasma is a chronic hyperpigmentary disorder characterized by light-brown to bluish-gray patches. No single treatment is universally efficacious. Thus, a combination treatment should be applied. This Systematic review and meta-analysis aims to evaluate the efficacy of fractional erbium: YAG laser combined with tranexamic acid (TXA) delivery methods compared to TXA alone for melasma treatment. A comprehensive search was conducted across PubMed, Google Scholar, and Web of Science, including Randomized controlled trials (RCTs), cohort studies, and case series of patients diagnosed with melasma, excluding studies with high bias risk or low quality, studies involved patients with active skin infections, inflammatory skin conditions, or systemic diseases affecting healing, patients with keloid history or with concurrent anticoagulant or steroid use, and non-compliance with protocols. Studies should report at least one of the following outcomes such as improvement in melasma, incidence/severity of adverse events, objective pigment reduction, or treatment effect duration and relapse time. The risk of bias was assessed using the Newcastle-Ottawa Scale and the meta-analysis was conducted using a random-effects model (restricted maximum-likelihood estimator) to account for study variability. We included 13 studies involving a total of 585 participants. Most studies involved between 30 and 60 participants. Subgroup analysis of the modified Melasma Area and severity index showed no overall effect (standardized mean differences (SMDs) = -0.0802, <i>p</i> = 0.8685), with high heterogeneity (I² = 92.5%, <i>p</i> &lt; 0.0001). A large positive effect was observed at 3 months (SMD = 1.9802) and a negative effect at 6 months (SMD = -0.7190) with significant differences. The overall effect of interventions on the Melasma Area and severity index was minimal (SMD = 0.0039, <i>p</i> = 0.9877), with moderate heterogeneity (I² = 50.3%, <i>p</i> = 0.1337). A small negative effect at 6 months was observed (SMD = -0.4234) and no significant effects at 3 months. There is no consistent or significant long-term impact on melasma severity. While some short-term improvements were observed, they often declined over time. Future studies are needed to better define the long-term effectiveness and safety.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comparative study of letibotulinum toxin A and onabotulinum toxin A in treatment of primary axillary hyperhidrosis","authors":"Sunatra Nitayavardhana,&nbsp;Romun Leaovitavat","doi":"10.1007/s00403-025-04069-2","DOIUrl":"10.1007/s00403-025-04069-2","url":null,"abstract":"<div><p>Primary axillary hyperhidrosis (PAH) is a challenging condition characterized by excessive underarm sweating. The U.S. Food and Drug Administration has approved onabotulinum toxin A (OnaBTX-A, Botox^®, Allergan Inc, USA) as the only botulinum toxin treatment for severe axillary hyperhidrosis, and it has demonstrated positive results. Recently, the off-label use of letibotulinum toxin A (LetiBTX-A, Hugel^®, Hugel Inc, Korea) has risen significantly for cosmetic purposes due to its effectiveness. For the treatment of primary axillary hyperhidrosis, the authors proposed that LetiBTX-A is at least as effective as OnaBTX-A. To evaluate the efficacy and safety of letibotulinum toxin A (LetiBTX-A) in comparison to onabotulinum toxin A (OnaBTX-A) for treating primary axillary hyperhidrosis (PAH). All participants with a diagnosis of moderate to severe primary axillary hyperhidrosis (Hyperhidrosis Disease Severity Scale (HDSS) score ≥ 2) received random injections of 50 U of LetiBTX-A in one armpit and 50 U of OnaBTX-A in the other site. HDSS score and hyperhidrosis area were measured by using the Minor’s iodine starch test. Participant satisfaction was evaluated at 1, 3, and 6 months following the injection. Onset of action and adverse events were also assessed. All 30 participants completed the study protocol, with the mean age was 34.44 ± 7.82 years and most of the participants were female. The mean age at onset was 20.47 ± 3.01 years and more than 50% of participants had a HDSS score of 3. There was no statistically significant difference observed in the reduction of HDSS scores, hyperhidrosis area, and participant satisfaction between the axillae treated with LetiBTX-A and those treated with OnaBTX-A at 1, 3 and 6 months after injections. The median onset of action of both LetiBTX-A and OnaBTX-A were 2 ± 1 day (<i>p</i> = 0.317). Procedure-related pain was comparable between 2 formulations (<i>P</i> = 0.876). No serious adverse event was observed. This study concluded that LetiBTX-A and OnaBTX-A demonstrate comparable efficacy and safety profiles in treating primary axillary hyperhidrosis (PAH).</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of tranexamic acid and botulinum toxin in treating patients with acne vulgaris: a split face comparative study","authors":"Mohamed Metwalli,&nbsp;Amina Ali Mohamed,&nbsp;Reham Essam","doi":"10.1007/s00403-025-04127-9","DOIUrl":"10.1007/s00403-025-04127-9","url":null,"abstract":"<div><h3>Background</h3><p>Many causes can lead to acne, such as increased sebum production, altered sebum lipid quality from increased androgen activity, abnormal keratinization of the infundibular epithelium, and Propionibacterium acnes (P. acnes) colonizing the follicles.</p><h3>Aim</h3><p>The present study aimed to evaluate and compare the clinical efficacy of botulinum toxin-A vs. tranexamic acid intradermal injection in the treatment of acne vulgaris.</p><h3>Methods</h3><p>This split face study includes forty patients with varying grades of acne vulgaris. They were injected intradermally with tranexamic acid (20 mg/ml) on the left side for three sessions two weeks apart and once with botulinum toxin-A on the right side.</p><h3>Results</h3><p>After treatment, the Total Lesion Count, Comprehensive Acne severity Scale, and Clinical Erythema Assessment Scale significantly reduced, with a greater reduction in erythema on the tranexamic acid side and a greater reduction of comedones on the botulinum toxin side.</p><h3>Conclusion</h3><p>Tranexamic acid and botulinum toxin-A can be promising adjuvants in treating acne vulgaris by their specific mechanisms in the dermatological domain.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}