Archives of Dermatological Research最新文献

{"title":"Enhancing oncodermatology support: assessing patient utilization and satisfaction with educational resources for managing dermatologic toxicities of cancer treatment","authors":"Sabrina Saeed,&nbsp;Tiffany X. Chen,&nbsp;Lenique Huggins,&nbsp;Jonathan Leventhal","doi":"10.1007/s00403-025-04262-3","DOIUrl":"10.1007/s00403-025-04262-3","url":null,"abstract":"<div><p>Dermatologic toxicities resulting from cancer treatments are common, debilitating, and can significantly impact a patient’s quality of life. In some cases, these toxicities may require dose adjustments or even discontinuation of treatment. Timely management of dermatologic adverse events (DAEs) is crucial to improving patient outcomes, and educational resources are instrumental in empowering patients to recognize and manage these issues. This cross-sectional survey study aims to characterize patient utilization of and satisfaction with educational resources regarding dermatologic toxicities of cancer treatments. Findings indicate that while 77.5% (<i>n</i> = 110) of patients received information on managing dermatologic toxicities, a larger proportion (<i>n</i> = 123; 86.5%) experienced these side effects. Healthcare providers were the primary source of information (<i>n</i> = 102/110; 92.7%), followed by self-searching on the internet (<i>n</i> = 59/110; 53.6%), and social media (<i>n</i> = 43/110; 39.1%). Despite most patients receiving educational content, patients expressed low satisfaction with both the quality and quantity of information provided, with only 31.3% (<i>n</i> = 41) reporting satisfaction with the amount of information and 33.8% (<i>n</i> = 44) reporting satisfaction with its quality, highlighting a significant gap in resource effectiveness. Notably, patients reported the highest satisfaction with information provided by healthcare providers, suggesting that integrating comprehensive dermatologic education into oncologic care could improve patient satisfaction and outcomes.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term malignancy risk of JAK inhibitors in severe alopecia areata: a multicenter cohort study","authors":"Jasmine Levine,&nbsp;Rahib K Islam,&nbsp;Lillian Mo,&nbsp;Alexander Maltese,&nbsp;Jonas Adalsteinsson,&nbsp;Jordan Talia,&nbsp;Nicholas Gulati,&nbsp;Benjamin Ungar","doi":"10.1007/s00403-025-04258-z","DOIUrl":"10.1007/s00403-025-04258-z","url":null,"abstract":"<div><p>Alopecia areata (AA) is an autoimmune hair loss disorder, with Janus kinase inhibitors (JAKis) emerging as an effective treatment. However, concerns about malignancy risk remain due to boxed warnings primarily based on studies in rheumatoid arthritis. This retrospective cohort study evaluated the association between JAKis and malignancy risk in AA using the TriNetX Global Collaborative Network. Patients with severe AA were categorized by treatment history, including JAKis, traditional immunosuppressants, and no systemic treatment. Propensity score-matched Cox proportional hazards models assessed the risks of squamous cell carcinoma (SCC)/basal cell carcinoma (BCC), internal malignancies, and hematologic malignancies. Among matched cohorts of 920 patients treated with traditional immunosuppressants and 920 treated with JAKis (mean follow-up: 1,302 and 1,229 days, respectively), SCC/BCC risk was not significantly different (HR = 0.324 [0.065, 1.609]). However, internal malignancy (HR = 4.906 [2.168, 11.101]) and hematologic malignancy (HR = 8.713 [1.104, 68.796]) risks were significantly higher with traditional immunosuppressants. No significant difference in malignancy risk was observed between 446 JAKi-treated and 446 untreated patients. These findings align with previous meta-analyses in autoimmune diseases, which have not linked JAKis to an increased malignancy risk. While this study found no evidence that JAKis elevate malignancy risk, the role of JAK-STAT signaling in cancer remains complex. Given AA’s unclear baseline malignancy risk and this study’s retrospective nature and limited follow-up, longer-term studies are needed to better understand the long-term safety of JAKis in AA and refine risk assessment and screening strategies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated systematic review and meta-analysis on the efficacy and safety of nivolumab/relatlimab combination therapy in melanoma patients","authors":"Mohammad-Salar Hosseini,&nbsp;Farhad Jadidi-Niaragh","doi":"10.1007/s00403-025-04270-3","DOIUrl":"10.1007/s00403-025-04270-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular associations with onychomycosis: a global database analysis","authors":"Dev Patel,&nbsp;Naeha Pathak,&nbsp;Omar Alani,&nbsp;Amit Singal,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-025-04261-4","DOIUrl":"10.1007/s00403-025-04261-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia in inflammatory cutaneous conditions: a retrospective cohort study","authors":"Rashwan Alameddine,&nbsp;Kyle C. Lauck,&nbsp;Abigail McKenzie,&nbsp;Hamza Malick,&nbsp;Stanislav Tolkachjov","doi":"10.1007/s00403-025-04251-6","DOIUrl":"10.1007/s00403-025-04251-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of skin tags: scissor excision versus non-ablative 532nm-LBO-laser in a randomized intraindividual controlled observer-blinded clinical trial","authors":"Ozan Haase,&nbsp;Charlotte Winkelmann-Schirmer,&nbsp;Petra Mrowka,&nbsp;Sven Krengel","doi":"10.1007/s00403-025-04242-7","DOIUrl":"10.1007/s00403-025-04242-7","url":null,"abstract":"<div><p>Fibroma pendulans, commonly known as skin tag, is a benign protrusion of connective tissue that often develops groupwise in areas subjected to mechanical friction. Although generally harmless, they can become cosmetically concerning or painful if infarcted. Traditional removal methods, such as electrocautery and cryotherapy, often result in hypopigmentation or scarring. Lasers became interesting for skin-tag removal, but are they really more effective than classical scissor snip exisions? This study aimed to compare the efficacy, healing outcomes, and patient acceptance of scissor snip excision versus 532 nm LBO laser therapy for the removal of skin tags. 68 patients with a total of 1,257 fibromas located on the neck or axillae were treated. Each patient received both treatments in a randomized split-neck/axillar manner. Fibromas were either excised using scissors or treated with the non-ablative 532 nm LBO laser. Outcomes were evaluated at 4 and 12 weeks post-treatment, focusing on complete healing, patient preference, pain perception, and cosmetic results. At 12 weeks, the scissor excision group exhibited a significantly higher healing rate of 85% compared to 71% in the laser group (<i>p</i> = 0.00001). The adjusted overall response rate was 92.64% for scissor excision and 84.19% for laser treatment. Patient preference favored scissor excision, with 63% of patients opting for this method for future treatments, while 19% preferred the laser, and 18% were indifferent. Pain scores were lower for scissor excision (mean: 2.6) compared to laser treatment (mean: 3.42). Laser therapy was 39% faster than scissor excision when accounting for wound dressing, although it had higher rates of redness, hyper- and hypopigmentation. The bloodless nature of the laser and the absence of dressings were perceived as advantages, but the persistence of necrotic fibromas for up to three weeks was a notable drawback. Despite the perceived advantages of a bloodless and dressing-free procedure with the 532 nm LBO laser, scissor snip excision demonstrated superior healing outcomes, lower pain scores, and higher patient satisfaction. These findings suggest that scissor snip excision remains the gold standard for treating pedunculated fibromas, though further studies exploring the effect of the 532 nm laser on small disseminated fibromas and other laser modalities are warranted.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurofibromatosis type 1 is associated with neurocognitive and psychiatric disorders in a national database","authors":"Kaya L. Curtis,&nbsp;Onajia Stubblefield,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-025-04250-7","DOIUrl":"10.1007/s00403-025-04250-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure changes in patients after Minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial","authors":"Flávia Machado Alves Basilio,&nbsp;Fabiane Mulinari-Brenner,&nbsp;Betina Werner,&nbsp;Nubia Vedovatto de Macedo","doi":"10.1007/s00403-025-04247-2","DOIUrl":"10.1007/s00403-025-04247-2","url":null,"abstract":"<div><h3>Background</h3><p>Microinfusion is a superficial microneedling procedure that infuses medications into the surface of the dermis through disposable needles attached to tattoo equipment. Various medications can be microinfused; minoxidil is frequently utilized as an adjuvant treatment for androgenetic alopecia, but little data is available on its systemic effects when administered via this technique.</p><h3>Objective</h3><p>To compare blood pressure readings before and after microinfusion of minoxidil in the scalp to assess this drug’s systemic effects when applied using this technique.</p><h3>Methods</h3><p>This randomized, controlled, blinded study was conducted with 24 patients divided into 2 groups to compare microinfusion with 0.5% minoxidil and saline solution (control group). Participants underwent 3 sessions at monthly intervals, and their blood pressure was measured before and after each microinfusion procedure.</p><h3>Results</h3><p>A statistically significant reduction in diastolic blood pressure was observed after the procedure in the minoxidil group (<i>p</i> = 0.037). In the control group, a statistically significant increase in systolic blood pressure was found (<i>p</i> = 0.013).</p><h3>Conclusion</h3><p>Reduction of diastolic blood pressure in the minoxidil group proved dermal delivery and systemic absorption of the medication after scalp microinfusion. Increased systolic pressure in the control group may be related to pain during the procedure.</p><h3>Brazilian registry of clinical trials</h3><p>(ReBEC): RBR-368fdb3; Date of registration: April, 11th, 2024 (retrospectively registered).</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shortage and distribution of autoimmune bullous disease providers in the United States: a cross-sectional analysis","authors":"Gaurav Pathak,&nbsp;Suraj Pathak,&nbsp;Amar Desai","doi":"10.1007/s00403-025-04255-2","DOIUrl":"10.1007/s00403-025-04255-2","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomics of human skin reveals age-associated specificity of distinct cell populations","authors":"Lingzhu Liao,&nbsp;Suzheng Zheng,&nbsp;Jiaxin Meng,&nbsp;Yunfeng Hu,&nbsp;Shi Wu","doi":"10.1007/s00403-025-04222-x","DOIUrl":"10.1007/s00403-025-04222-x","url":null,"abstract":"<div><h3>Background</h3><p>The skin, as the body’s largest organ, undergoes significant changes with aging, impacting its structural integrity, repair capacity, and immune function. Previous studies have highlighted the heterogeneity of skin cells, particularly fibroblasts, and their role in skin homeostasis. However, the molecular and functional dynamics of these cell populations during aging, especially in sun-protected areas, remain underexplored. This study aims to elucidate the age-related changes in skin cell populations, focusing on dermal fibroblasts, using single-cell RNA sequencing (scRNA-seq) to provide insights into the mechanisms of intrinsic skin aging.</p><h3>Methods</h3><p>We utilized single-cell RNA sequencing (scRNA-seq) to analyze skin samples from healthy human donors. A total of over 5,000 cells were included in the study, representing a variety of skin cell types, including fibroblasts, keratinocytes, and immune cells. To further investigate the biological functions and differences between cell types, we performed differential gene expression analysis, Gene Ontology (GO) enrichment, and KEGG pathway analysis. Additionally, pseudotime analysis was conducted to examine cellular differentiation trajectories, while CellChat analysis was used to assess intercellular communication in the skin. These methodologies allowed us to identify key cell populations, their functional properties, and the impact of aging on skin cell interactions.</p><h3>Results</h3><p>Study revealed significant diversity and functional specialization among skin cells, defining several major cell subgroups. These subgroups exhibited specific spatial localization in different regions of the skin and demonstrated distinct functional characteristics, such as secretion, mesenchymal activity, and immune regulation. Importantly, we found that with aging, there is a general reduction in the “activation” (i.e., activity and functionality) of skin cells. Aging not only affects individual cell types, such as fibroblasts, but also leads to a marked decrease in interactions between different skin cell types, including cell communication at the dermal-epidermal junction. These findings highlight the complexity of skin aging as a process involving multiple cell types and their interactions.</p><h3>Conclusion</h3><p>Our work provides new insights into the functional specialization and aging process of skin cells. We identified a key age-related change in human skin: the partial loss of cell identity and function. These findings contribute to the understanding of skin aging mechanisms and associated phenotypes, offering potential directions for future anti-aging therapeutic strategies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}