Archives of Dermatological Research最新文献_第2页

Sex disparities in cost related medication non-adherence in acne vulgaris patients: a national cross-sectional study.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-24 DOI: 10.1007/s00403-024-03753-z

Vedant Agrawal, David Garate, Juan Pinto-Cuberos, Ayezel Muñoz-Gonzalez

引用次数: 0

The impact of imprecise case definitions in electronic health record research: a melanoma case-study from the Million Veteran Program.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-24 DOI: 10.1007/s00403-024-03780-w

Lee Wheless, Dominique Mosley, Daniel Dochtermann, Saiju Pyarajan, Katlyn Gonzalez, Rachel Weiss, Kyle Maas, Siwei Zhang, Lydia Yao, Yaomin Xu, Christopher Madden, Jacqueline Ike, Isabelle T Smith, Sarah Grossarth, Otis Wilson, Adriana Hung, Nathanael R Fillmore, Kevin Brown, Maria Teresa Landi, Rebecca I Hartman

{"title":"The impact of imprecise case definitions in electronic health record research: a melanoma case-study from the Million Veteran Program.","authors":"Lee Wheless, Dominique Mosley, Daniel Dochtermann, Saiju Pyarajan, Katlyn Gonzalez, Rachel Weiss, Kyle Maas, Siwei Zhang, Lydia Yao, Yaomin Xu, Christopher Madden, Jacqueline Ike, Isabelle T Smith, Sarah Grossarth, Otis Wilson, Adriana Hung, Nathanael R Fillmore, Kevin Brown, Maria Teresa Landi, Rebecca I Hartman","doi":"10.1007/s00403-024-03780-w","DOIUrl":"https://doi.org/10.1007/s00403-024-03780-w","url":null,"abstract":"<p><p>Cases for a disease can be defined broadly using diagnostic codes, or narrowly using gold-standard confirmation that often is not available in large administrative datasets. These different definitions can have significant impacts on the results and conclusions of studies. We conducted this study to assess how using melanoma phecodes versus histologic confirmation for invasive or in situ melanoma impacts the results of a genome-wide association study (GWAS) using the Million Veteran Program. Melanoma status was determined three ways: (1) by the presence of two or more phecodes, (2) histologically-confirmed invasive melanoma, and (3) histologically-confirmed melanoma in situ. We conducted a GWAS for variants with minor allele frequencies of 1% or greater. There were 45,665 cases in the phecode cohort, 5364 cases in the confirmed invasive melanoma cohort, and 4792 cases in the confirmed melanoma in situ cohort. There were 20,457 variants significant at the genome-wide level in the phecode cohort, 2582 in the invasive melanoma cohort, and 1989 in the melanoma in situ cohort. Most of the variants identified in the phecode cohort did not replicate in the histologically-confirmed cohorts. The different case definitions led to large differences in sample size and variants associated at the genome-wide level. Unvalidated and imprecise case definitions can lead to less accurate results. Investigators should use validated phenotypes when gold-standard definitions are not available.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"308"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injection of hyaluronic acid versus platelet rich plasma for treatment of vulvovaginal atrophy in post-menopausal females.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-24 DOI: 10.1007/s00403-025-03820-z

Sylvia Ragy, Hanan El Kahky, Nehal Mohammed Zu Elfakkar, Salma Ashraf Mohamed Nassar, Rania Mahmoud El-Husseiny

{"title":"Injection of hyaluronic acid versus platelet rich plasma for treatment of vulvovaginal atrophy in post-menopausal females.","authors":"Sylvia Ragy, Hanan El Kahky, Nehal Mohammed Zu Elfakkar, Salma Ashraf Mohamed Nassar, Rania Mahmoud El-Husseiny","doi":"10.1007/s00403-025-03820-z","DOIUrl":"https://doi.org/10.1007/s00403-025-03820-z","url":null,"abstract":"<p><p>Female sexual dysfunction is highly prevalent among postmenopausal females approaching 50%, with vulvovaginal atrophy (VVA) being a cardinal sign. For decades, hormone replacement therapy was the only solution to relieve symptoms associated with this atrophy. However, it was limited by its serious side effects, raising the need for new treatment strategies. This study aims to compare the efficacy and safety of injection of hyaluronic acid (HA) versus platelet rich plasma (PRP) in post-menopausal females presented with VVA to improve female sexual dysfunction. Twenty post-menopausal females presented with VVA were randomly divided into two groups, 10 patients in each group. Both groups received three sessions of injections into the vulva and vagina, one month apart. Group I was injected with non cross linked HA while Group II received PRP injection. Subjective assessment was carried out through female sexual function index questionnaire and global aesthetic improvement scale.While objective assessment was carried out by measuring the labia majora length and reviewing the histopathological changes occurring in the vulva through skin biopsies before and after treatment. The change in vaginal thickness was estimated by transvaginal ultrasound. Results showed that both HA as well as PRP were effective in the treatment of post-menopausal vulvovaginal atrophy. However, HA showed more significant improvement in female sexual dysfunction. There were also higher values in vaginal wall thickness as measured by transvaginal ultrasound in favor of HA injected group. Histopathological assessment showed more collagen deposition in papillary dermis in HA treated group. No complications were reported in both groups.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"305"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associated factors related to production of autoantibodies and dermo-epidermal separation in bullous pemphigoid.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-24 DOI: 10.1007/s00403-024-03760-0

Liuyiyi Yang, Yulu Wang, Yagang Zuo

{"title":"Associated factors related to production of autoantibodies and dermo-epidermal separation in bullous pemphigoid.","authors":"Liuyiyi Yang, Yulu Wang, Yagang Zuo","doi":"10.1007/s00403-024-03760-0","DOIUrl":"https://doi.org/10.1007/s00403-024-03760-0","url":null,"abstract":"<p><p>Bullous pemphigoid (BP) is a debilitating autoimmune skin blistering disease, characterized by the deposition of specific autoantibodies at the dermal-epidermal junction. This leads to an inflammatory cascade involving the activation of complement proteins, mast cell degranulation, immune cell recruitment, and the release of proteases by granulocytes. While several cytokines and signaling pathways have been implicated in the pathogenesis of BP, the precise mechanism behind autoantibody production remains unclear. A variety of factors, including natural aging, genetic polymorphisms, microbiota, medications, vaccinations, and infection, may contribute to disease onset. Recent evidence also suggests that both vaccination against severe acute respiratory syndrome coronavirus-2 and infection with severe acute respiratory syndrome coronavirus-2 may also play a role in BP's development. This review aims to elucidate the mechanism underlying the production of autoantibodies in BP, address gaps in understanding disease progression, and explore opportunities for improving diagnosis and prognosis to enhance patient care.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"303"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of intralesional pentoxifylline versus intralesional steroid versus intralesional vitamin D in treatment of keloid.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-24 DOI: 10.1007/s00403-025-03799-7

Sara Ahmed Galal, Rasha Aly El-Barbary, Doaa Karam Abd El Wahed Madkour

{"title":"Efficacy of intralesional pentoxifylline versus intralesional steroid versus intralesional vitamin D in treatment of keloid.","authors":"Sara Ahmed Galal, Rasha Aly El-Barbary, Doaa Karam Abd El Wahed Madkour","doi":"10.1007/s00403-025-03799-7","DOIUrl":"https://doi.org/10.1007/s00403-025-03799-7","url":null,"abstract":"<p><p>Several treatment modalities have been used for the treatment of keloid scarring but the optimal treatment has not yet been identified. Corticosteroids reduce excessive scarring by reducing collagen synthesis. Vitamin D can curb inflammation by inhibiting the activation and migration of leukocytes. Pentoxifylline is a methyl xanthine derivative initially developed for its vasodilatory properties. Evaluation and comparison between three modalities of treatment for keloid; intralesional vitamin D, pentoxifylline, and steroid. Forty-five patients with keloid lesions were divided into 3 groups; The first group: 15 patients were treated with intralesional triamcinolone acetonide. The second group: 15 patients treated with intralesional pentoxifylline. The third group: 15 patients treated with intralesional vitamin D. The response was evaluated clinically, Vancouver scar scale and patient satisfaction scale. At the end of the study, all groups showed highly statistically significant improvement compared to the baseline. The first group which was treated with triamcinolone acetonide showed excellent and good improvement 53% and 47% respectively. The second group which was treated with pentoxifylline showed excellent and good improvement 6.7% and 73.3% respectively. The third group which was treated with vitamin D showed excellent and good 6.7% and 86.7% respectively. Intralesional vitamin D and pentoxifylline are safe and effective therapeutic options for keloid lesions.</p>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":"307"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing variations in electrodesiccation and curettage techniques for the treatment of non-melanoma skin cancer.

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-23 DOI: 10.1007/s00403-024-03673-y

Briana R Halle Brady, Ajay N Sharma, Natalie M Fragoso, Aditi A Sharma

引用次数: 0

Dual-center retrospective cohort analysis of high-risk cutaneous squamous cell carcinoma tumors 高危皮肤鳞状细胞癌的双中心回顾性队列分析

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-20 DOI: 10.1007/s00403-024-03712-8

Brandon Calley, Kendall Trieglaff, Nicole Boswell, Alan Vu, Sabrina Popatia, Daniel Benitez Rivera, Ulrich Kemmo Tsafack, Anjishnu Banerjee, Olushola Akinshemoyin Vaughn, Melanie A. Clark

{"title":"Dual-center retrospective cohort analysis of high-risk cutaneous squamous cell carcinoma tumors","authors":"Brandon Calley, Kendall Trieglaff, Nicole Boswell, Alan Vu, Sabrina Popatia, Daniel Benitez Rivera, Ulrich Kemmo Tsafack, Anjishnu Banerjee, Olushola Akinshemoyin Vaughn, Melanie A. Clark","doi":"10.1007/s00403-024-03712-8","DOIUrl":"10.1007/s00403-024-03712-8","url":null,"abstract":"<div><p>High-risk cutaneous squamous cell carcinoma (hr-cSCC) tumors exhibit aggressive behavior, leading to local recurrence, metastasis, and mortality. The management of hr-cSCC tumors is not well-defined. To clarify the impact of clinical risk factors and management strategies on disease-related outcomes (DROs) in patients with hr-cSCCs. This dual-center retrospective cohort study reviewed patient records from 2007 to 2023, focusing on hr-cSCC tumors classified as high-risk according to two staging systems. 160 adult patients with hr-cSCC were included. Tumors > 2 cm were associated with a higher risk of recurrence, metastasis, and mortality, with greater risk for tumors > 4 cm. Nonsurgical therapies were linked to higher recurrence and mortality rates compared to surgical monotherapy. Patients whose initial treatment was delayed > 60 days following biopsy had increased incidence of DROs. Other variables associated with at least one DRO included female sex, higher tumor grade, lymphovascular invasion, and advanced AJCC-8 stages. Limitations of this study include its retrospective design, narrow demographics, and variable follow-up times. This study identifies increased tumor diameter, non-surgical treatments, delayed treatment > 60 days after biopsy, female sex, tumor grade, lymphovascular invasion, and advanced tumor stage as significant risk factors for DROs in hr-cSCC. Importantly, our study provides new clarifying evidence that delayed surgical treatment of hr-cSCCs > 60 days after biopsy is associated with elevated incidence of DROs.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the efficacy and safety profiles of 0.025% tretinoin in treating axillary hyperpigmentation with acanthosis nigricans: a randomized double-blinded study 评估0.025%维甲酸治疗黑棘皮病腋窝色素沉着的有效性和安全性：一项随机双盲研究

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-20 DOI: 10.1007/s00403-025-03821-y

Puri Chunekamrai, Nattasit Chatpimolkul, Soravit Thummawatwimon, Arucha Treesirichod

{"title":"Assessing the efficacy and safety profiles of 0.025% tretinoin in treating axillary hyperpigmentation with acanthosis nigricans: a randomized double-blinded study","authors":"Puri Chunekamrai, Nattasit Chatpimolkul, Soravit Thummawatwimon, Arucha Treesirichod","doi":"10.1007/s00403-025-03821-y","DOIUrl":"10.1007/s00403-025-03821-y","url":null,"abstract":"<div><p>Acanthosis nigricans (AN) is a dermatological condition, marked by hyperpigmentation and skin thickening, frequently affecting body folds like the axillae. Treatment options for axillary hyperpigmentation remain underexplored. This study evaluated the efficacy of 0.025% tretinoin cream in treating axillary hyperpigmentation associated with AN. In a randomized, intra-individual, split-side design study, participants applied 0.025% tretinoin cream on one axilla and a cream-based on the other. The study spanned 12 weeks, with topical application for the first 8 weeks, followed by a 4-week cessation period. Efficacy was measured using the melanin (M) index via narrowband reflectance spectrophotometry. Overall success was evaluated through investigator- and participant-global evaluation (IGE and PGE) scales, with adverse effects monitored. Twenty participants completed the study. The 0.025% tretinoin cream significantly reduced hyperpigmentation compared to the control (<i>p</i> < 0.001). By week 8, the mean M index reduction with tretinoin was 28.05%±12.20%, versus 6.55%±12.66% with the control. Hyperpigmentation reappeared partially after treatment cessation. By week 8, 75% of participants in the tretinoin group achieved more than 75% improvement in IGE, compared to 35% in the cream-based group. Similarly, 75% of the tretinoin group reported more than 75% improvement in PGE, whereas only 15% of the cream-based group achieved more than 50% improvement. Adverse effects were mild and included slight erythema, peeling, and itching. The 0.025% tretinoin cream significantly improved AN patients’ axillary hyperpigmentation, demonstrating a safe and effective treatment option with minimal side effects.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination treatment of extracorporeal photopheresis and belumosudil for chronic graft-versus-host disease 体外光疗联合白莫硫地尔治疗慢性移植物抗宿主病

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-20 DOI: 10.1007/s00403-024-03770-y

Madisen A. Swallow, Jungsoo Chang, Kacie R. Carlson, Ian Odell, Michael Girardi

引用次数: 0

Recent advances in improved efficacies of gold nano-formulations in treatment of skin cancer: a systematic review 金纳米制剂治疗皮肤癌疗效的最新进展：系统综述

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-01-20 DOI: 10.1007/s00403-025-03817-8

Mohammadbagher Heydari, Mehrdad Saifi, Maryam Ghanbari-Movahed, Nader Salari, Sayed Hassan Faghihi, Masoud Mohammadi

{"title":"Recent advances in improved efficacies of gold nano-formulations in treatment of skin cancer: a systematic review","authors":"Mohammadbagher Heydari, Mehrdad Saifi, Maryam Ghanbari-Movahed, Nader Salari, Sayed Hassan Faghihi, Masoud Mohammadi","doi":"10.1007/s00403-025-03817-8","DOIUrl":"10.1007/s00403-025-03817-8","url":null,"abstract":"<div><p>Skin cancer is the commonest malignancy for the population. Conventional skin cancer treatments include chemotherapy and surgery, but a large number of the chemotherapeutic drugs applied currently have undesirable possessions. The aim of this study is to provide a complete and acute assessment of the antitumor capability of gold nano-formulations in skin cancer as a new and more effectual delivery system for targeted therapy. In this systematic review, we conducted our first search in December 2021. In order to find related studies, 3 databases PubMed, Scopus and ScienceDirect. In order to maintain comprehensiveness in the search, no time limit was considered in the search process and finally the information obtained from the search was transferred to the information management software (EndNote). In order to maximize the number of articles that were related to our topic, a list of references identified in relevant articles was also manually searched and reviewed. Our final search was updated in late December 2021. There was evidence for a correlation between anticancer activities and treatment with gold nano-formulations. Additionally, studies shown that specific functionalization of the gold nanoparticles (Au NPs) which increase targetability to specific populations of cells could increase the application of Au NPs to the effective delivery of drugs to tumor cells. Our study demonstrated that gold nano-formulations are possible candidates for skin cancer treatment and might provide additional support for the clinical use of these anticancer agents in the future.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142995088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0