Archives of Dermatological Research最新文献_第2页

Assessment of serum levels of ischemia modified albumin and interleukin-17 in children with atopic dermatitis. 评估特应性皮炎患儿血清中缺血修饰白蛋白和白细胞介素-17的水平。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-27 DOI: 10.1007/s00403-024-03366-6

Shaimaa Ismail Omar, Nagat Sobhy Mohamed, Nermeen Eldabah, Eman Abdalhakim

{"title":"Assessment of serum levels of ischemia modified albumin and interleukin-17 in children with atopic dermatitis.","authors":"Shaimaa Ismail Omar, Nagat Sobhy Mohamed, Nermeen Eldabah, Eman Abdalhakim","doi":"10.1007/s00403-024-03366-6","DOIUrl":"https://doi.org/10.1007/s00403-024-03366-6","url":null,"abstract":"Background: Atopic dermatitis (AD) is the most prevalent chronic inflammatory skin disease in childhood. Interleukin 17 (IL17) is one of the pro-inflammatory cytokines that has an important role in the pathogenesis of many skin diseases including AD. Ischemia modified albumin (IMA) is an indicator of oxidative stress, inflammation and ischemia. The aim of the study was to assess the IL-17 and IMA serum levels in the children patients with AD in comparison to a control group. Additionally, the study seeks to examine the correlation between these biomarkers and their association with disease severity, disease stages, and other clinical characteristics.Methods: The case-control study enrolled two groups: (patient group: 50 children with AD) and (control group: 50 healthy age and sex-matched children). Full history was taken from all cases along with full dermatologic examination. The assessment of AD severity was conducted by using Eczema Area and Severity Index (EASI). Evaluation of IL-17 and IMA was performed by using ELISA technique.Results: There was a statistically significant elevation in the mean levels of IL-17 and IMA in patients with AD compared to the control group. A strong positive correlation was observed between IL-17 and IMA levels. Additionally, both IL-17 and IMA levels exhibited a statistically significant negative correlation with the duration of the disease and the age of the patients.Conclusion: The elevated serum levels of IL17 and IMA and their positive correlation confirm that AD is a systemic inflammatory disease influenced and associated with increased oxidative stress.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"There is a life before and after cancer": experiences of resuming life and unmet care needs in stage I and II melanoma survivors. "癌症前后都有生命"：第一期和第二期黑色素瘤幸存者的复生经历和未满足的护理需求。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03376-4

N C W Kamminga, J E C Kievits, M Wakkee, S G W van Loon, M C W Joosen, D Verver, K Munte, P W P Plaisier, J A C Rietjens, T E C Nijsten, M Lugtenberg

{"title":"\"There is a life before and after cancer\": experiences of resuming life and unmet care needs in stage I and II melanoma survivors.","authors":"N C W Kamminga, J E C Kievits, M Wakkee, S G W van Loon, M C W Joosen, D Verver, K Munte, P W P Plaisier, J A C Rietjens, T E C Nijsten, M Lugtenberg","doi":"10.1007/s00403-024-03376-4","DOIUrl":"https://doi.org/10.1007/s00403-024-03376-4","url":null,"abstract":"Although the largest increase in melanoma incidence is observed for localised melanoma, little research has been done on its impact. Despite favourable prognoses and relatively short treatment trajectories, diagnosis and treatment may significantly impact life post-treatment. Therefore, the aim of this study was to gain an in-depth understanding of stage I and II melanoma survivors' experiences resuming life after treatment and their associated survivorship care (SSC) needs. A qualitative focus group study was conducted with 18 stage I or II melanoma survivors, divided over three focus groups with 6 survivors each. Transcripts were analysed through thorough thematic content analysis, using multiple phases of coding. In resuming life, survivors experienced profound initial impacts of disease and treatment, fed by a perceived lack of knowledge and underestimation of melanoma. They faced unexpected physical and emotional effects post-surgery, experiencing mixed feelings from relief to fear and uncertainty. Survivors felt misunderstood, had to adjust their lives, and managed personal and external expectations while experiencing a positive shift in life perspective, leading to a notable difference in life before and after cancer. In terms of SSC needs, survivors stressed the need for tailored information, accessible resources, patient-centered follow-up, and supportive care addressing the total impact of disease and treatment. These findings highlight the importance of improving melanoma awareness and providing holistic SSC not only to advanced, but also to localised melanoma survivors. A tailored survivorship care plan could facilitate access to information and supportive care, helping patients resume their lives.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the Dermoscopy Bowl for dermatology residents. 为皮肤科住院医师举办的皮肤镜碗赛的经验教训。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03400-7

Kendall L Buchanan, Konstantinos Liopyris, Kelly C Nelson, Jennifer A Stein, Stephen W Dusza, Arlene Ruiz de Luzuriaga, Elizabeth V Seiverling

引用次数: 0

Reactive oxygen species-inducing itraconazole and its anti-biofilm activity against resistant Candida parapsilosis sensu lato biofilm cells isolated from patients with recalcitrant onychomycosis. 诱导活性氧的伊曲康唑及其对从顽固性甲癣患者体内分离出的抗药性副丝状念珠菌生物膜细胞的抗生物膜活性。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03382-6

Monireh Kamali, Aliasghar Ghaderi, Pegah Tamimi, Alireza Firooz, Mansour Nasiri Kashani, Azin Ayatollahi, Farnaz Valizadeh, Maryam Fattahi, Mahsa Fattahi

{"title":"Reactive oxygen species-inducing itraconazole and its anti-biofilm activity against resistant Candida parapsilosis sensu lato biofilm cells isolated from patients with recalcitrant onychomycosis.","authors":"Monireh Kamali, Aliasghar Ghaderi, Pegah Tamimi, Alireza Firooz, Mansour Nasiri Kashani, Azin Ayatollahi, Farnaz Valizadeh, Maryam Fattahi, Mahsa Fattahi","doi":"10.1007/s00403-024-03382-6","DOIUrl":"https://doi.org/10.1007/s00403-024-03382-6","url":null,"abstract":"Candida parapsilosis was introduced as the second most responsible for nail involvement. The colonization of biotic and abiotic surfaces by Candida spp. can result in the formation of biofilms, which possess a high level of resistance to typical antifungal agents. Since Candida spp. can produce biofilm mass on the surface of the nails, dermatologists should consider appropriate antifungals to eliminate both the planktonic and biofilm cells. The aim of this research was to determine the antifungal efficacy of itraconazole against C. parapsilosis sensu lato biofilm formations, in addition to its static effects. Ten C. parapsilosis sensu lato isolates were enrolled in this study. The use of itraconazole results in the accumulation of reactive oxygen species (ROS) during treatment. In order to verify the correlation between ROS and itraconazole-induced cell death, the viability of cells was analyzed by administering the ROS scavenger Ascorbic acid. The apoptotic features of itraconazole were analyzed using the Annexin V-FITC method. Based on current data, it was found that the generation of intracellular stresses by itraconazole is not observed in cells upon ROS inhibition, emphasizing the importance of intracellular ROS in the apoptotic mechanism of itraconazole. Targeting the oxidative defense system is a powerful point to use ROS-inducing antifungals as a superior choice for more effective therapies in case of recalcitrant onychomycosis.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hair loss and religious head coverings: a pilot survey study of orthodox Jewish women. 脱发与宗教头饰：对正统犹太教妇女的试点调查研究。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03384-4

Raquel Klinger, Hailey Konisky, Kseniya Kobets

引用次数: 0

Leveraging the potential of 3D total body photography: a data-driven tool for quality improvement and clinical research. 利用三维全身摄影的潜力：质量改进和临床研究的数据驱动工具。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03391-5

Jorge A Rios-Duarte, Deborah B Cull, Heather D Hardway, Nneka I Comfere, Jenny L Link, Nahid Y Vidal, Addison M Demer

引用次数: 0

Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients. 免疫抑制方案和纬度对美国肝移植受者患角质细胞癌的风险有影响。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03404-3

Benjamin E Rosenthal, Douglas E Schaubel, James D Lewis, David J Margolis, David S Goldberg, Therese Bittermann

{"title":"Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients.","authors":"Benjamin E Rosenthal, Douglas E Schaubel, James D Lewis, David J Margolis, David S Goldberg, Therese Bittermann","doi":"10.1007/s00403-024-03404-3","DOIUrl":"https://doi.org/10.1007/s00403-024-03404-3","url":null,"abstract":"Immunosuppression after solid organ transplantation is associated with an increased risk of keratinocyte carcinoma (KC). Despite its established morbidity, KC risk in liver transplant (LT) recipients is understudied, including the contribution of immunosuppression regimen and latitude. A retrospective cohort of 9,966 adult first LT alone recipients alive with their native allograft at 1-year post-LT without prior KC between 2007 and 2016 were identified using linked data from the Organ Procurement and Transplantation Network and Medicare administrative claims. The primary exposures were immunosuppression regimen and latitude of residence. The primary outcome was incident, de novo KC occurring at least 1-year after LT. Adjusted Cox regression analysis stratified by transplant center was used in all analyses. The cohort was 63.4% male, 70.2% White and with median age 61 years (interquartile range, IQR, 54-66) at transplant. Calcineurin inhibitor (CNI) with anti-metabolite combination was independently associated with incident KC when measured as intention-to-treat (adjusted hazard ratio (aHR) 1.21 vs. CNI monotherapy, 95% CI 1.02-1.43, p = 0.026), in a time-updating as-treated analysis (aHR 1.61, 95% CI 1.34-1.93; p < 0.001) and when measured as cumulative exposure (aHR 1.13 per 6-month increase, 95% CI: 1.02-1.33; p = 0.027). More southern latitude of residence was also independently associated with incident KC with an aHR of 1.26 per 5°N decrease towards the Equator (95% CI: 1.08-1.47, p = 0.003). We demonstrate independent effects of CNI with antiM immunosuppression regimen and latitude of residence on the risk of post-LT KC, which will better inform screening practices and immunosuppression management.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of light-guiding microneedle patch for stimulating hair growth in androgenetic alopecia. 光导微针贴片刺激雄激素性脱发患者毛发生长的疗效。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03396-0

Sasin Charoensuksira, Suthasinee Rattanapirat, Jitlada Meephansan, Punyaphat Sirithanabadeekul, Punyanuch Adulyaritthikul, Sattra Thongma, Yossawat Rayanasukha, Kittipong Tantisantisom

{"title":"The efficacy of light-guiding microneedle patch for stimulating hair growth in androgenetic alopecia.","authors":"Sasin Charoensuksira, Suthasinee Rattanapirat, Jitlada Meephansan, Punyaphat Sirithanabadeekul, Punyanuch Adulyaritthikul, Sattra Thongma, Yossawat Rayanasukha, Kittipong Tantisantisom","doi":"10.1007/s00403-024-03396-0","DOIUrl":"https://doi.org/10.1007/s00403-024-03396-0","url":null,"abstract":"Androgenetic alopecia (AGA) is the most common form of hair loss characterized by miniaturization of hair follicles. Low-level light therapy (LLLT) and microneedling have shown potential in promoting hair regrowth. This study aims to evaluate the efficacy of an innovative light-emitting diode (LED) helmet cooperated with a novel light-guiding microneedle patch (LMNP) for stimulating hair growth in AGA. In this randomized clinical trial, 16 AGA patients received treatments using light-guiding microneedle patches (LMNPs) illuminated by a LED helmet equipped with green (522 nm) and red (633 nm) LEDs, delivering 50 mW/cm2 power and 40 J/cm2 energy. Treatments were applied weekly for 24 weeks, targeting the frontal recession area. The right side of the scalp was treated with green light and the left with red light, each combined with a LMNP featuring 900 µm height needles at a density of 105 per square centimeter. Hair density and diameter, along with patient and physician satisfaction scores, were assessed monthly. Both red and green LED treatments with LMNP, significantly enhanced hair density and diameter. Satisfaction scores, as reported by both physicians and participants, increased over time. Comparative analyses revealed no statistically significant differences in average satisfaction scores or in changes in hair density and diameter between the groups by the end of the study. Additionally, no serious adverse effects were reported, highlighting the safety of the treatments. The combined Light sources which is portable LED helmet and LMNPs shows promise as a non-invasive, effective treatment for AGA, with similar efficacy between red and green wavelengths.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of dermatofibrosarcoma protuberans among Asian-American sub-groups: a population-based study of the surveillance, epidemiology, and end results (SEER) program. 亚裔美国人中原发性皮纤维肉瘤的流行病学：一项基于人口的监测、流行病学和最终结果（SEER）计划研究。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03397-z

Tejas P Joshi, Nabor Mireles, Jennifer S Ranario

引用次数: 0

Demystifying drug reaction with eosinophilia and systemic symptoms (DRESS): a review of the literature and guidelines for management. 揭开伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）的神秘面纱：文献综述和处理指南。

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2024-09-26 DOI: 10.1007/s00403-024-03389-z

Chelsea L Wedel

{"title":"Demystifying drug reaction with eosinophilia and systemic symptoms (DRESS): a review of the literature and guidelines for management.","authors":"Chelsea L Wedel","doi":"10.1007/s00403-024-03389-z","DOIUrl":"https://doi.org/10.1007/s00403-024-03389-z","url":null,"abstract":"Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, adverse drug reaction that is notoriously complex in both its presentation and treatment. Although early diagnosis and cessation of the causative agent are universally accepted as the initial interventions for DRESS, the subsequent management lacks a standardized approach. Historically, systemic steroids have been used as first-line treatment, but there is debate about the optimal dosing and route of administration, and evidence persists on the long-term complications associated with steroid use. Novel treatment approaches with targeted therapy, cyclosporine, intravenous immunoglobulin, and plasmapheresis have been gaining interest as alternative mono- and adjuvant therapies, but their use has yet to be supported by clinical trials. This narrative review provides a summary of the current knowledge of DRESS, with a focus on clinical management. The various mono- and adjuvant therapy options are discussed, with literature-supported suggestions for their optimal use in clinical practice. The risks for relapses, viral reactivation, and long-term complications are also considered. The PubMed and Medline databases were searched for articles on DRESS, published between January 1, 2008, and May 1, 2023. 334 articles met the inclusion criteria. Based on the literature, a DRESS management tool with step-by-step guidance is provided. Further suggestions for management are woven throughout this review, giving clinicians a toolbelt of resources with which to approach diagnosis, treatment, and follow-up.","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0