Archives of Dermatological Research最新文献_第3页

Efficacy of oral traditional Chinese medicine combined with fire needling in treating psoriasis vulgaris: a meta-analysis 中药口服配合火针治疗寻常型银屑病疗效荟萃分析

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04074-5

Jingya Wang, BingAn Zheng, Peifang Chen, Yunxia Zhao

{"title":"Efficacy of oral traditional Chinese medicine combined with fire needling in treating psoriasis vulgaris: a meta-analysis","authors":"Jingya Wang, BingAn Zheng, Peifang Chen, Yunxia Zhao","doi":"10.1007/s00403-025-04074-5","DOIUrl":"10.1007/s00403-025-04074-5","url":null,"abstract":"<div><p>This meta-analysis investigates the efficacy of oral traditional Chinese medicine (TCM) combined with fire needling in the treatment of psoriasis vulgaris. Fifteen randomized controlled trials (RCTs) were included, evaluating key outcomes such as overall response rate (ORR), Psoriasis Area and Severity Index (PASI) scores, TCM syndrome scores, and pruritus severity scores. The results indicated that the combination of oral TCM and fire needling significantly improved the ORR (odds ratio (OR) 3.49, 95% confidence interval (CI) [2.48, 4.93], p < 0.0001) and significantly reduced PASI scores (mean difference (MD) − 5.31, 95% CI [− 7.37, − 3.25], p < 0.0001). In addition, it improved TCM syndrome scores (MD − 3.43, 95% CI [− 5.41, − 1.46], p < 0.0001) and reduced pruritus severity scores (MD − 0.77, 95% CI [− 0.90, − 0.65], p < 0.0001). Sensitivity analysis confirmed the robustness of the findings, and no significant publication bias was detected. The GRADE assessment indicated that evidence quality for ORR and PASI scores was moderate, while the quality for TCM syndrome and pruritus severity scores was low. Overall, this meta-analysis demonstrates that combining oral TCM with fire needling is an effective and reliable treatment for psoriasis vulgaris, with potential for broader clinical application. Future studies should focus on enhancing the rigor of RCTs and standardizing treatment protocols to further validate these findings.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the relationship between innate temperament and the occurrence of radiotherapy-induced dermatitis and its treatment with Iranian medicine products 探讨先天气质与放射性皮炎发生的关系及伊朗药物治疗

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04080-7

Atefeh Asadi, Seyed Alireza Javadiniya, Mahboubeh Neamatshahi, Mohammad Nematshahi, Shamim Shahrestani, Fereshteh Ghorat

引用次数: 0

Simultaneous versus stepwise treatment of acne and atrophic scars: a prospective split-face controlled trial 同时与逐步治疗痤疮和萎缩性疤痕：一项前瞻性裂脸对照试验

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04201-2

Chen Wenqiu, Duan Jingxian, Sun Sujiao

{"title":"Simultaneous versus stepwise treatment of acne and atrophic scars: a prospective split-face controlled trial","authors":"Chen Wenqiu, Duan Jingxian, Sun Sujiao","doi":"10.1007/s00403-025-04201-2","DOIUrl":"10.1007/s00403-025-04201-2","url":null,"abstract":"<div><p>Acne frequently coexists with atrophic scars, yet clinical management typically follows a stepwise approach, with limited evidence on the efficacy of simultaneous treatment strategies for both conditions. To address this gap, we conducted a prospective split-face controlled trial involving 30 patients with symmetrical bilateral facial acne lesions and atrophic scars. The right side of the face was assigned to the stepwise treatment group, receiving 30% supramolecular salicylic acid for acne every two weeks for a total of five sessions. Following the resolution of inflammatory lesions, microneedling and subcision were performed for atrophic scars once a month for three sessions. The left side was designated as the simultaneous treatment group, receiving combined therapy (supramolecular salicylic acid, microneedling, and subcision) for both acne and atrophic scars once a month for three sessions.Efficacy and safety were assessed during follow-up. Results demonstrated that the simultaneous treatment regimen was significantly more effective in reducing acne lesions compared to the stepwise approach (<i>P</i> < 0.05), while both regimens showed comparable efficacy in improving atrophic scars (<i>P</i> > 0.05). No significant adverse reactions were observed in either group. Notably, the simultaneous treatment regimen significantly reduced the overall treatment duration and achieved higher patient satisfaction compared to the stepwise approach.In conclusion, the simultaneous treatment of acne and atrophic scars is not only clinically effective and safe but also offers the advantages of shorter treatment duration and enhanced patient satisfaction, making it a promising therapeutic strategy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in level of service provided by advanced practice clinicians and dermatologists in outpatient setting, 2012–2020 2012-2020年，高级临床医生和皮肤科医生在门诊提供的服务水平趋势

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04249-0

Carina Shiau, Daniel Y. Kim, Peter A. Young, Andrew Baker, Justin M. Ko, Gordon H. Bae

引用次数: 0

Epidemiology and admission outcomes of generalized pustular psoriasis: a report from the national inpatient sample 广泛性脓疱性银屑病的流行病学和住院结果：一份来自全国住院患者样本的报告

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04243-6

Colin Wikholm, Sach Thakker, Pegah R. Bakhshi, Aamir Hussain, Helena B. Pasieka

引用次数: 0

Systemic Janus kinase inhibitors in the management of granuloma annulare 系统性Janus激酶抑制剂在环形肉芽肿治疗中的应用

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04248-1

Scott Stratman, Shivkar Amara, Kathryn Jayne Tan, Elisabeth A. George-Washburn, Neda Shokrian, William Lau, Saakshi Khattri, Mark Lebwohl, Emma Guttman Yassky

{"title":"Systemic Janus kinase inhibitors in the management of granuloma annulare","authors":"Scott Stratman, Shivkar Amara, Kathryn Jayne Tan, Elisabeth A. George-Washburn, Neda Shokrian, William Lau, Saakshi Khattri, Mark Lebwohl, Emma Guttman Yassky","doi":"10.1007/s00403-025-04248-1","DOIUrl":"10.1007/s00403-025-04248-1","url":null,"abstract":"<div><p>Granuloma Annulare (GA) is an inflammatory granulomatous disorder that is typically localized to the skin. First line therapies for localized GA include topical and intralesional corticosteroids. Systemic corticosteroids have been used for generalized; however, rates of partial and complete resolution are disappointing. Recent advances in understanding the pathophysiology of macrophage activation and granuloma formation have led to Janus Kinase (JAK) inhibition as a therapeutic target for GA. The objectives of our study were to provide insight into the pathophysiology of GA and describe the clinical course and findings in patients with GA on JAK inhibitor therapy. This is a retrospective case series of 9 adults (age ≥ 18 years) with a diagnosis of GA and concomitant use of an oral JAK inhibitor. All patients on oral JAK inhibitor therapy (upadacitinib or abrocitinib) had improvement and/or clearance of their GA lesions within the first three months of therapy. Few adverse events commonly implicated in JAK inhibitor therapy (e.g., URI symptoms, malaise, acne) were reported. This study is limited by small sample size. JAK inhibitor therapy can be used in patients with GA, especially if they failed other treatments. Furthermore, JAK inhibitor therapy resulted in faster clearance time compared to other conventional treatments (e.g., antimicrobials, antimalarials, apremilast, methotrexate, and anti-tumor necrosis factor inhibitors). Depending on extent of GA involvement and patient-provider preferences, oral JAK inhibition therapy can be used off-label. Generally, these medications are well tolerated with few side effects compared to other GA treatment options.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of USMLE Step 2 scores in the dermatology match process: a comparative analysis between Charting the Outcomes and Texas STAR USMLE第2步评分在皮肤科匹配过程中的作用：结果图表与Texas STAR的比较分析

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-29 DOI: 10.1007/s00403-025-04180-4

Vrinda Madan, Anjali D’Amiano, Angela Mihalic, Joel C. Sunshine

引用次数: 0

Decreased physical activity in lupus patients, an analysis of biometric data from the all of us database 狼疮患者体力活动减少，来自全美数据库的生物特征数据分析

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-25 DOI: 10.1007/s00403-025-04011-6

Evelyn F. Fagan, Christopher Reagen, Joseph T. McGrath, Meera Kattapuram, Sarah Lonowski, Erin X. Wei

引用次数: 0

LINC01711 modulates proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by targeting miR-34a-5p LINC01711通过靶向miR-34a-5p调节增生性瘢痕成纤维细胞的增殖、迁移和细胞外基质沉积

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-25 DOI: 10.1007/s00403-025-04200-3

Lun Pan, Chengshuai Sun, Hua Jin, Shaocong Lv

{"title":"LINC01711 modulates proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by targeting miR-34a-5p","authors":"Lun Pan, Chengshuai Sun, Hua Jin, Shaocong Lv","doi":"10.1007/s00403-025-04200-3","DOIUrl":"10.1007/s00403-025-04200-3","url":null,"abstract":"<div><p>Hypertrophic scar (HS) is a proliferative disorder that occurs after skin injury and generally leads to disfigurement and impaired skin function in patients. This study aims to delve into the biological role of long intergenic non-protein coding RNA 1711 (LINC01711) in HS, thereby identifying novel therapeutic approaches for HS. HS tissues and corresponding normal tissues were obtained from 35 patients. The expression of LINC01711 was evaluated by qRT-PCR. The effect of LINC01711 knockdown on HS fibroblasts (HSFs) was measured by CCK-8 assay, migration assay, and apoptosis assay. The molecular mechanisms were investigated through bioinformatics analysis and dual-luciferase reporter assay. The impact of LINC01711 on the expression of extracellular matrix (ECM) deposition markers was measured using ELISA assay. LINC01711 was upregulated in HS tissues and positively correlated with disease severity. The silencing of LINC01711 induced the suppression of cell viability, migration, and the promotion of apoptosis in HSFs. LINC01711 negatively modulated microRNA-34a-5p (miR-34a-5p) expression. Suppression of miR-34a-5p reversed the biological function of LINC01711 knockdown in HSFs. Furthermore, LINC01711 modulated collagen type I alpha 1 chain (COL1A1), tissue inhibitor of metalloprotease-1 (TIMP1), and actin alpha 2 (Acta2) expression in HSFs mediated by miR-34a-5p. The results demonstrated that LINC01711 functioned as a regulatory factor in the proliferation, migration, apoptosis, and ECM deposition of HSFs mediated by miR-34a-5p.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of adverse outcomes between oral tranexamic acid and topical triple combination therapy for treatment of melasma 口服氨甲环酸与外用三联疗法治疗黄褐斑不良结局的比较

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-25 DOI: 10.1007/s00403-025-04246-3

Aashish Batheja, Sara Lamb

引用次数: 0