Archives of Dermatological Research最新文献

{"title":"Identifying key targets and immune environment in wound healing based on iron overload-related genes","authors":"Yinbo Peng,&nbsp;Juxiang Sheng,&nbsp;Tiantian Liu,&nbsp;Ruizhe He,&nbsp;Peng Xu","doi":"10.1007/s00403-025-04140-y","DOIUrl":"10.1007/s00403-025-04140-y","url":null,"abstract":"<div><p>Wound healing (WH) poses a significant socio-economic burden due to its high incidence and recurrence rates. Iron overload (IO) could be a factor leading to delayed WH. This study thus analyzed IO-related genes (IORGs) in WH, offering possibilities for developing new therapeutic strategies. Differential gene expression (DEGs) analysis was conducted between the WH group and intact skin (IS) group, intersected with IORGs to obtain differentially expressed IORGs (DE-IORGs). Functional enrichment analysis and potential drug screening were performed on DE-IORGs. A protein–protein interaction (PPI) network of DE-IORGs was constructed, and hub genes were identified using CytoHubba and MCODE methods. ROC curves of hub genes were plotted, and their expression levels in WH and IS groups as well as inter-gene correlations were analyzed. Additionally, immune infiltration variances in WH and IS groups, along with miRNA and TFs of hub genes, were examined. Finally, the effect of EGFR on skin wound healing was verified by scratch healing assay. 39 DE-IORGs were predominantly enriched in signaling pathways like HIF-1 signaling pathway and Th17 cell differentiation. Potential drugs for treating WH (e.g., felbamate, SA-94315, GANT-58, rucaparib) were identified. Three hub genes related to IO in WH were pinpointed (HIF1A, CDKN2A, EGFR) with diagnostic value. Immune infiltration analysis showed higher levels of immune cells like endothelial cells and macrophages in the WH group. Additionally, 55 miRNAs (e.g., hsa-mir-200a-3p, hsa-mir-218-5p) and 2 TFs (L3MBTL2, ZNF76) regulating the three hub genes were predicted. Cell experiments showed that EGFR could promote skin wound healing. The study suggested HIF1A, CDKN2A, and EGFR as potential diagnostic biomarkers for effective WH diagnosis, offering new insights into identifying potenti1al therapeutic targets for WH treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enduring outcomes of minimally ınvasive approaches for facial rejuvenation","authors":"Elif Sari,&nbsp;Aynur Aliyeva","doi":"10.1007/s00403-025-04238-3","DOIUrl":"10.1007/s00403-025-04238-3","url":null,"abstract":"<div><p>Facial rejuvenation procedures have gained popularity as individuals seek nonsurgical methods to address signs of aging. These procedures encompass a range of minimally invasive techniques, including botulinum toxin applications, dermal fillers, PRP, and thread lifting. This study aimed to assess patient satisfaction and evaluate the short- and long-term outcomes of these minimal invasive facial rejuvenation procedures. Patients aged 18–65 who underwent facial rejuvenation at an Ear, Nose, and Throat Clinic were included. Procedures had botulinum toxin applications, dermal fillers, PRP, and PDO threads. Follow-up evaluations were conducted at 4–6 months for botulinum toxin and PRP and one year for other procedures. Visual analog scales and self-satisfaction measured beauty perception data after treatments. Botulinum toxin applications effectively reduced dynamic wrinkles, while dermal fillers provided volumetric support with varying longevity. PRP improved skin tone, brightness, moisture, and fine wrinkles. Patient satisfaction levels varied across procedures. Minimal invasive facial rejuvenation procedures offer a nonsurgical approach to address aging-related concerns. Botulinum toxin, dermal fillers, PRP, and PDO threads provide unique benefits, but their outcomes and satisfaction levels differ among patients. Understanding these variations is crucial for informed decision-making in facial rejuvenation.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of sleep disturbances and signs of attention deficit and hyperactivity disorder in schoolchildren with atopic dermatitis","authors":"Priscila Vernizi Roth,&nbsp;Marcela Fisher de Almeida,&nbsp;Enzo Paolo Brandão Gouveia,&nbsp;Renata Drizlionoks,&nbsp;Rafaela Cachiolo Antunes,&nbsp;Mariana Aparecida Pasa Morgan,&nbsp;Ana Chrystina Souza Crippa,&nbsp;Vânia Oliveira Carvalho","doi":"10.1007/s00403-025-04235-6","DOIUrl":"10.1007/s00403-025-04235-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Assessment of miR-19b-3p, miR-182-5p, and miR-155-5p expression and its relationship with alopecia areata severity","authors":"Ahmed Ibrahim AbdElneam,&nbsp;Mohammed Saleh Al-Dhubaibi,&nbsp;Saleh Salem Bahaj,&nbsp;Ghada Farouk Mohammed,&nbsp;Lina Mohammed Atef","doi":"10.1007/s00403-025-04240-9","DOIUrl":"10.1007/s00403-025-04240-9","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligilactobacillus salivarius Lac45 inhibits MRSA and suppresses inflammation in human keratinocyte","authors":"Punploy Klawkla,&nbsp;Hung Gia Tran,&nbsp;Poorichaya Somparn,&nbsp;Somying Tumwasorn,&nbsp;Tanittha Chatsuwan,&nbsp;Jongkonnee Wongpiyabovorn","doi":"10.1007/s00403-025-04227-6","DOIUrl":"10.1007/s00403-025-04227-6","url":null,"abstract":"<div><p>Dysbiosis, an imbalance in skin microflora, is a key contributor to inflammatory skin conditions, including atopic dermatitis (AD), seborrheic dermatitis (SD), and psoriasis. In AD, <i>Staphylococcus aureus</i> colonization of skin lesions is prevalent approximately 70% of cases, with disease severity positively correlating with bacterial presence. Moreover, methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is found in 10–30% of AD skin lesions, highlighting the need for novel therapeutic strategies that target both microbial imbalance and inflammation. This study evaluates <i>Ligilactobacillus salivarius</i> Lac45 (LS-Lac45), a breast milk-derived bacterial strain, for its antimicrobial and anti-inflammatory potential in dermatology. We assessed its antimicrobial activity against MRSA using an agar disk-diffusion assay and its anti-inflammatory effects in a peptidoglycan (PGN)-induced inflammation model in HaCaT keratinocytes. To elucidate its mechanisms of action, mass spectrometry was used to analyze protein expression changes in LS-Lac45-treated keratinocytes. Our results demonstrate that live LS-Lac45 effectively inhibits MRSA growth. Additionally, heat-killed LS-Lac45 significantly reduces PGN-induced production of pro-inflammatory cytokines IL-6, IL-8, and TNF-α. Proteomic analysis further identifies LS-Lac45-mediated modulation of immune-related proteins, including heat shock protein 60, metallothionein 2A, and antioxidant-1, suggesting a role in inflammatory regulation. These findings highlight LS-Lac45 as a candidate for managing MRSA-associated inflammatory skin conditions, particularly AD. While this study provides key insights into its antimicrobial and immunomodulatory properties, further research is needed to evaluate its probiotic characteristics and clinical applicability in dermatology.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous epidermal growth factor receptor expression (EGFR) and soluble EGFR levels are elevated in patients with pemphigus vulgaris: a longitudinal study","authors":"Kanmani Indra Couppoussamy,&nbsp;Medha Rajappa,&nbsp;Laxmisha Chandrashekar","doi":"10.1007/s00403-025-04207-w","DOIUrl":"10.1007/s00403-025-04207-w","url":null,"abstract":"<div><p>Epidermal Growth Factor Receptor (EGFR) signalling is thought to be involved in the pathogenesis of pemphigus vulgaris. The objective was to assess the cutaneous EGFR mRNA expression and serum soluble EGFR (sEGFR) levels among Pemphigus patients in comparison to the healthy controls. This was a cross-sectional study with a longitudinal follow up. Thirty patients with pemphigus vulgaris and 30 controls were recruited. We measured cutaneous EGFR mRNA expression and sEGFR serum levels in pemphigus vulgaris patients at baseline, at three- and six-months following treatment. There was a significant (<i>p</i> = 0.007) difference of the EGFR mRNA fold expression between cases (3.07 (IQR (Interquartile range) 0.76 to 13.20)) at baseline as compared to the controls (1.005 (Interquartile range (IQR) 0.63 to 2.30)). The median sEGFR levels were significantly (<i>p</i> &lt; 0.0001) higher in the cases (4.33 ng/ml (IQR 3.01 ng/ml to 9.33 ng/ml)) compared to controls (1.52 ng/ml (IQR 0.79 ng/ml to 2.75 ng/ml)) at the baseline. There was a significant positive correlations of EGFR mRNA expression (<i>r</i> = 0.47) and sEGFR levels (<i>r</i> = 0.46) with pemphigus disease activity. The limitation of the study was smaller sample size. EGFR gene expression and sEGFR levels are significantly increased in pemphigus vulgaris. They significantly correlate with disease activity and decrease with treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, sleep, and psychological well-being in chronic spontaneous urticaria patients receiving omalizumab: a case–control study","authors":"Mustafa Esen,&nbsp;Abdullah Demirbaş,&nbsp;Esin Diremsizoglu","doi":"10.1007/s00403-025-04231-w","DOIUrl":"10.1007/s00403-025-04231-w","url":null,"abstract":"<div><p>Chronic spontaneous urticaria (CSU) impacts both physical and mental well-being, causing distress and sleep disturbances. While omalizumab reduces disease activity, its effects on mental health and quality of life remain unclear. This study assesses the psychosocial burden and sleep disturbances in CSU patients receiving omalizumab compared to healthy controls and explores their relationship with disease parameters. This case––control study included 210 CSU patients receiving omalizumab for at least three months and 210 age- and sex-matched healthy controls. Disease severity was assessed using the Urticaria Activity Score over 7 Days (UAS7) and Urticaria Control Test (UCT), while quality of life was evaluated with the Chronic Urticaria Quality of Life Questionnaire (CU-Q₂oL). Psychological distress and sleep disturbances were measured using validated scales, including the Perceived Stress Scale (PSS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). CSU patients had significantly higher scores for perceived stress, depression, anxiety, and daytime sleepiness compared to controls (p &lt; 0.001). Patients with a good response to omalizumab also showed significantly higher psychological distress and poorer sleep quality than controls (p &lt; 0.001). Omalizumab response was good in 29.5%, moderate in 38.6%, and limited in 31.9% of patients. Despite treatment, 32.9% reported no change in quality of life, while 35.7% had mild and 31.4% had moderate improvement. A history of atopic disease was present in 55.7% of patients, who had significantly higher daytime sleepiness scores than those without (p = 0.045). In CSU patients, while omalizumab improves symptoms and quality of life, psychological distress persists in substantial subsets, highlighting the need to address mental health and lifestyle factors.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04231-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Abrocitinib as a novel therapeutic approach for refractory prurigo nodularis: real world evidence","authors":"Abdullah Demirbas,&nbsp;Esin Diremsizoglu,&nbsp;Gizem Cınar,&nbsp;Cigdem Vural","doi":"10.1007/s00403-025-04217-8","DOIUrl":"10.1007/s00403-025-04217-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine is safe and efficacious in oral lichen planus: data from a large outpatient cohort","authors":"Khava Abdusalamova,&nbsp;Margitta Worm,&nbsp;Farzan Solimani","doi":"10.1007/s00403-025-04226-7","DOIUrl":"10.1007/s00403-025-04226-7","url":null,"abstract":"<div><p>Lichen planus (LP) is a chronic inflammatory T-cell mediated disease affecting the skin, mucous membranes and skin appendages. Data on clinical phenotypes and systemic treatment of LP are limited. We analyzed a cohort of LP patients (equal or older than 18 years) regarding their clinical phenotypes (subtype, demographics, comorbidities) and treatment. Patients were selected from 2017 to 2023 who were seen in our outpatient clinic during a treatment period of at least 2 years. We identified 85 patients (62 females, 73% and 76 above 50 years; 89%) who met selection criteria. 33 had oral LP (39%), 23 had cutaneous LP (27%) and 2% had both or other manifestations (32%). Frequent comorbidities were hypertension (n = 40), hypothyroidism (n = 17), asthma (n = 11), diabetes (n = 10) and dyslipidemia (n = 8). 44% were taking a medication known to favor LP onset. 2/85 patients had a malignant transformation. 33 patients were treated topically and 50 required systemic therapy. Hydroxychloroquine (HCQ) (n = 18; 36%) and retinoids (n = 17; 34%) were the most commonly used systemic medications. Both were efficacious as determined by the investigator global response reaching rates 78% and 71%, respectively. The tolerability of retinoids was lower than HCQ (adverse event rate 29% versus 6%). Our results confirm previous data on clinical phenotypes and comorbidity patterns in LP patients. The treatment assessment suggests that HCQ may be an efficacious and safe first-line treatment for mucosal lichen planus. Further data from prospective controlled clinical trials are needed to prove the optimal treatment approach for different clinical phenotypes of LP.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04226-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants and their derivatives for skin and hair: a Mediterranean perspective of women care","authors":"Latifa Bouissane,&nbsp;Yahya Elfardi,&nbsp;Sohaib Khatib,&nbsp;Ahmed Fatimi,&nbsp;Carla Pereira,&nbsp;Natália Cruz-Martins","doi":"10.1007/s00403-025-04202-1","DOIUrl":"10.1007/s00403-025-04202-1","url":null,"abstract":"<div><p>Since olden days, medicinal and aromatic plants have been consumed due to their well-known therapeutic, ornamental, culinary, and cosmetic properties. Plant-based cosmetics comprise a growing market offering brands of sustainable products with the ultimate goal of responding to the woman needs to boost their natural beauty, such as soothing, toning, moisturizing and protecting skin and hair. The increasing focus on body and beauty care, combined with a better understanding of the diverse biological effects of plants and their derivatives, has revitalized their significance in aesthetic, cosmetic, and dermatological contexts. Concurrently, the increasing prevalence of allergies and hypersensitivity reactions to synthetic additives commonly found in cosmetics and other skin products has spurred interest in seeking healthier and more efficacious natural alternatives. An intense investigation has been stated around the formulation of medicinal plants- and other plant-based cosmetic products for dermatological and aesthetic purposes. Similarly, a raising awareness by cosmetics’ manufacturers and related industries have been progressively stated, culminating with the emergence of a line of plant-based cosmetics increasingly safe and with reliable quality features for multiple purposes. Although a high demand for natural-based products for cosmetic purposes has been stated, further studies are required to deepening knowledge on their beneficial properties, safety and quality features and to identify the main limitations and likelihood of side effects occurrence. In this review, an outlook of the current scenario regarding the use of medicinal and aromatic plants as cosmetic ingredients in the formulation of skin care and other dermatological products traditionally used by the Mediterranean woman for prevention and even cure of skin and hair diseases or for beautification is provided.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04202-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}