Archives of Dermatological Research最新文献_第4页

First-in-kind 3D bioprinted human skin model using recombinant human collagen 首个使用重组人胶原蛋白的3D生物打印人体皮肤模型

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04236-5

Hemanth Gudapati, Rafaela Mayumi Simoes Torigoe, Aydin Tahmasebifar, K-Raman Purushothaman, Saranya Wyles

{"title":"First-in-kind 3D bioprinted human skin model using recombinant human collagen","authors":"Hemanth Gudapati, Rafaela Mayumi Simoes Torigoe, Aydin Tahmasebifar, K-Raman Purushothaman, Saranya Wyles","doi":"10.1007/s00403-025-04236-5","DOIUrl":"10.1007/s00403-025-04236-5","url":null,"abstract":"<div><p>Reliable translational human skin models are lacking for modeling skin diseases and screening effective therapeutics. 3D bioprinting is an emerging technology that enables the fabrication of human skin models that mimic the structure and functions of human skin in a dish (in-vitro). As a prototype, we present a first-in-kind fully humanized 3D bioprinted skin model as an alternative to animal testing for preclinical research. This model utilizes a plant-derived recombinant human collagen and human skin fibroblasts, melanocytes, and keratinocytes. The 3D bioprinted human skin model expresses involucrin and cytokeratin 14, contains melanin granules, and structurally resembles human skin. However, the morphology of keratinocytes is slightly different, containing a thicker layer of proliferative keratinocytes and a thinner layer of differentiated, cornified keratinocytes. Nevertheless, the model shows epidermal stratification, which indicates skin maturation. Further, the model lacks skin appendages such as hair follicles and sweat glands, as current bioprinting technology cannot deliver distinct cells at the single-cell resolution. Recent advances in 3D bioprinting such as spheroid-based bioprinting show potential to address these limitations. Hence, 3D bioprinting of skin using plant-derived recombinant human collagen, presents significant advantages, including high-throughput production of personalized human skin models, reduction of animal testing, and potential applications in regenerative medicine.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A split face study comparing intralesional tranexamic acid versus 1064 nm long pulsed Nd: YAG laser for acne vulgaris treatment 一项比较局部内氨甲环酸与1064nm长脉冲Nd: YAG激光治疗寻常痤疮的裂面研究

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04164-4

Heba Hussien Muhammad Eltanany, Faten Abdel Wadoud Abdel Qawy, Mervat Hamdino, Mona S. Ali

{"title":"A split face study comparing intralesional tranexamic acid versus 1064 nm long pulsed Nd: YAG laser for acne vulgaris treatment","authors":"Heba Hussien Muhammad Eltanany, Faten Abdel Wadoud Abdel Qawy, Mervat Hamdino, Mona S. Ali","doi":"10.1007/s00403-025-04164-4","DOIUrl":"10.1007/s00403-025-04164-4","url":null,"abstract":"<div><p>Acne is among most prevalent skin conditions that adversely impacts patients’ quality of life and self-confidence. Conventional treatment methods face issues with high recurrence rates and unwanted side effects, prompting the need to explore new acceptable treatment options. Comparing the safety and clinical efficacy of intralesional tranexamic acid (TXA) versus 1064 nm long pulsed Nd:YAG laser in the treatment of facial inflammatory acne vulgaris. 30 patients with facial acne vulgaris were involved in a prospective randomized split-face comparative study. Each patient was treated with long-pulsed Nd: YAG laser on one side, and intralesional TXA on the other side at 2-week interval for 4 sessions. Cases were assessed through Investigator Global Assessment of acne (IGA) scale, lesions counting, and erythema score at baseline, after end of treatment, and after follow-up for 3 months. A statistically significant reduction in IGA, lesions count, and erythema score was found in both treated sides (p-value < 0.001). Improvement of IGA and non-inflammatory lesions count was better in laser side more than TXA side after end of treatment and follow-up (p-value < 0.05). Improvement of inflammatory lesions count was non-significant in both sides after end of treatment, while after follow-up it was better on laser side. Improvement of erythema score was non-significant between both therapy modalities after end of treatment and follow-up. 1064 nm long-pulsed Nd: YAG laser and intralesional TXA are effective, and safe treatment modalities for acne. However, Nd-YAG laser has prolonged therapeutic effect over intralesional TXA so, TXA can be considered a promising lunch-time procedure enhancing the outcome.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders 综述了微针技术在皮肤疾病局部强化治疗中的最新进展和挑战

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04239-2

Hema, Anu Jindal, Rajni Bala, Amrinder singh

{"title":"A review on recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders","authors":"Hema, Anu Jindal, Rajni Bala, Amrinder singh","doi":"10.1007/s00403-025-04239-2","DOIUrl":"10.1007/s00403-025-04239-2","url":null,"abstract":"<div><p>Microneedles are tiny, minimally invasive needles that are made to create microchannels over a subcutaneous layer of the skin. These micro-injuries encourage the secretion of growth factors and prompt collagen synthesis. The reasons for using microneedling therapy have increased significantly, leading to its widespread adoption in dermatology. This review article discussed recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders. It discussed the effective and safe use of microneedles for treating different types of skin conditions like acne, scars, alopecia, melasma, skin rejuvenation, and photo-damage. The drug delivery through the skin was enhanced and rare or permanent adverse effects were not mentioned, while temporary redness and post-inflammatory hyperpigmentation were frequently seen. Microneedling seems to be a generally reliable and secure treatment choice for various skin conditions. More extensive and randomized clinical trials were necessary to ensure their safety and efficacy across diverse populations, conditions, and treatment durations. This trial helps to identify optimal dosages, long-term outcomes, and any adverse effects that may not appear in smaller studies. They also enable comparisons with existing therapies, ensuring the technology’s generalizability and value. Moreover, such trials are essential for regulatory approval and to determine which microneedle technologies work best for specific uses.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychodermatology: a bibliometric perspective on dermatologic and psychiatric intersections 心理皮肤病学：一个文献计量学的观点在皮肤病学和精神病学的交叉

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04233-8

Waseem Hassan, Antonia Eliene Duarte

引用次数: 0

Delayed regional metastasis from small face/scalp cutaneous squamous carcinoma: outcomes and predictors 小面部/头皮皮肤鳞状癌的延迟区域转移：结果和预测因素

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04224-9

Courtney B. Shires, John D. Boughter, Christopher P. Golembeski, Nicholas M. Sharp, Arabella T. Hall, Merry E. Sebelik

{"title":"Delayed regional metastasis from small face/scalp cutaneous squamous carcinoma: outcomes and predictors","authors":"Courtney B. Shires, John D. Boughter, Christopher P. Golembeski, Nicholas M. Sharp, Arabella T. Hall, Merry E. Sebelik","doi":"10.1007/s00403-025-04224-9","DOIUrl":"10.1007/s00403-025-04224-9","url":null,"abstract":"<div><p>Objective: CSCC (cutaneous squamous cell carcinoma) of the face/scalp generally has a favorable outcome. However, patients with delayed regional metastasis from scalp/facial CSCC do very poorly. Historically, prophylactic treatment of the N0 neck for the T1-T2 (as staged in the AJCC 7th edition) face/scalp cancers has not been recommended. This study aims to determine predictors of delayed regional metastases in < 4 cm CSCC of the face and scalp. Methods: We retrospectively analyzed medical records of patients diagnosed regional metastasis of CSCC of the scalp/face at least 6 months after the diagnosis of the primary CSCC at a tertiary academic head and neck clinic during a period between 2012 and 2018. Results: A total of 50 patients with CSCC of the face/scalp were diagnosed and treated for delayed cervical lymph node metastasis during a 6-year period. All patients were male. Areas affected were the scalp, cheeks, and forehead. No patient had neck lymph node metastases at initial presentation for their scalp/face cancer. The presence of perineural invasion in the primary tumor was the only observed predictor of delayed neck lymph node recurrence. We did not observe an association between diameter/depth of the primary skin tumor or lymphovascular invasion and the presence of regional lymph node recurrence. Conclusion: In our review, perineural invasion (PNI) was the one factor predictive of delayed regional lymph node metastasis. This observation confirms the use of PNI to upstage even small CSCC to T3. Prophylactic treatment of the neck in patients with small scalp/face cancers with PNI should be strongly considered, especially in the age of immunotherapy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04224-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actigraphy, a valuable tool for objective sleep evaluation in psoriasis: a review 活动描记术：银屑病患者客观睡眠评价的重要工具

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04187-x

Katerina Vlami, Kleoniki Pantelidi, Maria Dalamaga, Evangelia Papadavid

{"title":"Actigraphy, a valuable tool for objective sleep evaluation in psoriasis: a review","authors":"Katerina Vlami, Kleoniki Pantelidi, Maria Dalamaga, Evangelia Papadavid","doi":"10.1007/s00403-025-04187-x","DOIUrl":"10.1007/s00403-025-04187-x","url":null,"abstract":"<div><p>Psoriasis, a form of chronic inflammatory skin disease, shows wide variations in severity and comorbidities. Considering the relatively clear scientific evidence concerning its great physical and psychological effects, researchers began to use actigraphy as a scientific monitoring tool for its bidirectional relationship with sleep. To evaluate the usefulness of actigraphy as a means to diagnose sleep disturbances in psoriatic patients. We performed a systematic review using PubMed, Scopus and Google Scholar to look at the use of actigraphy in research into psoriasis and sleep disorders. This review covered publications through February 2024. Included records were primary and secondary research papers. Actigraphy consistently revealed strong links between pruritus nighttime arousal, and poorer subjective sleep, although next-day psoriasis symptoms did not always worsen. Systematic analyses emphasized actigraphy’s role in measuring nocturnal scratching, supported by emerging smartwatch apps. Psoriatic arthritis studies likewise reported significant sleep disruptions, though evidence remains limited. From these studies, actigraphy presented as a useful tool in both clinical and research contexts, for diagnosing and monitoring sleep disorders among psoriatic patients. Actigraphy is an important test for psoriatic sleep disorders, providing useful objective data. This way the bridge between psoriasis and sleep be clearly understood, and treatment methods improved.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04187-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of digit ratio (2D:4D) and its relationship with skin sebum level in patients with basal cell carcinoma 基底细胞癌患者手指比值（2D:4D）及其与皮肤皮脂水平的关系

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-12 DOI: 10.1007/s00403-025-04225-8

Ismail Can, Fatma Tuncez Akyurek

{"title":"Evaluation of digit ratio (2D:4D) and its relationship with skin sebum level in patients with basal cell carcinoma","authors":"Ismail Can, Fatma Tuncez Akyurek","doi":"10.1007/s00403-025-04225-8","DOIUrl":"10.1007/s00403-025-04225-8","url":null,"abstract":"<div><h3>Introduction</h3><p>The main factor in the development of basal cell carcinoma (BCC) is UV (ultraviolet) exposure. In most cases of BCC there is upregulation of the ‘Sonic Hedgehog’ (SHH) pathway components. Some recent studies have shown that overactivity of the SHH pathway leads to an increase in the number of sebocytes in the skin. Sex differences in tumor formation suggest a possible role of sex hormones in the development of skin cancers.</p><h3>Objective</h3><p>We aimed to evaluate the 2D:4D ratio and its relationship with skin sebum level in patients with BCC.</p><h3>Methods</h3><p>Finger length measurements were made using digital calipers. Skin sebum levels were measured using sebumeter.</p><h3>Results</h3><p>The study included 64 patients with BCC(mean age 67) and 64 healthy subjects(mean age 71) aged 37–92 years. T score (average of sebum levels on forehead, nose and chin) and total sebum score (TSS) were higher in patients with BCC. U score (average of sebum levels of right and left cheeks) was similar in patients and control group. In male subjects, T score, U score and TSS were significantly higher in the patient group. In female subjects, there was no significant difference between the patient and control groups in T score, U score and TSS. The 2D:4D ratio in both hands was similar in the patient and control groups. When evaluated according to the localization of the lesions, the T score and the TSS were found to be higher in male subjects with BCC lesions in the T region than in the control group. In the female patient group, the T score was found to be significantly higher than in the control group.</p><h3>Conclusion</h3><p>There was no correlation between BCC and 2D:4D ratio. We found that skin sebum levels were higher in male patients with BCC compared to the control group. Defining the relationship between BCC and sebum levels may play an important role in the evaluation of the occurrence and prognosis of the disease.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usage of thermal spring water for optimal skin health: bridging traditional therapy with modern dermatology 使用温泉水为最佳的皮肤健康：桥梁传统疗法与现代皮肤病学

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-11 DOI: 10.1007/s00403-025-04189-9

Pedro Emanuel Rocha, Maria José Alves, Cátia Fidalgo, Daniela Correia, Silvia Pedrosa, Ana Raquel Madureira

引用次数: 0

Energy-based device innovations including laser and non-laser therapies in hidradenitis suppurativa treatment 基于能量的设备创新，包括激光和非激光治疗化脓性汗腺炎

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-11 DOI: 10.1007/s00403-025-04184-0

Sino Mehrmal, Mojahed Mohammad K. Shalabi, Seo Won Cho, Stanislav N. Tolkachjov, Alexander B. Aria

{"title":"Energy-based device innovations including laser and non-laser therapies in hidradenitis suppurativa treatment","authors":"Sino Mehrmal, Mojahed Mohammad K. Shalabi, Seo Won Cho, Stanislav N. Tolkachjov, Alexander B. Aria","doi":"10.1007/s00403-025-04184-0","DOIUrl":"10.1007/s00403-025-04184-0","url":null,"abstract":"<div><p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that is often difficult to treat. When initial medical treatments fail, surgical interventions, including laser and non-laser procedures, may be considered. This review examines recent studies investigating the effectiveness of these procedures, focusing on publications since March 2019. The review included English-language case reports, studies, and clinical trials sourced from PubMed using search terms such as “hidradenitis suppurativa,” “Nd: YAG,” “photodynamic therapy,” “intense pulsed light,” “alexandrite,” “diode,” “CO2,” “radiofrequency,” “ablative,” “fractionated,” “laser,” and “hair removal.” Review articles and animal studies were excluded. The review found strong evidence supporting the use of Nd: YAG and CO2 lasers for reducing inflammatory lesions and excising sinus tracts. Alexandrite lasers also showed promise, with 50% of treated patients achieving a Hidradenitis Suppurativa Clinical Response (HiSCR) at 15 weeks, increasing to 70% by week 30. Fractional radiofrequency (RF) microneedling and radiofrequency-intense pulsed light (RF-IPL) combinations led to reduced inflammation and improved tissue remodeling by weeks 6 and 24, respectively. Both intralesional and traditional photodynamic therapy (PDT) approaches demonstrated efficacy in reducing lesion size and associated symptoms. In conclusion, various laser and non-laser energy-based therapies show promise for managing HS, particularly in cases refractory to conventional treatments. Further research with robust study designs is warranted to optimize treatment protocols and establish long-term efficacy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of modified Wendan Decoction combined with acupuncture on inflammatory factors and immune function in urticaria patients 温胆汤加味配合针刺对荨麻疹患者炎症因子及免疫功能的影响

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-04-11 DOI: 10.1007/s00403-025-04210-1

Zan Tian, Jianlong Dong, Yanjun Wang

{"title":"Effects of modified Wendan Decoction combined with acupuncture on inflammatory factors and immune function in urticaria patients","authors":"Zan Tian, Jianlong Dong, Yanjun Wang","doi":"10.1007/s00403-025-04210-1","DOIUrl":"10.1007/s00403-025-04210-1","url":null,"abstract":"<div><p>This study aimed to explore the effects of modified Wendan Decoction combined with acupuncture on serum inflammatory markers and immune function in patients suffering from urticaria. A total of 150 urticaria patients admitted to our hospital were randomly assigned to two groups: the observation group (<i>n</i> = 75) and the control group (<i>n</i> = 75). The control group received levocetirizine tablets, while the observation group was treated with modified Wendan Decoction along with acupuncture. Following treatment, the observation group demonstrated a higher clinical efficacy compared to the control group, with a statistically significant difference (<i>P</i> < 0.05). Both groups experienced reductions in symptom scores, including erythema, burning sensation, pruritus, wheals, fever accompanied by epigastric pain, nausea and vomiting, fatigue, and poor appetite. However, the observation group showed significantly lower symptom scores than the control group (<i>P</i> < 0.05). Additionally, levels of IL-4, IL-10, IL-25, IL-33, and IFN-γ decreased in both groups after treatment, but the observation group exhibited lower levels than the control group, again with a statistically significant difference (<i>P</i> < 0.05). The recurrence rate was notably lower in the observation group compared to the control group (<i>P</i> < 0.05). The combination of modified Wendan Decoction and acupuncture effectively reduces serum inflammatory markers and enhances immune function in patients with urticaria. This treatment demonstrates significant clinical effectiveness and holds potential for broader application in clinical settings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0