Archives of Dermatological Research最新文献

{"title":"Identifying transcriptomic predictors of brodalumab response in psoriasis using CART analysis","authors":"Vikram R. Shaw,&nbsp;Jay Patel,&nbsp;Vamsi Varra","doi":"10.1007/s00403-025-04158-2","DOIUrl":"10.1007/s00403-025-04158-2","url":null,"abstract":"<div><p>Precision medicine is a topic of growing interest in psoriasis. Many novel biologics are now available to clinicians and identifying who will be a responder or non-responder to a given biologic prior to treatment is an exciting area of inquiry with strong potential clinical utility. In the present study, we use an interpretable classification and regression tree (CART) model to predict week 12 PASI75 and PASI90 response to brodalumab treatment based on clinical variables and transcriptomic data from lesional biopsy tissue samples. We identify KRT16 normalized RNA expression levels and BMI as pre-treatment predictors of a PASI75 response and FERMT1, HLA_DQA1, TMPRSS11D, and S100P normalized RNA expression levels as pre-treatment predictors of a PASI90 response. The CART models demonstrated strong AUC values for the PASI75 (0.90) and PASI90 (0.88) analyses. Taken together, focused transcriptomics has the potential to be used clinically for the pre-treatment prediction of treatment response.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04158-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of bentonite-containing soap in a patient with epidermolytic ichthyosis","authors":"Kayla Zafar,&nbsp;Austin Lee,&nbsp;Margaret Kabakova,&nbsp;Terry Melton,&nbsp;Jared Jagdeo","doi":"10.1007/s00403-025-04137-7","DOIUrl":"10.1007/s00403-025-04137-7","url":null,"abstract":"<div><p>Epidermolytic ichthyosis (EI), a rare autosomal dominant skin disorder caused by mutations in the KRT1 and KRT10 genes, results in thickened, scaly, and blister-prone skin. Traditional treatments, such as ammonium lactate and retinoids, often fail to adequately manage symptoms. This case report explores the use of a bentonite-containing soap, as a novel and efficacious therapy for a 70-year-old female patient with EI. Despite long-term treatment with ammonium lactate and exfoliating baths, the patient continued to experience persistent scaling and thickened skin. After the addition of the bentonite-containing soap, the patient reported significant improvement in scaling, particularly on the hands and feet, with smoother skin and reduced scaling. Bentonite’s exfoliating, antibacterial, and wound-healing properties, along with its ability to restore the skin barrier, likely contributed to these improvements. These promising results highlight the potential of bentonite-based products for managing EI, though further clinical trials are needed to evaluate long-term safety and efficacy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04137-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental factors and the development of frontal fibrosing alopecia: insight from a retrospective case–control investigation","authors":"Kamran Balighi,&nbsp;Zahraa Abdulsattar,&nbsp;Arghavan Azizpour,&nbsp;Narges Ghandi,&nbsp;Vahideh Lajevardi,&nbsp;Mahshid Sadat Ansari","doi":"10.1007/s00403-025-04144-8","DOIUrl":"10.1007/s00403-025-04144-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial neuromodulator expectations of treatment naïve millennials","authors":"Jennifer Y. Wang,&nbsp;Paras Patel,&nbsp;Raichel Philip,&nbsp;David Bitterman,&nbsp;Kayla Zafar,&nbsp;Jared Jagdeo","doi":"10.1007/s00403-025-04156-4","DOIUrl":"10.1007/s00403-025-04156-4","url":null,"abstract":"<div><p>As the millennial generation increasingly dominates the consumer landscape of facial neuromodulator treatments, a comprehensive understanding of their perceptions is crucial for tailoring effective aesthetic medical practices. However, there is currently a lack of comprehensive understanding of millennials' knowledge, attitudes, and expectations regarding facial neuromodulator treatments. We aim to understand millennials’ perceptions and expectations regarding neuromodulator treatments. We conducted a cross-sectional survey to uncover the perceptions and expectations of millennials towards facial neuromodulator treatments. Of the 150 participants, the primary reasons for considering treatment were the desire to look good for one’s age (48%) and to appear more youthful (26%). The main reasons for not pursuing treatment were the belief that it was not yet necessary (57%) and concerns about safety or side effects (11%). Millennials were most interested in treating their forehead (75%), lateral canthal area (49%), and glabella (39%). Expectations varied in terms of treatment outcomes, recovery times, and result duration. Most respondents anticipated a positive impact on self-esteem (52%) and would “probably” or “definitely” disclose undergoing treatments to their friends and peers (65%). Herein, we reveal a complex landscape of millennial understanding of and expectations towards facial neuromodulator treatments. The findings underscore the necessity for physicians to engage in detailed patient education and adapt communication strategies to align with millennial expectations and values. A better understanding of millennials’ expectations may guide clinical practices and allow dermatologists to significantly improve patient satisfaction and outcomes, driving forward the field of aesthetic medicine.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing laser test spot practices among dermatologists: a cross-sectional survey of the association of academic cosmetic dermatology members","authors":"Jennifer Y. Wang,&nbsp;Paras Patel,&nbsp;Margaret Kabakova,&nbsp;Marc Cohen,&nbsp;Jared Jagdeo","doi":"10.1007/s00403-025-04159-1","DOIUrl":"10.1007/s00403-025-04159-1","url":null,"abstract":"<div><p>Laser treatments are associated with adverse events such as pain, dyspigmentation, and scarring. Laser test spots may mitigate these risks by assessing patients’ skin reactions before full treatment. We aim to explore the factors influencing dermatologists’ use of test spots. A survey on the factors influencing dermatologists’ use of laser test spots was conducted among Association of Academic Cosmetic Dermatology members. Sixty-six dermatologists took part in this study, resulting in a response rate of 48.2%. Top factors influencing the decision to perform a test spot include “darker skin type” (96.9%) and the “type of laser” (71.9%). A majority of dermatologists believe patients feel more comfortable if a test spot is performed (87.3%). Common reasons dermatologists chose not to perform test spots include “familiarity with the patient's skin type and reaction” (87.9%) and “using a laser type/setting with well-known outcomes based on previous experience” (86.4%). This study provides crucial insights into factors influencing dermatologists' use of laser test spots and underscores the importance of developing standardized protocols. Future research is needed to assess changes in laser test spot practices over time and to develop standardized guidelines to improve treatment safety and efficacy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of the 589/1319 nm solid-state dual-wavelength laser combined with topical benzoyl peroxide for inflammatory acne vulgaris: a split-face randomized controlled trial","authors":"Suphagan Boonpethkaew,&nbsp;Yanisa Ratanapokasatit,&nbsp;Sonphet Chirasuthat,&nbsp;Penpun Wattanakrai","doi":"10.1007/s00403-025-04146-6","DOIUrl":"10.1007/s00403-025-04146-6","url":null,"abstract":"<div><p>The 589/1319 nm solid-state dual-wavelength (SSDW) laser, which does not require consumable dye, has the potential to target inflammation and sebum production in acne vulgaris pathogenesis. To assess the efficacy and safety of 598/1319 nm SSDW laser as an adjunctive treatment to conventional treatment, 18 patients with bilateral facial acne, with inflammatory papules or pustules, were recruited. Patients were instructed to apply 2.5% benozoyl peroxide (BPO), the drug for inflammatory acne, to their entire face throughout the study. One side of the face was randomly assigned to receive 4 sessions of 589/1319 nm SSDW laser treatments, administered every 2 weeks. After the last laser treatment, 3 monthly follow-ups were scheduled. Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and skin roughness were measured. Adverse events (AEs) and patients’ satisfaction were assessed. At the 3-month follow-up, the ILC reduced by 46% on the adjunctive laser (BPO + laser) side (<i>p</i> = 0.0080), compared with a 29% reduction on the BPO monotherapy side (<i>p</i> = 0.1875). On the adjunctive laser side, the change in ILC positively correlated with the change in melanin level (<i>r</i> = 0.51, <i>p</i> = 0.0301) and showed a trend towards a positive correlation with the change in depression volume (<i>r</i> = 0.45, <i>p</i> = 0.0606) and roughness level (<i>r</i> = 0.42, <i>p</i> = 0.0806). The patients reported a pain score of 3.4 ± 2.3 on scale of 10. No serious AEs occurred. Patients’ satisfaction scores were higher with the adjunctive laser therapy, although this was not statistically significant (<i>p</i> = 0.2758). In conclusion, the 589/1319 nm SSDW laser provided a synergistic effect as an adjunctive treatment to BPO in inflammatory acne in terms of reducing ILC and improving post inflammatory hyperpigmentation without causing discomfort or downtime.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04146-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK inhibitors and the risk of infection: a meta-analysis","authors":"Hao-Long Ran,&nbsp;Huan Liu,&nbsp;Wen-Ting Xu,&nbsp;Jin-Rui Zhang,&nbsp;Wei Chen,&nbsp;Han-Yue Dong,&nbsp;Hongmin Li,&nbsp;Cheng Tan","doi":"10.1007/s00403-025-04153-7","DOIUrl":"10.1007/s00403-025-04153-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04153-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of intravenous immunoglobulin on kidney functions and thromboembolic events in dermatology patients","authors":"Ceylan Avcı,&nbsp;Aygün Talibova,&nbsp;Ozlem Ozbagcivan,&nbsp;Cihan Heybeli,&nbsp;Emel Fetil","doi":"10.1007/s00403-025-04160-8","DOIUrl":"10.1007/s00403-025-04160-8","url":null,"abstract":"<div><p>Although intravenous immunoglobulin (IVIG) treatment is generally well tolerated, some adverse effects, ranging from mild to severe, can occur. Nephrotoxicity and thromboembolism are the significant adverse effects of IVIG. However, data on the frequency of thromboembolism and the impact of continuous treatment on renal functions in dermatology patients is limited. This retrospective study was conducted in a cohort of patients who received at least one high-dose (2 g/kg) IVIG cycle due to different dermatological indications, including pemphigus vulgaris, bullous pemphigoid, Stevens-Johnson syndrome, pyoderma gangrenosum, hidradenitis suppurativa and toxic epidermal necrolysis at a university hospital. Demographic and clinical information, thromboembolic events, and kidney function tests were systematically extracted from patient records. The study included 48 patients who received a total of 196 IVIG cycles with a mean dose of two cycles (range 1–41). A significant difference in renal function was observed between baseline and post-treatment in patients who received three or more IVIG cycles. In comparison, no significant difference was found in those receiving one or two IVIG cycles. Five patients (10.4%) experienced a decline of ≥ 20% in the estimated glomerular filtration rate (eGFR). In multivariate analysis, cumulative IVIG dose emerged as the sole independent predictor for a ≥ 20% decline in eGFR (OR 1.61, 95% CI 1.05–2.46, p = 0.02). Thromboembolism occurred in five patients (10.4%), with three cases arising during the first cycle. Thromboembolism, especially during the initial IVIG cycles, and decline in kidney functions related to cumulative IVIG dose were the common and significant side effects in this cohort of dermatology patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04160-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High interest in dietary modifications for acne management: insights from a United States-based patient survey","authors":"Sherry Ershadi,&nbsp;Laura R. Saslow,&nbsp;John S. Barbieri","doi":"10.1007/s00403-025-04150-w","DOIUrl":"10.1007/s00403-025-04150-w","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Employing acetowhitening to identify mohs micrographic surgery margins in squamous cell carcinoma in situ","authors":"Anthony Concilla,&nbsp;Alexander Howell,&nbsp;David H. Ciocon,&nbsp;Karthik Krishnamurthy","doi":"10.1007/s00403-025-04163-5","DOIUrl":"10.1007/s00403-025-04163-5","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}