Archives of Dermatological Research最新文献

{"title":"Extended fragrance ingredients surveillance study (EFISS)—protocol for a clinical surveillance study on contact allergy to 7 fragrance materials in widespread use but hitherto not systematically patch tested","authors":"Wolfgang Uter,&nbsp;Ana Carolina Figueiredo,&nbsp;Anna Belloni Fortina,&nbsp;John Bourke,&nbsp;Jim Bridges,&nbsp;Margarida Gonçalo,&nbsp;Stamatis Gregoriou,&nbsp;Claudia Lang,&nbsp;Suzana Ljubojević Hadžavdić,&nbsp;Joseph Huggard,&nbsp;Marléne Isaksson,&nbsp;Karl-Heinz Jöckel,&nbsp;Ian Kimber,&nbsp;Dimitra Koumaki,&nbsp;Elena Pezzolo,&nbsp;Thomas Rustemeyer,&nbsp;Marie L. A. Schuttelaar,&nbsp;Cecilia Svedman,&nbsp;Matthias Vey,&nbsp;Ian White,&nbsp;Anna Zambello,&nbsp;Magnus Bruze","doi":"10.1007/s00403-025-04286-9","DOIUrl":"10.1007/s00403-025-04286-9","url":null,"abstract":"<div><p>Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a conclusion will be drawn as to whether present risk management regarding maximum recommended concentrations of each of these, based on quantitative risk assessment (QRA2), is adequate. The planned study is a surveillance study based on consecutive patients, patch tested in 10 European departments of dermatology with a series of allergens as indicated by their personal history, including the European baseline series, supplemented with the seven additional fragrance ingredients. The patch test procedure will follow the guideline of the European Society of Contact Dermatitis (ESCD) with additional standardization procedures. The envisaged sample size is 8100; recruitment will be in three data cycles with brief intervals allowing for descriptive interim analyses. Those patients reacting positively to any of the study allergens will be followed-up specifically to identify the source of sensitizing and/or eliciting exposure(s). Results will inform risk reassessment and subsequent risk management measures. Study results will be published in an open-access peer-reviewed scientific journal. Structured post-marketing surveillance of consumer risk of contact allergy by monitoring prevalences of positive patch test reactions in a dedicated European expert network is developed which can serve as a model for further chemicals. Important outcomes will be either a confirmation of effectiveness of risk management measures in place, or alternatively identifying aspects needing improvement (for certain cosmetic product categories). DRKS registration (DRKS00033263) 16.09.2024, mirrored at https://trialsearch.who.int</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04286-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of health insurance delays on biologic therapy access in autoimmune bullous disease: a single-center retrospective analysis","authors":"Paige E. Adams,&nbsp;Elise K. Brunsgaard,&nbsp;Nikki Rezania,&nbsp;Diana Silver,&nbsp;Rebecca A. Strong,&nbsp;Marc Yale,&nbsp;Kyle T. Amber","doi":"10.1007/s00403-025-04266-z","DOIUrl":"10.1007/s00403-025-04266-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04266-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missed Mohs surgical appointments: Investigating factors associated with non-attendance","authors":"Alyssa Breneman,&nbsp;Emily R. Gordon,&nbsp;Megan H. Trager,&nbsp;Faramarz H. Samie","doi":"10.1007/s00403-025-04281-0","DOIUrl":"10.1007/s00403-025-04281-0","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pityriasis versicolor in the paediatric age group: a descriptive observational study of 415 children","authors":"Zhuodi Luo,&nbsp;Xiaowei Li,&nbsp;Zhen Zhou,&nbsp;Jing Shi,&nbsp;Hulin Chen,&nbsp;Yunan Wang,&nbsp;Linli Xu,&nbsp;Huazhuo Liang","doi":"10.1007/s00403-025-04276-x","DOIUrl":"10.1007/s00403-025-04276-x","url":null,"abstract":"<div><p>Pityriasis versicolor (PV) is a common chronic superficial fungal infection caused by the lipophilic yeast <i>Malassezia</i>, which is highly prevalent in young and middle-aged people, and its incidence in children, especially infants, has been poorly studied. The aim was to study the epidemiology, clinical features and mycological correlates of PV in children. A total of 415 patients under 14 years of age with a clinical diagnosis of PV who presented to the Department of Dermatology between 1 January 2023 and 31 December 2024 were included. Skin scrapings from these patients were examined by fluorescence microscopy. Of the 415 patients with PV, 71.57% were male and 28.43% were female; the age group with the highest percentage of patients was the group aged less than 6 months (35.42%); the youngest patient affected was a 1-month, 15-day-old boy, and the oldest was a 14-year-old male. The duration of infection ranged from 1 to 6 months in 46.75% of the children, and 4.10% of the patients had infections lasting longer than 1 year. The face was the most frequently involved site (65.29%), and hypopigmented PV was the most common clinical presentation, observed in 96.87% of the patients. A fluorescence microscope revealed that <i>Malassezia</i> was most commonly observed in hyphal and spore forms (38.80%), followed by spore forms alone (31.80%). The retrospective nature of the study. PV is common in children, especially in infants less than 6 months old, and the face is a frequently involved site in children with PV.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive bibliometric analysis of the association between atopic dermatitis and depression (1994–2024)","authors":"Yan Yang,&nbsp;Jun-xiong Li,&nbsp;Zi-ling Wang,&nbsp;Si-en Zhu,&nbsp;Jian-zhou Xie","doi":"10.1007/s00403-025-04269-w","DOIUrl":"10.1007/s00403-025-04269-w","url":null,"abstract":"<div><p>In recent decades, the prevalence of atopic dermatitis (AD) has dramatically risen due to modern environmental exposures and drastic lifestyle changes. Furthermore, many studies emphasize that the prevalence of mental health issues, such as depression and anxiety, is much higher among patients with AD compared to the general population. Consequently, there is an urgent imperative to delve into emerging research trends and focal points concerning the association between AD and depression. By analyzing the literature on the correlation between AD and Depression in the Web of Science Core Collection (WoSCC) over the past three decades, our study aims to investigate the key research areas and trends related to the connection between AD and depression through bibliometric analysis, offering useful insights for future researchers in this area. Publications from January 1, 1994, to December 31, 2024, were retrieved from WoSCC on January 5, 2025, and visualized with Excel and Vosviewer software. Summing up to 729 papers were included, authored by 3,670 individuals. The United States, Germany, and the United Kingdom were prominent in researching the link between AD and depression, with the US publishing the highest number of papers—216 in total. Jonathan I. Silverberg stood out as the most prolific author in this field. Keywords visualization analysis revealed that “atopic dermatitis” and “depression” were core topics. It is noteworthy that there has been a significant evolution in research emphasis over time, with studies of AD associated with depression moving from early “pruritus” “psoriasis”, and “stress” studies, gradually transitioning into the field of adolescent mental health, suggesting that society’s interest in dermatologic conditions and their psychological impact is gradually extending from purely physical symptoms to the broader implications of mental health and quality of life. A thorough bibliometric analysis was initially performed to outline the current state and knowledge framework of the connection between AD and depression, aiming to offer guidance and new insights for future research in this area.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04269-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome-derived biological and immunological profiles of psoriasis vulgaris, non-pustular palmoplantar psoriasis, and palmoplantar pustular psoriasis","authors":"Michael J. Diaz,&nbsp;Jasmine T. Tran,&nbsp;Run Q. Gan","doi":"10.1007/s00403-025-04230-x","DOIUrl":"10.1007/s00403-025-04230-x","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional injection of vitamin D3, platelet rich plasma versus their combination in treatment of keloid: a clinical, radiological and immunohistochemical study","authors":"Nagwa Mohammad Elwan,&nbsp;Yomna Mazid El-Hamd Neinaa,&nbsp;Radwa Mostafa Elkhouly,&nbsp;Raghdah Magdy Dagher,&nbsp;Shady Fikry Abdel Salaam","doi":"10.1007/s00403-025-04244-5","DOIUrl":"10.1007/s00403-025-04244-5","url":null,"abstract":"<div><p>Management of keloid is still a challenge. Many treatment modalities are available, yet no definitive treatment protocol exists. Vitamin D3 (Vit. D3) has an anti-inflammatory role in preventing tissue fibrosis. Platelet-rich plasma (PRP) contains plentiful various peptides that have anti-inflammatory and tissue repair activities. The study aimed to assess the safety and efficacy of injecting either Vit. D3 or PRP versus their combination in keloid treatment. There were sixty keloid patients in all, randomly split into three matched groups for this research. Group I received an intralesional vitamin D3 injection; Group II got an intralesional PRP. While group III received both alternatively. All patients received treatment session biweekly until clinical cure or for a maximum of 4 successive sessions. Therapeutic efficacy was assessed by Verbal rating scale (VRS), Vancouver scar scale (VSS), dermoscopic, and ultrasonic examinations. Additionally, H&amp;E and immunohistochemical expression of Caveolin-1 (Cav-1) were studied. Significant improvements in both VSS and VRS of keloid scars were detected in the three groups studied. These findings were significantly higher among patients treated by combined Vit. D3 and PRP followed by Vit. D3 monotherapy, and lastly PRP monotherapy. Parallel dermoscopic and radiological findings were detected confirming the clinical results. In the three groups studied, histopathological examination reported significant reduction in collagen with more compact orientation, and significant increase of Cav-1 immunohistochemical expression in keloid scars after treatment. Intralesional injection of either Vit. D3, PRP or their combination are safe and effective in keloid treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway","authors":"Zhenyu Liu,&nbsp;Shenyu Li,&nbsp;Qilin Yang,&nbsp;Guiyuan Cao,&nbsp;Wenjie Yan,&nbsp;Siyuan Jiang,&nbsp;Ruilong Qiao,&nbsp;Bozhi Cai,&nbsp;Zhihao Wu,&nbsp;Changmin Lin,&nbsp;Ningxia Zhu","doi":"10.1007/s00403-025-04267-y","DOIUrl":"10.1007/s00403-025-04267-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the accuracy of patient-reported hair outcomes versus trichometric measurements in PRP therapy","authors":"Anna Brinks,&nbsp;Deesha D. Desai,&nbsp;Carli Needle,&nbsp;Caitlin A. Kearney,&nbsp;Ambika Nohria,&nbsp;Michelle Sikora,&nbsp;Christina S. Oh,&nbsp;Nnaemeka Anyanwu,&nbsp;Jerry Shapiro,&nbsp;Kristen I. Lo Sicco","doi":"10.1007/s00403-025-04264-1","DOIUrl":"10.1007/s00403-025-04264-1","url":null,"abstract":"<div><p>Monitoring both subjective and objective responses to alopecia treatment is critical for assessing patient perception and therapeutic efficacy. Platelet-rich plasma (PRP) therapy is a widely used treatment for alopecia, particularly androgenetic alopecia (AGA), yet the correlation between patient-reported outcomes and trichometric measurements remains poorly defined. This retrospective study analyzed data from 56 alopecia patients treated with PRP at NYU Langone Health between November 2017 and March 2025. Patients were categorized as “improved,” “stable,” or “worse” based on self-assessments, and changes in hair density and width were evaluated over the course of PRP treatment. Spearman’s rank correlation and Kruskal-Wallis Rank Sum Tests were used for statistical analysis. Results showed that patient-reported outcomes correlated significantly with changes in hair density (<i>p</i> = 0.0006), but not hair width (<i>p</i> = 0.2688). The greatest increase in hair density was observed in the “improved” group (+ 18.9 hairs/cm²), with a more modest gain in the “stable” group (+ 7.6 hairs/cm²), while the “worse” group experienced a decrease (− 19.7 hairs/cm²). Differences in density across all three groups were statistically significant (<i>p</i> = 0.0012), whereas width changes were not (<i>p</i> = 0.5009). Subgroup analysis of AGA patients yielded similar findings. These results suggest that patient perception aligns more closely with density changes than width changes. Combining subjective assessments with objective measurements enhances clinical decision-making, expectation management, and holistic evaluation of PRP treatment efficacy in alopecia patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USP41 plays carcinogenic roles in human cutaneous melanoma through PI3K/Akt signaling pathway","authors":"Congcong Shen,&nbsp;Xin Wang,&nbsp;Lixiong Gu,&nbsp;Xiaomei Cui,&nbsp;Wenyan Zhu,&nbsp;Yixiao Wang,&nbsp;Xin Zhang,&nbsp;Xiaodong Chen","doi":"10.1007/s00403-025-04114-0","DOIUrl":"10.1007/s00403-025-04114-0","url":null,"abstract":"<div><p>Cutaneous melanoma is a malignant tumor with a high mortality rate. Ubiquitin-specific protease 41 (USP41) has recently been reported to be overexpressed in various malignancies. However, its role in melanoma remains unclear. Gene Expression Profiling Interactive Analysis (GEPIA) was used to perform pan-cancer analysis using data from the the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. Melanoma tissue microarray (TMA), clinical patient tissues, and cells were used to explore USP41 expression profiles by immunohistochemistry (IHC), RT-qPCR or Western blotting. Small interfering RNAs (siRNAs) were used to knock down USP41 in melanoma cells. Cell proliferation, migration, and invasion were assessed using CCK-8, EdU staining, wound healing, and transwell assays, respectively. Cell apoptosis was detected by flow cytometry and TUNEL staining. GEPIA revealed that USP41 is highly expressed in most human cancers, including melanoma. USP41 is overexpressed in melanoma tumor tissues and cells. IHC showed that USP41 was positively stained in melanoma tissues and was significantly correlated with the TNM stage of melanoma. USP41 knockdown inhibited cell proliferation, migration, and invasion while promoting cell apoptosis and inhibiting phosphorylated PI3K, AKT, and mTOR in the PI3K/AKT signaling pathway. The results indicate that USP41 may play a carcinogenic role in melanoma partly via the PI3K/AKT signaling pathway, suggesting that USP41 may be an effective therapeutic target for the treatments of cutaneous melanoma.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}