Archives of Dermatological Research最新文献_第4页

Describing atopic dermatitis in real-world clinical practice: a retrospective health system analysis

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-07 DOI: 10.1007/s00403-025-03892-x

Meredith Tyree Polaskey, Raj Chovatiya

{"title":"Describing atopic dermatitis in real-world clinical practice: a retrospective health system analysis","authors":"Meredith Tyree Polaskey, Raj Chovatiya","doi":"10.1007/s00403-025-03892-x","DOIUrl":"10.1007/s00403-025-03892-x","url":null,"abstract":"<div><p>Effective management of atopic dermatitis (AD) is hindered by gaps in the comprehensive documentation of clinician-observed signs and patient-reported experiences. Our objective was to assess the comprehensiveness of AD documentation in clinical practice. A retrospective analysis of electronic health records from a regional health system (2010–2022, <i>n</i> = 17,053) was conducted. Manual review of 2,193 records confirmed 600 AD patients. Documentation of skin signs, disease burden, and disease progression was evaluated. Narrative descriptions of lesion morphology and location were documented in 76.2% and 92.7% of notes, respectively. Only a minority commented on chronicity (6.2%), signs other than erythema (≤ 25.0%), disease extent (38.2%), or severity (IGA/PGA: 26.8%; EASI: 4.7%). Itch, skin pain, sleep disturbances, and mental health symptoms were reported in 58.7%, 14.5%, 10.2%, and 1.0% of notes, respectively, with numerical rating scales rarely applied. Patient-assessed global severity was recorded in 6.2% of notes, and QoL impact in 3.8%. Documentation of flare frequency, duration, and post-treatment changes was rare. Our findings reveal strikingly incomplete clinical documentation of AD, underscoring the need for a structured approach to better document activity and address true disease burden.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143361632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory cytokines and alopecia areata: insights from bidirectional mendelian randomisation and observational study

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-07 DOI: 10.1007/s00403-025-03854-3

Wenjun Lin, Ge Shi, Fengchuan Zhang, Weihao Jiang, Shuying Lv, Ying Wang, Dingquan Yang

引用次数: 0

308 nm–Excimer light together with topical betamethasone valerate in treating alopecia areata

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03833-8

Yasmin M. Tawfik, Eman R. M. Hofny, Fatma Magdy Zidan, Alaa Ghazally

{"title":"308 nm–Excimer light together with topical betamethasone valerate in treating alopecia areata","authors":"Yasmin M. Tawfik, Eman R. M. Hofny, Fatma Magdy Zidan, Alaa Ghazally","doi":"10.1007/s00403-025-03833-8","DOIUrl":"10.1007/s00403-025-03833-8","url":null,"abstract":"<div><p>Excimer light was reported to be effective in treating alopecia areata (AA), as it induces T-cell apoptosis, however its combination with topical steroids in the management of AA still needs to be investigated. The study <b>objectives were</b> to determine the efficacy and safety of combining 308 nm–Excimer light and topical steroid versus either Excimer light or topical steroid alone in treating AA. Thirty AA patients were included, each patient had at least three patches, patches in each patient were randomly classified in to 3 groups. Group I patch: was treated by topical steroid only. Group II patch: was treated by Excimer light only. Group III patch: was treated by topical steroid and Excimer light. The response for hair growth was assessed at the baseline, week 8, week 12 then at 3months after the last session using a hair regrowth scale and trichoscopy. Any encountered adverse effects were recorded. All treatment groups showed significant improvement at the end of the study compared to the baseline, although hair regrowth was significantly better in group III where 60% of patches showed > 50% hair regrowth. All treatment groups showed significant decrease in black dots (BD) (trichoscopic sign of activity), and increase in signs of improvement (upright growing and pigtail hairs). However, BD and exclamation mark hair (EMH) were significantly reduced in the mixed therapy group compared to the other two groups. We concluded that excimer light is an effective and safe treatment option for AA, particularly when combined with topical steroid.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the use of vitamin D-fortified sunscreen cream be the solution to the vitamin D deficiency pandemic?

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03837-4

Hayrettin Kara, Ümit Polat, Özgür Baykan, Eda Selçuk, Gülay Turan

{"title":"Can the use of vitamin D-fortified sunscreen cream be the solution to the vitamin D deficiency pandemic?","authors":"Hayrettin Kara, Ümit Polat, Özgür Baykan, Eda Selçuk, Gülay Turan","doi":"10.1007/s00403-025-03837-4","DOIUrl":"10.1007/s00403-025-03837-4","url":null,"abstract":"<div><p>Current approaches to vitamin D supplementation are generally limited to its oral intake. In this experimental study, the effects of applying vitamin D-fortified sunscreen creams to the skin on the absorption, and therefore levels of serum vitamin D metabolites were investigated. Forty 8-week-old male Wistar Albino rats were used in the study. Eight rats (Group B) were sacrificed to determine the baseline values of biochemical parameters. The remaining 32 rats were randomly divided into 4 equal groups as follows: Group S, only the back skin of the rats were shaved; Group SD, only vitamin D<sub>3</sub> diluted with sunflower oil was applied to the shaved area; Group SC, only sunscreen cream was applied to the shaved area; and Group SDC, sunscreen cream fortified with vitamin D<sub>3</sub> was applied to the shaved area. Serum 25(OH)D<sub>3</sub> and 24,25(OH)<sub>2</sub>D<sub>3</sub> levels were determined at the end of 8 weeks. Mean (± SD) serum 25(OH)D<sub>3</sub> levels of groups B, S, SD, SC, and SDC were determined as 17.7 ± 5.7, 13.5 ± 3.1, 54.1 ± 13.0, 19.6 ± 2.7, 67.2 ± 16.5 ng/mL, respectively. There were statistically significant differences in serum 25(OH)D<sub>3</sub> values between groups S and SD (<i>p</i> < 0.001) and between groups SC and SDC (<i>p</i> = 0.002). A positive correlation was found between serum 25(OH)D<sub>3</sub> and 24,25(OH)<sub>2</sub>D<sub>3</sub> parameters (<i>r</i> = 0.772; <i>p</i> < 0.001). With this study, it was concluded that vitamin D-fortified sunscreen cream increases serum vitamin D levels by exerting transdermal activity. Further studies are required to confirm this observations.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03884-x

Georgina H. Wren, Peter O’Callaghan, Abbas Zaidi, Andrew R. Thompson, Trevor Humby, William Davies

{"title":"Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study","authors":"Georgina H. Wren, Peter O’Callaghan, Abbas Zaidi, Andrew R. Thompson, Trevor Humby, William Davies","doi":"10.1007/s00403-025-03884-x","DOIUrl":"10.1007/s00403-025-03884-x","url":null,"abstract":"<div><p>The rare dermatological condition X-linked ichthyosis (XLI) is associated with a substantially-increased risk of cardiac arrhythmias. Arrhythmias predispose to multiple serious health conditions, and there is a need to identify them at an early stage, ideally using non-invasive, convenient, cost-effective, and reliable wearable technology methods. We tested the feasibility of monitoring heart rhythms using an Apple Watch in five adult males from the United Kingdom diagnosed with XLI. Participants returned routine electrocardiogram (ECG) traces from the watch three times per week for eight weeks (plus any traces associated with ‘watch alerts’ indicating arrhythmic episodes) for cardiologist review. Participant feedback was also obtained on the perceived usability/wearability of the watch/app, and on the study requirements. Participants were generally happy with the study conduct, found the watch/app straightforward to use, and there was a > 95% data return rate. Minor protocol improvements were suggested. There were few issues reported with wearability of the watch. Three participants exhibited no ECG abnormalities, but two presented with ventricular ectopic beats (VEs). Only one watch ‘alert’ ECG was returned, and this was considered normal sinus rhythm, suggesting the possibility of ‘false positive’ calls. Based on our small sample, smartwatch-based screening for cardiac rhythm abnormalities in the high-risk male XLI population appears useful, feasible, and acceptable to patients and a larger-scale clinical trial is warranted. Potentially, such devices may be more suited to detecting persistent abnormalities rather than unpredictable, acute, arrhythmic episodes. The high VE burden in some participants with XLI is consistent with septal defects underlying arrhythmia risk.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-03884-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of phloridzin carbomer gel for skin inflammatory healing in atopic dermatitis

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03866-z

Fulu Lv, Yanxia Chen, Haohui Xie, Manzhi Gao, Ruohong He, WanYing Deng, Weiqiang Chen

{"title":"Therapeutic potential of phloridzin carbomer gel for skin inflammatory healing in atopic dermatitis","authors":"Fulu Lv, Yanxia Chen, Haohui Xie, Manzhi Gao, Ruohong He, WanYing Deng, Weiqiang Chen","doi":"10.1007/s00403-025-03866-z","DOIUrl":"10.1007/s00403-025-03866-z","url":null,"abstract":"<div><p>Phloridzin (PL), a natural compound derived from apples, exhibits diverse pharmacological properties including anti-inflammatory, anti-tumor, antioxidant, and anti-aging effects. The present study aimed to evaluate the impact of Phloridzin Carbomer Gel (PL-CG) on skin inflammatory healing in a mouse model of atopic dermatitis (AD). In vitro experiments initially determined the non-toxic concentration range of PL in cells, established a cellular inflammation model by stimulating cells with histamine to ascertain the optimal therapeutic concentration of PL, and subsequently detected decreased mRNA expression levels of relevant inflammatory cytokines, interleukins, through RT-qPCR experiments following PL treatment. For in vivo experiments, an AD mouse model was constructed. Histopathological analysis, along with assessments of epidermal thickness, reduction in scratch counts on the back of mice, and healing rates of inflammatory areas, indicated that PL-CG facilitates epidermal tissue regeneration and wound repair, thereby accelerating skin inflammatory healing. Additionally, PL-CG was subjected to microstructural observation using scanning electron microscopy (SEM), and experiments were conducted to determine its optimal pH value, stability, viscosity, and the influence of different concentrations of carbomer gel on drug release. The study demonstrated that PL-CG possesses anti-inflammatory and antipruritic properties, as well as the ability to promote skin inflammatory healing. Compared to traditional corticosteroids, PL-CG exhibits a higher safety profile and fewer side effects, suggesting broad prospects for its clinical application in the treatment of atopic dermatitis.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSV-1 inhibits melanogenesis of PIG1 cells through downregulation of VN1R5/ERK pathway

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03844-5

Yuxin Feng, Shibin Jiang, Jinping Yuan, Kun Zhou, Yansong Lu, Fenglin Zhuo, Xing-Hua Gao, Hong-Duo Chen, Rui-Qun Qi, Yan Wu

{"title":"HSV-1 inhibits melanogenesis of PIG1 cells through downregulation of VN1R5/ERK pathway","authors":"Yuxin Feng, Shibin Jiang, Jinping Yuan, Kun Zhou, Yansong Lu, Fenglin Zhuo, Xing-Hua Gao, Hong-Duo Chen, Rui-Qun Qi, Yan Wu","doi":"10.1007/s00403-025-03844-5","DOIUrl":"10.1007/s00403-025-03844-5","url":null,"abstract":"<div><p>Herpes simplex virus type 1 (HSV-1) is an ubiquitous pathogen that can infect humans through skin or mucous regions. This study was to explore the effects and underlying mechanism of HSV-1 as examined within the human epidermal melanocyte cell line, PIG1. Our results showed that following HSV-1 infection, PIG1 cells shrank and acquired a rounded shape, while the numbers and lengths of their dendrites decreased and melanogenesis was inhibited. Meanwhile, the HSV-1 receptors (nectin-1, herpes virus entry mediator, paired immunoglobulin-like type 2 receptor alpha) and phospho-extracellular signal-regulating kinase (p-ERK) were all substantially decreased, while vomeronasal type-1 receptor 5 (VN1R5) increased. Results of RNA interference and protein inhibitor assays revealed that knockdown of VN1R5 increased the expression of p-ERK and microphthalmia-associated transcription factor (MITF), while an inhibition of ERK decreased VN1R5 expression. Taken together, our study provides the first evidence that HSV-1 can infect human normal melanocytes and inhibit melanogenesis through VN1R5/ERK pathway.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical insights on “Factors associated with comorbidity development in atopic dermatitis: a cross-section study”

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03828-5

Rizwan Ahmad, Saad Khan, Ayesha Khan, Faraz Arshad, Fatima Naveed

引用次数: 0

Elucidating the need for inclusion of burn in graduate and continuing dermatologic medical education

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03853-4

Richard Moraga

引用次数: 0

Quantitative lipidomics profiling of skin surface lipids and skin barrier function evaluation in patients with acne vulgaris

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-02-06 DOI: 10.1007/s00403-025-03840-9

Yahong Cheng, Qingmiao Sun, Jiefang Gao, Qin Liu, Hui Tian, Hong Ding, Jianjun Qiao, Haijiang Chen

{"title":"Quantitative lipidomics profiling of skin surface lipids and skin barrier function evaluation in patients with acne vulgaris","authors":"Yahong Cheng, Qingmiao Sun, Jiefang Gao, Qin Liu, Hui Tian, Hong Ding, Jianjun Qiao, Haijiang Chen","doi":"10.1007/s00403-025-03840-9","DOIUrl":"10.1007/s00403-025-03840-9","url":null,"abstract":"<div><p>Sebum composition may be more important than amount for acne lesions, and current research on skin surface lipids (SSLs) focuses on determining their relative content. The objective of this study was to analyze the changes in the absolute content of SSLs in acne patients and their relationship with skin barrier function. To evaluate skin barrier function, transepidermal water loss (TEWL), skin moisture, sebum content, skin elasticity, and whiteness were measured, while SSL changes were investigated using LC-MS/MS. The results indicated that adult acne patients have reduced skin barrier function, as demonstrated by changes in skin moisture, sebum content, skin flexibility, and whitening. Notably, AGlcSiE, Cer, CL, Co, LPC, PA, PC, PE, PI, SM, So, SQDG, and TG were considerably enhanced in acne patients’ SSLs, whereas CerG1, DG, DGDG, MGDG, PG, and phSM were decreased. Furthermore, side chain analysis showed that the ratio of linoleic acid to linolenic acid in acne patients’ skin surface lipids was higher than in healthy controls, and the caprylic acid/capric acid ratio was likewise greater. The correlation study of SSLs and skin barrier function demonstrated that increasing LPC and decreasing PG are associated with skin barrier function deterioration. In conclusion, acne patients have compromised skin barrier function and altered SSL absolute content, and certain SSL species identified in this study could serve as potential targets for research into acne pathogenesis.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0