Archives of Dermatological Research最新文献

{"title":"Differences in clinical presentation and melanoma-specific survival among female and male veterans with cutaneous melanoma","authors":"Daniel Y. Kim, Michelle Pavlis, Linden Huhmann, Jonathan C. Hwang, Mary T. Brophy, Nhan V. Do, Nathanael Fillmore, Rebecca I. Hartman","doi":"10.1007/s00403-025-04372-y","DOIUrl":"10.1007/s00403-025-04372-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of keratinocyte carcinoma incidence on the scalp and forehead of non-alopecic women: a retrospective review","authors":"Lydia A. Luu,&nbsp;Wendy Novicoff,&nbsp;Julian Stashower,&nbsp;Seth Martin,&nbsp;Mark Russell","doi":"10.1007/s00403-025-04378-6","DOIUrl":"10.1007/s00403-025-04378-6","url":null,"abstract":"<div><p>Keratinocyte carcinomas are the most frequently diagnosed form of malignancy, and ultraviolet radiation exposure is a primary risk factor. Human head hair offers some protection from ultraviolet radiation, and women often wear hairstyles that result in variable scalp exposure to sunlight. The distribution of keratinocyte carcinomas of the forehead and scalp of women has not been previously studied. To better characterize the incidence and distribution of keratinocyte carcinomas on the scalp and forehead of non-alopecic females, a retrospective chart review was performed of keratinocyte carcinomas diagnosed and treated at a single tertiary care center between July 2017 and October 2021. Tumor and patient characteristics were compiled and analyzed. 302 cases of keratinocyte carcinomas occurring on the scalp and forehead of non-alopecic women were identified. Basal cell carcinoma occurred at a higher rate than squamous cell carcinoma (231 vs. 71). Both basal cell carcinomas and squamous cell carcinomas were more likely to occur within the part line on the scalp (<i>p</i> = 0.036). There was also an increased risk of developing keratinocyte carcinomas on the upper third of the forehead, although this observation did not reach statistical significance (<i>p</i> = 0.165). Keratinocyte carcinomas of the scalp and forehead are more likely to occur in the part line of the scalp. This information can guide dermatologists during clinical exams and when counseling patients on performing proper sun-protective measures.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04378-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a case finding algorithm for cicatricial alopecias using administrative coding from a clinical database","authors":"Mackenzie Johnson,&nbsp;Andrew Strunk,&nbsp;Amit Garg","doi":"10.1007/s00403-025-04365-x","DOIUrl":"10.1007/s00403-025-04365-x","url":null,"abstract":"<div><p>Small cohort sizes limit the ability to characterize the incidence, prevalence, comorbidities and other health outcomes, and therapeutic strategies for patients with cicatricial alopecias (CA). Establishing larger cohorts of patients within clinical databases for observational study of CAs requires a method to accurately identify cases. We aimed to assess the accuracy of using diagnostic codes to identify female patients with subtypes of primary CAs in an outpatient clinical database. Female patients aged 18 or older with at least one International Classification of Diseases, 10th Revision (ICD-10) code of “other cicatricial alopecia” (L66.8) or “cicatricial alopecia, unspecified (L66.9) applied during a dermatology encounter at Northwell Health between October 1st, 2015, and May 10th, 2024 were randomly sampled. Cases of lichen planopilaris (LPP) were excluded, since a validated case definition for LPP has previously been reported. There were 149 charts reviewed for confirmation of a diagnosis of non-LPP CA. Among confirmed cases of non-LPP CAs, 84.4% identified as African American. Among confirmed CA cases, 82.9%, 13.5% and 3.6% were diagnosed with central centifugal cicatricial alopecia, traction alopecia, and frontal fibrosing alopecia, respectively. The positive predictive value (PPV) for at least 1 code for L66.8 or L66.9 applied by a dermatologist was 74.5% [111/149 (95% CI 69.2–79.8%)]. The PPV for at least 2 codes of interest, with at least 1 applied by a dermatologist, was 75.0% [57/76 (95% CI 67.8–82.2%)]. Requiring at least 2 codes of interest applied by a dermatologist yielded a PPV of 75% [48/64 (95% CI 67.0–83.0%)]. Restriction to at least 1 code for either L66.8 or L66.9 and no code for LPP (L66.1) resulted in a slightly increased PPV of 80.0% [108/135 (95% CI 74.9–85.1%)]. In conclusion, administrative data can be used with a moderate to high degree of reliability to identify patients with non-LPP CAs in clinical databases.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of AI integration into dermatology EHRs","authors":"Mohamad Goldust,&nbsp;Jane M. Grant-Kels","doi":"10.1007/s00403-025-04386-6","DOIUrl":"10.1007/s00403-025-04386-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association between low-dose oral minoxidil and edema: a retrospective study of non-scarring alopecia patients","authors":"Zachary J. K. Neubauer,&nbsp;Michael M. Ong,&nbsp;Henry I. Lipner,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-025-04364-y","DOIUrl":"10.1007/s00403-025-04364-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of efficacy and safety of intralesional ionic contraviral therapy versus intralesional methotrexate in treatment of plantar warts","authors":"Norhan Raafat Mohamed Omar,&nbsp;Moshira Mohamed Ali,&nbsp;Asmaa Mohamed Elbakery Mohamed,&nbsp;Hala M. Elsadek","doi":"10.1007/s00403-025-04358-w","DOIUrl":"10.1007/s00403-025-04358-w","url":null,"abstract":"<div><p>Warts are a common dermatological problem caused by human papillomavirus (HPV). There are various therapeutic techniques for warts, including chemical, physical, destructive, anti-proliferative and immunotherapy. Ionic contra-viral therapy (ICVT) (furosemide and digoxin) is a novel therapeutic approach for the treatment of warts. Methotrexate (MTX) is a chemotherapeutic agent with cytotoxic properties commonly prescribed in dermatology. This clinical study aimed to assess and compare the efficacy and safety of intralesional ICVT (digoxin and furosemide) versus intralesional methotrexate in the treatment of plantar warts. This comparative study included forty patients with multiple plantar warts who were classified into 2 groups: Group I (20 patients) treated with intralesional ICVT and group II (20 patients) treated with intralesional methotrexate, weekly till improvement or for a maximum of 5 sessions. Clinical and dermoscopic evaluation at base line, each session and monthly for 3 months after last session. Group I showed a statistically significant reduction of number and size of warts, (70%) of patients showed complete clearance compared with only (10%) in group II. Regarding dermoscopic findings, in group I there was a highly statistically significant reduction of dotted, linear blood vessels, pink or red background and well or ill-defined margin of warts before and after treatment. Additionally, there was a statistically significant reduction of yellow or grey background and smooth surface scales. However, group I has more frequent side effects with 70% reporting pain, (15%) reporting burning sensation and 5% having erythema compared with (20%) only in group II complaining of pain. In Conclusion Intralesional injection of ICVT (digoxin and furosemide) was effective and superior to intralesional methotrexate in treatment of planter wart.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of disease severity with adropin levels and thyroid hormones in psoriasis patients","authors":"Fikret Akyurek,&nbsp;Fatma Tuncez-Akyurek,&nbsp;Fatma Sengul-Bag","doi":"10.1007/s00403-025-04366-w","DOIUrl":"10.1007/s00403-025-04366-w","url":null,"abstract":"<div>\u0000 \u0000 <p>Psoriasis is a complex disease that goes beyond the skin lesions and is accompanied by systemic inflammation, metabolic disorders and endocrine disorders. Adropin is a peptide with regulatory effects on energy metabolism, inflammatory reactions and vascular functions. The aim of this study was to determine serum adropin levels and thyroid hormone parameters in patients with psoriasis and to investigate the relationship between adropin levels and disease severity, metabolic profile and inflammatory markers. The study included 50 patients with psoriasis and 39 healthy volunteers. Anthropometric measurements, metabolic and inflammatory parameters, thyroid function tests and serum adropin levels were analyzed in all participants. The severity of the disease was assessed using the Psoriasis Area and Severity Index (PASI). The differences between the groups were statistically compared and the correlations between adropin levels and clinical/biochemical variables were analyzed. In addition, the diagnostic value of adropin in discriminating disease status was assessed by ROC analysis. In the patient group, body mass index (BMI), waist circumference, hs-CRP, triglycerides and TPO-Ab levels were statistically significantly higher, while HDL-C and adropin levels were significantly lower compared to the control group (<i>p</i> &lt; 0.05). Serum adropin levels showed a negative correlation with hs-CRP, BMI and waist circumference. The ROC analysis revealed poor discriminatory power of adropin in distinguishing patients from controls (AUC = 0.252), with low sensitivity (4.0%) but high specificity (100.0%). Although adropin did not demonstrate diagnostic utility, its inverse association with systemic inflammation highlights its biological relevance in the pathophysiology of psoriasis. Elevated TPO-Ab levels in the patient group further support the coexistence of autoimmune and endocrine components in psoriasis. These findings suggest that adropin may serve as a biomarker of systemic involvement rather than skin lesion severity in psoriasis and could contribute to understanding disease pathophysiology and related comorbidities. Therefore, while adropin does not appear to be suitable for diagnostic use in psoriasis, it retains biological significance in reflecting systemic metabolic and inflammatory dysregulation.</p>\u0000 </div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of COVID-19 infection and vaccination on adults with atopic dermatitis","authors":"Kuo-Tung Tang,&nbsp;Wen-Nan Huang,&nbsp;Wei-Ting Hung,&nbsp;Yi-Hsing Chen","doi":"10.1007/s00403-025-04349-x","DOIUrl":"10.1007/s00403-025-04349-x","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures in Stevens–Johnson syndrome/toxic epidermal necrolysis: a systematic review","authors":"Sushila A. Toulmin,&nbsp;Melissa Hoffman,&nbsp;Megan H. Noe,&nbsp;Arash Mostaghimi,&nbsp;Robert G. Micheletti","doi":"10.1007/s00403-025-04362-0","DOIUrl":"10.1007/s00403-025-04362-0","url":null,"abstract":"<div><p>Evidence supporting Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) management strategies is limited by small sample sizes and heterogeneous, poorly defined outcomes. An improved understanding of the selection and definition of commonly reported SJS/TEN outcome measures may facilitate the adoption of more precise, clinically meaningful metrics for use in future studies. A systematic review was performed using searches of PubMed, Scopus, and Embase databases, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All English language articles with at least 10 patients that reported outcomes of SJS/TEN and met prespecified criteria were included. A total of 282 studies met inclusion criteria. Out of 304 primary outcomes identified, only 47 (15.5%) were explicitly stated. The most common primary outcome was mortality (231/304; 76.0%), the timing and cause of which was clearly defined in only 39.8% of cases (92/231). The next most common primary outcome was skin healing (6.9%; 21/304), which was poorly defined and extremely heterogeneous across studies. A wide variety of other primary and secondary outcome measures were reported, such as hospital length of stay and infectious, pulmonary, and other complications. In summary, in most SJS/TEN studies, reported outcomes needed to be inferred, were poorly defined, and varied widely across studies, limiting generalizability and posing significant barriers to understanding SJS/TEN natural history and response to therapy. Future studies should seek rigorous definition and validation of standardized outcome measures for use in SJS/TEN clinical trials.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Specific factors associated with emergency department visits for flares in patients with hidradenitis suppurativa: a case-control study","authors":"Bruna G. O. Wafae,&nbsp;Karla Santiago-Soltero,&nbsp;Natalie M. Baker,&nbsp;Megan H. Noe,&nbsp;Alexandra P. Charrow","doi":"10.1007/s00403-025-04363-z","DOIUrl":"10.1007/s00403-025-04363-z","url":null,"abstract":"<div><p>Adults with hidradenitis suppurativa (HS) often present to the Emergency Department (ED) for flare management despite long waits and non-dermatologic expertise. A case-control study was conducted at a US academic medical center to identify patient-specific factors contributing to ED visits for HS flares. The study included 676 HS patients who visited either the ED or dermatology clinic for an HS flare. Patient-level data was collected including demographics, socioeconomic factors, HS treatments, disease severity, and comorbidities. The primary outcome was ED visit for HS flare. Multivariable logistic regression was used to identify risk factors for ED visits. Of 676 flaring patients, 394 presented to the dermatology clinic and 283 to the ED. ED patients were younger, more likely to identify as Black (35.3% vs. 30%, <i>p</i> &lt; 0.001), be publicly insured (26.9% vs. 15.3%, <i>p</i> &lt; 0.001), and have prior ED use (OR = 1.73, 95% CI 1.42–2.12) versus clinic patients. Repeat ED visits were associated with male gender (OR = 1.21, 95% CI 1.01–1.45) and ED visits for other reasons (OR = 1.13, 95% CI 1.07–1.18). In sum, this study identifies patient-specific factors driving ED visits for HS flares, providing a more nuanced understanding of patients at higher risk for ED presentation, and highlighting potential opportunities to improve patient outcomes.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}