Archives of Dermatological Research最新文献

{"title":"Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy","authors":"Chou-Yi Hsu,&nbsp;Harish C. Chandramoorthy,&nbsp;Jaafaru Sani Mohammed,&nbsp;Shaker Al-Hasnaawei,&nbsp;Mohammed Yaqob,&nbsp;Mayank Kundlas,&nbsp;Krishnakumar Samikan,&nbsp;Samir Sahoo,&nbsp;S. K. Sunori,&nbsp;Zainab Ahmed Abbas","doi":"10.1007/s00403-025-04237-4","DOIUrl":"10.1007/s00403-025-04237-4","url":null,"abstract":"<div><p>Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between vitiligo and allergic diseases: a bidirectional two-sample Mendelian randomization study","authors":"Ri Zhang,&nbsp;Zeqi Shi,&nbsp;Xiaoqi Nie,&nbsp;Yujia Wei,&nbsp;Dong Li","doi":"10.1007/s00403-025-04047-8","DOIUrl":"10.1007/s00403-025-04047-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04047-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and disease burden in Chinese patients with prurigo nodularis","authors":"Xinming Mai,&nbsp;Yan Liao,&nbsp;Chener Yang,&nbsp;Lu Wei,&nbsp;Mengting Yin,&nbsp;Xu Yang,&nbsp;Jiaying Chen,&nbsp;Ruimiao Wu,&nbsp;Xia Dou","doi":"10.1007/s00403-025-04229-4","DOIUrl":"10.1007/s00403-025-04229-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin levels in scarring and nonscarring alopecia: a cross-sectional study from the All of Us database","authors":"Shanelle Jackson,&nbsp;Arielle Carolina Mora Hurtado,&nbsp;Kevin Puerta Durango,&nbsp;Charissa Obeng-Nyarko,&nbsp;Jack Rodman,&nbsp;Susan C. Taylor,&nbsp;Nada Elbuluk","doi":"10.1007/s00403-025-04228-5","DOIUrl":"10.1007/s00403-025-04228-5","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast view on the first resistant dermatophyte to terbinafine, Trichophyton rubrum","authors":"Ali Abdul Hussein S. AL-Janabi","doi":"10.1007/s00403-025-04220-z","DOIUrl":"10.1007/s00403-025-04220-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Simvastatin in the treatment of vitiligo: a systematic review and meta-analysis of randomized controlled trials","authors":"Song Zhang,&nbsp;Ibrahim Serag,&nbsp;Shereen Mohamed Olama,&nbsp;Mahmoud G. A. Saleh,&nbsp;E. A. Shaban,&nbsp;Mostafa Hossam El Din Moawad","doi":"10.1007/s00403-025-04234-7","DOIUrl":"10.1007/s00403-025-04234-7","url":null,"abstract":"<div><p>Vitiligo is an autoimmune skin disorder characterized by progressive depigmentation due to melanocyte destruction. Despite various treatment options, achieving complete repigmentation remains challenging. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has demonstrated anti-inflammatory and immunomodulatory effects, making it a promising candidate for vitiligo treatment. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of Simvastatin in vitiligo treatment. A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted following PRISMA guidelines. Only RCTs comparing Simvastatin with a control or pre-post Simvastatin assessments in vitiligo patients were included. Six RCTs with a total of 371 patients met the eligibility criteria. The primary outcomes analyzed were VASI reduction and excellent repigmentation response (≥ 75% repigmentation). Secondary outcomes included changes in total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels. Meta-analyses were performed using a random-effects model, and heterogeneity was assessed using the I² statistic. Simvastatin significantly reduced VASI scores (SMD = −0.30; 95% CI −0.52–−0.07, p = 0.010; I² = 0%). The likelihood of achieving excellent repigmentation (≥ 75%) was significantly higher in the Simvastatin group (OR = 6.54; 95% CI 1.08–38.42, p = 0.04; I² = 0%). Additionally, Simvastatin led to a significant reduction in total cholesterol (−62.1 mg/dL; 95% CI −74.0–−50.2, p &lt; 0.00001; I² = 0%), triglycerides (−65.08 mg/dL; 95% CI −89.81–−40.35, p &lt; 0.00001; I² = 69%), and LDL (−66.13 mg/dL; 95% CI −77.50–−54.76, p &lt; 0.00001; I² = 90%). Simvastatin demonstrates significant efficacy in vitiligo treatment, improving VASI scores and repigmentation while also lowering lipid levels. This is the first meta-analysis on this topic, providing evidence for Simvastatin as a potential adjunct therapy. Further large-scale RCTs are needed to validate these findings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of current dermatopathology training across U.S. residency programs","authors":"Evelyn F. Fagan,&nbsp;Joseph T. McGrath,&nbsp;Divya Sharma,&nbsp;Sierra Thomas,&nbsp;Corey Georgesen,&nbsp;Erin X. Wei","doi":"10.1007/s00403-025-04185-z","DOIUrl":"10.1007/s00403-025-04185-z","url":null,"abstract":"<div><p>Dermatopathology (DP) is integral to dermatology residency training, aiding in accurate diagnoses and clinical interpretations. This study evaluates the current state of DP education and faculty backgrounds in dermatology residency programs, using information available on 142 ACGME-accredited dermatology residency programs. The focus was on DP training, including dedicated rotations, training years, and duration as well as DP faculty and fellowship opportunities. Of the programs analyzed, 53.52% offered distinct DP rotations. Residents in these programs spent an average of 11.37 weeks in DP training, with 70.83% providing DP exposure in the first year. The average number of board-certified dermatopathologists per program was 2.91 (SD = 2.11); however, 23.19% of programs lacked dermatology-trained dermatopathologists. DP fellowships were available in 36.62% of programs and among fellowship directors, 63.46% were board-certified in anatomic pathology and 51.98% in dermatology. While DP training is widely offered, the extent and structure of this training vary across residency programs with many lacking dedicated rotations or first-year exposure. Both dermatology-trained and pathology-trained dermatopathologists contribute to academic settings, although fellowship directors are more commonly trained in pathology. This highlights the need for greater consistency and clarity in DP training across residency programs to ensure comprehensive exposure in this essential field.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying key targets and immune environment in wound healing based on iron overload-related genes","authors":"Yinbo Peng,&nbsp;Juxiang Sheng,&nbsp;Tiantian Liu,&nbsp;Ruizhe He,&nbsp;Peng Xu","doi":"10.1007/s00403-025-04140-y","DOIUrl":"10.1007/s00403-025-04140-y","url":null,"abstract":"<div><p>Wound healing (WH) poses a significant socio-economic burden due to its high incidence and recurrence rates. Iron overload (IO) could be a factor leading to delayed WH. This study thus analyzed IO-related genes (IORGs) in WH, offering possibilities for developing new therapeutic strategies. Differential gene expression (DEGs) analysis was conducted between the WH group and intact skin (IS) group, intersected with IORGs to obtain differentially expressed IORGs (DE-IORGs). Functional enrichment analysis and potential drug screening were performed on DE-IORGs. A protein–protein interaction (PPI) network of DE-IORGs was constructed, and hub genes were identified using CytoHubba and MCODE methods. ROC curves of hub genes were plotted, and their expression levels in WH and IS groups as well as inter-gene correlations were analyzed. Additionally, immune infiltration variances in WH and IS groups, along with miRNA and TFs of hub genes, were examined. Finally, the effect of EGFR on skin wound healing was verified by scratch healing assay. 39 DE-IORGs were predominantly enriched in signaling pathways like HIF-1 signaling pathway and Th17 cell differentiation. Potential drugs for treating WH (e.g., felbamate, SA-94315, GANT-58, rucaparib) were identified. Three hub genes related to IO in WH were pinpointed (HIF1A, CDKN2A, EGFR) with diagnostic value. Immune infiltration analysis showed higher levels of immune cells like endothelial cells and macrophages in the WH group. Additionally, 55 miRNAs (e.g., hsa-mir-200a-3p, hsa-mir-218-5p) and 2 TFs (L3MBTL2, ZNF76) regulating the three hub genes were predicted. Cell experiments showed that EGFR could promote skin wound healing. The study suggested HIF1A, CDKN2A, and EGFR as potential diagnostic biomarkers for effective WH diagnosis, offering new insights into identifying potenti1al therapeutic targets for WH treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enduring outcomes of minimally ınvasive approaches for facial rejuvenation","authors":"Elif Sari,&nbsp;Aynur Aliyeva","doi":"10.1007/s00403-025-04238-3","DOIUrl":"10.1007/s00403-025-04238-3","url":null,"abstract":"<div><p>Facial rejuvenation procedures have gained popularity as individuals seek nonsurgical methods to address signs of aging. These procedures encompass a range of minimally invasive techniques, including botulinum toxin applications, dermal fillers, PRP, and thread lifting. This study aimed to assess patient satisfaction and evaluate the short- and long-term outcomes of these minimal invasive facial rejuvenation procedures. Patients aged 18–65 who underwent facial rejuvenation at an Ear, Nose, and Throat Clinic were included. Procedures had botulinum toxin applications, dermal fillers, PRP, and PDO threads. Follow-up evaluations were conducted at 4–6 months for botulinum toxin and PRP and one year for other procedures. Visual analog scales and self-satisfaction measured beauty perception data after treatments. Botulinum toxin applications effectively reduced dynamic wrinkles, while dermal fillers provided volumetric support with varying longevity. PRP improved skin tone, brightness, moisture, and fine wrinkles. Patient satisfaction levels varied across procedures. Minimal invasive facial rejuvenation procedures offer a nonsurgical approach to address aging-related concerns. Botulinum toxin, dermal fillers, PRP, and PDO threads provide unique benefits, but their outcomes and satisfaction levels differ among patients. Understanding these variations is crucial for informed decision-making in facial rejuvenation.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of sleep disturbances and signs of attention deficit and hyperactivity disorder in schoolchildren with atopic dermatitis","authors":"Priscila Vernizi Roth,&nbsp;Marcela Fisher de Almeida,&nbsp;Enzo Paolo Brandão Gouveia,&nbsp;Renata Drizlionoks,&nbsp;Rafaela Cachiolo Antunes,&nbsp;Mariana Aparecida Pasa Morgan,&nbsp;Ana Chrystina Souza Crippa,&nbsp;Vânia Oliveira Carvalho","doi":"10.1007/s00403-025-04235-6","DOIUrl":"10.1007/s00403-025-04235-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}