Archives of Dermatological Research最新文献

{"title":"Can good sleep quality enhance the benefits of oral collagen supplementation in the prevention of skin aging? A brief report","authors":"Ellen M. S. Xerfan,&nbsp;Maingredy Rodrigues Souza,&nbsp;Anamaria S. Facina,&nbsp;Sergio Tufik,&nbsp;Monica L. Andersen","doi":"10.1007/s00403-025-03860-5","DOIUrl":"10.1007/s00403-025-03860-5","url":null,"abstract":"<div><h3>Introduction</h3><p>Collagen is essential to skin structure and integrity, and it is continually degraded with aging due to higher oxidative stress. Sleep deprivation accelerates skin aging and reduces collagen production. Good sleep may be a potential adjuvant to the efficacy of oral supplementation with collagenic peptides for the skin.</p><h3>Objectives</h3><p>To summarize clinical benefits to the skin of collagen intake, and consider the role of sleep in its effectiveness.</p><h3>Methods</h3><p>Studies in the PubMed database that reported the effects of oral administration of collagen peptides were searched; and studies presenting the association of collagen metabolism with sleep.</p><h3>Results</h3><p>A total of 1117 articles were initially identified; 66 were reviewed in full. Most involved women at third or fourth decade of life. Daily collagen doses ranged from 1 to 10 g, with intervention periods lasting from 4 to 8 weeks. Consistent improvements in skin elasticity, hydration, and wrinkle reduction were observed, with increase in dermal density and structural proteins. Collagen combined with vitamins, minerals, and antioxidants provided additional benefits, including improved skin radiance and reduced pore size. Studies on sleep and skin indicated that poor sleep can impair skin hydration, increase transepidermic water loss, and reduce elasticity, highlighting the potential role of sleep in maximizing the benefits of collagen supplementation.</p><h3>Conclusions</h3><p>Hydrolyzed collagen supplementation, particularly at 2.5 g/day, has shown benefits for skin after 4 weeks of use. Sleep quality may enhance these effects by supporting immune function and reducing oxidative stress. Further studies are needed on sleep’s role in enhancing collagen supplementation benefits.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Project ECHO® dermatology in the deep south: a comprehensive SWOT assessment","authors":"Carlie Reeves,&nbsp;Rahib K. Islam,&nbsp;Chelsea S. Mockbee,&nbsp;Stephen E. Helms,&nbsp;Thy N. Huynh,&nbsp;La’Kitha Hughes,&nbsp;Deangela M. Ivory,&nbsp;Josh T. Clark,&nbsp;Jeremy D. Jackson,&nbsp;Robert T. Brodell,&nbsp;Vinayak K. Nahar","doi":"10.1007/s00403-025-03874-z","DOIUrl":"10.1007/s00403-025-03874-z","url":null,"abstract":"<div><p>There are nearly 45,000 patients for each dermatologist in the rural State of Mississippi, causing many patients to wait months for an appointment in a city that may be hours away [1]. To address this critical gap, Project ECHO^® (Extension for Community Healthcare Outcomes) was launched at the University of Mississippi Medical Center (UMMC) in 2020 to teach rural primary care providers (PCPs) to care for common skin conditions. PCPs present images of their patients in a once monthly video teleconference that provides immediate feedback. A SWOT analysis (Strengths, Weaknesses, Opportunities, and Threats) of the UMMC dermatology Project ECHO^® was conducted to assess the efficacy of this approach. The greatest strength is the perception of value by attendees which is reflected by growing numbers of primary care physician participants. This engagement is tracked by the number of people who join the teleconference virtually. The greatest threat is the inability to motivate participants to complete post-teleconference surveys for program feedback. This limits the ability of the program to fully assess its efficacy and identify opportunities for improvement. Looking forward, UMMC plans to offer incentives for survey completion and expand Project ECHO’s reach by collaborating with other institutions to permit harmonization of metrics and facilitate data analysis for publications and grant applications.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample mendelian randomization analysis","authors":"Chenyang Yu,&nbsp;Wei Yan,&nbsp;Huidi Shucheng,&nbsp;Yingzhao Huang,&nbsp;Xian Jiang","doi":"10.1007/s00403-024-03702-w","DOIUrl":"10.1007/s00403-024-03702-w","url":null,"abstract":"<div><p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with unique lesional dysbiotic features. However, the role of the microbiology in the pathogenesis of HS remains in dispute. We aimed to conduct a two-sample Mendelian randomization study to investigate the relationship between skin microbiota and HS. A two-sample Mendelian randomization study was performed using the summary statistics of skin microbiota from summary GWAS data of the European descent from two cross-sectional, population-based German cohorts, KORA FF4 (<i>n</i> = 324) and PopGen (<i>n</i> = 273). The summary statistics of hidradenitis suppurativa were obtained from the FinnGen DF10 (1,070 cases and 394,105 controls). Inverse variance weighted (IVW), MR-Egger regression, weighted median, simple mode, weighted mode, and MRPRESSO were used to examine the causal association between skin microbiota and hidradenitis suppurativa. Cochran’s Q statistics were used to quantify the heterogeneity of instrumental variables. Our study suggested that genus <i>Corynebacterium</i> in dry skin is significantly associated with HS after false discovery rate (FDR) correction (odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02–1.06, <i>P</i> = 0.0002, FDR adjusted <i>P</i> = 0.035). Additionally, we found genus <i>Micrococcus</i> in moist skin (OR = 1.10, 95% CI: 1.03–1.18, <i>P</i> = 0.0060, FDR adjusted <i>P</i> = 0.360), species <i>Streptococcus salivarius</i> in dry skin (OR = 1.03, 95% CI: 1.01–1.05, <i>P</i> = 0.0070, FDR adjusted <i>P</i> = 0.360), and species <i>Propionibacterium granulosum</i> (OR = 1.02, 95% CI: 1.00–1.04, <i>P</i> = 0.0460, FDR adjusted <i>P</i> = 0.970) are potentially associated with HS before FDR adjustment. No evidence of the effect in the reverse direction for HS on skin microbial features. This two-sample Mendelian randomization study found that genus <i>Corynebacterium</i> was causally associated with HS. Further studies are needed to clarify the protective effect of prebiotics, probiotics or microbiome transplants on HS.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daylight versus pro yellow laser (577 nm) photodynamic therapy mediated with methylene blue (10%) in plane warts: a comparative study","authors":"Osama Elshabory,&nbsp;Zakaria M. Obaid,&nbsp;Magda A. Abdelfattah,&nbsp;Mohamed L. Elsaie","doi":"10.1007/s00403-025-03851-6","DOIUrl":"10.1007/s00403-025-03851-6","url":null,"abstract":"<div><p>Warts are small, benign growths caused by human papilloma virus (HPV) infection of the skin or mucous membrane. Photodynamic therapy in dermatology is simplified by the accessibility of the skin to light application and allows using any light source with the appropriate spectrum. This study aimed to compare the efficacy and safety of daylight-PDT versus pro yellow laser (577 nm)-PDT mediated by 10% methylene blue (MB) gel in the treatment of plane warts. This prospective comparative study was carried out on 34 patients presented with common warts (≥ 1 warts). Patients were divided into two equal groups by simple randomization process. Group 1: treated with daylight PDT using MB (MB-DL PDT), group 2: treated with Pro yellow laser as PDT using MB. The results of the present study revealed excellent response of warts in 9 patients (52.9%), very good response in 4 patients (23.5%) and poor response in 2 patients (11.8%) of group (1). In group (2), excellent response of the treated warts was observed in 5 patients (29.4%), poor response in 5 patients (29.4%) and no response in 7 patients (41.2%). Daylight-photodynamic therapy (DL-PDT) using MB is an effective treatment, nearly pain free and of convenience to patients. Careful consideration should be given to patient-specific factors such as immune status and previous treatment history. Future research with larger sample sizes, HPV genotyping, and longer follow-up periods is warranted to optimize patient-tailored PDT protocols.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin is not associated with an increased risk of diabetes: a retrospective cohort study","authors":"David Garate,&nbsp;Christopher J. Thang,&nbsp;Jenny Lai,&nbsp;George Golovko,&nbsp;Michael G. Wilkerson,&nbsp;John S. Barbieri","doi":"10.1007/s00403-025-03876-x","DOIUrl":"10.1007/s00403-025-03876-x","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large-scale analysis of racial disparities in management of psoriatic disease","authors":"Sammer Marzouk,&nbsp;Amaan Musabji,&nbsp;Osama Hassan,&nbsp;Sawsan Alkhalili,&nbsp;Taaha Hassan,&nbsp;Ramzy Issa,&nbsp;Sara Muttar,&nbsp;Peter Lio","doi":"10.1007/s00403-025-03904-w","DOIUrl":"10.1007/s00403-025-03904-w","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phthalate exposure and rash eczema disease: based on NHANES 2005–2006","authors":"Qiming Mu,&nbsp;Fan Hu,&nbsp;Yingying Shen,&nbsp;Yong Zheng,&nbsp;Xiao Ye,&nbsp;Yufang Liu","doi":"10.1007/s00403-025-03858-z","DOIUrl":"10.1007/s00403-025-03858-z","url":null,"abstract":"<div><p>Phthalates are commonly found in plastic products, personal care products, and food packaging. In recent years, the relationship between phthalates and skin diseases such as eczema has been gaining attention. As endocrine disruptors, phthalates may increase the risk of eczema by affecting the immune system or skin barrier function. This study used a cross-sectional design based on data from the 2005–2006 National Health and Nutrition Examination Survey to assess the association between phthalate exposure and eczema in adults using generalized linear models, restricted cubic spline plots and weighted quantile sum regression. Eczema diagnosis was determined by participants' self-report of whether they had ever been diagnosed with eczema by doctors. Phthalate exposure was assessed by urinary concentrations of phthalates. A total of 1203 subjects, aged 18 years and over, were recruited for the study, comprising 627 males and 576 females. We found that females had significantly higher phthalate exposure concentrations than males. There was a significant positive correlation between monoisononyl phthalate (MiNP) and eczema. Mixture analysis similarly found a positive correlation between phthalates and rash eczema, and MiNP was the main contributor. Further sex-stratified analyses showed that this association occurred predominantly in females, while no significant association was found in the male population. Phthalates may have adverse effects on skin health, particularly in women. Future studies should further investigate the mechanisms of this association and focus on other types of phthalates and their effects on skin health.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on helicobacter pylori and acne vulgaris: is there a relationship?","authors":"Saad Khan,&nbsp;Syeda Mashal Fatima,&nbsp;Bilal Ahmad,&nbsp;Tirath Patel,&nbsp;Iftikhar Khan","doi":"10.1007/s00403-025-03834-7","DOIUrl":"10.1007/s00403-025-03834-7","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Spironolactone in treating patients with acne vulgaris: a systematic review and meta-analysis of 1,086 patients","authors":"Mohamed Farrag,&nbsp;Ahmed A. Abo Elnaga,&nbsp;Mohamed A. Alsaied,&nbsp;Ibrahim Serag,&nbsp;Mohamed Karam Allah Elkholy,&nbsp;Omar H. Ibrahim,&nbsp;Abdelrahman M. Elettreby","doi":"10.1007/s00403-025-03815-w","DOIUrl":"10.1007/s00403-025-03815-w","url":null,"abstract":"<div><p>Acne vulgaris affects 9% of the global population, particularly women, affecting their quality of life. Topical treatments are preferred for mild acne, while systemic management is necessary for moderate and severe cases. Spironolactone, an androgen receptor inhibitor, may be effective for severe acne, although no concrete evidence exists. A comprehensive literature search was conducted on five databases up until July 25th, 2024, to evaluate the effectiveness or safety of Spironolactone for acne vulgaris. A meta-analysis using R software was conducted to assess the total number of lesions, acne severity score, adverse events, mean count of comedones, papules, and pustules, and acne severity. Search process identified 14 studies (<i>n</i> = 1,086). Meta-analysis found that Spironolactone 5% was more effective than placebo in reducing total lesion count and acne severity index (ASI) (MD − 6.85, 95% CI [-10.94; −2.76], <i>P</i> &lt; 0.01) and (MD − 6.33, 95% CI [− 8.89; −3.76], <i>P</i> &lt; 0.01) respectively. The 100 mg group showed a significant improvement in ASI compared to the topical group. A meta-analysis of randomized controlled trials found no significant difference in comedones and pustules count over 6–8 weeks, while single-arm studies showed significant improvement after 8 weeks. Meta-analysis found that spironolactone 5% significantly reduced total lesion count and acne severity index after eight weeks, while also reducing comedones and papules. The safety profile is excellent. The limited number of eligible studies and evidence from single-arm studies indicates the need for more randomized controlled trials.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keyword mapping and publication trends in autophagy in immune-related skin diseases","authors":"Waseem Hassan","doi":"10.1007/s00403-025-03843-6","DOIUrl":"10.1007/s00403-025-03843-6","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}