Archives of Dermatological Research最新文献

{"title":"The effect of plasma exosomal microRNA- 148a- 3p on the CD4+ T cell function and its mechanism in the pathogenesis of psoriasis","authors":"Ling Lin,&nbsp;Wei Li,&nbsp;Xinjing Gao,&nbsp;Qian Li,&nbsp;Xin Zhou,&nbsp;Weiyu Liu,&nbsp;Xuelian Zhong,&nbsp;Yunqing Yang,&nbsp;Xibao Zhang,&nbsp;Quan Luo","doi":"10.1007/s00403-025-04197-9","DOIUrl":"10.1007/s00403-025-04197-9","url":null,"abstract":"<div><p>Psoriasis represents a chronic inflammatory skin disease occurring globally. We investigated the role of plasma exosomal microRNA (miR)- 148a- 3p and its target gene Bim in psoriasis. Plasma exosomes (Exos) and CD4⁺ T cells were extracted from psoriatic patients. miR- 148a- 3p expression in Exos and CD4⁺ T cells of psoriatic patients, the proportions of CD4⁺ T cell subsets, and the contents of anti-inflammatory/pro-inflammatory factors were determined by RT-qPCR, flow cytometry and ELISA. The correlation between plasma exosomal miR- 148a- 3p and CD4⁺ T cell subsets in psoriatic patients was analyzed by Pearson’s analysis. The psoriatic mouse was treated with Exos/antagomir miR- 148a- 3p. Histopathological changes in the skin were observed. The CD4⁺ T cell subset levels, serum cytokine contents and miR- 148a- 3p expression in the blood were measured. The miR- 148a- 3p-Bim targeted binding relationship was predicted and verified by Starbase database and dual-luciferase assay. The Bim expression in psoriatic mice was determined. Psoriatic patients had highly-expressed miR- 148a- 3p in both Exos and CD4⁺ T cells, and abnormal CD4⁺ T cell subsets and cytokine levels. Plasma exosomal miR- 148a- 3p was correlated with the CD4⁺ T cell subsets in psoriatic patients. Exos caused down-regulated miR- 148a- 3p level in skin tissues of mouse, regulated CD4⁺ T cell function and aggravated the symptoms in psoriatic mice. miR- 148a- 3p repression partially reversed the role of Exos in CD4⁺ T cell function and psoriasis-like symptoms. Exos-carried miR- 148a- 3p targeted Bim in CD4⁺ T cells of psoriatic mice. Plasma exosomal miR- 148a- 3p targeted Bim to affect the dysfunction of CD4⁺ T cells in psoriatic mice, thereby aggravating the psoriasis-like symptoms.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pruritus biomarkers expression in chronic spontaneous urticaria","authors":"Gabriel Paschoaleto Rodrigues Lopes,&nbsp;Yasmim Álefe Leuzzi Ramos,&nbsp;Naiura Vieira Pereira,&nbsp;Mírian Nacagami Sotto,&nbsp;Joyce Tiyeko Kawakami,&nbsp;Marcella Soares Pincelli,&nbsp;Maria Notomi Sato,&nbsp;Maira Pedreschi Marques Baldassin,&nbsp;Alessandra Dellavance,&nbsp;Luis Eduardo Coelho Andrade,&nbsp;Raquel Leão Orfali,&nbsp;Celina Wakisaka Maruta","doi":"10.1007/s00403-025-04170-6","DOIUrl":"10.1007/s00403-025-04170-6","url":null,"abstract":"<div><p>Chronic urticaria (CU) is a skin disease characterized by recurrent episodes of urticaria and/or angioedema, persisting for more than six weeks. Chronic urticaria is classified as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). Histamine, released by mast cells and basophils, is the central mediator in the development of signs and symptoms, especially pruritus. IL-31 activates pruritus via IL-31RA. Th2 cytokines also contributes to the inflammatory environment, releasing further IL-31. We aimed to investigate the quantification of mast cells, expression of pro-inflammatory cytokines in skin samples from individuals with CU and cell activation by the basophil activation test. Thirteen patients with CSU, 11 patients with CIndU and 10 healthy controls (HC) were enrolled in the study. We performed histologic quantification of the mast cells, metachromatic stained with toluidine blue, in CSU and CIndU lesional samples; IL-31, IL-31RA, IL-4 and IFN-γ expression by immunohistochemistry; and basophil activation test (BAT) by flow cytometry. The main findings were increased mast cell quantification in CSU; increased epidermal and dermal expression of IL-31 in CSU lesional samples and increased dermal expression in CIndU samples; augmented IL-31RA expression at epidermis and dermis of CSU group; augmented expression IL-4 at epidermis of CSU patients. We also found enhanced BAT positivity in CSU, reinforcing the autoimmune profile of our CSU patients. The analysis of the proinflammatory cytokines related to pruritus, showed increased expression of the evaluated components. These remarkable findings in CSU emphasize their relevance as potential disease biomarkers and targets for immunomodulatory interventions.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis vulgaris and circulating metabolic biomarkers: a mendelian randomization analysis","authors":"Dezhao Bi,&nbsp;Jianxin Shi,&nbsp;Yunyao Hu,&nbsp;Jin Tong Tey,&nbsp;Dan Yao,&nbsp;Songmao Hua,&nbsp;Xiaochen Zhu,&nbsp;Jia Liu,&nbsp;Shun Guo","doi":"10.1007/s00403-025-04232-9","DOIUrl":"10.1007/s00403-025-04232-9","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric disorders in psoriatic patients: a cross-sectional study in multi-government hospitals","authors":"Amira Adel Abdel -Azim,&nbsp;Reda Mohammed Ismail,&nbsp;Hala Saad Ahmed Elshabasy,&nbsp;Doaa Abdel-Maleek Hassan Pessar","doi":"10.1007/s00403-025-04181-3","DOIUrl":"10.1007/s00403-025-04181-3","url":null,"abstract":"<div><p>Psoriasis is chronic skin condition that leads to disfigurement and disability. Individuals with psoriasis often face stigma in their everyday lives. This research aims to evaluate the coexistence of psychiatric diseases in patients with chronic plaque psoriasis and seeks to assess the impact of these psychiatric disorders on patients’ quality of life, raise awareness among healthcare professionals, and enhance the standard of care for the assessment and management of psoriasis. A total number of 246 patients with chronic psoriatic (patients’ group) and additional 246 age and sex-matched individuals served as the control group. Informed consent was obtained, and ethical approval was granted. The study followed case-control, cross-sectional design with thorough examinations, and assessment tools including mental health questionnaire based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-4 and DSM-5), along with the PCASEE model for assessing health status and quality of life. There was a strong association between psoriasis and psychiatric disorders, particularly in patients with visible lesions and severe disease. Depression is strongly associated with the severity of psoriasis, while anxiety and social phobia appear unrelated to disease severity. In conclusion, this work highlights the importance for comprehensive care strategies that include both the physical and mental health needs of psoriatic patients. We highly recommend that dermatologists screen psoriasis patients for depression, anxiety, and suicidality, and remain vigilant for severe psychiatric conditions.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the use of population descriptors in dermatology trials and beyond: disentangling race and ethnicity from skin color","authors":"Valerie M. Harvey,&nbsp;Jenna C. Lester,&nbsp;Tarannum Jaleel,&nbsp;Junko Takeshita,&nbsp;Amy J. McMichael,&nbsp;Yvette Miller-Monthrope,&nbsp;Nina G. Jablonski,&nbsp;Jade Lewis,&nbsp;Andrew F. Alexis,&nbsp;Stafford G. Brown,&nbsp;Cheryl M. Burgess,&nbsp;Angel S. Byrd,&nbsp;Suephy C. Chen,&nbsp;Caryn Cobb,&nbsp;Roxana Daneshjou,&nbsp;Seemal R. Desai,&nbsp;Candrice R. Heath,&nbsp;Chidubem A.V. Okeke,&nbsp;Hema Sundaram,&nbsp;Susan C. Taylor,&nbsp;Jonathan S. Weiss,&nbsp;Jane Y. Yoo,&nbsp;Valerie D. Callender","doi":"10.1007/s00403-025-04219-6","DOIUrl":"10.1007/s00403-025-04219-6","url":null,"abstract":"<div><p><b>Importance</b>: Race and ethnicity as population descriptors in research and clinical practice have often been a subject of debate, drawing heightened scrutiny in recent years. Criticism focuses on their oversimplification and misapplication, which fail to capture the complexity of human health and genetic diversity. There is growing recognition that these categories, rooted in outdated social constructs, do not accurately reflect biological differences. <b>Observations</b>: Historically, race and ethnicity have been used as proxies for genetic variation and skin color, despite the understanding that these constructs are not biologically defined. The Skin of Color Society’s second <i>Meeting the Challenge</i> Summit, attended by over 100 U.S. and international participants, highlighted several key themes: (1) the need for transparency in the rationale behind using population descriptors and decision-making processes; (2) recognizing the role of race and racism in dermatology; (3) exploring the intersection of dermatology, skin color, and cultural influences; (4) understanding the context of population descriptor usage; (5) developing improved, objective tools for classifying skin color; and (6) advancing research and creating guidelines. <b>Conclusions and Relevance</b>: There is an urgent need to reconsider the use of race and ethnicity as population descriptors in dermatology research. Current systems, which conflate social identity with biological markers, perpetuate health disparities and limit the accuracy of clinical data. Moving forward, more specific descriptors such as skin color, alongside socially determined factors, will be crucial in achieving meaningful diversity and inclusivity in clinical research.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined subcision with polydioxanone monofilament (PDO) threads versus polydioxanone monofilament (PDO) threads alone in treatment of atrophic post-acne scars","authors":"Manar Abd-Elbadea Ahmed Mohamed,&nbsp;Hanan Mohamed Ali Darwish,&nbsp;Hala Shawky Abd-Elhafiz","doi":"10.1007/s00403-025-04204-z","DOIUrl":"10.1007/s00403-025-04204-z","url":null,"abstract":"<div><p>Acne scaring negatively impacts life quality. Treatment options vary in clinical effectiveness, side effects, and downtime. Polydioxanone threads (PDO) stimulate neo-collagenesis and create mechanical lift through artificial ligaments, while subcision is an office surgical method for managing atrophic scars. Both methods have their advantages and disadvantages. To assess the clinical efficiency and safety of PDO threads alone against combined subcision in the management of atrophic following-acne scars. Twenty patients with facial atrophic following acne scars were involved. The right side of the face was managed with PDO threads, while the left side was managed with subcision and PDO threads. Patients were assessed after three months using the Goodman and Baron qualitative and quantitative acne scarring grading systems. On the right side, improvement was excellent in two patients (10%), good in fourteen patients (70%), and poor in four patients (20%). On the left side, the improvement was excellent in six patients (30%), good in twelve patients (60%), and poor in two patients (10%). There was a statistically insignificant variance between both sides with a p-value of 0.308. There were no reported serious side effects, and the pain was tolerable. PDO thread insertion, either alone or combined with subcision, is safe and efficient in managing atrophic post-acne scars.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing hair regrowth in Alopecia areata: the power duo of CO2 fractional laser and Bimatoprost","authors":"Ahmed Hassan Nouh,&nbsp;Ayaat Abd Elghany Behairy,&nbsp;Fatma Badr El-Koumy,&nbsp;Ahmed Mohamed Abdel Aal,&nbsp;Maryna S. Zhuravlova","doi":"10.1007/s00403-025-04183-1","DOIUrl":"10.1007/s00403-025-04183-1","url":null,"abstract":"<div><p>Alopecia Areata (AA) is a chronic, immune-mediated inflammatory condition primarily targeting hair follicles, leading to non-scarring hair loss. Traditional therapeutic approaches, including topical and systemic immunosuppressive treatments, often yield inconsistent results and carry significant side effects. Recently, laser therapy has emerged as a promising modality for AA treatment, particularly when combined with adjunctive agents that enhance hair follicle stimulation. This study evaluates the efficacy and safety of a novel therapeutic combination: CO2 fractional laser therapy with Bimatoprost 0.03% solution application. Conducted at Al-Azhar University Hospital between January 2019 and May 2023, the study involved 60 patients with clinically and dermoscopically confirmed AA. Participants were randomly assigned into two groups: Group A (<i>n</i> = 30) received three CO2 fractional laser sessions with subsequent daily application of Bimatoprost 0.03%, while Group B (<i>n</i> = 30) underwent laser therapy alone. Clinical outcomes were assessed using standardized photographic documentation, dermoscopic evaluation, and patient-reported improvement scores. Results demonstrated a significantly higher response rate in Group A compared to Group B (80% vs. 40%, <i>p</i> = 0.025). The combination therapy led to faster and more pronounced hair regrowth, with notable improvements in hair density, pigmentation, and thickness. Minimal adverse effects were reported, limited to transient erythema and mild procedural discomfort. Statistical analysis confirmed a superior treatment response in Group A across all assessment parameters (<i>p</i> &lt; 0.05). These findings suggest that the combination of CO2 fractional laser therapy with Bimatoprost 0.03% offers a safe and effective treatment modality for AA, outperforming laser therapy alone. This study provides a foundation for further research and highlights the potential integration of prostaglandin analogs with laser-based interventions in AA management. Future studies with larger sample sizes and extended follow-up periods are necessary to validate these promising results and assess long-term treatment sustainability.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy","authors":"Chou-Yi Hsu,&nbsp;Harish C. Chandramoorthy,&nbsp;Jaafaru Sani Mohammed,&nbsp;Shaker Al-Hasnaawei,&nbsp;Mohammed Yaqob,&nbsp;Mayank Kundlas,&nbsp;Krishnakumar Samikan,&nbsp;Samir Sahoo,&nbsp;S. K. Sunori,&nbsp;Zainab Ahmed Abbas","doi":"10.1007/s00403-025-04237-4","DOIUrl":"10.1007/s00403-025-04237-4","url":null,"abstract":"<div><p>Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between vitiligo and allergic diseases: a bidirectional two-sample Mendelian randomization study","authors":"Ri Zhang,&nbsp;Zeqi Shi,&nbsp;Xiaoqi Nie,&nbsp;Yujia Wei,&nbsp;Dong Li","doi":"10.1007/s00403-025-04047-8","DOIUrl":"10.1007/s00403-025-04047-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04047-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and disease burden in Chinese patients with prurigo nodularis","authors":"Xinming Mai,&nbsp;Yan Liao,&nbsp;Chener Yang,&nbsp;Lu Wei,&nbsp;Mengting Yin,&nbsp;Xu Yang,&nbsp;Jiaying Chen,&nbsp;Ruimiao Wu,&nbsp;Xia Dou","doi":"10.1007/s00403-025-04229-4","DOIUrl":"10.1007/s00403-025-04229-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}