Archives of Dermatological Research最新文献

{"title":"Demographic characteristics and comorbidity associations in chronic hand eczema","authors":"Alejandra Curbelo-Paz, Christopher Guirguis, Joe K. Tung","doi":"10.1007/s00403-026-04975-z","DOIUrl":"10.1007/s00403-026-04975-z","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumescent vs. non-tumescent techniques for split-thickness skin grafting: a prospective observational study","authors":"Madan Mohan Reddy Kambaiahgari,&nbsp;Akash Sivamurugan,&nbsp;A. Pravin Dhas,&nbsp;D. Debarath Das,&nbsp;Lakshmana Raman","doi":"10.1007/s00403-026-04878-z","DOIUrl":"10.1007/s00403-026-04878-z","url":null,"abstract":"<div><p>Split-thickness skin grafting (STSG) remains the primary reconstructive technique; however, donor-site morbidity, characterized by bleeding, pain, and delayed epithelialization, poses a significant clinical challenge. The tumescent technique (TT), which involves the infiltration of a dilute local anesthetic and adrenaline, has been proposed to mitigate these complications. This study aimed to compare the clinical outcomes of TT and the traditional non-tumescent technique (NTT) in patients undergoing STSG. This prospective observational study was conducted at a tertiary care facility (July 2024–November 2025). We enrolled 140 patients with clean, granulating wounds who were eligible for STSG. Participants were allocated into two groups (<i>n</i> = 70 per group) based on the graft harvesting technique employed by the operating surgeon: Group A (<i>n</i> = 70) underwent TT (using a super-wet infiltration approach), and Group B (<i>n</i> = 70) underwent standard NTT for graft harvesting at a standardized thickness. Primary endpoints included percentage of graft acceptance at Days 5, 10, and Week 3, donor site healing at Day 10 and Week 3, and postoperative pain measured via the Visual Analogue Scale (VAS). Statistical analysis was performed using Student’s t-test and chi-square test, with <i>p</i> &lt; 0.05 considered significant. The TT group showed significantly superior graft acceptance across all time points: day 5 (97.5% vs. 94.0%, <i>p</i> &lt; 0.001), day 10 (94.9% vs. 88.9%, <i>p</i> &lt; 0.001), and week 3 (88.0% vs. 83.1%, <i>p</i> &lt; 0.001). TT also accelerated donor site healing, with a higher proportion achieving complete healing by Day 10 (87.1% vs. 70.0%, <i>p</i> = 0.013). Furthermore, complete healing was observed in the entire TT arm within 1–2 weeks compared to 31.4% in the NTT arm (<i>p</i> &lt; 0.001). Postoperative analgesia was significantly reduced in the TT group (<i>p</i> &lt; 0.001). TT demonstrated a statistically significant reduction in overall complications (7.1% vs. 20.0%, chi-square = 3.897, <i>p</i> = 0.048), driven primarily by a significant reduction in graft loss (1.4% vs. 10.0%, <i>p</i> = 0.011). The tumescent technique for STSG is associated with improved short-term clinical outcomes, including enhanced graft acceptance, faster donor-site epithelialization, and reduced postoperative pain when compared to the non-tumescent technique. These encouraging observational findings warrant broader evaluation in prospective randomized controlled trials to establish its definitive integration into standard clinical practice.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of an urban resident-run free dermatology clinic","authors":"Amy Johnson,&nbsp;Jennifer E. Murphy,&nbsp;Kelly Scarberry","doi":"10.1007/s00403-026-04872-5","DOIUrl":"10.1007/s00403-026-04872-5","url":null,"abstract":"<div><p>Preliminary data from several volunteer dermatology-related academic hospital events show that there are certain conditions and findings such as eczematous dermatitis and disorders of the skin appendages that are commonly presented by populations without regular dermatology care and/or inadequate health insurance. Current literature is piecemeal and mostly involves individual institutional reports of their clinical experiences, which is quite variable not only in terms of conditions seen but also treatment capabilities available at those particular clinics. However, it is helpful to gather information even from single clinic reports to pick and choose the “best of all worlds” approaches to clinic operations and patient care. Analysis of the patient and provider-completed intake forms from twelve months of monthly free clinic events was performed to identify patterns such as zip code, history of skin cancer, most common chief concerns, most common findings, demographics of the patients seen, and more. We hope these data may inform other clinics with a similar patient demographic and be used to better address the needs of this patient population in a more customized, evidence-driven way.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demodex infestation in benign and malignant skin tumors","authors":"Fakhriyeh Kelavari,&nbsp;Rana Rafiei,&nbsp;Narges Alizadeh,&nbsp;Kaveh Gharaei Nejad,&nbsp;Hojat Eftekhari,&nbsp;Parinaz Skandarzadeh,&nbsp;Elahe Rafiei","doi":"10.1007/s00403-026-04910-2","DOIUrl":"10.1007/s00403-026-04910-2","url":null,"abstract":"<div><p>Demodex mites are ectoparasites living in hair follicles, which results in inflammatory reactions. This mite has been detected in melanocytic nevi, actinic keratosis, melanoma, basal cell carcinoma, and lymphoproliferative tumors. Role of this parasite in skin tumors is unclear. This study aimed to only compare the frequency of mite infestation in benign and malignant lesions to propose the triggering effect of mites in skin tumors. This retrospective cross-sectional study was conducted on 602 skin biopsy samples with diagnoses of benign, premalignant, and malignant lesions over three years. Demodex infestation was evaluated according to sex, age, location, and histopathological diagnosis. A total of352 benign lesions and 250 malignant lesions were evaluated. There was a significant difference according to age, sex, location, and Demodex infestation rate between the benign and malignant groups (P&lt;0.001). A total of 10.5% of the benign lesions and 23.6% of the malignant lesions were infested with Demodex mites (P&lt;0.001). In the benign group, 38.5% of sebaceous nevi, 15.4% of vascular lesions, 13.8% of melanocytic nevi, and 11.6% of seborrheic keratoses showed mite infestation. In the malignant group, 55.6% of actinic keratosis, 27.3% of basosquamous cell carcinoma, 25.2% of basal cell carcinoma, and 14.6% of squamous cell carcinoma lesions had mite infestation. Actinic keratosis was significantly more infested compared to malignant lesions (P&lt;0.001). This study revealed a significant difference in the frequency of Demodex infestation between malignant and benign lesions, but it is not clear whether Demodex infestationoccurred first or skin tumors.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional retrospective analysis assessing the role of GLP-1 receptor agonists in reducing cardiovascular risk, inflammation, and disease severity in hidradenitis suppurativa","authors":"Megan Lau,&nbsp;Dev Patel,&nbsp;Kristina Navrazhina,&nbsp;Joseph Largen,&nbsp;Daniel Liu,&nbsp;David Wang,&nbsp;Mahaa Ayub,&nbsp;Benjamin Ungar,&nbsp;Emma Guttman-Yassky","doi":"10.1007/s00403-026-04968-y","DOIUrl":"10.1007/s00403-026-04968-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin colour representation in dedicated ethnic and skin of colour dermatology textbooks","authors":"Melody Li,&nbsp;William Liu,&nbsp;Jincheng Shi","doi":"10.1007/s00403-026-04979-9","DOIUrl":"10.1007/s00403-026-04979-9","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think small: a smarter approach to formalin use in dermatology clinics and offices","authors":"Rachel Anderson,&nbsp;Abigail Washington,&nbsp;Simran Multani,&nbsp;Bryan Anderson,&nbsp;Thomas Helm","doi":"10.1007/s00403-026-04900-4","DOIUrl":"10.1007/s00403-026-04900-4","url":null,"abstract":"<div><p>Prefilled formalin containers are essential in dermatology for preserving biopsy specimens. However, formalin is a toxic and carcinogenic chemical requiring careful handling and requires proper disposal. Reducing its use without compromising specimen integrity can offer both environmental and financial benefits. We analyzed all skin biopsies performed from January 1 to December 31, 2024, across Penn State Dermatology clinics (<i>N</i> = 11,284). We conducted a theoretical cost and waste assessment comparing three commonly available prefilled formalin container sizes: 20 mL with 10 mL fill (20/10 mL), 40/20 mL, and 60/30 mL. Using institutional pricing and biopsy volumes, we projected cost and formalin waste over 1, 5, and 10 years. The 20/10 mL container had the lowest annual cost at $5,303.48, compared to $6,996.08 and $6,883.24 for the 40/20 mL and 60/30 mL containers, respectively. Currently, the 60/30 mL container is standard across clinics. Transitioning to the 20/10 mL option would reduce formalin waste by 2,256.8 L over 10 years and save approximately $17,000. In addition, new clinic racks designed to secure smaller containers reduce tipping and potential spills, enhancing safety. Switching to smaller formalin containers for skin biopsies is a simple, effective intervention to cut costs, reduce toxic waste, and improve safety in dermatology practice. Further gains could be realized through the adoption of formalin recycling systems. This initiative underscores the importance of sustainable practices in dermatologic care and serves as a model for environmentally conscious clinical decision-making, while also improving safety.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to clinical severity and quality of life in hidradenitis suppurativa: findings from a cross-sectional digital survey","authors":"Olivia Babich,&nbsp;Sydney DeVore,&nbsp;Selina J. Chang,&nbsp;Alana Sadur,&nbsp;Zeshan Tariq,&nbsp;Vrusha K. Shah,&nbsp;Sonal Choudhary","doi":"10.1007/s00403-026-04981-1","DOIUrl":"10.1007/s00403-026-04981-1","url":null,"abstract":"<div><p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful nodules and abscesses that develop in intertriginous regions. Despite the prevalence and impact of HS, there remains a paucity of patient-oriented data directly analyzing demographic and socioeconomic factors and their association with quality of life. The aim was to investigate associations between medical, demographic, and socioeconomic participant factors and disease severity and quality of life in HS. This cross-sectional, survey-based study of 102 participants was conducted from January 2022 to January 2025. Patients with HS were consecutively identified and sent a survey containing questions related to their experiences living with HS, assessment of treatment success, and interactions with the healthcare system. The survey included a Dermatology Life Quality Index (DLQI) to evaluate correlation with quality of life. Participant EMR data, including Hurley stage, was collected to pair with survey responses. Univariate and multivariate investigation of associations between patient variables and disease outcomes was performed. 102/343 patients (29.7%) completed the survey and were included in the study (mean [SD] age, 38.6 [11.1] years; 12 males [11.8%]). Those with a DLQI &gt; 10 were typically diagnosed at a younger age (OR: 0.957; 95% CI: 0.916–0.999; <i>p</i> = 0.047), had concerns regarding transportation access (OR: 5.471; 95% CI: 1.440–20.783; p = 0.013), and more often required assistance when reading written material from their doctor/pharmacy (OR: 6.298; 95% CI: 1.194–33.238; <i>p</i> = 0.030). Based on our survey, higher DLQI scores– not Hurley stages– were significantly associated with several participant factors including poorer understanding of written material from doctors or pharmacies, lower attendance rates at scheduled medical appointments, and lack of access to reliable transportation. This study was exploratory and hypothesis-generating in nature. As such, additional research involving patient-reported outcomes and relationships between patient factors and disease course is needed to aid in the development of more effective and comprehensive care plans.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of topical 0.05% clobetasol propionate and topical 0.1% tacrolimus in the treatment of early-stage mycosis fungoides","authors":"Aslı Aksu,&nbsp;Ayşegül Öz,&nbsp;Hazel Ezgi Kaya,&nbsp;Pinar Ozdemir Cetinkaya,&nbsp;Birgül Özkesici Kurt,&nbsp;İlknur Altunay","doi":"10.1007/s00403-026-04958-0","DOIUrl":"10.1007/s00403-026-04958-0","url":null,"abstract":"<div><p>Comparative data on the efficacy of topical therapies in early-stage mycosis fungoides (MF) remain limited. Topical calcineurin inhibitors have been proposed as steroid-sparing alternatives; however, direct comparative evidence is scarce. This retrospective study included 40 patients with stage IA–IB MF treated with either 0.1% tacrolimus ointment (<i>n</i> = 20) or 0.05% clobetasol propionate ointment (<i>n</i> = 20). In the tacrolimus group, 60% of patients achieved complete clinical response (CCR) and 20% achieved partial response (PR), whereas in the clobetasol group, 95% achieved CCR and 5% achieved PR. The median time to CCR was 3.5 months in the tacrolimus group and 2 months in the clobetasol group (<i>p</i> = 0.520). Among patients achieving CCR, relapse occurred in 25% of tacrolimus-treated patients compared with 63.2% in the clobetasol group (Fisher’s exact <i>p</i> = 0.066). Kaplan–Meier analysis showed a trend toward longer relapse-free survival with tacrolimus, although the difference did not reach statistical significance (log-rank <i>p</i> = 0.060). Although clobetasol propionate was associated with higher initial CCR rates, tacrolimus may represent a steroid-sparing therapeutic option in selected patients with early-stage MF.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric comorbidities and treatment strategies in dermatitis artefacta: a narrative review","authors":"Ingyun Park,&nbsp;Ali Bayrouti,&nbsp;Duncan MacIntyre,&nbsp;Christian Awad,&nbsp;Michael O. Nguyen","doi":"10.1007/s00403-026-04973-1","DOIUrl":"10.1007/s00403-026-04973-1","url":null,"abstract":"<div><p>Dermatitis artefacta (DA) is a rare psychodermatologic condition characterized by self-inflicted skin lesions that patients typically deny causing. These lesions often present with atypical morphologies and distributions, which can delay diagnosis and complicate management. DA is strongly associated with underlying psychiatric conditions such as depression, anxiety, trauma-related disorders, and personality disorders. Clinicians should adopt a non-confrontational, supportive approach to foster trust and improve patient engagement, as confrontational strategies may increase shame and reduce follow-up adherence. Optimizing management requires an integrated dermatologic and psychiatric treatment model, as addressing comorbid psychiatric conditions can reduce the severity of DA. Current therapeutic recommendations are primarily based on case reports, case studies, and expert opinion, as controlled studies in DA remain scarce. Consequently, psychotherapeutic and pharmacologic interventions such as CBT, AEBT, EMDR, SSRIs, and mood stabilizers may be considered as individualized treatment options based on the patient’s psychiatric presentation rather than established standards of care. Long-term management relies on consistent follow-up, empathetic communication, and individualized treatment planning.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04973-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}