外泌体作为免疫和癌细胞相互作用的关键介质:黑色素瘤进展和治疗的见解

IF 1.8 4区 医学 Q3 DERMATOLOGY
Chou-Yi Hsu, Harish C. Chandramoorthy, Jaafaru Sani Mohammed, Shaker Al-Hasnaawei, Mohammed Yaqob, Mayank Kundlas, Krishnakumar Samikan, Samir Sahoo, S. K. Sunori, Zainab Ahmed Abbas
{"title":"外泌体作为免疫和癌细胞相互作用的关键介质:黑色素瘤进展和治疗的见解","authors":"Chou-Yi Hsu,&nbsp;Harish C. Chandramoorthy,&nbsp;Jaafaru Sani Mohammed,&nbsp;Shaker Al-Hasnaawei,&nbsp;Mohammed Yaqob,&nbsp;Mayank Kundlas,&nbsp;Krishnakumar Samikan,&nbsp;Samir Sahoo,&nbsp;S. K. Sunori,&nbsp;Zainab Ahmed Abbas","doi":"10.1007/s00403-025-04237-4","DOIUrl":null,"url":null,"abstract":"<div><p>Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy\",\"authors\":\"Chou-Yi Hsu,&nbsp;Harish C. Chandramoorthy,&nbsp;Jaafaru Sani Mohammed,&nbsp;Shaker Al-Hasnaawei,&nbsp;Mohammed Yaqob,&nbsp;Mayank Kundlas,&nbsp;Krishnakumar Samikan,&nbsp;Samir Sahoo,&nbsp;S. K. Sunori,&nbsp;Zainab Ahmed Abbas\",\"doi\":\"10.1007/s00403-025-04237-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.</p></div>\",\"PeriodicalId\":8203,\"journal\":{\"name\":\"Archives of Dermatological Research\",\"volume\":\"317 1\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Dermatological Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00403-025-04237-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Dermatological Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00403-025-04237-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

外泌体(30 - 150nm)是细胞分泌到细胞外环境的小细胞外囊泡,已知介导细胞间通讯。外泌体含有相对丰富的蛋白质、脂质和RNA分子,能够改变靶细胞的活性。黑色素瘤来源的外泌体(MEXs)促进致癌信号和免疫抑制因子向免疫细胞的转移,导致免疫反应偏向肿瘤促进过程。MEXs可以抑制T细胞和树突状细胞的活化和增殖,诱导髓源性抑制细胞(MDSCs)和调节性T细胞(Tregs)的分化。它们可以诱导抗原特异性CD8 + T细胞凋亡,促进肿瘤抗原的转移,导致免疫逃逸。具体来说,MEXs可以将白细胞介素-10 (IL-10)和转化生长因子-β (TGF-β)等细胞因子输送到免疫细胞或表达程序性死亡配体1 (PD-L1或CD274),创造促进肿瘤发生的免疫抑制微环境。由于外泌体优先在黑色素瘤组织中积累,这种靶向递送可以提高治疗的生物利用度,同时限制副作用。在这里,我们回顾了黑色素瘤来源的外泌体的分子组成,它们的作用机制,以及它们作为黑色素瘤治疗靶点或生物标志物的潜力。对这些适当影响外泌体介导的相互作用的机制的总结可以产生新的策略来引发抗黑色素瘤免疫或增强当前疗法的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy

Exosomes (30–150 nm) are small extracellular vesicles that are secreted by cells into the extracellular environment and are known to mediate cell-to-cell communication. Exosomes contain proteins, lipids, and RNA molecules in relative abundance, capable of modifying the activity of target cells. Melanoma-derived exosomes (MEXs) promote the transfer of oncogenic signals and immunosuppressive factors into immune cells, resulting in a bias of the immune response towards tumor-promoting processes. MEXs could suppress the activation and proliferation of T cells and dendritic cells and induce differentiation of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). They can induce apoptosis of antigen-specific CD8 + T cells and promote the transfer of tumor antigens, resulting in immune evasion. Specifically, MEXs can shuttle cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) to immune cells or express programmed death-ligand 1 (PD-L1 or CD274), creating an immune-suppressive microenvironment that promotes tumorigenesis. Since exosomes preferentially accumulate in melanoma tissues, this targeted delivery could enhance the bioavailability of treatments while limiting side effects. Here, we review the molecular composition of melanoma-derived exosomes, their mechanisms of action, and their potential as therapeutic targets or biomarkers in melanoma. The summarizations of these mechanisms to appropriately influence exosome-mediated interactions could yield new tactics to elicit anti-melanoma immunity or augment the therapeutic effects of current therapies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信