Archives of Dermatological Research最新文献_第9页

Changes of plasma amino acid levels and metabolic pathways in isotretinoin therapy: ınsights into managing acne vulgaris side effects

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04106-0

Tugrul Cagri Akman, Mustafa Yazıcı, Alptug Atila

{"title":"Changes of plasma amino acid levels and metabolic pathways in isotretinoin therapy: ınsights into managing acne vulgaris side effects","authors":"Tugrul Cagri Akman, Mustafa Yazıcı, Alptug Atila","doi":"10.1007/s00403-025-04106-0","DOIUrl":"10.1007/s00403-025-04106-0","url":null,"abstract":"<div><p>Acne vulgaris can be effectively treated with isotretinoin, however, there are several side effects both during and after the treatment. Preventing these side effects is important for continued treatment. This study focused on the relationship between the changes in the levels of plasma amino acids of patients with acne vulgaris after three months of isotretinoin treatment and the side effects. A pre- and post-treatment plasma sample of 35 patients was collected. Samples were analyzed by liquid chromatography-tandem mass spectrometry. After treatment, the plasma levels of 15 amino acids changed statistically. While L-arginine, taurine, L-asparagine, and L-proline levels decreased, L-serine, L-alanine, and L-cystine levels also increased. (<i>p</i> < 0.05) When the amino acid profiles of male and female patients before and after treatment were compared, the plasma levels of L-arginine (<i>p</i> = 0.0017), L-cystine (<i>p</i> = 0.0224) and L-histidine (<i>p</i> = 0.0167) were statistically different. Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between L-leucine, L-isoleucine, L-norvaline, and L-valine. The effect of isotretinoin treatment on eighteen metabolic pathways such as cysteine and methionine metabolism, glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism is strongly related to the treatment of therapeutic and side effects of isotretinoin. According to the results of the study, the use of L-arginine, L-asparagine, N-acetylcysteine and taurine supplements during isotretinoin treatment may help avoid side effects of skin dryness, blepharitis, nail fragility, and fatigue. As a result, the study provided useful information for enhancing the safety and efficacy of isotretinoin treatment, as well as lowering isotretinoin-related side effects.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of an oral supplement containing Polypodium leucotomos in enhancing sun protection: a clinical evaluation of minimal erythema dose pre- and post-consumption

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04055-8

Aamir Hussain, Sach Thakker, Noreen Galaria

{"title":"Effectiveness of an oral supplement containing Polypodium leucotomos in enhancing sun protection: a clinical evaluation of minimal erythema dose pre- and post-consumption","authors":"Aamir Hussain, Sach Thakker, Noreen Galaria","doi":"10.1007/s00403-025-04055-8","DOIUrl":"10.1007/s00403-025-04055-8","url":null,"abstract":"<div><p>Ultraviolet (UV) radiation contributes to skin erythema, photoaging, and an increased risk of skin cancer. Although topical sunscreens and protective clothing remain standard photoprotection measures, poor adherence often limits their efficacy. Oral supplements containing Polypodium leucotomos extract (PLE) have gained attention as convenient adjuncts that may bolster the skin’s defenses against UV-induced damage. This study aimed to evaluate the photoprotective effects of a novel oral supplement, Sol Defense Gummies containing PLE, on the minimal erythema dose (MED) and erythema intensity in individuals with Fitzpatrick skin types I–III. Twenty-seven participants were enrolled; 25 completed the study. After baseline MED assessments without supplementation on Day 1, participants consumed 240 mg of PLE bid for five days. MED was reassessed on Day 5 to determine any changes attributable to supplementation. Erythema intensity was further evaluated via colorimetry, visual grading, and standardized photography. Participant compliance and adverse events were monitored through daily diaries and staff reviews. By blinded visual grading following a five-day supplementation period, 64% of subjects showed improvement in MED. When evaluated by colorimeter 80% of subjects demonstrated some degree of enhanced photoprotection. 20% of participants demonstrated no improvement. The mean MED increased from approximately 223 J/cm² to 234 J/cm², and 44% of participants showed a quantifiable rise in MED. Short-term oral supplementation with Sol Defense Gummies containing PLE was associated with measurable improvements in photoprotection as evidenced by increases in MED and reductions in erythema. These findings support the potential of this novel PLE delivery method as a convenient adjunct to conventional photoprotection strategies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipopolysaccharide-binding protein functions as factor VIII inhibitor in bullous pemphigoid associated with acquired hemophilia A

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04078-1

Senlin Ma, Yuxin Sun, Wenzhen Zhou, Yinuo Yuan, Yifan Yang, Yanchao Zheng, Qiuxin Lu, Qingjiang Chen, Mingyue Ding, Guoyan Wang, Mingquan Chen

{"title":"Lipopolysaccharide-binding protein functions as factor VIII inhibitor in bullous pemphigoid associated with acquired hemophilia A","authors":"Senlin Ma, Yuxin Sun, Wenzhen Zhou, Yinuo Yuan, Yifan Yang, Yanchao Zheng, Qiuxin Lu, Qingjiang Chen, Mingyue Ding, Guoyan Wang, Mingquan Chen","doi":"10.1007/s00403-025-04078-1","DOIUrl":"10.1007/s00403-025-04078-1","url":null,"abstract":"<div><p>Bullous pemphigoid (BP) represents an autoimmune blistering disorder that may coexist with acquired hemophilia A (AHA), a rare autoimmune condition arising from the formation of circulating autoantibodies directed against factor VIII (FVIII). The underlying pathomechanisms of BP-AHA remain elusive. This study conducted a retrospective analysis of data from 196 BP patients admitted to our hospital. We have collected serum samples from a recently admitted BP-AHA patient and healthy controls to isolate, screen and identify the potential FVIII inhibitors. The expression and function of lipopolysaccharide-binding protein (LBP) in BP-AHA were further validated by a series of biochemical experiments. The retrospective analysis showed that the activated partial thromboplastin time (APTT) values of seven patients exceeded 33.8 s (normal value) in 196 BP patients. FVIII: C (%) and FVIII inhibitors in the plasma of partial prolonged-APTT patients were significantly altered compared with control group or non-prolonged-APTT group. LBP was identified as a potential inhibitory protein of FVIII. Consistently, a notable alteration in LBP expression was observed in the plasma of BP patients with prolonged-APTT. Moreover, the amount of LBP bound to FVIII in the BP-AHA patient was notably higher than that in control group, which was also markedly reversed after treatment. In vitro experiments finally confirmed that exogenous LBP directly bound to FVIII and significantly inhibited FVIII activity. In conclusion, the incidence of AHA in BP patients may be substantially underestimated, which needs more vigilance towards indicators such as APTT, LBP, and FVIII. LBP emerges as an inhibitory protein of FVIII, indicating the potential involvement in the progression of BP-AHA.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient preferences for peer support in cutaneous autoimmune disease: a pilot cross-sectional survey study

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04077-2

Sabrina Saeed, Lenique Huggins, Tiffany E. Jiang, Fotios Koumpouras, Sarika Ramachandran

引用次数: 0

The influence of genetic factors on the clinical manifestations and response to systemic treatment of plaque psoriasis

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04132-y

Michał Majewski, Piotr Konopelski, Lidia Rudnicka

{"title":"The influence of genetic factors on the clinical manifestations and response to systemic treatment of plaque psoriasis","authors":"Michał Majewski, Piotr Konopelski, Lidia Rudnicka","doi":"10.1007/s00403-025-04132-y","DOIUrl":"10.1007/s00403-025-04132-y","url":null,"abstract":"<div><p>Plaque psoriasis is a common, chronic, papulosquamous skin disorder. TNF, IL-17 and IL-23 have been identified as key cytokines in the pathogenesis of psoriasis. Certain human leukocyte antigen (HLA) variants, such as HLA-Cw6 and HLA-B27, were proposed to affect the clinical course of the disease and the response to standard and biological treatment. In individuals positive for HLA-B27, psoriatic arthritis tends to progress more rapidly, with a higher prevalence of dactylitis and nail changes, suggesting HLA-B27 being a genetic biomarker for early-onset psoriatic arthritis. HLA-Cw6 is associated with the early onset of cutaneous manifestations in psoriasis. In these cases, cutaneous lesions are commonly localised on the chest and limbs, with less pronounced scalp and nail involvement. Psoriatic arthritis tends to develop later in HLA-Cw6-positive patients. The presence of HLA-Cw6 is associated with a more favourable therapeutic response to methotrexate and p40IL-12/23 inhibitors than to TNF inhibitors. Therefore, HLA-Cw6 testing may be a valuable tool for identifying patients who are likely to benefit from treatment with specific monoclonal antibodies, especially p40IL-12/23 inhibitors.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of Steven-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in children

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04073-6

Azwin Mengindra Putera, Damayanti, Liviana Sugito

引用次数: 0

Dermoscopy combined with reflectance confocal microscopy for basal cell carcinoma diagnosis

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04133-x

Xianhe Deng, Ziyu Guo, Ping Wang, Yang Lu, Weiwei Wu

{"title":"Dermoscopy combined with reflectance confocal microscopy for basal cell carcinoma diagnosis","authors":"Xianhe Deng, Ziyu Guo, Ping Wang, Yang Lu, Weiwei Wu","doi":"10.1007/s00403-025-04133-x","DOIUrl":"10.1007/s00403-025-04133-x","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the characteristic manifestations of basal cell carcinoma (BCC) under dermoscopy and reflectance confocal microscopy (RCM) and explore the diagnostic value of dermoscopy combined with RCM for BCC.</p><h3>Methods</h3><p>A cohort of 71 patients with the suspected clinical diagnosis of BCC underwent dermoscopy, RCM, and histopathological examinations. The concordance of dermoscopy, RCM, and dermoscopy combined with RCM with histopathology was individually assessed. Receiver operating characteristic (ROC) curves were constructed to compare the diagnostic performance of these modalities.</p><h3>Results</h3><p>Using histopathology as the reference standard, the sensitivity, specificity, and overall agreement rate were 95%, 81.82%, and 92.96% for dermoscopy; 96.67%, 72.73%, and 92.96% for RCM; and 98.30%, 81.80%, and 95.80% for dermoscopy + RCM, respectively. Assessment of the concordance of dermoscopy, RCM, and dermoscopy + RCM with histopathology yielded kappa values of 0.741, 0.721, and 0.832, respectively. The area under the ROC curve for dermoscopy, RCM, and dermoscopy + RCM were 0.884, 0.847, and 0.901, respectively, with dermoscopy + RCM demonstrating the best diagnostic efficacy.</p><h3>Conclusion</h3><p>This study elucidated the common characteristic features of BCC, as visualized on dermoscopy and RCM, indicating the enhanced diagnostic efficacy of combining dermoscopy with RCM in BCC.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid facial filler complications in the East Asian population: a systematic review

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04053-w

Megan Park, Edgar Akuffo-Addo, Alexandria Veitch, Amn Marwaha, Ilya Mukovozov

引用次数: 0

Analysis of the effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04087-0

Xiaoping Zhang, Lu Wang, Fumin Fang

{"title":"Analysis of the effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria","authors":"Xiaoping Zhang, Lu Wang, Fumin Fang","doi":"10.1007/s00403-025-04087-0","DOIUrl":"10.1007/s00403-025-04087-0","url":null,"abstract":"<div><h3>Objective</h3><p>Effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria(CU) was examined.</p><h3>Methods</h3><p>100 patients with CU were divided into an observation group (treatment with levocetirizine hydrochloride dispersible tablets) and a control group (conventional treatment).</p><h3>Results</h3><p>The total effective rate and incidence of adverse reactions in the control group were lower than those in the observation group. Following a four-week course of therapy, the observation group’s levels of serotonin (5-HT), interleukin-4 (IL-4), and interleukin-17 (IL-17) were all greater. Both the UAS and DLQI scores were much lower than they were prior to therapy, and the observation group’s scores were considerably lower. The relief time of symptoms such as skin itching, redness, tingling, and fever in the observation group was shorter; suggesting that the therapy of persistent urticaria with dispersible tablets containing levocetirizine hydrochloride is viable.</p><h3>Conclusion</h3><p>When levocetirizine hydrochloride dispersible tablets are used to treat CU, the patient’s inflammatory response is decreased, inflammatory factors 5-HT, IL-4, and IL-17 levels are improved, the associated symptoms are encouraged to resolve, adverse responses are prevented, and a better prognosis is provided.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04087-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnostic potential of Asprosin and Meteorin-like proteins in basal and squamous cell carcinomas

IF 1.8 4区医学

Archives of Dermatological Research Pub Date : 2025-03-17 DOI: 10.1007/s00403-025-04099-w

Mehmet Mustafa Erdogan, Esra Erdogan, Nevin Kocaman, Seyma Yasar, Songul Yerlikaya Kavak

{"title":"The diagnostic potential of Asprosin and Meteorin-like proteins in basal and squamous cell carcinomas","authors":"Mehmet Mustafa Erdogan, Esra Erdogan, Nevin Kocaman, Seyma Yasar, Songul Yerlikaya Kavak","doi":"10.1007/s00403-025-04099-w","DOIUrl":"10.1007/s00403-025-04099-w","url":null,"abstract":"<div><p>Non-melanoma skin cancer (NMSC) is the most prevalent malignancy worldwide, encompassing primarily BCC and SCC. Differentiating between these two carcinomas and distinguishing them from normal skin tissue can pose diagnostic challenges in certain cases. Adipokines, as regulators of various biological processes, have garnered attention for their potential roles in tumorigenesis. Asprosin (Asp) and Meteorin-like (Metrnl) are newly identified proteins implicated in several diseases, including cancer. Their potential contribution to the pathogenesis of skin cancers such as BCC and SCC remains underexplored. This study aimed to evaluate the expression profiles of Asp and Metrnl in BCC and SCC and to assess their potential utility as diagnostic biomarkers. The expression of Asp and Metrnl proteins was examined by immunohistochemical staining in biopsy samples from 60 control, 60 BCC, and 60 SCC cases obtained from the archive of the Pathology Laboratory of Malatya Turgut Ozal University Training and Research Hospital. Asp immunoreactivity was higher in BCC tissues compared to the other two groups, and it was statistically higher in SCC tissues compared to healthy control tissues. Metrnl immunoreactivity was also higher in BCC tissues compared to the other two groups, and statistically significant in SCC tissues when compared to healthy control tissues. The findings suggest that Asp and Metrnl proteins may serve as valuable biomarkers for distinguishing between BCC and SCC, the two most common non-melanoma skin cancers encountered in routine dermatopathology practice. These adipokines may also provide insights into the underlying pathophysiology of these malignancies, offering potential avenues for diagnostic and therapeutic advancements.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0