Archives of Dermatological Research最新文献_第9页

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04948-2

Miranda Baumbick, Simran Chadha, Jennifer N. Choi

引用次数: 0

Evaluation of Itch severity and automatic thoughts in patients with Lichen Simplex Chronicus and Chronic Idiopathic Pruritus: a preliminary report 慢性单纯性地衣和慢性特发性瘙痒患者瘙痒严重程度和自动思维的评估：初步报告

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04892-1

Yesim Akpinar Kara, Bilge Bilgin Kapucu

{"title":"Evaluation of Itch severity and automatic thoughts in patients with Lichen Simplex Chronicus and Chronic Idiopathic Pruritus: a preliminary report","authors":"Yesim Akpinar Kara, Bilge Bilgin Kapucu","doi":"10.1007/s00403-026-04892-1","DOIUrl":"10.1007/s00403-026-04892-1","url":null,"abstract":"<div><p>Psychological factors are thought to play an important role in Chronic Idiopathic Pruritus (CIP) and Lichen Simplex Chronicus (LSC). This study examines the association between itch severity and negative automatic thoughts, and compares psychiatric symptom profiles between patients with CIP and LSC. Nineteen patients with Lichen Simplex Chronicus. and 17 patients with Chronic Idiopathic Pruritus who presented to a dermatology outpatient clinic were enrolled. CIP was diagnosed in patients without systemic or skin diseases. LSC was diagnosed based on clinical findings and confirmed by skin biopsy from lesional skin. Itch severity was assessed using a Visual Analog Scale (VAS). During psychiatric evaluation, the Brief Psychiatric Rating Scale (BPRS) and the Automatic Thoughts Questionnaire (ATQ) were administered. Statistical analyses were performed using SPSS version 26.0; group comparisons were conducted with the Kruskal–Wallis test. Total ATQ scores were significantly higher in the LSC group than in the IP group (Kruskal–Wallis, p = 0.011). VAS itch scores did not differ significantly between groups. Mean VAS scores of LSC and CIP is 6,53 and 6,58 respectively (Kruskal Wallis, p = 0,746). Clinically relevant anxiety and depressive symptoms were observed in both groups. No significant correlation was found between VAS scores and psychiatric symptoms. Incorporating psychiatric assessment—particularly the evaluation of negative automatic thoughts using ATQ may be beneficial in the clinical management of Chronic Idiopathic Pruritus, especially in patients with Lichen Simplex Chronicus.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of tyndallized lactic acid bacteria separated from Phellinus linteus on inflammation and skin barrier damage induced by DNCB 毛茛中分离的粉末状乳酸菌对DNCB诱导的炎症和皮肤屏障损伤的影响

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04963-3

Seon Gyeong Bak, Ye Ji Cheon, Nisansala Chandimali, Hyung Jin Lim, Yeong-Seon Won, Hyuck Se Kwon, Hyunjeong Oh, Soon-Il Yun, Seung Woong Lee, Jaehoon Bae, Seokho Kim, Seung-Jae Lee

{"title":"Effects of tyndallized lactic acid bacteria separated from Phellinus linteus on inflammation and skin barrier damage induced by DNCB","authors":"Seon Gyeong Bak, Ye Ji Cheon, Nisansala Chandimali, Hyung Jin Lim, Yeong-Seon Won, Hyuck Se Kwon, Hyunjeong Oh, Soon-Il Yun, Seung Woong Lee, Jaehoon Bae, Seokho Kim, Seung-Jae Lee","doi":"10.1007/s00403-026-04963-3","DOIUrl":"10.1007/s00403-026-04963-3","url":null,"abstract":"<div><p>The fruiting bodies of the Sanghwang mushroom (Phellinus linteus) have a long history of use in traditional medicine throughout Asia, particularly in Korea, Japan, and China. In this study, we investigated the effects of tyndallized lactic acid bacteria isolated from P. linteus (PL-tLB) in experimental models of atopic dermatitis (AD). HaCaT keratinocytes were stimulated with TNF-α/IFN-γ and subsequently treated with PL-tLB. PL-tLB suppressed inflammatory cytokine and chemokine expression in a concentration-dependent manner. We further evaluated PL-tLB in a DNCB-induced AD-like mouse model. DNCB increased ear thickness and mast cell infiltration, whereas PL-tLB administration attenuated these changes. Real-time PCR analysis of ear tissue showed reduced expression of inflammatory cytokines and chemokines and partial recovery of genes associated with the skin barrier and tight junctions following PL-tLB administration. These preclinical findings indicate that PL-tLB may have potential as a functional material for supporting the management of AD-like inflammation and skin-barrier disruption. However, the active bacterial components and the respective contributions of the two constituent strains remain to be determined.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04963-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fear of isotretinoin in moderate-to-severe acne: clinical impact and a new assessment approach 对异维甲酸在中重度痤疮中的恐惧：临床影响和新的评估方法

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04905-z

Simge Ünal Işık, Tuğcan Yüksek, Sema Koç Yıldırım, Lütfi Işık

{"title":"Fear of isotretinoin in moderate-to-severe acne: clinical impact and a new assessment approach","authors":"Simge Ünal Işık, Tuğcan Yüksek, Sema Koç Yıldırım, Lütfi Işık","doi":"10.1007/s00403-026-04905-z","DOIUrl":"10.1007/s00403-026-04905-z","url":null,"abstract":"<div><p>Systemic isotretinoin is an effective treatment for moderate-to-severe acne vulgaris; however, concerns about adverse effects often cause treatment refusal or poor adherence. The phenomenon of “isotretinoin phobia” is underexplored in terms of prevalence and clinical impact. This study aimed to determine the prevalence of isotretinoin phobia, its associated factors, and its impact on treatment behavior and quality of life using a newly developed Isotretinoin Phobia Scale. This cross-sectional study was conducted between June and December 2025 at Uşak University with 312 patients diagnosed with moderate-to-severe acne vulgaris. Data were collected through a five-part questionnaire, including the 11-item Isotretinoin Phobia Scale (Cronbach’s alpha = 0.86). Statistical analyses comprised descriptive statistics, ROC analysis, Chi-square tests, correlation analyses, and logistic regression to identify predictors of clinically significant phobia (score > 21.5). Of the 312 patients (mean age 20.16 ± 3.96 years), 45.2% had low, 50.3% moderate, and 4.5% high phobia scores. The cut-off for significant phobia was > 21.5 (AUC = 0.806). Higher education correlated positively with phobia scores (ρ = 0.191, <i>p</i> < 0.001). Previous isotretinoin users showed significantly lower scores (<i>p</i> = 0.003). Clinically significant phobia was linked to treatment refusal, impaired quality of life, and increased healthcare-seeking, but not treatment discontinuation. Behavioral hesitation, social influence, and fear of side effects were the most common concerns. Isotretinoin phobia represents a significant barrier to acne management. The Isotretinoin Phobia Scale is a reliable tool for detecting at-risk patients. Early recognition and targeted counseling are crucial to reduce fears, improve treatment adherence, and prevent long-term acne complication.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the management of pediatric morphea: a narrative review 儿童睡眠不足的治疗进展：叙述性回顾

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04890-3

Alisha Kashyap, Alexander J. Jafari, Natasha Klimas, Misha Koshelev, Steven R. Mays, Adelaide A. Hebert

引用次数: 0

Insulin resistance and metabolic syndrome in patients with vitiligo: a systematic review and narrative synthesis 白癜风患者的胰岛素抵抗和代谢综合征：系统综述和叙事综合

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04909-9

Barbara Kamińska, Aleksandra Białczyk, Rafał Czajkowski

{"title":"Insulin resistance and metabolic syndrome in patients with vitiligo: a systematic review and narrative synthesis","authors":"Barbara Kamińska, Aleksandra Białczyk, Rafał Czajkowski","doi":"10.1007/s00403-026-04909-9","DOIUrl":"10.1007/s00403-026-04909-9","url":null,"abstract":"<div><p>Vitiligo is a chronic autoimmune skin disorder characterized by the loss of melanocytes. Recent studies suggest an association between vitiligo and systemic metabolic abnormalities, including insulin resistance (IR) and metabolic syndrome (MetS). This systematic review aimed to assess the prevalence of IR and MetS in patients with vitiligo and examine their potential relationship with disease severity and duration. Following PRISMA guidelines, a systematic search of PubMed and Web of Science databases was conducted up to April 16, 2025. A total of 33 studies involving 4,286 vitiligo patients were included. Data regarding metabolic parameters, IR (primarily assessed using HOMA-IR), and MetS (most commonly defined by NCEP-ATP III criteria) were extracted and analyzed. The prevalence of MetS among vitiligo patients ranged from 6.7% to 50.7%, with a pooled rate of 34.3%, compared to 18.6% in control groups. IR, based on HOMA-IR values, was more frequent in vitiligo patients (56.5%) than in controls (32.9%). Several studies reported positive associations between metabolic abnormalities and higher vitiligo severity scores (e.g., VASI, VIDA) or longer disease duration, although findings were inconsistent across studies. Vitiligo appears to be linked to an increased metabolic risk profile. Further prospective, multicenter studies are needed to better understand this relationship and its potential implications for clinical management.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-026-04909-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating optimal ICD-10 classification approaches to identify patients with rosacea: a retrospective chart review 验证最佳ICD-10分类方法来识别酒渣鼻患者：回顾性图表回顾

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04817-y

Lorena A. Acevedo-Fontanez, Nora Bensellam, Sherry Ershadi, Ursula Biba, Katherine Sanchez, Debby Cheng, Samantha Gregoire, Maria C. Vazquez-Machado, Arash Mostaghimi, John S. Barbieri

引用次数: 0

The association between atopic dermatitis with anemia in pediatric patients: a systematic review and meta-analysis 儿科患者特应性皮炎与贫血之间的关系：一项系统综述和荟萃分析

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04939-3

Dennis Chu, Ashley Yu, William Guo, Joann Salvemini, Jeremy Hugh, Neal Shah

引用次数: 0

Hematologic malignancies in pityriasis rubra pilaris: a retrospective matched cohort study 毛疹糠疹的血液恶性肿瘤：一项回顾性匹配队列研究

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04938-4

Henry O. Herrera, Jeremy S. Bordeaux

{"title":"Hematologic malignancies in pityriasis rubra pilaris: a retrospective matched cohort study","authors":"Henry O. Herrera, Jeremy S. Bordeaux","doi":"10.1007/s00403-026-04938-4","DOIUrl":"10.1007/s00403-026-04938-4","url":null,"abstract":"<div><p>Pityriasis rubra pilaris (PRP) is a rare inflammatory dermatosis traditionally considered non-paraneoplastic. However, isolated case reports have described its co-occurrence with various malignancies, including hematologic cancers. Our objective was to assess whether PRP is associated with an increased risk of hematologic malignancies compared to a matched inflammatory skin disease comparator. We conducted a retrospective cohort study using TriNetX, a multicenter U.S. electronic health record database. Adults (≥ 18 years) with a diagnosis of PRP (ICD-10 L44.0) or psoriasis (ICD-10 L40) were identified. Cohorts were 1:1 propensity score matched for demographics and key clinical variables. Primary outcomes included leukemia (C91–C95), lymphoma (ICD-10 C81–C86), and multiple myeloma and plasma cell neoplasms (ICD-10 C90). Odds ratios (OR) and 95% confidence intervals (CI) were calculated. After matching, 1,501 patients with PRP were compared to 1,501 matched psoriasis controls. PRP was associated with higher odds of leukemia (OR 2.20, 95% CI 1.07–4.51) and lymphoma (OR 2.99, 95% CI 1.66–5.40). No significant difference was observed for multiple myeloma and malignant plasma cell neoplasms (OR 1.00, 95% CI 0.42–2.41). This is the largest population-based study to date, suggesting an association between PRP and hematologic malignancies, particularly leukemia and lymphoma. Further studies are warranted to clarify underlying mechanisms.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"318 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergency department vs. outpatient dermatology care for atopic dermatitis: a cross-sectional analysis of 632,916 encounters in epic cosmos 急诊与门诊皮肤科治疗特应性皮炎：在史诗宇宙632,916次遭遇的横断面分析

IF 2.5 4区医学

Archives of Dermatological Research Pub Date : 2026-09-20 DOI: 10.1007/s00403-026-04957-1

Mihir M. Shah, Arash Pour Mohammad, Mahi Bhatt, Justin M. Ko, Gordon H. Bae

引用次数: 0