Archives of Dermatological Research最新文献

{"title":"Unveiling the genetic link and pathogenesis between psoriasis and IgA nephropathy based on Mendelian randomization and transcriptome data analyses","authors":"Yingwen Chen,&nbsp;Min Huang,&nbsp;Ziqing You,&nbsp;Rule Sa,&nbsp;Lu Zhao,&nbsp;Congwen Ku,&nbsp;Wenying Wang,&nbsp;Xingwu Duan","doi":"10.1007/s00403-024-03465-4","DOIUrl":"10.1007/s00403-024-03465-4","url":null,"abstract":"<div><p>It has been reported that many people with psoriasis have been diagnosed with secondary IgA nephropathy (IgAN). However, the mechanisms behind the association between psoriasis and IgAN have not been well clarified. The connection between psoriasis and IgAN deserves deeper exploration. Mendelian randomization (MR) analysis would be employed to explore the link of causality between IgAN and psoriasis, psoriasis vulgaris, other and unspecified psoriasis, guttate psoriasis, and arthropathic psoriasis. Transcriptomic analyses were carried out against the Gene Expression Omnibus databases. We identified crosstalk genes through the analysis of Differentially expressed genes and weight gene co-expression network analysis. Functional annotations were enriched for these crosstalk genes. Subsequently, we established a protein-protein interaction network, and candidate genes would be discovered through the utilization of the MCODE and CytoHubba plug-in applications. Lastly, the predictive efficacy of these genes was examined via creating receiver operating characteristic curves. The MR analysis suggested that psoriasis vulgaris patients were at a higher risk for IgAN. [OR = 1.040, 95%CI (1.005,1.076), <i>p</i> = 0.026 &lt; 0.05]. Additionally, arthropathic psoriasis may augment the incidence of IgAN [OR = 1.081, 95%CI (1.040–1.124), <i>p</i> &lt; 0.01] in the European population. Through the analysis of DEGs and WGCNA, we identified 12 significant genes (NETO2, RRM2, SLAMF7, GBP1, KIF20A, CCL4, MMP1, IL1β, NDC80, CXCL9, C15orf48, GSTA3), which may be potential crosstalk genes between the two diseases. Then, the functional annotation results indicated that the crosstalk genes seemed primarily involved in immune and inflammatory responses. By establishing the PPI network, we further discovered that CXCL9, IL1β, CCL4, and MMP1 play a vital part in psoriasis and IgAN, and all have good diagnostic values. Our MR analysis provided evidence that genetic vulnerability to IgAN may be associated with an elevated risk of psoriasis vulgaris and arthropathic psoriasis respectively among Europeans. Doctors should be aware of these associations when patients with psoriasis present with renal dysfunction, especially those with psoriasis vulgaris and arthropathic psoriasis. Chronic inflammation, drug effects, and immunity may contribute to the generation and development of both diseases. IL1β, CXCL9, CCL4, and MMP1 may be core biomarkers for psoriasis and IgAN.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A marker of systemic inflammation in hidradenitis suppurativa patients without cardiovascular disease: aortic arch calcification","authors":"Uğur Köktürk,&nbsp;Naile Eriş Güdül,&nbsp;İlke Erbay,&nbsp;Pelin Ertop Doğan,&nbsp;Emel Hazinedar,&nbsp;Furkan Kısa,&nbsp;Rafet Koca,&nbsp;Ahmet Avcı","doi":"10.1007/s00403-024-03461-8","DOIUrl":"10.1007/s00403-024-03461-8","url":null,"abstract":"<div><h3>Background</h3><p>In this study, we aimed to investigate whether there is a relationship between aortic arch calcification (AAC) and hidradenitis suppurativa (HS) in HS patients without cardiovascular disease.</p><h3>Methods</h3><p>In this study, patients over 18 years of age who applied to the dermatology outpatient clinic between January 2023 and February 2024 were followed up with the diagnosis of HS without cardiovascular disease, and a healthy control group matched in terms of age and gender were included retrospectively.</p><h3>Results</h3><p>In total, 130 patients with HS without cardiovascular disease and 130 control patients were included in the study. AAC was significantly higher in the HS group compared to the control group (<i>p</i> = 0.028). In the multivariate analysis, we found that age and HS were independent predictors of AAC (OR: 1.048 (1.009–1.089); <i>p</i> = 0.015, OR: 3.158 (1.181–8.445); <i>p</i> = 0.022, respectively). When we divided the groups as having AAC (grade 1–3) and not having AAC (grade 0), the rate of HS disease was significantly higher in the group with AAC compared to the group without AAC (75.0% vs. 47.5% <i>p</i> = 0.010).</p><h3>Conclusions</h3><p>AAC is observed more frequently in patients with HS without cardiovascular disease than in healthy individuals. Moreover, HS can be considered as an independent predictor of AAC. AAC may contribute to developing treatment strategies in HS patients without cardiovascular disease.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, treatment and outcome of subacute cutaneous lupus erythematosus induced by PD-1/PD-L1 inhibitors","authors":"Zhaoquan Wu,&nbsp;Rui Huang,&nbsp;Wei Sun,&nbsp;Binsheng He,&nbsp;Chunjiang Wang","doi":"10.1007/s00403-024-03484-1","DOIUrl":"10.1007/s00403-024-03484-1","url":null,"abstract":"<div><p>PD-1/PD-L1 inhibitors have increasingly been associated with the occurrence of subacute cutaneous lupus erythematosus (SCLE), but the clinical characteristics and outcomes remain under-explored. Literature on PD-1/PD-L1 inhibitors induced SCLE was retrieved from Chinese and English databases until June 31, 2024, and clinical data of patients were extracted for retrospective analysis. Twenty-nine patients participated, with a median age of 63 years (range 43, 80). The most frequently reported drugs were Nivolumab (51.7%) and pembrolizumab (31.0%). The median time from treatment initiation to SCLE onset was 3 months (range 0.5, 47). Cutaneous manifestations presented primarily as papulosquamous lesions (65.5%) and erythema annulare (31.0%), predominantly occurring on the trunk (51.7%) and arms (51.7%). Serological analysis revealed positive anti-Ro antibodies in 91.7% of patients, positive antinuclear antibodies in 75.0%, and positive anti-La antibodies in 50.0%. Skin biopsies showed interface dermatitis in 65.5% of cases and lymphocyte infiltration in 82.8%. Treatment with topical corticosteroids, systemic corticosteroids, and hydroxychloroquine led to gradual improvement or resolution of the rash, with a median recovery time of 1 month (range 0.5, 11). As the use of PD-1/PD-L1 inhibitors in oncology increases, SCLE should be recognized as a rare cutaneous adverse effect. Histological and serological evaluations play a critical role in diagnosing SCLE. Typically, SCLE resolves on its own with appropriate local and systemic treatment.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and development of a prognostic model for overall survival in pediatric and adolescent liposarcoma: a SEER database analysis","authors":"Zhenqi Liao,&nbsp;Yinuo Wu,&nbsp;Peng Wu,&nbsp;Xian Liu","doi":"10.1007/s00403-024-03482-3","DOIUrl":"10.1007/s00403-024-03482-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation and quality of life following the use of tranexamic acid in rosacea","authors":"J. Peruzzo,&nbsp;P. Barea,&nbsp;D. V. S. Crusius,&nbsp;L. F. Brum,&nbsp;O. A. G. D. Cionek,&nbsp;A. B. Fiegenbaum,&nbsp;J. C. Boza,&nbsp;R. R. Bonamigo","doi":"10.1007/s00403-024-03476-1","DOIUrl":"10.1007/s00403-024-03476-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia","authors":"Nadia Liquat,&nbsp;Mahreen Ul Hassan,&nbsp;Farheen Shafique,&nbsp;Sana Khan,&nbsp;Abdullah R. Alanzi,&nbsp;Najeeb Ullah Khan","doi":"10.1007/s00403-024-03436-9","DOIUrl":"10.1007/s00403-024-03436-9","url":null,"abstract":"<div><p>The purpose of this research was to identify the role of keratin proteins in causing inherited as well as pathogenic alopecia, pinpoint deleterious SNPs, and predict structural changes affecting protein-protein interactions in hair disorders. To elucidate the role of keratin proteins and genetic mutations in alopecia by analyzing protein structures through bioinformatics and identifying a mutation in the <i>LPAR6</i> gene. It sought to identify the microorganisms linked to alopecia and conducted a comprehensive bioinformatics analysis of proteins with unknown experimental structures and molecular simulation analysis. The study identified a genetic mutation (c.188 A &gt; T, p.Asp63Val) in the <i>LPAR6</i> gene associated with hereditary hair loss. Pathogenic alopecia was identified to be associated with <i>S. aureus</i> and two ic keratinophilic fungi namely <i>M. canis</i>, and <i>T. violaceum</i>. Additionally, among 14 proteins lacking prior structural information, four proteins namely Keratin, type II cuticular Hb3 (KR1), Keratin, type II cuticular Hb6 (KR2), Keratin, type II cytoskeletal 74 (KR3) and Keratin, type II cuticular Hb1 (KR4) exhibited common ‘K-head’ and ‘F’ domains. Docking analysis revealed five distinct binding sites (C1-C5) for each protein. The ‘K-head’ displayed the highest predicted binding affinities with Vina scores of -5.6 for KR2 and − 4.7 for KR4 whereas the ‘F’ domain showed Vina scores of -6.0 for KR3 and − 5.7 for KR2. This research underscores the crucial role of keratin proteins in both hereditary and pathogenic alopecia, emphasizing their significance for future investigations.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-024-03436-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety and quality improvement education in dermatology residency programs: a nationwide survey of program directors","authors":"Krithika Nayudu,&nbsp;David Xiang,&nbsp;Alice J. Watson,&nbsp;Vinod E. Nambudiri,&nbsp;Connie R. Shi","doi":"10.1007/s00403-024-03486-z","DOIUrl":"10.1007/s00403-024-03486-z","url":null,"abstract":"<div><h3>Background</h3><p>Patient Safety and Quality Improvement (PSQI) are key components of graduate medical training, as detailed by the Accreditation Council for Graduate Medical Education (ACGME), with specific requirements that residents participate in experiential learning in PSQI during residency training. This study aimed to analyze the breadth of available and required PSQI educational experiences across dermatology residency programs in the United States.</p><h3>Objectives/Methods</h3><p>The objective of this study was to characterize the scope of PSQI educational experiences across dermatology residency programs. We electronically surveyed program directors of all ACGME-accredited dermatology residency programs from September 2023 to March 2024. Responses to the survey were anonymously collected with Research Electronic Data Capture (REDCap).</p><h3>Results</h3><p>Of the 145 dermatology programs surveyed, 37 program directors responded (25.5%). 89.2% of programs reported requiring residents to participate in PSQI educational experiences, with the most common being participation in a resident-led QI project (70.3%), which was also the most commonly available experience (91.2%). The least common required experience was observed simulated patient safety events and analyses. 83.8% of programs reported formal mechanisms to assess residents’ competency in QI.</p><h3>Conclusions</h3><p>This study highlights variation in PSQI experiences within dermatology residency programs across the United States. More than 10% of surveyed programs reported no required QI experiences during residency training despite ACGME program requirements. Additional gaps include variation in assessment of resident PSQI competencies. This study provides insight on the current landscape of PSQI education across dermatology residency programs and identifies opportunities to strengthen dermatology programs’ PSQI educational offerings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary cutaneous malignancy after treatment of basal cell carcinoma with hedgehog pathway inhibitor: a systematic review","authors":"Christina M. Pierce,&nbsp;Rebecca J. Wang,&nbsp;Rebecca Howe,&nbsp;Brooke A. Burgess,&nbsp;Joshua L. Owen","doi":"10.1007/s00403-024-03471-6","DOIUrl":"10.1007/s00403-024-03471-6","url":null,"abstract":"<div><p>Several studies have been published describing development of cutaneous malignancy after vismodegib therapy; no systematic review has been conducted to interpret these data. Our objective was to systemically review reported cases of same-site or different-site cutaneous malignancy after smoothened inhibitor (SMOi) therapy for primary basal cell carcinoma (BCC). PubMed, CINAHL, and Scopus were systematically searched January 1, 2012 – March 28, 2024. Inclusion criteria: primary BCC, SMOi therapy, and biopsy-proven secondary malignancy. Exclusion criteria: non-human subjects. Bias was assessed using Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) tool. Twenty-three cases describing same-site secondary malignancy were included. Average patient age was 67.2 years, mean treatment time 8.4 months, and average latency period to secondary malignancy development of 10.2 months. Five cases describing different-site secondary cutaneous malignancies were included. Mean patient age was 80.4 years, mean treatment time 2.9 months, and mean latency period 4.5 months. Twenty-seven cases were associated with vismodegib, while one case described vismodegib then sonidegib therapy. Pathologies included squamous cell carcinoma, BCC, basosquamous carcinoma, and malignant melanoma. The mechanism(s) by which same-site and different-site secondary malignancy occur are not known; mechanisms may differ depending on location type and secondary tumor type. We discuss multiple mechanistic hypotheses including pharmacologic selective pressure leading to hedgehog pathway mutant cells and activation of pro-growth signaling, and potential protective effect of hedgehog inhibition from melanoma given reports of rapid growth after SMOi discontinuation. This study is limited by the small number of reported cases. Additional research is needed to investigate these hypotheses.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-024-03471-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of air pollution on skin microbiome: a link to skin barrier dysfunction","authors":"Suphagan Boonpethkaew,&nbsp;Sasin Charoensuksira,&nbsp;Jitlada Meephansan,&nbsp;Punyaphat Sirithanabadeekul,&nbsp;Chutinan Chueachavalit,&nbsp;Patlada Ingkaninanda,&nbsp;Suthida Visedthorn,&nbsp;Prangwalai Chanchaem,&nbsp;Pavaret Sivapornnukul,&nbsp;Sunchai Payungporn","doi":"10.1007/s00403-024-03448-5","DOIUrl":"10.1007/s00403-024-03448-5","url":null,"abstract":"<div><p>An equilibrium of skin microbiome is crucial for maintaining skin barrier function. However, external factors such as air pollution have the potential to disrupt this equilibrium. Hence, further investigation into the influence of air pollution on the skin microbiome emerges as a critical imperative. Healthy women matched for age from two different ambient air cities in Thailand: Bangkok, characterized by highly polluted air (HPA) (<i>n</i> = 33), and Songkhla, characterized by less polluted air (LPA) (<i>n</i> = 33) were recruited. Skin barrier physiological parameters were measured on the forehead skin. Microbiome samples were collected via the scraping and swabbing technique from the forehead skin and analyzed for microbiome profiles using amplicon sequencing. We found that the abundant microbiome at the phylum level was comparable between HPA- and LPA-exposed skin. However, microbiome diversity was decreased at genus level of fungus and species level of bacteria on HPA-exposed skin. Interestingly, some relatively higher enriched microbiome correlated with skin barrier physiological parameters. Specifically, a higher enrichment of <i>Streptococcus parasanguinis</i> on LPA-exposed skin correlated with both lower skin pH and higher stratum corneum (SC) hydration. Conversely, a higher enrichment of <i>Malassezia</i> spp. and <i>Aureobasidum</i> spp. on HPA-exposed skin was correlated with increased transepidermal water loss and decreased SC hydration, respectively. In conclusion, air pollution potentially affects the skin microbiome by reducing its diversity, disrupting its beneficial correlations with barrier physiology, and promoting the overgrowth of pathogenic microbiome, resulting in decreased hydration and increased pH levels. These factors could ultimately lead to skin barrier dysfunction.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridioides difficile and mortality in Hidradenitis Suppurativa patients: a retrospective cohort study","authors":"Marc A. Hill,&nbsp;Brock K. Montgomery,&nbsp;Jeremy S. Bordeaux","doi":"10.1007/s00403-024-03474-3","DOIUrl":"10.1007/s00403-024-03474-3","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"316 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}