Archives of Dermatological Research最新文献

{"title":"The comparative study of letibotulinum toxin A and onabotulinum toxin A in treatment of primary axillary hyperhidrosis","authors":"Sunatra Nitayavardhana,&nbsp;Romun Leaovitavat","doi":"10.1007/s00403-025-04069-2","DOIUrl":"10.1007/s00403-025-04069-2","url":null,"abstract":"<div><p>Primary axillary hyperhidrosis (PAH) is a challenging condition characterized by excessive underarm sweating. The U.S. Food and Drug Administration has approved onabotulinum toxin A (OnaBTX-A, Botox^®, Allergan Inc, USA) as the only botulinum toxin treatment for severe axillary hyperhidrosis, and it has demonstrated positive results. Recently, the off-label use of letibotulinum toxin A (LetiBTX-A, Hugel^®, Hugel Inc, Korea) has risen significantly for cosmetic purposes due to its effectiveness. For the treatment of primary axillary hyperhidrosis, the authors proposed that LetiBTX-A is at least as effective as OnaBTX-A. To evaluate the efficacy and safety of letibotulinum toxin A (LetiBTX-A) in comparison to onabotulinum toxin A (OnaBTX-A) for treating primary axillary hyperhidrosis (PAH). All participants with a diagnosis of moderate to severe primary axillary hyperhidrosis (Hyperhidrosis Disease Severity Scale (HDSS) score ≥ 2) received random injections of 50 U of LetiBTX-A in one armpit and 50 U of OnaBTX-A in the other site. HDSS score and hyperhidrosis area were measured by using the Minor’s iodine starch test. Participant satisfaction was evaluated at 1, 3, and 6 months following the injection. Onset of action and adverse events were also assessed. All 30 participants completed the study protocol, with the mean age was 34.44 ± 7.82 years and most of the participants were female. The mean age at onset was 20.47 ± 3.01 years and more than 50% of participants had a HDSS score of 3. There was no statistically significant difference observed in the reduction of HDSS scores, hyperhidrosis area, and participant satisfaction between the axillae treated with LetiBTX-A and those treated with OnaBTX-A at 1, 3 and 6 months after injections. The median onset of action of both LetiBTX-A and OnaBTX-A were 2 ± 1 day (<i>p</i> = 0.317). Procedure-related pain was comparable between 2 formulations (<i>P</i> = 0.876). No serious adverse event was observed. This study concluded that LetiBTX-A and OnaBTX-A demonstrate comparable efficacy and safety profiles in treating primary axillary hyperhidrosis (PAH).</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythm disruption promotes M1 macrophages polarization exacerbating the inflammatory response in rosacea","authors":"Ying Tu,&nbsp;Zhenghui Yang,&nbsp;Yunting He,&nbsp;Tingyu Wang,&nbsp;Piyan Hua,&nbsp;Qiuyan Yao,&nbsp;Hua Gu","doi":"10.1007/s00403-025-04060-x","DOIUrl":"10.1007/s00403-025-04060-x","url":null,"abstract":"<div><p>To explore the role of macrophage polarization induced by circadian rhythm disorder (CRD) in the aggravated inflammatory response of rosacea. The rosacesis-like animal model was established by intradermal injection of Cathelicidin antimicrobial peptide LL-37 (LL37) into the back of mice. HE staining, Western blot and immunofluorescence detection were used to investigate the effect of circadian rhythm disorder on the expression of inflammatory factors and macrophage polarization in rosacea. Overexpression of Brain and Muscle ARNT-Like 1 (Oe-Bmal1) was transfected into HaCaT cells and M0 macrophages treated with LL37 in vitro to investigate the role of Muscle ARNT-Like 1 (Bmal1) on rosacea. In LL37-induced rosacea mice, circadian rhythm disruption (CRD) suppressed the expression of circadian clock proteins, including Bmal1, Circadian Locomotor Output Cycles Kaput (Clock), Period Circadian Protein 1 (Per1), Period Circadian Protein 2 (Per2), Nuclear Receptor Subfamily 1 Group D Member 1 (Rev-erbα), and Retinoic Acid Receptor-Related Orphan Receptor Alpha (RORα), and induced the polarization of macrophages in rosacea-like mice towards the M1 phenotype. Subsequently, the expression of inflammatory factors, including Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and Interleukin-1 beta (IL-1β), was promoted, which aggravated the inflammatory response of skin lesions. Over-expression of Bmal1 significantly increased the expression level of clock proteins and inhibited the polarization of macrophages to M1 type, consequently inhibiting the expression of inflammatory factors in the cell model of rosacea. Circadian rhythm disorder may aggravate the inflammatory response of rosacea by affecting macrophage polarization, which indicates that paying attention to regular sleep and rest may be necessary for the treatment and management of rosacea.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sleep disorders in atopic dermatitis: a systematic review and meta-analysis","authors":"Ningxin Zhang,&nbsp;Huiyan Chi,&nbsp;Qiubai Jin,&nbsp;Meiqi Sun,&nbsp;Yuechun Zhao,&nbsp;Ping Song","doi":"10.1007/s00403-025-04176-0","DOIUrl":"10.1007/s00403-025-04176-0","url":null,"abstract":"<div><p>The aim of this meta-analysis was to determine the prevalence of sleep disorders among patients with atopic dermatitis (AD) and to explore the association between AD and sleep disorders. This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was prospectively registered in the International Prospective Systematic Review Registry (PROSPERO) database (registration number: CRD42024498045). Only English-written cross-sectional studies reporting the prevalence of sleep disorders in patients with AD were included in this analysis. We searched four databases: EMBASE, Web of Science, PubMed and the Cochrane Library as of 9 February 2025. Studies were screened using EndNote X9.1. Data were analyzed using STATA V15.0 software. Initially, a total of 861 studies were searched from databases. Ultimately, 32 studies including 85,921 participants were included in this meta-analysis. The prevalence of sleep disorders among individuals with AD was estimated using a random-effects model. The degree of heterogeneity was assessed by I² statistic. If significant heterogeneity was detected, the source of heterogeneity was determined by meta-regression, and sensitivity analyses were then conducted by sequentially excluding each study to assess the robustness of the findings. This analysis revealed that the combined prevalence of sleep disorders among patients with AD was 43.4% (95% confidence interval: 39.7%-47.1%). Subgroup analyses were conducted according to region, data source, year of publication, severity of AD, sleep disorder assessment scales, classification of sleep problems, nocturnal awakenings, and number of days of sleep disorders experienced per week.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04176-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study","authors":"Mahmoud A. Rageh,&nbsp;Emad M. Elrewiny,&nbsp;Ahmed S. Kadah,&nbsp;Hazem B. Zakaria,&nbsp;Mohamed Abdelshakour,&nbsp;Sara M. Mohy,&nbsp;Waleed Ahmed Mahmoud,&nbsp;Ahmed A. Suliman,&nbsp;Ahmed Abdelkader Mohamed","doi":"10.1007/s00403-025-04112-2","DOIUrl":"10.1007/s00403-025-04112-2","url":null,"abstract":"<div><p>Atrophic acne scarring is a prevalent problem that has been treated with a variety of procedures, each with various degrees of success. For better results, combined regimens of treatment are recommended. Our aim was to compare the efficacy of topical insulin against topical platelet-rich plasma (PRP) as an adjunct treatment to fractional CO2 laser for atrophic acne scars. The study comprised 30 patients with atrophic acne scars. All patients underwent four sessions of fractional CO2 laser on both sides of the face at one-month intervals, followed by topical PRP treatment on one side of the face and topical insulin on the other. Two non-treating dermatologists used the Acne Scar Assessment Scale (ASAS) to assess the outcome. At their last follow-up appointment, patients were asked to assess their improvement on each side of the face in a percentage from 0 to 100%. Prior to treatment, there was no difference in the ASAS scores between the two sides of the face. One month after the last treatment session, ASAS scores improved significantly on both sides of the face. No significant difference (<i>p</i> = 0.794) between both sides were detected. Both techniques helped to improve atrophic acne scars and may have a synergistic outcome regarding efficacy and safety.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salidroside alleviates atopic dermatitis-like responses by inhibiting MAPKs and NF-κB signaling pathways","authors":"Miaomiao Wang,&nbsp;Yujie Xiong","doi":"10.1007/s00403-025-04091-4","DOIUrl":"10.1007/s00403-025-04091-4","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is a chronic inflammatory skin disease. Salidroside, a major component of <i>Acer tegmentosum</i>, may be a valuable candidate for developing anti-AD agents. In this study, we investigated the therapeutic roles of salidroside and its related mechanisms in AD. For in vivo experiments, male BALB/c mice were challenged with 2,4-dinitrochlorobenzene (DNCB) to induce AD-like lesions and orally administered with salidroside for AD-like manifestations were induced by DNCB. Histological changes were assessed via hematoxylin-eosin staining and toluidine blue staining. Scratching numbers and spleen weight were evaluated. For in vitro experiments, TNF-α/IFN-γ-treated HaCaT cells and primary keratinocytes were used. Pro-inflammatory factors and pathway-associated proteins levels were measured by RT-qPCR and western blotting. Salidroside reduced the release of pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-treated HaCaT cells and primary keratinocytes. Salidroside alleviated DNCB-induced AD-like symptoms in mice. Salidroside attenuated the DNCB-induced atopic skin inflammation in vivo. Mechanistically, salidroside inactivated MAPK and NF-κB pathways in vitro and in vivo. Salidroside ameliorates AD-like responses via inactivating the MAPK and NF-κB pathways.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial evaluation of Melaleuca alternifolia essential oil for its antifungal activity against Trichophyton violaceum and its synergistic effects with ITZ and KTZ","authors":"Tanzeela Qayyum,&nbsp;Aroosh Shabbir,&nbsp;Najeeb Ullah,&nbsp;Abid Sarwar,&nbsp;Tariq Aziz,&nbsp;Nada K. Alharbi,&nbsp;Fatma Alshehri,&nbsp;Ashwag Shami,&nbsp;Fahad Al- Asmari,&nbsp;Maher S. Alwethaynani,&nbsp;Fakhria A. Al-Joufi","doi":"10.1007/s00403-025-04157-3","DOIUrl":"10.1007/s00403-025-04157-3","url":null,"abstract":"<div><p>This study was designed to evaluate the effects of <i>Melaleuca alternifolia</i> essential oil for its antifungal activity as mono-therapeutic agent, and in combination with current antifungal agents, like itraconazole and ketoconazole. To assess the significance of TTO (Tea Tree Oil), ITZ (Itraconazole) and KTZ (Ketoconazole), for in vitro susceptibility pattern of dermatophyte, which was obtained from the cases of clinically examined dermatophytosis, attending the dermatology outpatient department of Sheikh Zayed Hospital. The tea tree essential oil was extracted through steam distillation method using 500 g of fresh <i>Melaleuca alternifolia</i> leaves from Lawrence Garden and obtained the yield of 3 mL that comes to be 0.6%. <i>Trichophyton violaceum</i> grown on SDA Sabouraud dextrose agar ager plates for 48 h were tested for fungicidal activity using equal quantity of TTO employing well method technique. In a comparative study assessing the minimum fungicidal concentration (MFC) of ITZ and KTZ, the MFC of KTZ was found to be greater than the MFC of ITZ because the solution of same concentration produced lesser inhibition zones in case of ITZ as compared to KTZ. In another study to ascertain the synergistic effects of TTO with ITZ, it was established that TTO significantly potentiated the effect of azoles in combination therapy reducing the MFC of ITZ up to 8 folds from 4 to 0.07 ug/mL. In yet another study to cross check the synergistic effects of TTO with KTZ in combination therapy. It was positively found that TTO potentiated the fungicidal activity of KTZ, reducing the MFC of KTZ up to 8 folds from 0.25 to 0.03 μg/mL. Comparing the synergistic effects of TTO with ITZ and TTO with KTZ in combination therapies the inhibition zones produced by TTO with KTZ are found to be prominently biggest. Hence Synergy of TTO with KTZ is most proficient because it reduces the MFC of azole maximally while potentiating the fungicidal activity of KTZ.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential drugs associated with toxic epidermal necrolysis: a disproportionality analysis based on the FAERS database (2004–2024)","authors":"Xiaojian Li,&nbsp;Zhangren Yan,&nbsp;Shiyu Chen,&nbsp;Yunbo Wu,&nbsp;Guirong Qiu,&nbsp;Fengming Hu","doi":"10.1007/s00403-025-04107-z","DOIUrl":"10.1007/s00403-025-04107-z","url":null,"abstract":"<div><p>Toxic epidermal necrolysis (TEN) is a severe and potentially fatal skin reaction often associated with the use of multiple medications. Given the severity and potentially high fatality rate of TEN, identifying high-risk drugs is essential for improving clinical medication safety. The reporting odds ratio (ROR) was used to assess drug-related TEN reports in the FAERS database between Q1 2004 and Q3 2024. Univariate analysis, LASSO regression, and multivariate logistic regression were employed to explore the risk factors associated with drug-induced TEN. Bonferroni correction was applied for multiple comparisons. A total of 218 drugs were identified as being associated with TEN, including anticonvulsants (26/218), antibiotics (54/218), non-steroidal anti-inflammatory drugs (12/218), antineoplastic agents (3/218), and immunomodulatory drugs (8/218). Multivariate regression analysis revealed that the age group 37–66 years, as well as 26 specific drugs, including lamotrigine, phenytoin, carbamazepine, ciprofloxacin, sulfamethoxazole, and amoxicillin, might be risk factors factors for drug-induced TEN. These findings provide valuable insights to assist clinicians in early identification of drug-induced TEN, and offer a theoretical foundation for future drug safety evaluations and personalized treatment strategies.Constrained by the inherent limitations of disproportionality analysis, the current research findings on drugs related to TEN have a certain degree of uncertainty. Future research can utilize more advanced and rigorous research methods to earnestly explore the causal relationship between drugs and TEN.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA SNHG1 regulates human keratinocyte function by targeting miR-199a-3p to delay skin wound healing","authors":"Xuejuan Zan,&nbsp;Bin Liu,&nbsp;Huajiang Liu,&nbsp;Ting Yu,&nbsp;Yu Cao","doi":"10.1007/s00403-025-03868-x","DOIUrl":"10.1007/s00403-025-03868-x","url":null,"abstract":"<div><p>The persistence of wounds can cause limitations in the normal movement of patients. This study investigated the effects of long noncoding RNA (lncRNA) SNHG1 and miR-199a-3p on wound healing. In vitro skin wound modelling using LPS-induced keratinocytes. SNHG1 and miR-199a-3p levels were assessed by RT-qPCR. CCK-8 was used to determine the cells proliferative. Cell migration was analyzed using Transwell. Cell apoptosis was detected using flow cytometry. The inflammatory factors levels by ELISA assay. DLR assay was used to validate the binding of SNHG1 to miR-199a-3p targets. Increased SNHG1 levels, decreased proliferation and migration, and increased apoptosis in successfully modelled cells. Inflammatory factors levels were notably increased in the treated cells. The cells proliferative and migratory were restored, the apoptosis rate decreased and inflammatory factors levels decreased after SNHG1 knockdown. Molecularly, SNHG1 targets miR-199a-3p. The increase in cell proliferation and migration caused by SNHG1 knockdown was reversed by the addition of miR-199a-3p inhibitor. Apoptosis rate was increased, as were the levels of inflammatory factors. Silencing SNHG1 induced miR-199a-3p high expression, which contributed to the proliferative and migratory activities of HaCaT cells, promoting the shift of cells from the inflammatory phase to the proliferative phase and facilitating wound healing.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for predicting overall survival in patients with lower extremity melanoma: based on the Surveillance, Epidemiology, and End Results (SEER) database","authors":"Chunrong Ma,&nbsp;Li Hao,&nbsp;Jiyue Luo,&nbsp;Bin He,&nbsp;Si Liao,&nbsp;Fan Wang,&nbsp;Hongyi Fu,&nbsp;Shun Zhang","doi":"10.1007/s00403-025-04141-x","DOIUrl":"10.1007/s00403-025-04141-x","url":null,"abstract":"<div><p>Lower extremity melanoma (LEM) is a relatively common malignant tumor with a poor prognosis. This study aims to identify prognostic factors and develop a nomogram model to predict overall survival (OS) in patients with LEM. A total of 4257 LEM patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into a training set (2979 cases) and a validation set (1278 cases). In the training set, univariate and multivariate Cox regression analyses were conducted to identify independent prognostic factors associated with patient outcomes, and a nomogram model was constructed. The model’s validity was then assessed by generating ROC curves, C-index, clinical decision curve analysis (DCA), and calibration curves, and validated using the validation set. Multivariate Cox regression analysis in the training set revealed that age, gender, AJCC stage, AJCC.M, Breslow thickness, radiotherapy, mitotic rate, ulceration, first malignant primary indicator, and marital status were independent variables associated with OS. In both the training and validation sets, the area under the curve (AUC) for predicting 1-year, 3-year, and 5-year OS was 0.887, 0.868, and 0.859, and 0.859, 0.872, and 0.848, respectively. The C-index, calibration curves, and DCA demonstrated good agreement in both the training and validation sets. In this study, we developed and validated a nomogram to predict OS in patients with LEM, demonstrating good reliability and clinical applicability.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal relationship between vitiligo and psoriasis: a bidirectional Mendelian randomization analysis","authors":"Zhengxing Xu,&nbsp;Chao Yang,&nbsp;Xuehui Gan,&nbsp;Peijing Yan,&nbsp;Changfeng Xiao,&nbsp;Yunli Ye,&nbsp;Xia Jiang","doi":"10.1007/s00403-025-04102-4","DOIUrl":"10.1007/s00403-025-04102-4","url":null,"abstract":"<div><p>Observational studies have demonstrated an association between vitiligo and psoriasis. However, to date, the causal nature of this association remains uncertain. The objective of this study was to investigate the potential bidirectional causal relationship between vitiligo and psoriasis by employing a bidirectional two-sample Mendelian randomization (MR) approach. We utilized summary statistics obtained from the genome-wide association study (GWAS) conducted in European ancestry for vitiligo (<i>N</i> = 44,266) and psoriasis (<i>N</i> = 373,338). We first performed univariate MR analysis to detect potential bidirectional causality between vitiligo and psoriasis. Then, for directions in which univariate MR confirmed a causal relationship, we further conducted multivariate MR analysis to investigate independent causal effects on the outcome considering exposure to confounders. The bidirectional two-sample MR analysis showed genetic liability to vitiligo was significantly associated with an increased risk of psoriasis (<i>OR</i> = 1.094, 95% <i>CI</i>: 1.052, 1.138), but there was no significant association between genetic liability to psoriasis and risk of vitiligo (<i>OR</i> = 1.176, 95% <i>CI</i>: 0.915, 1.511). For the vitiligo to psoriasis direction, multivariate MR adjusting for smoking, drinking, body mass index, and rheumatoid arthritis showed the presumed causality was despite attenuated (<i>OR</i> = 1.060, 95% <i>CI</i>:1.035, 1.085), and remained statistically significant. Our study suggests that vitiligo is a causal risk factor for psoriasis, but the reverse may not be true. It is emphasized by the evidence from this study that enhanced early screening for psoriasis among patients with vitiligo may help to reduce the incidence of psoriasis.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04102-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}