Archives of Dermatological Research最新文献

{"title":"Cross-sectional study of skin diseases in Iranians using the global burden of disease database","authors":"Dev Patel,&nbsp;Atef Fayed,&nbsp;Naeha Pathak,&nbsp;Omar Alani,&nbsp;Dany Alkurdi,&nbsp;Shari R. Lipner","doi":"10.1007/s00403-025-04115-z","DOIUrl":"10.1007/s00403-025-04115-z","url":null,"abstract":"<div><p>Our study aimed to characterize the dermatologic health needs among Iranians by utilizing data from the Global Burden of Disease (GBD) database.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping access to care: a powerful medium to visualize barriers to care","authors":"Ashima Agarwal,&nbsp;Alaina J. James","doi":"10.1007/s00403-025-04122-0","DOIUrl":"10.1007/s00403-025-04122-0","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitiligo treatment trends in underrepresented groups","authors":"Sara D. Ragi,&nbsp;Megan M. Tran,&nbsp;Megan Hoang,&nbsp;Zachary Lin,&nbsp;Mayra BC Maymone,&nbsp;John Kawaoka,&nbsp;Neelam A. Vashi","doi":"10.1007/s00403-025-04116-y","DOIUrl":"10.1007/s00403-025-04116-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regulatory effects of vitamins on immunity and skin health","authors":"Agatha Ngukuran Jikah,&nbsp;Great Iruoghene Edo,&nbsp;Ali B. M. Ali,&nbsp;Patrick Othuke Akpoghelie,&nbsp;Emad Yousif,&nbsp;Endurance Fegor Isoje,&nbsp;Ufuoma Augustina Igbuku,&nbsp;Khalid Zainulabdeen,&nbsp;Joseph Oghenewogaga Owheruo,&nbsp;Arthur Efeoghene Athan Essaghah,&nbsp;Huzaifa Umar,&nbsp;Dina S. Ahmed,&nbsp;Ahmed A. Alamiery","doi":"10.1007/s00403-025-04086-1","DOIUrl":"10.1007/s00403-025-04086-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype-endotype relationship in elderly atopic dermatitis and effects of dupilumab therapy: prospective study","authors":"Giuseppina Caiazzo,&nbsp;Maddalena Napolitano,&nbsp;Maria Quaranta,&nbsp;Vincenzo Picone,&nbsp;Gabriella Fabbrocini,&nbsp;Cataldo Patruno","doi":"10.1007/s00403-025-04090-5","DOIUrl":"10.1007/s00403-025-04090-5","url":null,"abstract":"<div><p>Atopic dermatitis is a chronic inflammatory systemic disease that can persist or start in adulthood, even in elderly age, with several clinical phenotypes. The aim of this study was to evaluate the relationship between phenotype and endotype in elderly patients, and the long-term effects of dupilumab on molecular signature in these patients. A total of 50 elderly patients had been treated with dupilumab during the follow up period. Regarding effectiveness parameters, mean EASI score at Week 0 was 25.12 ± 4.23 and significantly reduced to 2.42 ± 3.15 at Week 52 (<i>p</i> &lt; 0.05). Regarding safety, none of the registered adverse events led to the discontinuation of dupilumab therapy. Moreover, after 52 weeks of dupilumab treatment, Th2 cytokines expression was decreased, with IL-13 and IL-31 downregulated in both patient groups at Week 52, at both gene and protein levels when compared with Week 0. Our data also revealed a significant increase in both IL-4 gene expression and protein production at Week 52 when compared with Week 0. Unexpectedly, our results also revealed that IL-22 cutaneous expression was significantly increased, while circulating levels were decreased at Week 52 when compared to Week 0. In conclusion, our results highlight the effectiveness of dupilumab at a late time point as Week 52. Of note, a dumping of the Th2- and Th17- immune response at both systemic and in situ level and a possible remodelling role of IL-22 in the skin is suggested.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04090-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous viral infection comorbidities in patients with basal cell carcinoma","authors":"Amritpal Kooner,&nbsp;Rawle. A Sekhon,&nbsp;Justin Chen,&nbsp;Aditya Dutt","doi":"10.1007/s00403-025-04124-y","DOIUrl":"10.1007/s00403-025-04124-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key considerations of injectable minoxidil for alopecia","authors":"Carli D. Needle,&nbsp;Anna L. Brinks,&nbsp;Caitlin A. Kearney,&nbsp;Jerry Shapiro,&nbsp;Kristen I. Lo Sicco","doi":"10.1007/s00403-025-04068-3","DOIUrl":"10.1007/s00403-025-04068-3","url":null,"abstract":"<div><p>Minoxidil has become an increasingly popular treatment option for hair loss disorders including androgenetic alopecia, cicatricial alopecia, and alopecia areata. There are various minoxidil formulations available including topical, oral, and injectable minoxidil. While injectable minoxidil may offer certain advantages, potential risks and costs should also be considered. First, we explore the enhanced bioavailability of injectable minoxidil in comparison to topical and oral formulations, as well as the variability in sulfotransferase enzyme levels and its role in the activation of minoxidil at hair follicles. Furthermore, we expand upon the potential adverse effects associated with injectable minoxidil given its widespread systemic distribution. We also highlight the importance of considering cost, access, and availability of injectable minoxidil given that injections are significantly more expensive than oral minoxidil tablets and involve the additional obstacle of frequent dermatology visits. Depending on geographic region and socioeconomic status, many patients may not live in sufficiently close proximity to a dermatologist for this level of care. Finally, we emphasize the need for ongoing research efforts to compare the efficacy, access, and tolerability of injectable minoxidil, alternative minoxidil formulations, and other alopecia medications.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of skin of color in patient education materials for discoid lupus erythematosus","authors":"Sabrina M. Saeed,&nbsp;Ebere Ajoku,&nbsp;Madisen A. Swallow,&nbsp;Matthew D. Vesely,&nbsp;Jeff R. Gehlhausen,&nbsp;Alicia J. Little,&nbsp;Fotios Koumpouras,&nbsp;Sarika Ramachandran","doi":"10.1007/s00403-025-04094-1","DOIUrl":"10.1007/s00403-025-04094-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of the skin microbiome with human infertility: insights from a bidirectional two-sample Mendelian randomization","authors":"Shucheng Hu,&nbsp;Jiaojiao Dong,&nbsp;Yuhui Che,&nbsp;Jing Guo","doi":"10.1007/s00403-025-04098-x","DOIUrl":"10.1007/s00403-025-04098-x","url":null,"abstract":"<div><p>Infertility is a disorder characterized by the inability to achieve a clinical pregnancy after 12 months of regular and unprotected sexual activity. Affecting 8–12% of the global population, with the continuous progress of microbial research in recent years, a variety of microorganisms may be associated with the onset of infertility. We therefore used a two-sample MR Analysis to investigate the association between skin microbes and infertility. we used preprocessed exposure data to correlate infertility measures (infertility in women, associated with anovulation; Female infertility, cervical infertility, vaginal infertility, other infertility or unknown causes; Female infertility, fallopian tube origin; ED; Based on this, the positive results were subjected to horizontal pleiotropy analysis and heterogeneity analysis. Finally, Steiger test was performed to confirm the absence of reverse causality. The data used in this study were obtained from the published GWAS data sets. skin microbiota from the study conducted by Moitinho-Silva et al., and the exposure from the Finn. In this study, we found a positive causal association between Lactobacillales, Clostridiales, Pseudomonadales, and Moraxellaceae and female infertility and anovulation by MR Analysis of two samples. Enhydrobacter, Betaproteobacteria have a negative causal association with female infertility and anovulation. Lactobacillales and Alphaproteobacteria had positive causal association with female infertility, cervical infertility, vaginal infertility, other infertility or unknown causes. There was a negative causal association between Haemophilus and female infertility, cervical infertility, vaginal infertility, other infertility or unknown causes. Alphaproteobacteria are positively correlated with female infertility and fallopian tube origin. Bacteroidetes is negatively correlated with female infertility and fallopian tube origin. Rhodobacteraceae, Clostridiales and Flavobacteriaceae had a negative causal association with male infertility. Corynebacterium had a positive causal association with ED, and Micrococcus had a negative causal association with ED. Our study reveals a causal association between skin microbiota and infertility, and provides a theoretical basis for the inclusion of skin microbiota in the prevention and treatment of infertility. To the best of our knowledge, our study is the first MR Analysis to explore the potential causal association between skin microbiota and infertility. On this basis, we make a reasonable hypothesis that skin microbes cause infertility, and propose possible mechanisms. Our research contributes to the prevention and treatment of clinical infertility.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and dermoscopic features of Merkel cell carcinoma: insights from 16 cases, including two reflectance confocal microscopy evaluation and the identification of four representative MCC subtypes.","authors":"Biagio Scotti,&nbsp;Elena Cama,&nbsp;Federico Venturi,&nbsp;Gulia Veronesi,&nbsp;Emi Dika","doi":"10.1007/s00403-025-04118-w","DOIUrl":"10.1007/s00403-025-04118-w","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}